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CA2171531A1 - Multiple branch peptide constructions for use against hiv - Google Patents

Multiple branch peptide constructions for use against hiv

Info

Publication number
CA2171531A1
CA2171531A1 CA002171531A CA2171531A CA2171531A1 CA 2171531 A1 CA2171531 A1 CA 2171531A1 CA 002171531 A CA002171531 A CA 002171531A CA 2171531 A CA2171531 A CA 2171531A CA 2171531 A1 CA2171531 A1 CA 2171531A1
Authority
CA
Canada
Prior art keywords
hiv
amino acids
cell membrane
receptors
multiple branch
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002171531A
Other languages
French (fr)
Other versions
CA2171531C (en
Inventor
Jean Marc Sabatier
Abdelaziz Benjouad
Nouara Yahi
Emmanuel Fenouillet
Kamel Mabrouk
Jean-Claude Gluckman
Jurphaas Van Rietschoten
Herve Rochat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cellpep SA
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939318901A external-priority patent/GB9318901D0/en
Application filed by Individual filed Critical Individual
Priority claimed from PCT/GB1994/001992 external-priority patent/WO1995007929A1/en
Publication of CA2171531A1 publication Critical patent/CA2171531A1/en
Application granted granted Critical
Publication of CA2171531C publication Critical patent/CA2171531C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Multiple branch peptide constructions formed from peptides derived from the V3 loop of gp120 protein of HIV-1, and including the consensus sequence GPGR preceded by 0 to 4 amino acids and succeeded by 2 to 4 amino acids, preferably not including I in the 3 amino acids immediately preceding GPGR and most preferably GPGRAF, show increased receptor affinity and prevent cell-to-cell fusion. They have a direct virostatic effect. Because they present the same peptide sequence several times, these MBPCs are able to neutralize in vitro the different steps of virus envelope/cell membrane fusion, and infected cell membrane/uninfected cell membrane fusion of several strains of HIV-1 and HIV-2. Notably, they are effective in blockading both CD4 receptors on lymphocytes and macrophages and GalCer receptors on colon epithelial cells. These results open a potential use in treatment of HIV-1 and HIV-2 infection.
CA002171531A 1993-09-13 1994-09-13 Multiple branch peptide constructions for use against hiv Expired - Fee Related CA2171531C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB939318901A GB9318901D0 (en) 1993-09-13 1993-09-13 Multiple branch peptide construction
GB9318901.7 1993-09-13
US08/260,086 US5622933A (en) 1993-09-13 1994-06-15 Multiple branch peptide constructions for use against HIV
US08/260,086 1994-06-15
PCT/GB1994/001992 WO1995007929A1 (en) 1993-09-13 1994-09-13 Multiple branch peptide constructions for use against hiv

Publications (2)

Publication Number Publication Date
CA2171531A1 true CA2171531A1 (en) 1995-03-23
CA2171531C CA2171531C (en) 2005-11-22

Family

ID=35474752

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002171531A Expired - Fee Related CA2171531C (en) 1993-09-13 1994-09-13 Multiple branch peptide constructions for use against hiv

Country Status (1)

Country Link
CA (1) CA2171531C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117700490A (en) * 2022-12-30 2024-03-15 云南沃森生物技术股份有限公司 A four-branched polypeptide and its preparation method

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117700490A (en) * 2022-12-30 2024-03-15 云南沃森生物技术股份有限公司 A four-branched polypeptide and its preparation method

Also Published As

Publication number Publication date
CA2171531C (en) 2005-11-22

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed