[go: up one dir, main page]

CA2077712A1 - Process and device for the production of a contrast medium from a concentrate - Google Patents

Process and device for the production of a contrast medium from a concentrate

Info

Publication number
CA2077712A1
CA2077712A1 CA002077712A CA2077712A CA2077712A1 CA 2077712 A1 CA2077712 A1 CA 2077712A1 CA 002077712 A CA002077712 A CA 002077712A CA 2077712 A CA2077712 A CA 2077712A CA 2077712 A1 CA2077712 A1 CA 2077712A1
Authority
CA
Canada
Prior art keywords
contrast medium
production
concentrate
liters
liter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002077712A
Other languages
French (fr)
Other versions
CA2077712C (en
Inventor
Michael Kampfe
Bernard Better
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24766346&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2077712(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering AG filed Critical Schering AG
Publication of CA2077712A1 publication Critical patent/CA2077712A1/en
Application granted granted Critical
Publication of CA2077712C publication Critical patent/CA2077712C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/005—Devices for introducing or retaining media, e.g. remedies, in cavities of the body for contrast media
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804—Flow controllers
    • A61M5/16827—Flow controllers controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Process for the production of a contrast medium from a contrast medium concentrate in an amount of 350-450 I/ml or 0.5-4 mol of contrast medium compound/liter in a container of 0.1-100 liters by mixing with an aqueous solution.
CA002077712A 1991-04-22 1992-09-08 Process and device for the production of a contrast medium from a concentrate Expired - Fee Related CA2077712C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68892291A 1991-04-22 1991-04-22
EP92250170.5 1992-06-29

Publications (2)

Publication Number Publication Date
CA2077712A1 true CA2077712A1 (en) 1993-12-30
CA2077712C CA2077712C (en) 2003-06-17

Family

ID=24766346

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002077712A Expired - Fee Related CA2077712C (en) 1991-04-22 1992-09-08 Process and device for the production of a contrast medium from a concentrate

Country Status (7)

Country Link
EP (1) EP0576740B1 (en)
JP (1) JPH069435A (en)
AT (1) ATE168888T1 (en)
CA (1) CA2077712C (en)
DE (1) DE4121568C2 (en)
DK (1) DK0576740T3 (en)
ES (1) ES2121816T3 (en)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9238099B2 (en) 2004-11-24 2016-01-19 Bayer Healthcare Llc System and apparatus for modeling pressures generated during an injection procedure
US9302044B2 (en) 2006-12-29 2016-04-05 Bayer Healthcare Llc Patient-based parameter generation systems for medical injection procedures
US9421330B2 (en) 2008-11-03 2016-08-23 Bayer Healthcare Llc Mitigation of contrast-induced nephropathy
US9616166B2 (en) 2004-11-16 2017-04-11 Bayer Healthcare Llc Systems and methods of determining injection protocols for diagnostic imaging procedures
US9949704B2 (en) 2012-05-14 2018-04-24 Bayer Healthcare Llc Systems and methods for determination of pharmaceutical fluid injection protocols based on x-ray tube voltage
US9959389B2 (en) 2010-06-24 2018-05-01 Bayer Healthcare Llc Modeling of pharmaceutical propagation and parameter generation for injection protocols
US10898638B2 (en) 2016-03-03 2021-01-26 Bayer Healthcare Llc System and method for improved fluid delivery in multi-fluid injector systems
US11141535B2 (en) 2017-08-31 2021-10-12 Bayer Healthcare Llc Fluid path impedance assessment for improving fluid delivery performance
US11278853B2 (en) 2013-03-13 2022-03-22 Bayer Healthcare Llc Method for controlling fluid accuracy and backflow compensation
US11478581B2 (en) 2017-08-31 2022-10-25 Bayer Healthcare Llc Fluid injector system volume compensation system and method
US11598664B2 (en) 2017-08-31 2023-03-07 Bayer Healthcare Llc Injector pressure calibration system and method
US11779702B2 (en) 2017-08-31 2023-10-10 Bayer Healthcare Llc Method for dynamic pressure control in a fluid injector system
US11786652B2 (en) 2017-08-31 2023-10-17 Bayer Healthcare Llc System and method for drive member position and fluid injector system mechanical calibration
US12208239B2 (en) 2018-08-28 2025-01-28 Bayer Healthcare Llc Fluid injector system, method of preventing fluid backflow, and computer program product
US12251544B2 (en) 2018-04-19 2025-03-18 Bayer Healthcare Llc System and method for air detection in fluid injector

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5827219A (en) * 1993-10-28 1998-10-27 Medrad, Inc. Injection system and pumping system for use therein
EP0650738B1 (en) * 1993-10-28 2003-05-02 Medrad, Inc. Multi-patient fluid dispensing
US5569181A (en) * 1993-10-28 1996-10-29 Medrad, Inc. Sterility assurance for contrast delivery system
DE69432167T2 (en) * 1993-10-28 2003-07-24 Medrad, Inc. Contrast delivery system
DE69526613T2 (en) * 1994-07-12 2002-08-29 Medrad, Inc. Information path control loop for a system that delivers medical fluids
US5840026A (en) 1994-09-21 1998-11-24 Medrad, Inc. Patient specific dosing contrast delivery systems and methods
DE19648650C2 (en) * 1996-01-29 1998-07-02 Schering Ag Buffer systems and their use to stabilize pharmaceutical preparations
US7267667B2 (en) 2002-07-11 2007-09-11 Boston Scientific Scimed, Inc. Fluid management system for coronary intervention
JP4620929B2 (en) 2002-09-26 2011-01-26 株式会社根本杏林堂 Chemical injection device
US20050277833A1 (en) * 2004-05-27 2005-12-15 E-Z-Em, Inc. System, method, and computer program product for handling, mixing, dispensing, and injecting radiopharmaceutical agents
CN101742967B (en) 2007-07-17 2014-06-11 梅德拉股份有限公司 Devices, systems and methods for determination of parameters for a procedure, for estimation of cardiopulmonary function and for fluid delivery
ITFI20080186A1 (en) * 2008-09-30 2010-04-01 Maspres Di Alfredo Speranzi MSA MIXER 206
CA2987358A1 (en) 2011-09-21 2013-03-28 Bayer Healthcare Llc Continuous multi-fluid pump device, drive and actuating system, and method
DE102014017402A1 (en) 2014-11-25 2016-05-25 Fidica Gmbh & Co. Kg Arrangement for storing and administering rinsing solutions
DE102014017399A1 (en) 2014-11-25 2016-05-25 Fidica Gmbh & Co. Kg Mixing plant for ready-to-use rinse solutions
DE102014017403A1 (en) 2014-11-25 2016-05-25 Fidica Gmbh & Co. Kg RO plant for rinsing solutions
DE102014017397B4 (en) 2014-11-25 2018-06-21 Fidica Gmbh & Co. Kg Mobile flush solution tank
DE102014017404A1 (en) 2014-11-25 2016-05-25 Fidica Gmbh & Co. Kg Monitoring RO system for rinsing solutions
DE102014017420A1 (en) * 2014-11-25 2016-05-25 Fidica Gmbh & Co. Kg Concentrate for rinsing solutions
KR20240145046A (en) 2015-01-09 2024-10-04 바이엘 헬쓰케어 엘엘씨 Multiple fluid delivery system with multi-use disposable set and features thereof
JP6516584B2 (en) * 2015-06-22 2019-05-22 大陽日酸株式会社 Contrast agent supply device
GB201703227D0 (en) * 2017-01-20 2017-04-12 Ge Healthcare As Plastic containers
GB201721463D0 (en) * 2017-12-20 2018-01-31 Ge Healthcare As Tailored dose of contrast agent
CN109984772A (en) * 2019-05-20 2019-07-09 广东省人民医院(广东省医学科学院) A kind of left cardiography check device

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4467844A (en) * 1982-06-24 1984-08-28 Baxter Travenol Laboratories, Inc. Flow monitoring method and apparatus
DE3315031C2 (en) * 1983-04-26 1985-09-05 Pfrimmer-Viggo GmbH & Co KG, 8520 Erlangen Method and device for producing mixtures of pharmaceutical liquids

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9616166B2 (en) 2004-11-16 2017-04-11 Bayer Healthcare Llc Systems and methods of determining injection protocols for diagnostic imaging procedures
US9950107B2 (en) 2004-11-24 2018-04-24 Bayer Healthcare Llc Systems and methods for managing workflow for injection procedures
US10166326B2 (en) 2004-11-24 2019-01-01 Bayer Healthcare Llc Devices, systems and methods for determining parameters of one or more phases of an injection procedure
US9238099B2 (en) 2004-11-24 2016-01-19 Bayer Healthcare Llc System and apparatus for modeling pressures generated during an injection procedure
US9302044B2 (en) 2006-12-29 2016-04-05 Bayer Healthcare Llc Patient-based parameter generation systems for medical injection procedures
US10463782B2 (en) 2006-12-29 2019-11-05 Bayer Healthcare Llc Patient-based parameter generation systems for medical injection procedures
US9421330B2 (en) 2008-11-03 2016-08-23 Bayer Healthcare Llc Mitigation of contrast-induced nephropathy
US9959389B2 (en) 2010-06-24 2018-05-01 Bayer Healthcare Llc Modeling of pharmaceutical propagation and parameter generation for injection protocols
US11191501B2 (en) 2012-05-14 2021-12-07 Bayer Healthcare Llc Systems and methods for determination of pharmaceutical fluid injection protocols based on x-ray tube voltage
US9949704B2 (en) 2012-05-14 2018-04-24 Bayer Healthcare Llc Systems and methods for determination of pharmaceutical fluid injection protocols based on x-ray tube voltage
US11278853B2 (en) 2013-03-13 2022-03-22 Bayer Healthcare Llc Method for controlling fluid accuracy and backflow compensation
US11672902B2 (en) 2016-03-03 2023-06-13 Bayer Healthcare Llc System and method for improved fluid delivery in multi-fluid injector systems
US10898638B2 (en) 2016-03-03 2021-01-26 Bayer Healthcare Llc System and method for improved fluid delivery in multi-fluid injector systems
US11141535B2 (en) 2017-08-31 2021-10-12 Bayer Healthcare Llc Fluid path impedance assessment for improving fluid delivery performance
US11478581B2 (en) 2017-08-31 2022-10-25 Bayer Healthcare Llc Fluid injector system volume compensation system and method
US11598664B2 (en) 2017-08-31 2023-03-07 Bayer Healthcare Llc Injector pressure calibration system and method
US11779702B2 (en) 2017-08-31 2023-10-10 Bayer Healthcare Llc Method for dynamic pressure control in a fluid injector system
US11786652B2 (en) 2017-08-31 2023-10-17 Bayer Healthcare Llc System and method for drive member position and fluid injector system mechanical calibration
US11826553B2 (en) 2017-08-31 2023-11-28 Bayer Healthcare Llc Fluid path impedance assessment for improving fluid delivery performance
US12214155B2 (en) 2017-08-31 2025-02-04 Bayer Healthcare Llc Fluid injector system volume compensation system and method
US12251544B2 (en) 2018-04-19 2025-03-18 Bayer Healthcare Llc System and method for air detection in fluid injector
US12208239B2 (en) 2018-08-28 2025-01-28 Bayer Healthcare Llc Fluid injector system, method of preventing fluid backflow, and computer program product

Also Published As

Publication number Publication date
CA2077712C (en) 2003-06-17
DE4121568A1 (en) 1992-10-29
DE4121568C2 (en) 1997-07-03
EP0576740B1 (en) 1998-07-29
ATE168888T1 (en) 1998-08-15
JPH069435A (en) 1994-01-18
EP0576740A1 (en) 1994-01-05
DK0576740T3 (en) 1999-04-26
ES2121816T3 (en) 1998-12-16

Similar Documents

Publication Publication Date Title
CA2077712A1 (en) Process and device for the production of a contrast medium from a concentrate
AU3107093A (en) Synthesis of creping aids based on polyamides containing methyl bis(3-aminopropylamine)
KR0135639B1 (en) Ink used for high-image quality recording system
AU2538192A (en) Condiment container with closure member
CA2158343A1 (en) Bottle for containing a fluid
AU3186093A (en) Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
CA2136492A1 (en) Pharmaceutical composition containing diclofenac and 2-hydroxypropyl-.beta.-cyclodextrin
CA2036283A1 (en) Effervescent composition, its production and use
ZA937112B (en) 17-aryl and 17-heterocyclyl-14beta-5alpha-androstane, androstene and androstaniene derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions contning same
CA2069171A1 (en) Stabilization of aqueous polymers in the presence of hydroxylamine
AP9600810A0 (en) Crystalline n-acetyl neuraminic acid derivatives and processes for their preparation.
CA2018229A1 (en) Carboplatin composition
TW282464B (en)
CA2153663A1 (en) Separation of nylon 6 from mixtures with nylon 6,6
AU5629694A (en) Cryoprotective aqueous solutions useful for the preservation of (in vitro) cultured epithelial sheets
CA2052640A1 (en) Method for destroying cyst of noxious plankton
TW276983B (en)
AU5065190A (en) A non-acidified milk-based drink with a ph value of between 3.6 and 4.2, together with the production process for such a drink
AU2947084A (en) Bicyclo (3.2.1) octane carboxylic acid derivatives
EP0636604A3 (en) Process for the preparation of substantially salt-free aqueous Bis-aminooxy-alkane solutions.
AU8174894A (en) Nourishing composition for animals
HU9601582D0 (en) Microbial process for the preparation of heteroaromatic carbonic acids by microorganisms of the genus alcaligenes
AU684260B2 (en) 1,4-benzoxazine-2-acetic acid compound, process for producing the same, and use thereof
CA2189088A1 (en) 2-amino-6-chloropurine and method for preparing the same
GB9623846D0 (en) Electrodeposition of thin films of iron-manganese from aqueous solutions of sulfate salts(using pH 0.85 through pH of 9)to achieve 12 to 15+% manganese)

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed