CA2210631A1 - Tricyclic benzazepine vasopressin antagonists - Google Patents
Tricyclic benzazepine vasopressin antagonistsInfo
- Publication number
- CA2210631A1 CA2210631A1 CA002210631A CA2210631A CA2210631A1 CA 2210631 A1 CA2210631 A1 CA 2210631A1 CA 002210631 A CA002210631 A CA 002210631A CA 2210631 A CA2210631 A CA 2210631A CA 2210631 A1 CA2210631 A1 CA 2210631A1
- Authority
- CA
- Canada
- Prior art keywords
- vasopressin antagonists
- tricyclic benzazepine
- compounds
- benzazepine vasopressin
- exhibit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940116211 Vasopressin antagonist Drugs 0.000 title abstract 2
- 239000003038 vasopressin antagonist Substances 0.000 title abstract 2
- DQFQCHIDRBIESA-UHFFFAOYSA-N 1-benzazepine Chemical compound N1C=CC=CC2=CC=CC=C12 DQFQCHIDRBIESA-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102000004136 Vasopressin Receptors Human genes 0.000 abstract 2
- 108090000643 Vasopressin Receptors Proteins 0.000 abstract 2
- 239000005557 antagonist Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000008060 renal absorption Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Tricyclic compound of general formula (I) as defined herein which exhibit antagonist activity at V1 and/or V2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and process for preparing such compounds.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/373,132 | 1995-01-17 | ||
| US08/373,132 US5536718A (en) | 1995-01-17 | 1995-01-17 | Tricyclic benzazepine vasopressin antagonists |
| PCT/US1996/001076 WO1996022293A1 (en) | 1995-01-17 | 1996-01-16 | Tricyclic benzazepine vasopressin antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2210631A1 true CA2210631A1 (en) | 1996-07-25 |
| CA2210631C CA2210631C (en) | 2006-03-14 |
Family
ID=36095739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002210631A Expired - Fee Related CA2210631C (en) | 1995-01-17 | 1996-01-16 | Tricyclic benzazepine vasopressin antagonists |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2210631C (en) |
-
1996
- 1996-01-16 CA CA002210631A patent/CA2210631C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2210631C (en) | 2006-03-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |