CA2152684A1 - Administration de midazolam sous forme d'aerosol - Google Patents
Administration de midazolam sous forme d'aerosolInfo
- Publication number
- CA2152684A1 CA2152684A1 CA 2152684 CA2152684A CA2152684A1 CA 2152684 A1 CA2152684 A1 CA 2152684A1 CA 2152684 CA2152684 CA 2152684 CA 2152684 A CA2152684 A CA 2152684A CA 2152684 A1 CA2152684 A1 CA 2152684A1
- Authority
- CA
- Canada
- Prior art keywords
- midazolam
- propellant
- group
- base form
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- DDLIGBOFAVUZHB-UHFFFAOYSA-N midazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NC=C2CN=C1C1=CC=CC=C1F DDLIGBOFAVUZHB-UHFFFAOYSA-N 0.000 title claims abstract description 53
- 229960003793 midazolam Drugs 0.000 title claims abstract description 44
- 239000000443 aerosol Substances 0.000 title claims abstract description 9
- 239000003380 propellant Substances 0.000 claims abstract description 29
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000000203 mixture Substances 0.000 claims abstract description 21
- 238000009472 formulation Methods 0.000 claims abstract description 20
- LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical compound FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000002904 solvent Substances 0.000 claims abstract description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229940071648 metered dose inhaler Drugs 0.000 claims abstract description 9
- 239000007921 spray Substances 0.000 claims abstract description 9
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 claims abstract description 8
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims abstract description 8
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 8
- 235000019441 ethanol Nutrition 0.000 claims abstract description 8
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 8
- 229920001451 polypropylene glycol Polymers 0.000 claims abstract description 8
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims abstract description 8
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims abstract 5
- 229960004756 ethanol Drugs 0.000 claims abstract 5
- 229960000984 tocofersolan Drugs 0.000 claims abstract 5
- 229940042585 tocopherol acetate Drugs 0.000 claims abstract 5
- 239000003814 drug Substances 0.000 claims description 18
- YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 claims description 17
- 229940079593 drug Drugs 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 10
- 239000005557 antagonist Substances 0.000 claims description 7
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 claims description 6
- 229960003529 diazepam Drugs 0.000 claims description 6
- 210000004072 lung Anatomy 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 4
- 210000004877 mucosa Anatomy 0.000 claims description 4
- DIWRORZWFLOCLC-HNNXBMFYSA-N (3s)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one Chemical compound N([C@H](C(NC1=CC=C(Cl)C=C11)=O)O)=C1C1=CC=CC=C1Cl DIWRORZWFLOCLC-HNNXBMFYSA-N 0.000 claims description 3
- SEQDDYPDSLOBDC-UHFFFAOYSA-N Temazepam Chemical compound N=1C(O)C(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 SEQDDYPDSLOBDC-UHFFFAOYSA-N 0.000 claims description 3
- 229960004782 chlordiazepoxide Drugs 0.000 claims description 3
- ANTSCNMPPGJYLG-UHFFFAOYSA-N chlordiazepoxide Chemical compound O=N=1CC(NC)=NC2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 ANTSCNMPPGJYLG-UHFFFAOYSA-N 0.000 claims description 3
- DGBIGWXXNGSACT-UHFFFAOYSA-N clonazepam Chemical compound C12=CC([N+](=O)[O-])=CC=C2NC(=O)CN=C1C1=CC=CC=C1Cl DGBIGWXXNGSACT-UHFFFAOYSA-N 0.000 claims description 3
- 229960003120 clonazepam Drugs 0.000 claims description 3
- 229960004391 lorazepam Drugs 0.000 claims description 3
- 229960003188 temazepam Drugs 0.000 claims description 3
- 229960003528 flurazepam Drugs 0.000 claims 2
- SAADBVWGJQAEFS-UHFFFAOYSA-N flurazepam Chemical compound N=1CC(=O)N(CCN(CC)CC)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1F SAADBVWGJQAEFS-UHFFFAOYSA-N 0.000 claims 2
- -1 triazepam Chemical compound 0.000 claims 2
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 abstract description 5
- 230000000779 depleting effect Effects 0.000 abstract description 2
- 239000003874 central nervous system depressant Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 239000000243 solution Substances 0.000 description 6
- 239000002585 base Substances 0.000 description 5
- 206010002091 Anaesthesia Diseases 0.000 description 3
- ZAKOWWREFLAJOT-UHFFFAOYSA-N DL-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 3
- 230000037005 anaesthesia Effects 0.000 description 3
- 229940049706 benzodiazepine Drugs 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 150000002632 lipids Chemical class 0.000 description 3
- 210000002850 nasal mucosa Anatomy 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 208000004793 anterograde amnesia Diseases 0.000 description 2
- 150000001557 benzodiazepines Chemical class 0.000 description 2
- 230000000747 cardiac effect Effects 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000013355 food flavoring agent Nutrition 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 210000002200 mouth mucosa Anatomy 0.000 description 2
- 210000001331 nose Anatomy 0.000 description 2
- 230000036470 plasma concentration Effects 0.000 description 2
- 230000001624 sedative effect Effects 0.000 description 2
- GUJAGMICFDYKNR-UHFFFAOYSA-N 1,4-benzodiazepine Chemical compound N1C=CN=CC2=CC=CC=C12 GUJAGMICFDYKNR-UHFFFAOYSA-N 0.000 description 1
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 229920004449 Halon® Polymers 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010039897 Sedation Diseases 0.000 description 1
- 206010047249 Venous thrombosis Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 239000002249 anxiolytic agent Substances 0.000 description 1
- 230000000949 anxiolytic effect Effects 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000749 benzodiazepine receptor blocking agent Substances 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 230000002802 cardiorespiratory effect Effects 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- KYKAJFCTULSVSH-UHFFFAOYSA-N chloro(fluoro)methane Chemical compound F[C]Cl KYKAJFCTULSVSH-UHFFFAOYSA-N 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 238000002574 cystoscopy Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000002716 delivery method Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001839 endoscopy Methods 0.000 description 1
- 125000005909 ethyl alcohol group Chemical group 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000002575 gastroscopy Methods 0.000 description 1
- 150000005826 halohydrocarbons Chemical class 0.000 description 1
- 231100001261 hazardous Toxicity 0.000 description 1
- 239000005554 hypnotics and sedatives Substances 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- PLYSCVSCYOQVRP-UHFFFAOYSA-N midazolam hydrochloride Chemical compound Cl.C12=CC(Cl)=CC=C2N2C(C)=NC=C2CN=C1C1=CC=CC=C1F PLYSCVSCYOQVRP-UHFFFAOYSA-N 0.000 description 1
- 229960002853 midazolam hydrochloride Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000002694 regional anesthesia Methods 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- GGCSSNBKKAUURC-UHFFFAOYSA-N sufentanil Chemical compound C1CN(CCC=2SC=CC=2)CCC1(COC)N(C(=O)CC)C1=CC=CC=C1 GGCSSNBKKAUURC-UHFFFAOYSA-N 0.000 description 1
- 229960004739 sufentanil Drugs 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 231100000048 toxicity data Toxicity 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26526894A | 1994-07-01 | 1994-07-01 | |
| US08/265.268 | 1994-07-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2152684A1 true CA2152684A1 (fr) | 1996-01-02 |
Family
ID=23009754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2152684 Abandoned CA2152684A1 (fr) | 1994-07-01 | 1995-06-27 | Administration de midazolam sous forme d'aerosol |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2152684A1 (fr) |
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6514482B1 (en) | 2000-09-19 | 2003-02-04 | Advanced Inhalation Research, Inc. | Pulmonary delivery in treating disorders of the central nervous system |
| US6613308B2 (en) | 2000-09-19 | 2003-09-02 | Advanced Inhalation Research, Inc. | Pulmonary delivery in treating disorders of the central nervous system |
| US6737043B2 (en) | 2001-05-24 | 2004-05-18 | Alexza Molecula Delivery Corporation | Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route |
| US6805853B2 (en) | 2001-11-09 | 2004-10-19 | Alexza Molecular Delivery Corporation | Delivery of diazepam through an inhalation route |
| US7090830B2 (en) | 2001-05-24 | 2006-08-15 | Alexza Pharmaceuticals, Inc. | Drug condensation aerosols and kits |
| US7458374B2 (en) | 2002-05-13 | 2008-12-02 | Alexza Pharmaceuticals, Inc. | Method and apparatus for vaporizing a compound |
| US7537009B2 (en) | 2001-06-05 | 2009-05-26 | Alexza Pharmaceuticals, Inc. | Method of forming an aerosol for inhalation delivery |
| US7540286B2 (en) | 2004-06-03 | 2009-06-02 | Alexza Pharmaceuticals, Inc. | Multiple dose condensation aerosol devices and methods of forming condensation aerosols |
| US7550133B2 (en) | 2002-11-26 | 2009-06-23 | Alexza Pharmaceuticals, Inc. | Respiratory drug condensation aerosols and methods of making and using them |
| US7581540B2 (en) | 2004-08-12 | 2009-09-01 | Alexza Pharmaceuticals, Inc. | Aerosol drug delivery device incorporating percussively activated heat packages |
| US7585493B2 (en) | 2001-05-24 | 2009-09-08 | Alexza Pharmaceuticals, Inc. | Thin-film drug delivery article and method of use |
| US7645442B2 (en) | 2001-05-24 | 2010-01-12 | Alexza Pharmaceuticals, Inc. | Rapid-heating drug delivery article and method of use |
| US7700588B2 (en) | 2004-01-14 | 2010-04-20 | Merkus Franciscus Wilhelmus He | Pharmaceutical compositions comprising midazolam in a high concentration |
| US7879358B2 (en) | 2002-03-20 | 2011-02-01 | Alkermes, Inc. | Pulmonary delivery for levodopa |
| US7913688B2 (en) | 2002-11-27 | 2011-03-29 | Alexza Pharmaceuticals, Inc. | Inhalation device for producing a drug aerosol |
| US8235037B2 (en) | 2001-05-24 | 2012-08-07 | Alexza Pharmaceuticals, Inc. | Drug condensation aerosols and kits |
| US8387612B2 (en) | 2003-05-21 | 2013-03-05 | Alexza Pharmaceuticals, Inc. | Self-contained heating unit and drug-supply unit employing same |
| US11642473B2 (en) | 2007-03-09 | 2023-05-09 | Alexza Pharmaceuticals, Inc. | Heating unit for use in a drug delivery device |
| US12214118B2 (en) | 2018-02-02 | 2025-02-04 | Alexza Pharmaceuticals, Inc. | Electrical condensation aerosol device |
-
1995
- 1995-06-27 CA CA 2152684 patent/CA2152684A1/fr not_active Abandoned
Cited By (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6514482B1 (en) | 2000-09-19 | 2003-02-04 | Advanced Inhalation Research, Inc. | Pulmonary delivery in treating disorders of the central nervous system |
| US6613308B2 (en) | 2000-09-19 | 2003-09-02 | Advanced Inhalation Research, Inc. | Pulmonary delivery in treating disorders of the central nervous system |
| US6979437B2 (en) | 2000-09-19 | 2005-12-27 | Advanced Inhalation Research, Inc. | Pulmonary delivery in treating disorders of the central nervous system |
| US8235037B2 (en) | 2001-05-24 | 2012-08-07 | Alexza Pharmaceuticals, Inc. | Drug condensation aerosols and kits |
| US6737043B2 (en) | 2001-05-24 | 2004-05-18 | Alexza Molecula Delivery Corporation | Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route |
| US7018619B2 (en) | 2001-05-24 | 2006-03-28 | Alexza Pharmaceuticals, Inc. | Delivery of alprazolam, estazolam midazolam or triazolam through an inhalation route |
| US10350157B2 (en) | 2001-05-24 | 2019-07-16 | Alexza Pharmaceuticals, Inc. | Drug condensation aerosols and kits |
| US7060255B2 (en) | 2001-05-24 | 2006-06-13 | Alexza Pharmaceuticals, Inc. | Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route |
| US9211382B2 (en) | 2001-05-24 | 2015-12-15 | Alexza Pharmaceuticals, Inc. | Drug condensation aerosols and kits |
| US7090830B2 (en) | 2001-05-24 | 2006-08-15 | Alexza Pharmaceuticals, Inc. | Drug condensation aerosols and kits |
| US7449173B2 (en) | 2001-05-24 | 2008-11-11 | Alexza Pharmaceuticals, Inc. | Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route |
| US9440034B2 (en) | 2001-05-24 | 2016-09-13 | Alexza Pharmaceuticals, Inc. | Drug condensation aerosols and kits |
| US7645442B2 (en) | 2001-05-24 | 2010-01-12 | Alexza Pharmaceuticals, Inc. | Rapid-heating drug delivery article and method of use |
| US7585493B2 (en) | 2001-05-24 | 2009-09-08 | Alexza Pharmaceuticals, Inc. | Thin-film drug delivery article and method of use |
| US7942147B2 (en) | 2001-06-05 | 2011-05-17 | Alexza Pharmaceuticals, Inc. | Aerosol forming device for use in inhalation therapy |
| US8074644B2 (en) | 2001-06-05 | 2011-12-13 | Alexza Pharmaceuticals, Inc. | Method of forming an aerosol for inhalation delivery |
| US11065400B2 (en) | 2001-06-05 | 2021-07-20 | Alexza Pharmaceuticals, Inc. | Aerosol forming device for use in inhalation therapy |
| US7537009B2 (en) | 2001-06-05 | 2009-05-26 | Alexza Pharmaceuticals, Inc. | Method of forming an aerosol for inhalation delivery |
| US8955512B2 (en) | 2001-06-05 | 2015-02-17 | Alexza Pharmaceuticals, Inc. | Method of forming an aerosol for inhalation delivery |
| US9687487B2 (en) | 2001-06-05 | 2017-06-27 | Alexza Pharmaceuticals, Inc. | Aerosol forming device for use in inhalation therapy |
| US7766013B2 (en) | 2001-06-05 | 2010-08-03 | Alexza Pharmaceuticals, Inc. | Aerosol generating method and device |
| US9308208B2 (en) | 2001-06-05 | 2016-04-12 | Alexza Pharmaceuticals, Inc. | Aerosol generating method and device |
| US9439907B2 (en) | 2001-06-05 | 2016-09-13 | Alexza Pharmaceutical, Inc. | Method of forming an aerosol for inhalation delivery |
| US7045119B2 (en) | 2001-11-09 | 2006-05-16 | Alexza Pharmaceuticals, Inc. | Delivery of diazepam through an inhalation route |
| US7087218B2 (en) | 2001-11-09 | 2006-08-08 | Alexza Pharmaceuticals, Inc. | Delivery of diazepam through an inhalation route |
| US7470421B2 (en) | 2001-11-09 | 2008-12-30 | Alexza Pharmaceuticals, Inc | Delivery of diazepam through an inhalation route |
| US6805853B2 (en) | 2001-11-09 | 2004-10-19 | Alexza Molecular Delivery Corporation | Delivery of diazepam through an inhalation route |
| USRE43711E1 (en) | 2002-03-20 | 2012-10-02 | Civitas Therapeutics, Inc. | Pulmonary delivery for levodopa |
| US7879358B2 (en) | 2002-03-20 | 2011-02-01 | Alkermes, Inc. | Pulmonary delivery for levodopa |
| US7987846B2 (en) | 2002-05-13 | 2011-08-02 | Alexza Pharmaceuticals, Inc. | Method and apparatus for vaporizing a compound |
| US7458374B2 (en) | 2002-05-13 | 2008-12-02 | Alexza Pharmaceuticals, Inc. | Method and apparatus for vaporizing a compound |
| US7550133B2 (en) | 2002-11-26 | 2009-06-23 | Alexza Pharmaceuticals, Inc. | Respiratory drug condensation aerosols and methods of making and using them |
| US8506935B2 (en) | 2002-11-26 | 2013-08-13 | Alexza Pharmaceuticals, Inc. | Respiratory drug condensation aerosols and methods of making and using them |
| US7913688B2 (en) | 2002-11-27 | 2011-03-29 | Alexza Pharmaceuticals, Inc. | Inhalation device for producing a drug aerosol |
| US8991387B2 (en) | 2003-05-21 | 2015-03-31 | Alexza Pharmaceuticals, Inc. | Self-contained heating unit and drug-supply unit employing same |
| US8387612B2 (en) | 2003-05-21 | 2013-03-05 | Alexza Pharmaceuticals, Inc. | Self-contained heating unit and drug-supply unit employing same |
| US9370629B2 (en) | 2003-05-21 | 2016-06-21 | Alexza Pharmaceuticals, Inc. | Self-contained heating unit and drug-supply unit employing same |
| AU2005205072B2 (en) * | 2004-01-14 | 2011-03-03 | Franciscus Wilhelmus Henricus Maria Merkus | Pharmaceutical compositions comprising midazolam in a high concentration |
| US7700588B2 (en) | 2004-01-14 | 2010-04-20 | Merkus Franciscus Wilhelmus He | Pharmaceutical compositions comprising midazolam in a high concentration |
| US8333197B2 (en) | 2004-06-03 | 2012-12-18 | Alexza Pharmaceuticals, Inc. | Multiple dose condensation aerosol devices and methods of forming condensation aerosols |
| US7540286B2 (en) | 2004-06-03 | 2009-06-02 | Alexza Pharmaceuticals, Inc. | Multiple dose condensation aerosol devices and methods of forming condensation aerosols |
| US7581540B2 (en) | 2004-08-12 | 2009-09-01 | Alexza Pharmaceuticals, Inc. | Aerosol drug delivery device incorporating percussively activated heat packages |
| US11642473B2 (en) | 2007-03-09 | 2023-05-09 | Alexza Pharmaceuticals, Inc. | Heating unit for use in a drug delivery device |
| US12138383B2 (en) | 2007-03-09 | 2024-11-12 | Alexza Pharmaceuticals, Inc. | Heating unit for use in a drug delivery device |
| US12214118B2 (en) | 2018-02-02 | 2025-02-04 | Alexza Pharmaceuticals, Inc. | Electrical condensation aerosol device |
| US12214119B2 (en) | 2018-02-02 | 2025-02-04 | Alexza Pharmaceuticals, Inc. | Electrical condensation aerosol device |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2152684A1 (fr) | Administration de midazolam sous forme d'aerosol | |
| EP2194965B1 (fr) | Compositions pharmaceutiques non aqueuses | |
| AU764126B2 (en) | Storable active substance concentrate with formoterol | |
| US6849263B2 (en) | Pharmaceutical compositions for buccal delivery of pain relief medications | |
| KR101517415B1 (ko) | 난용성 항경련제를 함유하는 경비 항경련성 약학 조성물 | |
| UA59385C2 (uk) | Інтраназальна композиція для лікування сексуальних розладів | |
| US20210077382A1 (en) | Compositions, devices, and methods for the treatment of opioid-receptor-mediated conditions | |
| JP2002541921A (ja) | オピオイド拮抗物質用スプレイディスペンサ | |
| JP2003533439A (ja) | 薬学的組成物 | |
| JP2002527473A (ja) | フォルモテロールを含む貯蔵可能な活性物質濃縮物 | |
| RU2767062C2 (ru) | Составы, устройства и способы для лечения алкогольной зависимости | |
| US5496537A (en) | Propofol hydrofluorocarbon propellant formulations | |
| JP2002528399A (ja) | Δ９テトラヒドロカナビノール（δ９ｔｈｃ）溶液計量ずみ投与量吸入器および使用方法 | |
| WO2017178663A1 (fr) | Benzodiazépines à usage nasal et inhalées par voie orale | |
| US6193954B1 (en) | Formulations for pulmonary delivery of dopamine agonists | |
| KR20030087072A (ko) | 비측 투여를 위한 이미다조트리아지논 함유 조성물 | |
| JP2002539240A (ja) | エアロゾル噴射剤に溶解した薬剤 | |
| US20020155068A1 (en) | Inhalatory compositions of formoterol | |
| IE920484A1 (en) | Pharmaceutical Formulations | |
| EP2030610A1 (fr) | Compositions pharmaceutiques non aqueuses | |
| US20210379080A1 (en) | Intranasal Formulation | |
| AU2003263416B2 (en) | Pharmaceutical compositions for buccal delivery of pain relief medications | |
| WO2017049181A1 (fr) | Produits médicamenteux d'administration par voie nasale et leurs méthodes d'utilisation | |
| US20240408003A1 (en) | Compositions, devices and methods for the treatment of alcohol use disorder | |
| RU2288757C2 (ru) | Композиция для лечения заболеваний полости рта и носа |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |