CA2181089A1 - Piperidine Derivatives and Process for Their Production - Google Patents
Piperidine Derivatives and Process for Their ProductionInfo
- Publication number
- CA2181089A1 CA2181089A1 CA2181089A CA2181089A CA2181089A1 CA 2181089 A1 CA2181089 A1 CA 2181089A1 CA 2181089 A CA2181089 A CA 2181089A CA 2181089 A CA2181089 A CA 2181089A CA 2181089 A1 CA2181089 A1 CA 2181089A1
- Authority
- CA
- Canada
- Prior art keywords
- hydrogen
- production
- substituents
- hydroxy
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003053 piperidines Chemical class 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- -1 piperidine derivative compounds Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
Landscapes
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to substantially pure piperidine derivative compounds as shown below, wherein R1 is hydrogen or hydroxy; R2 is hydrogen; or R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2; R3 is -COOH or -COOH4; R4 is an alkyl with 1 to 6 carbon atoms; A, B, and D are the substituents of their respective rings each of which may be different or the same and are hydrogen, halogens, alkyl, hydroxy, alkoxy, or other substituents. A process of preparing such piperidine derivative compounds in substantially pure form is also disclosed.
(see formula I) or (see formula II)
(see formula I) or (see formula II)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8310293A | 1993-06-24 | 1993-06-24 | |
| US08/083,102 | 1993-06-24 | ||
| CA002147126A CA2147126C (en) | 1993-06-24 | 1994-06-21 | Piperidine derivatives and process for their production |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002147126A Division CA2147126C (en) | 1993-06-24 | 1994-06-21 | Piperidine derivatives and process for their production |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2181089A1 true CA2181089A1 (en) | 1994-12-25 |
| CA2181089C CA2181089C (en) | 2000-05-23 |
Family
ID=25677908
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002254506A Expired - Lifetime CA2254506C (en) | 1993-06-24 | 1994-06-21 | Piperidine derivatives and process for their production |
| CA002181089A Expired - Lifetime CA2181089C (en) | 1993-06-24 | 1994-06-21 | Piperidine derivatives and process for their production |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002254506A Expired - Lifetime CA2254506C (en) | 1993-06-24 | 1994-06-21 | Piperidine derivatives and process for their production |
Country Status (1)
| Country | Link |
|---|---|
| CA (2) | CA2254506C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7135571B2 (en) | 1994-05-18 | 2006-11-14 | Aventis Pharmaceuticals, Inc. | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof |
-
1994
- 1994-06-21 CA CA002254506A patent/CA2254506C/en not_active Expired - Lifetime
- 1994-06-21 CA CA002181089A patent/CA2181089C/en not_active Expired - Lifetime
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7135571B2 (en) | 1994-05-18 | 2006-11-14 | Aventis Pharmaceuticals, Inc. | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof |
| US7138524B2 (en) | 1994-05-18 | 2006-11-21 | Aventis Pharmaceuticals, Inc. | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof |
| US7662835B2 (en) | 1994-05-18 | 2010-02-16 | Aventis Holdings, Inc. | Methods of treating allergic reactions using an anhydrous form of antihistaminic piperidine derivatives |
| US7666881B2 (en) | 1994-05-18 | 2010-02-23 | Aventis Holdings, Inc. | Methods of treating allergic reactions using hydrated forms of antihistaminic piperidine derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2254506A1 (en) | 1995-01-05 |
| CA2181089C (en) | 2000-05-23 |
| CA2254506C (en) | 2000-11-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20140623 |