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CA2208241A1 - Stable solutions of 2-chloro-2'-deoxyadenosine formulations - Google Patents

Stable solutions of 2-chloro-2'-deoxyadenosine formulations

Info

Publication number
CA2208241A1
CA2208241A1 CA002208241A CA2208241A CA2208241A1 CA 2208241 A1 CA2208241 A1 CA 2208241A1 CA 002208241 A CA002208241 A CA 002208241A CA 2208241 A CA2208241 A CA 2208241A CA 2208241 A1 CA2208241 A1 CA 2208241A1
Authority
CA
Canada
Prior art keywords
formulations
deoxyadenosine
chloro
stable solutions
cda
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002208241A
Other languages
French (fr)
Other versions
CA2208241C (en
Inventor
Michael Bornstein
Rosemary Rozman
Kevin Francis Long
Hsiao Yung Guh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/362,106 external-priority patent/US5641757A/en
Application filed by Individual filed Critical Individual
Publication of CA2208241A1 publication Critical patent/CA2208241A1/en
Application granted granted Critical
Publication of CA2208241C publication Critical patent/CA2208241C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Shelf stable formulations of 2-CdA in water are disclosed which contain benzyl alcohol, m-cresol, a buffer and sodium chloride or a solubilizing agent such as propylene glycol or polyethylene glycol.
CA002208241A 1994-12-21 1995-12-15 Stable solutions of 2-chloro-2'-deoxyadenosine formulations Expired - Lifetime CA2208241C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/362,106 US5641757A (en) 1994-12-21 1994-12-21 Stable 2-chloro-2'-deoxyadenosine formulations
US08/362,106 1994-12-22
PCT/US1995/016238 WO1996019229A1 (en) 1994-12-21 1995-12-15 Stable solutions of 2-chloro-2'-deoxyadenosine formulations

Publications (2)

Publication Number Publication Date
CA2208241A1 true CA2208241A1 (en) 1996-06-27
CA2208241C CA2208241C (en) 2007-05-22

Family

ID=38156704

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002208241A Expired - Lifetime CA2208241C (en) 1994-12-21 1995-12-15 Stable solutions of 2-chloro-2'-deoxyadenosine formulations

Country Status (1)

Country Link
CA (1) CA2208241C (en)

Also Published As

Publication number Publication date
CA2208241C (en) 2007-05-22

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Effective date: 20151215