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CA2216371A1 - Novel "burst-free" sustained release poly-(lactide/glycolide) microspheres - Google Patents

Novel "burst-free" sustained release poly-(lactide/glycolide) microspheres

Info

Publication number
CA2216371A1
CA2216371A1 CA002216371A CA2216371A CA2216371A1 CA 2216371 A1 CA2216371 A1 CA 2216371A1 CA 002216371 A CA002216371 A CA 002216371A CA 2216371 A CA2216371 A CA 2216371A CA 2216371 A1 CA2216371 A1 CA 2216371A1
Authority
CA
Canada
Prior art keywords
free
glycolide
lactide
sustained release
burst
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002216371A
Other languages
French (fr)
Other versions
CA2216371C (en
Inventor
Ramasubbu Jeyanthi
John F. Van Hamont
Phil Friden
Robert H. Reid
F. Donald Roberts
Charles E. Mcqueen
Jean A. Setterstrom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
United States Department of the Army
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from PCT/US1996/019440 external-priority patent/WO1997026869A1/en
Publication of CA2216371A1 publication Critical patent/CA2216371A1/en
Application granted granted Critical
Publication of CA2216371C publication Critical patent/CA2216371C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Novel burst-free, sustained release biocompatible and biodegradable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer as a blend of uncapped (free carboxyl end group) and end-capped forms ranging in ratios from 100/0 to 1/99.
CA002216371A 1996-01-24 1996-11-18 Novel "burst-free" sustained release poly-(lactide/glycolide) microspheres Expired - Fee Related CA2216371C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US59097396A 1996-01-24 1996-01-24
US08/590,973 1996-01-24
PCT/US1996/019440 WO1997026869A1 (en) 1996-01-24 1996-11-18 Novel 'burst-free' sustained release poly-(lactide/glycolide) microspheres

Publications (2)

Publication Number Publication Date
CA2216371A1 true CA2216371A1 (en) 1997-07-31
CA2216371C CA2216371C (en) 2005-11-01

Family

ID=35431048

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002216371A Expired - Fee Related CA2216371C (en) 1996-01-24 1996-11-18 Novel "burst-free" sustained release poly-(lactide/glycolide) microspheres

Country Status (1)

Country Link
CA (1) CA2216371C (en)

Also Published As

Publication number Publication date
CA2216371C (en) 2005-11-01

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20131119