CA2174731A1 - Rapamycin derivatives useful as immunosuppressants - Google Patents
Rapamycin derivatives useful as immunosuppressantsInfo
- Publication number
- CA2174731A1 CA2174731A1 CA002174731A CA2174731A CA2174731A1 CA 2174731 A1 CA2174731 A1 CA 2174731A1 CA 002174731 A CA002174731 A CA 002174731A CA 2174731 A CA2174731 A CA 2174731A CA 2174731 A1 CA2174731 A1 CA 2174731A1
- Authority
- CA
- Canada
- Prior art keywords
- immunosuppressants
- derivatives useful
- rapamycin derivatives
- formula
- rapamycin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229960003444 immunosuppressant agent Drugs 0.000 title abstract 2
- 239000003018 immunosuppressive agent Substances 0.000 title abstract 2
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical class C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Novel demethoxy derivatives of rapamycin of formula (I) are found to have pharmaceutical utility, particularly as an immunosuppressants. In formula (I) R2 = formula (II) or formula (III), X, Y, R1, R3, R3, R4, R5 are as defined in the application.
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939325800A GB9325800D0 (en) | 1993-12-17 | 1993-12-17 | Organic compounds |
| GB9325800.2 | 1993-12-17 | ||
| GB939325802A GB9325802D0 (en) | 1993-12-17 | 1993-12-17 | Organic compounds |
| GB9325802.8 | 1993-12-17 | ||
| GB9407138.8 | 1994-04-11 | ||
| GB9407138A GB9407138D0 (en) | 1994-04-11 | 1994-04-11 | Organic compounds |
| GB9421982.1 | 1994-11-01 | ||
| GB9421982A GB9421982D0 (en) | 1994-11-01 | 1994-11-01 | Organic compounds |
| PCT/EP1994/004191 WO1995016691A1 (en) | 1993-12-17 | 1994-12-16 | Rapamycin derivatives useful as immunosuppressants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2174731A1 true CA2174731A1 (en) | 1995-06-22 |
| CA2174731C CA2174731C (en) | 2006-10-31 |
Family
ID=37395713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002174731A Expired - Fee Related CA2174731C (en) | 1993-12-17 | 1994-12-16 | Rapamycin derivatives useful as immunosuppressants |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2174731C (en) |
-
1994
- 1994-12-16 CA CA002174731A patent/CA2174731C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2174731C (en) | 2006-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |