[go: up one dir, main page]

CA2131355A1 - Production d'une immunoglobuline codee par un gene unique - Google Patents

Production d'une immunoglobuline codee par un gene unique

Info

Publication number
CA2131355A1
CA2131355A1 CA 2131355 CA2131355A CA2131355A1 CA 2131355 A1 CA2131355 A1 CA 2131355A1 CA 2131355 CA2131355 CA 2131355 CA 2131355 A CA2131355 A CA 2131355A CA 2131355 A1 CA2131355 A1 CA 2131355A1
Authority
CA
Canada
Prior art keywords
gene
molecule
immunoglobulin
chain
monoclonal antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2131355
Other languages
English (en)
Other versions
CA2131355C (fr
Inventor
Syed V. S. Kashmiri
Liming Shu
Jeffrey Schlom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Government of the United States of America
Original Assignee
Government of the United States of America
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Government of the United States of America filed Critical Government of the United States of America
Priority to CA 2131355 priority Critical patent/CA2131355C/fr
Publication of CA2131355A1 publication Critical patent/CA2131355A1/fr
Application granted granted Critical
Publication of CA2131355C publication Critical patent/CA2131355C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
CA 2131355 1994-09-01 1994-09-01 Production d'une immunoglobuline codee par un gene unique Expired - Lifetime CA2131355C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA 2131355 CA2131355C (fr) 1994-09-01 1994-09-01 Production d'une immunoglobuline codee par un gene unique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA 2131355 CA2131355C (fr) 1994-09-01 1994-09-01 Production d'une immunoglobuline codee par un gene unique

Publications (2)

Publication Number Publication Date
CA2131355A1 true CA2131355A1 (fr) 1996-03-02
CA2131355C CA2131355C (fr) 2001-04-17

Family

ID=4154274

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2131355 Expired - Lifetime CA2131355C (fr) 1994-09-01 1994-09-01 Production d'une immunoglobuline codee par un gene unique

Country Status (1)

Country Link
CA (1) CA2131355C (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818749B1 (en) 1998-10-31 2004-11-16 The United States Of America As Represented By The Department Of Health And Human Services Variants of humanized anti carcinoma monoclonal antibody cc49
US7569673B2 (en) 2002-06-28 2009-08-04 The United States Of America As Represented By The Department Of Health And Human Services Humanized anti-tag 72 cc49 for diagnosis and therapy of human tumors
US7589181B2 (en) 2003-08-29 2009-09-15 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Minimally immunogenic variants of SDR-grafted humanized antibody CC49 and their use

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818749B1 (en) 1998-10-31 2004-11-16 The United States Of America As Represented By The Department Of Health And Human Services Variants of humanized anti carcinoma monoclonal antibody cc49
US7256004B2 (en) 1998-10-31 2007-08-14 United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Variants of humanized anti-carcinoma monoclonal antibody CC49
US7763719B2 (en) 1998-10-31 2010-07-27 The United States Of America As Represented By The Department Of Health And Human Services Variants of humanized anti-carcinoma MAb CC49
US8029788B2 (en) 1998-10-31 2011-10-04 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Variants of humanized anti-carcinoma MAb CC49
US7569673B2 (en) 2002-06-28 2009-08-04 The United States Of America As Represented By The Department Of Health And Human Services Humanized anti-tag 72 cc49 for diagnosis and therapy of human tumors
US7919607B2 (en) 2002-06-28 2011-04-05 The United States Of America As Represented By The Department Of Health And Human Services Nucleic acids encoding humanized anti-tag 72 CC49 antbodies
US8535890B2 (en) 2002-06-28 2013-09-17 The United of America as represented by the Secretary of the Department of Health and Human Services Methods to determine immunogenicity of humanized anti-tag 72 CC49 antibodies
US8835167B2 (en) 2002-06-28 2014-09-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Humanized anti-tag 72 CC49 for diagnosis and therapy of human tumors
US7589181B2 (en) 2003-08-29 2009-09-15 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Minimally immunogenic variants of SDR-grafted humanized antibody CC49 and their use
US7915396B2 (en) 2003-08-29 2011-03-29 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nucleic acid molecules encoding minimally immunogenic variants of SDR-grafted humanized antibody CC49

Also Published As

Publication number Publication date
CA2131355C (fr) 2001-04-17

Similar Documents

Publication Publication Date Title
JP3490437B2 (ja) 単量体および二量体抗体フラグメント融合タンパク質
JP3280376B2 (ja) 多価抗原結合性蛋白質
US5856456A (en) Linker for linked fusion polypeptides
AU673581B2 (en) Methods of delivering agents to target cells
JP2675380B2 (ja) 組換ｄｎａ産物及び方法
Whitlow et al. An improved linker for single-chain Fv with reduced aggregation and enhanced proteolytic stability
CA2235269C (fr) Anticorps monoclonal br110 et ses utilisations
US5892019A (en) Production of a single-gene-encoded immunoglobulin
AU627183B2 (en) Method for producing recombinant dna proteins
US5837821A (en) Antibody construct
Goshorn et al. Genetic construction, expression, and characterization of a single chain anti-carcinoma antibody fused to β-lactamase
Michael et al. In vitro and in vivo characterisation of a recombinant carboxypeptidase G2:: anti-CEA scFv fusion protein
WO1995009917A1 (fr) Anticorps bispecifiques et tetravalents, obtenus par genie genetique
US20070237771A1 (en) Multicomponent conjugates which bind to target molecules and stimulate T cell lysis
George et al. Redirection of T cell-mediated cytotoxicity by a recombinant single-chain Fv molecule.
US5965405A (en) Method for producing Fv fragments in eukaryotic cells
Love et al. Recombinant antibodies possessing novel effector functions
Brüsselbach et al. Enzyme recruitment and tumor cell killing in vitro by
CA2131355A1 (fr) Production d'une immunoglobuline codee par un gene unique
US20030148406A1 (en) Multivalent antigen-binding proteins
de Sutter et al. A bifunctional murine:: Human chimeric antibody with one antigen-binding arm replaced by bacterial β-lactamase
EP4397685A1 (fr) Anticorps humanisé anti-cd3
Xiang et al. Genetic engineering of a recombinant fusion possessing anti-tumor F (ab′) 2 and tumor necrosis factor
Munoz et al. The C (H) 1 domain of IgG is not essential for C3 covalent binding: importance of the other constant domains as targets for C3.
JP2004507205A (ja) Ｃａ１９−９抗原陽性細胞の検出および除去のためのポリペプチド

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20140902