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CA2037907A1 - Homologous recombination for universal donor cells and chimeric mammalian hosts - Google Patents

Homologous recombination for universal donor cells and chimeric mammalian hosts

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Publication number
CA2037907A1
CA2037907A1 CA002037907A CA2037907A CA2037907A1 CA 2037907 A1 CA2037907 A1 CA 2037907A1 CA 002037907 A CA002037907 A CA 002037907A CA 2037907 A CA2037907 A CA 2037907A CA 2037907 A1 CA2037907 A1 CA 2037907A1
Authority
CA
Canada
Prior art keywords
homologous recombination
mammalian hosts
donor cells
universal donor
chimeric mammalian
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002037907A
Other languages
French (fr)
Other versions
CA2037907C (en
Inventor
Raju S. Kucherlapati
Beverly H. Koller
Oliver. Smithies
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cell Genesys Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from PCT/US1990/004178 external-priority patent/WO1991001140A1/en
Publication of CA2037907A1 publication Critical patent/CA2037907A1/en
Application granted granted Critical
Publication of CA2037907C publication Critical patent/CA2037907C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Abstract

Homologous recombination is employed to inactivate genes, particularly genes associated with MHC antigens. particularly, the .beta.2-microglobulin gene is inactivated for reducing or eliminating Class I MHC antigens. The resulting cells may be used as universal donors. In addition, embryonic stem cells may be modified by homologous recombination for use in producing chimeric or transgenic mammalian hosts.
CA002037907A 1989-07-25 1990-07-25 Homologous recombination for universal donor cells and chimeric mammalian hosts Expired - Lifetime CA2037907C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US38565189A 1989-07-25 1989-07-25
US385,651 1989-07-25
US43187289A 1989-11-06 1989-11-06
US431,872 1989-11-06
PCT/US1990/004178 WO1991001140A1 (en) 1989-07-25 1990-07-25 Homologous recombination for universal donor cells and chimeric mammalian hosts

Publications (2)

Publication Number Publication Date
CA2037907A1 true CA2037907A1 (en) 1991-01-26
CA2037907C CA2037907C (en) 2006-04-04

Family

ID=36143205

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002037907A Expired - Lifetime CA2037907C (en) 1989-07-25 1990-07-25 Homologous recombination for universal donor cells and chimeric mammalian hosts

Country Status (1)

Country Link
CA (1) CA2037907C (en)

Also Published As

Publication number Publication date
CA2037907C (en) 2006-04-04

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed
MKEC Expiry (correction)

Effective date: 20121202