CA2218759A1 - Nouveaux variants de l'apolipoproteine a-i - Google Patents

Nouveaux variants de l'apolipoproteine a-i Download PDF

Info

Publication number: CA2218759A1
Authority: CA; Canada
Prior art keywords: apoa; nucleic acid; variant; sequence; vector
Prior art date: 1995-05-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002218759A

Other languages

English (en)

French (fr)

Inventor

Jean-Charles Fruchart

Harald Funke

Gerard Turpin

Gerd Assmann

Gerald Luc

Eric Bruckert

Patrick Benoit

Patrice Denefle

Nicolas Duverger

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Universite Pierre et Marie Curie

Institut Pasteur de Lille

Aventis Pharma SA

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-05-22

Filing date

1996-05-20

Publication date

1996-11-28

1996-05-20 Application filed by Individual filed Critical Individual

1996-11-28 Publication of CA2218759A1 publication Critical patent/CA2218759A1/fr

Status Abandoned legal-status Critical Current

Links

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239000011780 sodium chloride Substances 0.000 description 1
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000000527 sonication Methods 0.000 description 1
150000003431 steroids Chemical class 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
229960005322 streptomycin Drugs 0.000 description 1
210000004304 subcutaneous tissue Anatomy 0.000 description 1
230000001629 suppression Effects 0.000 description 1
239000012581 transferrin Substances 0.000 description 1
238000011830 transgenic mouse model Methods 0.000 description 1
230000007704 transition Effects 0.000 description 1
230000032258 transport Effects 0.000 description 1
108700004896 tripeptide FEG Proteins 0.000 description 1
238000005199 ultracentrifugation Methods 0.000 description 1
230000002792 vascular Effects 0.000 description 1
238000012795 verification Methods 0.000 description 1
108090000195 villin Proteins 0.000 description 1
210000005048 vimentin Anatomy 0.000 description 1
230000006648 viral gene expression Effects 0.000 description 1
210000002845 virion Anatomy 0.000 description 1
238000012800 visualization Methods 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Plant Pathology (AREA)
Toxicology (AREA)
Heart & Thoracic Surgery (AREA)
Microbiology (AREA)
Cardiology (AREA)
Physics & Mathematics (AREA)
Gastroenterology & Hepatology (AREA)
Vascular Medicine (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Virology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)

CA002218759A 1995-05-22 1996-05-20 Nouveaux variants de l'apolipoproteine a-i Abandoned CA2218759A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9506061A FR2734568B1 (fr)	1995-05-22	1995-05-22	Nouveaux variants de l'apolipoproteine
FR9506061		1995-05-22

Publications (1)

Publication Number	Publication Date
CA2218759A1 true CA2218759A1 (fr)	1996-11-28

Family

ID=9479241

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002218759A Abandoned CA2218759A1 (fr)	1995-05-22	1996-05-20	Nouveaux variants de l'apolipoproteine a-i

Country Status (16)

Country	Link
EP (1)	EP0827538A1 (hu)
JP (1)	JPH11505712A (hu)
KR (1)	KR19990021828A (hu)
AU (1)	AU717202B2 (hu)
BR (1)	BR9608813A (hu)
CA (1)	CA2218759A1 (hu)
CZ (1)	CZ291376B6 (hu)
FR (1)	FR2734568B1 (hu)
HU (1)	HUP9802926A3 (hu)
IL (1)	IL118336A0 (hu)
MX (1)	MX9708727A (hu)
NO (1)	NO975367D0 (hu)
SK (1)	SK156397A3 (hu)
TW (1)	TW434260B (hu)
WO (1)	WO1996037608A1 (hu)
ZA (1)	ZA964097B (hu)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6518412B1 (en)	1997-09-29	2003-02-11	Jean-Louis Dasseux	Gene therapy approaches to supply apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6046166A (en)	1997-09-29	2000-04-04	Jean-Louis Dasseux	Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6004925A (en)	1997-09-29	1999-12-21	J. L. Dasseux	Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6037323A (en)	1997-09-29	2000-03-14	Jean-Louis Dasseux	Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
JP2004500105A (ja) *	2000-03-13	2004-01-08	アムジエン・インコーポレーテツド	Ｔ細胞シグナル伝達のアポリポタンパク質−ａ−１調節
JP4344136B2 (ja)	2000-11-10	2009-10-14	エフ・ホフマン−ラ・ロシュ・リミテッド	アポリポタンパク質類似体
US8119590B2 (en)	2001-09-28	2012-02-21	Cedars-Sinai Medical Center	Prevention and treatment of restenosis by local administration of drug
US7223726B2 (en) *	2002-01-14	2007-05-29	The Regents Of The University Of California	Apolipoprotein A-I mutant proteins having cysteine substitutions and polynucleotides encoding same
BR0310099A (pt)	2002-05-17	2007-03-20	Esperion Therapeutics Inc	método para tratar dislipidemia ou uma doença associada com a dislipidemia
CA2515892C (en)	2003-02-14	2012-10-23	Children's Hospital & Research Center At Oakland	Lipophilic drug delivery vehicle and methods of use thereof
US8926958B2 (en)	2004-04-06	2015-01-06	Cedars-Sinai Medical Center	Prevention and treatment of vascular disease with recombinant adeno-associated virus vectors encoding apolipoprotein A-I and apolipoprotein A-I milano
KR100560102B1 (ko)	2004-06-25	2006-03-13	한국생명공학연구원	프로아포리포단백질 ａ－ⅰ 변이체와, 이를 포함하는고지혈증 또는 동맥경화증 예방 및 치료제
WO2006012632A2 (en) *	2004-07-23	2006-02-02	Xencor, Inc.	Apolipoprotein a-1 derivatives with altered immunogenicity
KR100725642B1 (ko) *	2006-01-20	2007-06-07	충남대학교산학협력단	저밀도 지단백질에 대해 항산화성을 갖는 펩타이드
EP2537526A1 (en)	2006-06-01	2012-12-26	Institut de Cardiologie de Montréal	Method and compound for the treatment of valvular stenosis
US8268796B2 (en)	2008-06-27	2012-09-18	Children's Hospital & Research Center At Oakland	Lipophilic nucleic acid delivery vehicle and methods of use thereof
US8153606B2 (en) *	2008-10-03	2012-04-10	Opko Curna, Llc	Treatment of apolipoprotein-A1 related diseases by inhibition of natural antisense transcript to apolipoprotein-A1
PL2396017T3 (pl)	2009-02-16	2015-12-31	Cerenis Therapeutics Holding Sa	Mimetyki apolipoproteiny A-l
RU2017126088A (ru)	2011-02-07	2019-01-31	Серени Терапеутикс Холдинг С.А.	Липопротеиновые комплексы и их получение и применения

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9103701D0 (sv) *	1991-12-13	1991-12-13	Kabi Pharmacia Ab	Apolipoprotein
FR2704556B1 (fr) *	1993-04-30	1995-07-13	Rhone Poulenc Rorer Sa	Virus recombinants et leur utilisation en thérapie génique.

1995
- 1995-05-22 FR FR9506061A patent/FR2734568B1/fr not_active Expired - Fee Related
1996
- 1996-05-20 JP JP8535430A patent/JPH11505712A/ja not_active Withdrawn
- 1996-05-20 CA CA002218759A patent/CA2218759A1/fr not_active Abandoned
- 1996-05-20 WO PCT/FR1996/000747 patent/WO1996037608A1/fr not_active Application Discontinuation
- 1996-05-20 IL IL11833696A patent/IL118336A0/xx unknown
- 1996-05-20 HU HU9802926A patent/HUP9802926A3/hu unknown
- 1996-05-20 BR BR9608813A patent/BR9608813A/pt not_active Application Discontinuation
- 1996-05-20 MX MX9708727A patent/MX9708727A/es unknown
- 1996-05-20 KR KR1019970708302A patent/KR19990021828A/ko not_active Application Discontinuation
- 1996-05-20 EP EP96916216A patent/EP0827538A1/fr not_active Withdrawn
- 1996-05-20 CZ CZ19973671A patent/CZ291376B6/cs not_active IP Right Cessation
- 1996-05-20 AU AU59048/96A patent/AU717202B2/en not_active Ceased
- 1996-05-20 SK SK1563-97A patent/SK156397A3/sk unknown
- 1996-05-22 ZA ZA964097A patent/ZA964097B/xx unknown
- 1996-05-22 TW TW085106086A patent/TW434260B/zh active
1997
- 1997-11-21 NO NO975367A patent/NO975367D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
IL118336A0 (en)	1996-09-12
CZ291376B6 (cs)	2003-02-12
FR2734568B1 (fr)	1997-06-20
KR19990021828A (ko)	1999-03-25
EP0827538A1 (fr)	1998-03-11
WO1996037608A1 (fr)	1996-11-28
FR2734568A1 (fr)	1996-11-29
SK156397A3 (en)	1998-07-08
ZA964097B (en)	1996-12-06
HUP9802926A2 (hu)	1999-03-29
CZ367197A3 (cs)	1998-03-18
NO975367L (no)	1997-11-21
AU717202B2 (en)	2000-03-23
JPH11505712A (ja)	1999-05-25
TW434260B (en)	2001-05-16
NO975367D0 (no)	1997-11-21
MX9708727A (es)	1997-12-31
AU5904896A (en)	1996-12-11
BR9608813A (pt)	1999-02-17
HUP9802926A3 (en)	2001-08-28

Publication	Publication Date	Title
CA2218759A1 (fr)	1996-11-28	Nouveaux variants de l'apolipoproteine a-i
US6258596B1 (en)	2001-07-10	Variants of apolipoprotein A-I
EP0701450B1 (fr)	1998-08-12	Virus recombinants et leur utilisation en therapie genique
CA2184841C (fr)	2009-08-18	Adenovirus recombinants codant pour le facteur neurotrophique des cellules gliales (gdnf)
JP2010000090A (ja)	2010-01-07	機能あるヒトリポタンパク質（ａ）を発現するトランスジェニックウサギ
WO1993015198A1 (fr)	1993-08-05	Polypeptides derives de l'apolipoproteine aiv humaine, leur preparation et leur utilisation
EP0750675A1 (fr)	1997-01-02	ADENOVIRUS RECOMBINANTS CODANT POUR LE FACTEUR DE CROISSANCE DES FIBROBLASTES ACIDES (aFGF)
CA2184297C (fr)	2009-09-29	Virus recombinants codant pour une activite glutamate decarboxylase (gad)
EP0763116B1 (fr)	2003-09-03	Virus recombinants, preparation et utilisation en therapie genique
EP0750676A1 (fr)	1997-01-02	Adenovirus recombinants codant pour le facteur neurotrophique derive du cerveau (bdnf)
EP0750674A1 (fr)	1997-01-02	ADENOVIRUS RECOMBINANTS POUR LE FACTEUR DE MATURATION DES CELLULES GLIALES DE TYPE BETA (GMF-$g(b))
FR2726575A1 (fr)	1996-05-10	Virus recombinants, preparation et utilisation en therapie genique
AU4237599A (en)	1999-09-30	Recombinant viruses, preparation and use thereof in gene therapy

Legal Events

Date	Code	Title	Description
2003-05-20	EEER	Examination request
2005-05-20	FZDE	Discontinued