CA2141039A1 - Surfactant free aerosol formulations containing beclomethasone dipropionate - Google Patents
Surfactant free aerosol formulations containing beclomethasone dipropionateInfo
- Publication number
- CA2141039A1 CA2141039A1 CA002141039A CA2141039A CA2141039A1 CA 2141039 A1 CA2141039 A1 CA 2141039A1 CA 002141039 A CA002141039 A CA 002141039A CA 2141039 A CA2141039 A CA 2141039A CA 2141039 A1 CA2141039 A1 CA 2141039A1
- Authority
- CA
- Canada
- Prior art keywords
- aerosol formulations
- beclomethasone dipropionate
- formulations containing
- surfactant free
- free aerosol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 title abstract 3
- 239000000443 aerosol Substances 0.000 title abstract 3
- 229950000210 beclometasone dipropionate Drugs 0.000 title abstract 3
- 238000009472 formulation Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 239000004094 surface-active agent Substances 0.000 title 1
- LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical compound FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 abstract 2
- 239000003380 propellant Substances 0.000 abstract 2
- YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 229940092705 beclomethasone Drugs 0.000 abstract 1
- -1 beclomethasone ester Chemical class 0.000 abstract 1
- KYKAJFCTULSVSH-UHFFFAOYSA-N chloro(fluoro)methane Chemical compound F[C]Cl KYKAJFCTULSVSH-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
This invention relates to novel aerosol formulations for administering drugs, in particular for administration of a beclomethasone ester by inhalation.
In particular the invention provides novel aerosol formulations consisting essentially of (a) beclomethasone dipropionate in the form of a solvate with 1,1,1,2-tetrafluoroethane (CF3CH2F) and one or more fluorocarbon or hydrogen-containing chlorofluorocarbon propellants or (b) anhydrous beclomethasone dipropionate and 1,1,1,2,3,3,3-heptafluoro-n-propane as propellant.
In particular the invention provides novel aerosol formulations consisting essentially of (a) beclomethasone dipropionate in the form of a solvate with 1,1,1,2-tetrafluoroethane (CF3CH2F) and one or more fluorocarbon or hydrogen-containing chlorofluorocarbon propellants or (b) anhydrous beclomethasone dipropionate and 1,1,1,2,3,3,3-heptafluoro-n-propane as propellant.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929216381A GB9216381D0 (en) | 1992-07-31 | 1992-07-31 | Medicaments |
| GB9216381.5 | 1992-07-31 | ||
| GB929216382A GB9216382D0 (en) | 1992-07-31 | 1992-07-31 | Medicaments |
| GB9216382.3 | 1992-07-31 | ||
| PCT/EP1993/002040 WO1994003153A1 (en) | 1992-07-31 | 1993-07-30 | Surfactant free aerosol formulations containing beclomethasone dipropionate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2141039A1 true CA2141039A1 (en) | 1994-02-17 |
| CA2141039C CA2141039C (en) | 2006-04-25 |
Family
ID=36251280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002141039A Expired - Fee Related CA2141039C (en) | 1992-07-31 | 1993-07-30 | Surfactant free aerosol formulations containing beclomethasone dipropionate |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2141039C (en) |
-
1993
- 1993-07-30 CA CA002141039A patent/CA2141039C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2141039C (en) | 2006-04-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |