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CA2116753A1 - Monoclonal antibodies recognizing the epidermal growth factor-receptor, cells and methods for producing them and compositions containing them - Google Patents

Monoclonal antibodies recognizing the epidermal growth factor-receptor, cells and methods for producing them and compositions containing them

Info

Publication number
CA2116753A1
CA2116753A1 CA 2116753 CA2116753A CA2116753A1 CA 2116753 A1 CA2116753 A1 CA 2116753A1 CA 2116753 CA2116753 CA 2116753 CA 2116753 A CA2116753 A CA 2116753A CA 2116753 A1 CA2116753 A1 CA 2116753A1
Authority
CA
Canada
Prior art keywords
monoclonal antibodies
receptor
cells
producing
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2116753
Other languages
French (fr)
Other versions
CA2116753C (en
Inventor
Alicia F. Ordonez
Cristina M. Mateo De Acosta Del Rio
Amparo E. M. Abraham
Pedro P. M. Perez
Blanca R. T. Bravo
Rolando P. Rodriguez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centro de Immunologia Molecular
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2116753A1 publication Critical patent/CA2116753A1/en
Application granted granted Critical
Publication of CA2116753C publication Critical patent/CA2116753C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention relates to a monoclonal antibodies capable of recognizing the EGF receptor in human placenta or A-431 cells with high affinity and capable of inhibiting EGF binding to the receptor. The monoclonal antibodies also has the ability to produce antibody dependent cellular cytotoxicity; to develop complement-mediated cytotoxic activity; to inhibit tumoral growth in certain cell lines and to show a synergetic effect to inhibit these cell lines proliferation when they are in combination with gangliosides or monoclonal antibodies against EGF.
CA 2116753 1993-03-01 1994-03-01 Monoclonal antibodies recognizing the epidermal growth factor-receptor, cells and methods for producing them and compositions containing them Expired - Lifetime CA2116753C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CU17/93 1993-03-01
CU1993017 1993-03-01

Publications (2)

Publication Number Publication Date
CA2116753A1 true CA2116753A1 (en) 1994-09-02
CA2116753C CA2116753C (en) 2001-09-04

Family

ID=5459200

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2116753 Expired - Lifetime CA2116753C (en) 1993-03-01 1994-03-01 Monoclonal antibodies recognizing the epidermal growth factor-receptor, cells and methods for producing them and compositions containing them

Country Status (2)

Country Link
CN (1) CN1103404A (en)
CA (1) CA2116753C (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU24070B1 (en) * 2011-12-27 2015-01-29 Ct De Inmunología Molecular PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF TUMORS EXPRESSING REGF AND GM3 N-GLYCOLLATED GANGLIOSIDS (NEUGCGM3)

Also Published As

Publication number Publication date
CA2116753C (en) 2001-09-04
CN1103404A (en) 1995-06-07

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Legal Events

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MKEX Expiry

Effective date: 20140303