CA2164308C - Sodium hypochlorite based disinfectant and sterilizer for medical-surgical instruments - Google Patents
Sodium hypochlorite based disinfectant and sterilizer for medical-surgical instruments Download PDFInfo
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- CA2164308C CA2164308C CA002164308A CA2164308A CA2164308C CA 2164308 C CA2164308 C CA 2164308C CA 002164308 A CA002164308 A CA 002164308A CA 2164308 A CA2164308 A CA 2164308A CA 2164308 C CA2164308 C CA 2164308C
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- aqueous disinfectant
- disinfectant composition
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 48
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 title claims description 18
- 239000005708 Sodium hypochlorite Substances 0.000 title claims description 17
- 239000002585 base Substances 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 229910052783 alkali metal Inorganic materials 0.000 claims abstract description 19
- 150000001340 alkali metals Chemical class 0.000 claims abstract description 18
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims abstract description 17
- 229910001868 water Inorganic materials 0.000 claims abstract description 16
- 230000000249 desinfective effect Effects 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims abstract description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 54
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 30
- 239000000460 chlorine Substances 0.000 claims description 30
- 229910052801 chlorine Inorganic materials 0.000 claims description 30
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 26
- 239000000203 mixture Substances 0.000 claims description 21
- 239000011780 sodium chloride Substances 0.000 claims description 13
- 150000001342 alkaline earth metals Chemical class 0.000 claims description 5
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims 2
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Inorganic materials Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 abstract description 18
- -1 alkaline earth metal hypochlorite Chemical class 0.000 abstract description 12
- 230000001954 sterilising effect Effects 0.000 abstract description 8
- 239000000243 solution Substances 0.000 description 42
- 229910052751 metal Inorganic materials 0.000 description 7
- 239000002184 metal Substances 0.000 description 7
- 239000008213 purified water Substances 0.000 description 6
- 238000004659 sterilization and disinfection Methods 0.000 description 6
- 230000007797 corrosion Effects 0.000 description 4
- 238000005260 corrosion Methods 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 230000000721 bacterilogical effect Effects 0.000 description 2
- ZKQDCIXGCQPQNV-UHFFFAOYSA-N Calcium hypochlorite Chemical class [Ca+2].Cl[O-].Cl[O-] ZKQDCIXGCQPQNV-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 229910000272 alkali metal oxide Inorganic materials 0.000 description 1
- 229910001860 alkaline earth metal hydroxide Inorganic materials 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000004061 bleaching Methods 0.000 description 1
- 150000001805 chlorine compounds Chemical class 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000013307 optical fiber Substances 0.000 description 1
- 239000005304 optical glass Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 239000010865 sewage Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/08—Alkali metal chlorides; Alkaline earth metal chlorides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Inorganic Chemistry (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A first embodiment of the present invention is directed to an aqueous disinfectant solution comprising an alkali metal or alkaline earth metal hypochlorite, an amount of base sufficient to raise the pH of the solution to at least 12, and water. A second embodiment of the present invention is directed to a method for sterilizing medical and dental instruments and hard surfaces which comprises contacting the medical or dental instruments or hard surface with an aqueous disinfecting solution comprising an alkali metal or alkaline earth metal hypochlorite, an amount of a base sufficient to raise the pH of the solution to at least 12, and water, for a time sufficient to disinfect the medical or dental instruments or hard surface.
Description
2 ~ ~ ~ PCT/US93/05091 n.
Description SODIUM HYPOCHLORITE BASED DISINFECTANT AND
STERILIZER FOR MEDICAL-SURGICAL INSTRUMENTS
Field of the Invention The present invention relates to a composition containing an alkali metal or alkaline earth metal hypochlorite as the active ingredient for the disinfection and sterilization of hard surfaces and plastic, metal and glass instruments for surgery and dentistry. The present invention also relates to a method of disinfecting or sterilizing hard surfaces.or surgical and dental instruments with solutions of alkali metal or alkaline earth metal hypochlorites.
BACKGROUND OF INVENTION
Since the 18th century, chlorine-based disinfectants have been employed in medical applications for their rapid, potent and broad-spectrum bactericidal activity. For example, Dakin developed a chlorine solution which subsequently proved useful for lavaging foul wounds. See H.D. Dakin, Brit. Med. J., ii:809 (December 1915). Chlorine has also been widely used as a germicide in water and sewage treatment.
Among the useful chlorine-based disinfectants are alkali metal and alkaline earth metal hypochlorites. Sodium, potassium, lithium and calcium hypochlorites are known for their disinfecting and bleaching properties. See, ela., U.S.
Patent No. 3,717,580 to Echols et al.
Despite the long history of efficacious use of chlorine-based disinfectants, few chlorine compounds are used today as sterilants in medical and dental practice. The many problems associated with chlorine-based disinfectants limit their usefulness for disinfecting or sterilizing instruments or hard surfaces. For example, the instability of the active ~ ingredient causes the effectiveness of some hypochlorite disinfectant solutions to deteriorate significantly within a few hours of preparation.
r , s :, ~,. ., t ..
WO 94/28722 '~ ~ ~ PCT/US93/05091 An even more significant problem associated with use of chlorine-based disinfectants, however, is the highly corrosive nature of these solutions due to high oxidation Y
potential. For example, concentrations of hypochlorous acid sufficient to sterilize standard bacteriological challenges also quickly attack metals, even stainless steel, causing discoloration and pitting. Metal instruments soaked in chlorine solutions tend to be irreversiblyrdamaged; sharp edges are destroyed and metal surfaces are~~itted and darkened.
As a result, corrosion inhibitors have been recommended for use with hypochlorites. See, e.a., G.H. Botham et al., "Corrosion by Commercial Sodium Hypochlorite and its Inhibition," J. Dairy Res., vol. 16, 37 (1949). The use of corrosion inhibitors, however, has been plagued with problems, such as the reactivity of many inhibitors with chlorine and the resulting deactivation of the disinfectant solution.
Accordingly, there is a great need in the medical and dental arts for a disinfectant which will allow the rapid and effective sterilization of medical and dental instruments and hard surfaces at room temperature without corrosive effects and which exhibits sufficient chemical stability.
SUMMARY OF INVENTION
A first embodiment of the present invention is directed to an aqueous disinfectant solution comprising an alkali metal or alkaline earth metal hypochlorite, an amount of base sufficient to raise the pH of the solution to at least 12, and water.
A second embodiment of the present invention is directed to a method for sterilizing medical and dental instruments and hard surfaces which comprises contacting the medical or dental instruments or hard surface with an aqueous disinfecting solution comprising an alkali metal or alkaline earth metal hypochlorite, an amount of a base sufficient to raise the pH of the solution to at least 12, and water, for a 6682-24p time sufficient to disinfect the medical or dental instruments or hard surface.
In one aspect, the invention provides an aqueous disinfectant composition consisting essentially of: (A) an electrolyzed chloroxidizer solution which: (i) contains sodium hypochlorite, and (ii) provides 11 g of available chlorine per liter of said solution; (B) an amount of alkali metal or alkaline earth metal base sufficient to raise the pH of said composition to at least 12; (C) sodium chloride;
and (D) water.
In a further aspect, the invention provides an aqueous disinfectant composition consisting essentially of a diluted electrolyzed chloroxidizer solution which contains sodium hypochlorite and provides 11 g of available chlorine per liter of solution, an amount of alkali metal or alkaline earth metal base sufficient to raise the pH of said composition to at least 12, sodium chloride, and water.
DESCRIPTION OF PREFERRED EMBODIMENTS
The present invention is directed to an aqueous disinfectant solution which comprises an alkali metal or alkaline earth metal hypochlorite, an amount of base sufficient to raise the pH of the solution to at least 12, and water. The disinfectant solution according to the present invention allows for the rapid and effective sterilization of medical and dental instruments and hard surfaces, without corrosion of metal or damage to plastic, optical fibers or glass.
The active ingredient in the acqueous disinfectant solution is an alkali metal or alkaline earth metal hypochlorite. Preferably, the active ingredient is an - 3a -alkali metal hypochlorite. More preferably, the alkali metal hypochlorite is sodium hypochlorite.
Sodium hypochlorite is commercially available from sources such as Sigma. A particularly preferred sodium hypochlorite is commercially available from Amuchina, Inc.
under the name AmuchinaTM. AmuchinaTM is an electrolytic chloroxidizer which provides 11 grams of chlorine per liter.
The use of AmuchinaTM in the present invention is particularly preferred on account of the high purity with respect to metal content and increased stability of the active agent in AmuchinaTM as compared to other commercially available sodium hypochlorites.
The amount of alkali metal or alkaline earth metal hypochlorite employed in the acqueous disinfectant solution according to the present invention can be the minimum amount needed to show a positive disinfecting effect in any of the known methods for determining disinfecting capacity, such as standard bacteriological challenges, or such higher concentrations as may be appropriate. In general, any amount which elicits disinfecting effects is appropriate.
The amount of hypochlorite employed is preferably sufficient to provide a concentration of available chlorine within the 66822-240~
Description SODIUM HYPOCHLORITE BASED DISINFECTANT AND
STERILIZER FOR MEDICAL-SURGICAL INSTRUMENTS
Field of the Invention The present invention relates to a composition containing an alkali metal or alkaline earth metal hypochlorite as the active ingredient for the disinfection and sterilization of hard surfaces and plastic, metal and glass instruments for surgery and dentistry. The present invention also relates to a method of disinfecting or sterilizing hard surfaces.or surgical and dental instruments with solutions of alkali metal or alkaline earth metal hypochlorites.
BACKGROUND OF INVENTION
Since the 18th century, chlorine-based disinfectants have been employed in medical applications for their rapid, potent and broad-spectrum bactericidal activity. For example, Dakin developed a chlorine solution which subsequently proved useful for lavaging foul wounds. See H.D. Dakin, Brit. Med. J., ii:809 (December 1915). Chlorine has also been widely used as a germicide in water and sewage treatment.
Among the useful chlorine-based disinfectants are alkali metal and alkaline earth metal hypochlorites. Sodium, potassium, lithium and calcium hypochlorites are known for their disinfecting and bleaching properties. See, ela., U.S.
Patent No. 3,717,580 to Echols et al.
Despite the long history of efficacious use of chlorine-based disinfectants, few chlorine compounds are used today as sterilants in medical and dental practice. The many problems associated with chlorine-based disinfectants limit their usefulness for disinfecting or sterilizing instruments or hard surfaces. For example, the instability of the active ~ ingredient causes the effectiveness of some hypochlorite disinfectant solutions to deteriorate significantly within a few hours of preparation.
r , s :, ~,. ., t ..
WO 94/28722 '~ ~ ~ PCT/US93/05091 An even more significant problem associated with use of chlorine-based disinfectants, however, is the highly corrosive nature of these solutions due to high oxidation Y
potential. For example, concentrations of hypochlorous acid sufficient to sterilize standard bacteriological challenges also quickly attack metals, even stainless steel, causing discoloration and pitting. Metal instruments soaked in chlorine solutions tend to be irreversiblyrdamaged; sharp edges are destroyed and metal surfaces are~~itted and darkened.
As a result, corrosion inhibitors have been recommended for use with hypochlorites. See, e.a., G.H. Botham et al., "Corrosion by Commercial Sodium Hypochlorite and its Inhibition," J. Dairy Res., vol. 16, 37 (1949). The use of corrosion inhibitors, however, has been plagued with problems, such as the reactivity of many inhibitors with chlorine and the resulting deactivation of the disinfectant solution.
Accordingly, there is a great need in the medical and dental arts for a disinfectant which will allow the rapid and effective sterilization of medical and dental instruments and hard surfaces at room temperature without corrosive effects and which exhibits sufficient chemical stability.
SUMMARY OF INVENTION
A first embodiment of the present invention is directed to an aqueous disinfectant solution comprising an alkali metal or alkaline earth metal hypochlorite, an amount of base sufficient to raise the pH of the solution to at least 12, and water.
A second embodiment of the present invention is directed to a method for sterilizing medical and dental instruments and hard surfaces which comprises contacting the medical or dental instruments or hard surface with an aqueous disinfecting solution comprising an alkali metal or alkaline earth metal hypochlorite, an amount of a base sufficient to raise the pH of the solution to at least 12, and water, for a 6682-24p time sufficient to disinfect the medical or dental instruments or hard surface.
In one aspect, the invention provides an aqueous disinfectant composition consisting essentially of: (A) an electrolyzed chloroxidizer solution which: (i) contains sodium hypochlorite, and (ii) provides 11 g of available chlorine per liter of said solution; (B) an amount of alkali metal or alkaline earth metal base sufficient to raise the pH of said composition to at least 12; (C) sodium chloride;
and (D) water.
In a further aspect, the invention provides an aqueous disinfectant composition consisting essentially of a diluted electrolyzed chloroxidizer solution which contains sodium hypochlorite and provides 11 g of available chlorine per liter of solution, an amount of alkali metal or alkaline earth metal base sufficient to raise the pH of said composition to at least 12, sodium chloride, and water.
DESCRIPTION OF PREFERRED EMBODIMENTS
The present invention is directed to an aqueous disinfectant solution which comprises an alkali metal or alkaline earth metal hypochlorite, an amount of base sufficient to raise the pH of the solution to at least 12, and water. The disinfectant solution according to the present invention allows for the rapid and effective sterilization of medical and dental instruments and hard surfaces, without corrosion of metal or damage to plastic, optical fibers or glass.
The active ingredient in the acqueous disinfectant solution is an alkali metal or alkaline earth metal hypochlorite. Preferably, the active ingredient is an - 3a -alkali metal hypochlorite. More preferably, the alkali metal hypochlorite is sodium hypochlorite.
Sodium hypochlorite is commercially available from sources such as Sigma. A particularly preferred sodium hypochlorite is commercially available from Amuchina, Inc.
under the name AmuchinaTM. AmuchinaTM is an electrolytic chloroxidizer which provides 11 grams of chlorine per liter.
The use of AmuchinaTM in the present invention is particularly preferred on account of the high purity with respect to metal content and increased stability of the active agent in AmuchinaTM as compared to other commercially available sodium hypochlorites.
The amount of alkali metal or alkaline earth metal hypochlorite employed in the acqueous disinfectant solution according to the present invention can be the minimum amount needed to show a positive disinfecting effect in any of the known methods for determining disinfecting capacity, such as standard bacteriological challenges, or such higher concentrations as may be appropriate. In general, any amount which elicits disinfecting effects is appropriate.
The amount of hypochlorite employed is preferably sufficient to provide a concentration of available chlorine within the 66822-240~
range of 225.0 to 287.5 parts per million. When sodium hypochlorite is employed in the aqueous disinfectant solution, 0.0225 to 0.0288 grams of sodium hypochlorite (as available chlorine) are preferably used per 10o milliliters of solution.
According to the present invention, the aqueous disinfectant solution also contains a base. The base may be any of the known compounds which cause an aqueous solution to have an alkaline pH, i.e., a pH greater than 7. Suitable bases are readily available from commercial sources, such as Sigma~. Preferably, the base employed in the aqueous disinfectant solution is an alkali metal or alkaline earth metal base. Particularly preferred are the alkali metal and alkaline earth metal hydroxides. Most preferred is sodium hydroxide.
The amount of base employed in the aqueous disinfectant solution is at least the minimum amount of base sufficient to raise the pH of the solution to at least 12. Preferably, the amount of base employed is sufficient to raise the pH of the aqueous disinfectant solution to within the range of 12 to 13. When sodium hydroxide is employed as the base, 3.6 to 4.4 grams of sodium hydroxide are preferably used per 100 milliliters of solution.
A preferred embodiment of the present invention comprises: 0.0225 to 0.0288 grams of sodium hypochlorite (as available chlorine), 3.6 to 4.4 grams of sodium hydroxide, and purified water sufficient to make 100 milliliters. A
particularly preferred embodiment comprises: 0.025 grams of sodium hypochlorite (as available chlorine), 4.0 grams of sodium hydroxide, and purified water sufficient to make 100 milliliters.
In addition to the alkali metal or alkali earth metal hypochlorite and the base, the aqueous disinfectant solution may also contain conventional pharmaceutical additives and excipients. Preferably, the aqueous disinfectant solution also contains sodium chloride. One skilled in the art is able to determine the amount of any additives or excipients WO 94/28722 '" ~ . , a t 'PCT/IJS93/05091 _ 5 _ based on the intended use. For example, 100 milliliters of the aqueous disinfectant solution according to the present invention preferably also contains 0.35 to 0.45 grams of sodium chloride.
A preferred embodiment of the present invention comprises: 0.0225 to 0.0288 grams of sodium hypochlorite (as avai7.able chlorine), 3.6 to 4.4 grams of sodium hydroxide, 0.35 to 0.45 grams of sodium chloride, and purified water sufficient to make 100 milliliters. A particularly preferred embodiment comprises: 0.025 grams of sodium hypochlorite (as available chlorine), 4.0 grams of sodium hydroxide, 0.39 grams of sodium chloride, and purified water sufficient to make 100 milliliters.
The aqueous disinfectant solution according to the present invention may be prepared by any of the methods known to those skilled in the art. Preferably, the alkali metal or alkaline earth metal hypochlorite, the base, and water are added to a mixer and mixed at low speed for a time sufficient to prepare the aqueous disinfectant solution. During mixing, the solution can be sampled and tested for available chlorine, pH, and concentration of base. Preferably, the amount of available chlorine is within the range of 225.0 to 287.5 parts per million and the pH is within the range of 12 to 13. When sodium hydroxide is used as the base, the concentration of sodium hydroxide is preferably within the range of 3.6 to 4.4~.
The aqueous disinfectant solution according to the present invention may be used to sterilize and disinfect rapidly and effectively medical and dental instruments and hard surfaces. The aqueous disinfectant solution may be used to disinfect and sterilize metal surgical instruments, such ' as scalpels, plastic instruments, such as face masks, catheters, couplings, pipes for connections, collectors, and ' tubes for respiration, instruments with lenses, such as endoscopes, and instruments and devices used in dentistry.
The aqueous disinfectant solution may also be used to disinfect hard surfaces, such as tables and floors.
WO 94/28722 . - . . . . PCT/1JS93/05091 The aqueous disinfectant solution according to this invention may be used as a concentrate or diluted 1:5 or 1:10 with water. It is within the skill of the worker in the art to determine the appropriate c~a~icentration of the aqueous disinfectant solution based upon the intended application and the desired result.
For the disinfection and sterilization of medical and dental instruments, it is preferred that the aqueous disinfectant solution according to the present invention be poured into a suitable receptacle, such as a basin, and the instruments to be sterilized and disinfected be soaked in the solution for a time sufficient to disinfect and sterilize the instruments. Preferably, the instruments are soaked in the aqueous disinfectant solution for about 15 minutes at room temperature and then washed with sterile physiological solution or sterile distilled water prior to use.
The following examples are merely illustrative of the invention and should not be construed as limiting. One skilled in the art can make, without undue experimentation, various substitutions and variations and by equivalent means, performing in substantially the same manner, obtain substantially the same results without departing from the teaching and spirit of the invention.
EgAMPLES
Example 1 The following ingredients were poured into a 10 1 mixer:
purified water F.U. IX 8.4393 1 Amuchina~" 0.2273 1 (11 g/1 available chlorine) sodium hydroxide 30~ 1.3334 1 The mixer was turned on at low speed for 1 hour. Samples were taken at intervals to test for available chlorine (225.0 - 287.5 ppm), pH (12.0 - 13.0), sodium chloride (0.35 -0.45~) and sodium hydroxide (3.6 - 4.4~).
66822-24'0 Example 2 The following ingredients were poured into a 10 1 mixer:
purified water F.U. IX 8.6520 1 sodium hypochlorite 18% 0.0146 1 (17.1% available chlorine) sodium hydroxide 30% 1.3334 1 The mixer was turned on at low speed for 1 hour. Samples were taken at intervals to test for available chlorine (225.0 - 287.5 ppm), pH (12.0 - 13.0), and sodium hydroxide (3.6 -4.4%).
Although preferred embodiments of the invention are described herein in detail, it will be understood by those skilled in the art that variations may be made thereto without departing from the spirit of the invention or the scope of the appended claims.
According to the present invention, the aqueous disinfectant solution also contains a base. The base may be any of the known compounds which cause an aqueous solution to have an alkaline pH, i.e., a pH greater than 7. Suitable bases are readily available from commercial sources, such as Sigma~. Preferably, the base employed in the aqueous disinfectant solution is an alkali metal or alkaline earth metal base. Particularly preferred are the alkali metal and alkaline earth metal hydroxides. Most preferred is sodium hydroxide.
The amount of base employed in the aqueous disinfectant solution is at least the minimum amount of base sufficient to raise the pH of the solution to at least 12. Preferably, the amount of base employed is sufficient to raise the pH of the aqueous disinfectant solution to within the range of 12 to 13. When sodium hydroxide is employed as the base, 3.6 to 4.4 grams of sodium hydroxide are preferably used per 100 milliliters of solution.
A preferred embodiment of the present invention comprises: 0.0225 to 0.0288 grams of sodium hypochlorite (as available chlorine), 3.6 to 4.4 grams of sodium hydroxide, and purified water sufficient to make 100 milliliters. A
particularly preferred embodiment comprises: 0.025 grams of sodium hypochlorite (as available chlorine), 4.0 grams of sodium hydroxide, and purified water sufficient to make 100 milliliters.
In addition to the alkali metal or alkali earth metal hypochlorite and the base, the aqueous disinfectant solution may also contain conventional pharmaceutical additives and excipients. Preferably, the aqueous disinfectant solution also contains sodium chloride. One skilled in the art is able to determine the amount of any additives or excipients WO 94/28722 '" ~ . , a t 'PCT/IJS93/05091 _ 5 _ based on the intended use. For example, 100 milliliters of the aqueous disinfectant solution according to the present invention preferably also contains 0.35 to 0.45 grams of sodium chloride.
A preferred embodiment of the present invention comprises: 0.0225 to 0.0288 grams of sodium hypochlorite (as avai7.able chlorine), 3.6 to 4.4 grams of sodium hydroxide, 0.35 to 0.45 grams of sodium chloride, and purified water sufficient to make 100 milliliters. A particularly preferred embodiment comprises: 0.025 grams of sodium hypochlorite (as available chlorine), 4.0 grams of sodium hydroxide, 0.39 grams of sodium chloride, and purified water sufficient to make 100 milliliters.
The aqueous disinfectant solution according to the present invention may be prepared by any of the methods known to those skilled in the art. Preferably, the alkali metal or alkaline earth metal hypochlorite, the base, and water are added to a mixer and mixed at low speed for a time sufficient to prepare the aqueous disinfectant solution. During mixing, the solution can be sampled and tested for available chlorine, pH, and concentration of base. Preferably, the amount of available chlorine is within the range of 225.0 to 287.5 parts per million and the pH is within the range of 12 to 13. When sodium hydroxide is used as the base, the concentration of sodium hydroxide is preferably within the range of 3.6 to 4.4~.
The aqueous disinfectant solution according to the present invention may be used to sterilize and disinfect rapidly and effectively medical and dental instruments and hard surfaces. The aqueous disinfectant solution may be used to disinfect and sterilize metal surgical instruments, such ' as scalpels, plastic instruments, such as face masks, catheters, couplings, pipes for connections, collectors, and ' tubes for respiration, instruments with lenses, such as endoscopes, and instruments and devices used in dentistry.
The aqueous disinfectant solution may also be used to disinfect hard surfaces, such as tables and floors.
WO 94/28722 . - . . . . PCT/1JS93/05091 The aqueous disinfectant solution according to this invention may be used as a concentrate or diluted 1:5 or 1:10 with water. It is within the skill of the worker in the art to determine the appropriate c~a~icentration of the aqueous disinfectant solution based upon the intended application and the desired result.
For the disinfection and sterilization of medical and dental instruments, it is preferred that the aqueous disinfectant solution according to the present invention be poured into a suitable receptacle, such as a basin, and the instruments to be sterilized and disinfected be soaked in the solution for a time sufficient to disinfect and sterilize the instruments. Preferably, the instruments are soaked in the aqueous disinfectant solution for about 15 minutes at room temperature and then washed with sterile physiological solution or sterile distilled water prior to use.
The following examples are merely illustrative of the invention and should not be construed as limiting. One skilled in the art can make, without undue experimentation, various substitutions and variations and by equivalent means, performing in substantially the same manner, obtain substantially the same results without departing from the teaching and spirit of the invention.
EgAMPLES
Example 1 The following ingredients were poured into a 10 1 mixer:
purified water F.U. IX 8.4393 1 Amuchina~" 0.2273 1 (11 g/1 available chlorine) sodium hydroxide 30~ 1.3334 1 The mixer was turned on at low speed for 1 hour. Samples were taken at intervals to test for available chlorine (225.0 - 287.5 ppm), pH (12.0 - 13.0), sodium chloride (0.35 -0.45~) and sodium hydroxide (3.6 - 4.4~).
66822-24'0 Example 2 The following ingredients were poured into a 10 1 mixer:
purified water F.U. IX 8.6520 1 sodium hypochlorite 18% 0.0146 1 (17.1% available chlorine) sodium hydroxide 30% 1.3334 1 The mixer was turned on at low speed for 1 hour. Samples were taken at intervals to test for available chlorine (225.0 - 287.5 ppm), pH (12.0 - 13.0), and sodium hydroxide (3.6 -4.4%).
Although preferred embodiments of the invention are described herein in detail, it will be understood by those skilled in the art that variations may be made thereto without departing from the spirit of the invention or the scope of the appended claims.
Claims (11)
1. An aqueous disinfectant composition consisting essentially of:
(A) an electrolyzed chloroxidizer solution which:
(i) contains sodium hypochlorite, and (ii) provides 11 g of available chlorine per liter of said solution;
(B) an amount of alkali metal or alkaline earth metal base sufficient to raise the pH of said composition to at least 12;
(C) sodium chloride; and (D) water.
(A) an electrolyzed chloroxidizer solution which:
(i) contains sodium hypochlorite, and (ii) provides 11 g of available chlorine per liter of said solution;
(B) an amount of alkali metal or alkaline earth metal base sufficient to raise the pH of said composition to at least 12;
(C) sodium chloride; and (D) water.
2. The aqueous disinfectant composition according to claim 1, wherein said base is an alkali metal hydroxide.
3. The aqueous disinfectant composition according to claim 2, wherein said alkali metal hydroxide is sodium hydroxide.
4. The aqueous disinfectant composition according to claim 1, 2 or 3, wherein the pH of said composition is within the range of 12 to 13.
5. The aqueous disinfectant composition according to any one of claims 1 to 4, wherein 100 milliliters of said aqueous disinfectant composition consists essentially of: a dilute electrolyzed chloroxidizer solution having 0.0225 to 0.0288 g of available chlorine, 3.6 to 4.4 g sodium hydroxide, sodium chloride and water sufficient to make 100 milliliters.
6. The aqueous disinfectant composition according to claim 5, wherein a dilute electrolyzed chloroxidizer solution having 0.025 g of available chlorine, 4.0 g sodium hydroxide, sodium chloride and water sufficient to make 100 milliliters are present.
7. An aqueous disinfectant composition consisting essentially of a diluted electrolyzed chloroxidizer solution which contains sodium hypochlorite and provides 11 g of available chlorine per liter of solution, an amount of alkali metal or alkaline earth metal base sufficient to raise the pH of said composition to at least 12, sodium chloride, and water.
8. The aqueous disinfectant composition according to claim 7, wherein 100 milliliters of said aqueous disinfectant composition consists essentially of a dilute electrolyzed chloroxidizer solution having 0.0225 to 0.0228 g of available chlorine, 3.6 to 4.4 g sodium hydroxide, 0.35 to 0.45 g sodium chloride, and water sufficient to make 100 milliliters.
9. The aqueous disinfectant composition according to claim 8, wherein for 100 milliliters: a dilute electrolyzed chloroxidizer solution having 0.025 g of available chlorine, 4.0 g sodium hydroxide, 0.39 g sodium chloride and water sufficient to make 100 milliliters are present.
10. A method of disinfecting medical and dental instruments and hard surfaces which comprises contacting the medical or dental instruments or hard surfaces with an effective amount of an aqueous disinfectant composition according to any one of claims 1 to 9.
11. The method according to claim 10, wherein said medical or dental instrument or hard surface is contacted with said aqueous disinfectant composition for 15 minutes.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1993/005091 WO1994028722A1 (en) | 1993-06-03 | 1993-06-03 | Sodium hypochlorite based disinfectant and sterilizer for medical-surgical instruments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2164308A1 CA2164308A1 (en) | 1994-12-22 |
| CA2164308C true CA2164308C (en) | 2004-01-27 |
Family
ID=22236636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002164308A Expired - Fee Related CA2164308C (en) | 1993-06-03 | 1993-06-03 | Sodium hypochlorite based disinfectant and sterilizer for medical-surgical instruments |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0701400A1 (en) |
| AU (1) | AU4524693A (en) |
| CA (1) | CA2164308C (en) |
| WO (1) | WO1994028722A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITGE950132A1 (en) * | 1995-11-29 | 1997-05-29 | Marco Rotondi | COMPOUND FOR ODONTOSTOMATOLOGICAL USE FOR CLEANSING AND DISINFECTION OF ROOT CANALS AND VITAL DENTIN. |
| CA2883955C (en) | 2012-09-07 | 2021-02-23 | Marcus E. MARTIN | Disinfectant formulation comprising calcium hydroxide and sodium hypochlorite |
| WO2019133844A1 (en) * | 2017-12-29 | 2019-07-04 | Cms Technology, Inc. | Systems and methods for high-ph treatment of foodstuffs and other substrates |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1937229A (en) * | 1929-12-24 | 1933-11-28 | Kantorowicz Hermann | Process of cleaning and disinfecting metallic articles |
| CH200962A (en) * | 1936-10-10 | 1938-11-15 | Ig Farbenindustrie Ag | Liquid detergent with disinfecting properties and process for its manufacture. |
| US4167561A (en) * | 1973-12-28 | 1979-09-11 | Lever Brothers Company | Hypochlorite disinfecting compositions and use thereof |
| GB2021947A (en) * | 1978-05-26 | 1979-12-12 | Dhp Corp | Hypochlorite-Containing Antiseptic and Disinfectant |
| NL7908798A (en) * | 1979-12-05 | 1981-07-01 | Unilever Nv | LIQUID, THICKENED CHLORINE BLEACH. |
| US4390448A (en) * | 1981-10-22 | 1983-06-28 | International Flavors & Fragrances Inc. | Perfumed stable aqueous hypochlorite bleach compositions containing 2-methyl-2-octanol and thickened variation thereof |
| FR2572419B1 (en) * | 1984-10-31 | 1988-01-08 | Diversey France | DETERGENT AND DISINFECTANT COMPOSITION, ITS USE IN PARTICULAR IN THE AGRICULTURAL AND FOOD FIELD, PARTICULARLY IN THAT OF THE CLEANING OF HARVESTING MACHINES |
| US4898681A (en) * | 1988-08-31 | 1990-02-06 | Burton Charles D | Hypochlorite distinfectant stabilized with calcium chelant |
-
1993
- 1993-06-03 CA CA002164308A patent/CA2164308C/en not_active Expired - Fee Related
- 1993-06-03 WO PCT/US1993/005091 patent/WO1994028722A1/en not_active Application Discontinuation
- 1993-06-03 AU AU45246/93A patent/AU4524693A/en not_active Abandoned
- 1993-06-03 EP EP93915151A patent/EP0701400A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP0701400A1 (en) | 1996-03-20 |
| WO1994028722A1 (en) | 1994-12-22 |
| CA2164308A1 (en) | 1994-12-22 |
| AU4524693A (en) | 1995-01-03 |
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