CA1301572C - Multi - unit delivery system - Google Patents

Multi - unit delivery system

Info

Publication number: CA1301572C
Authority: CA; Canada
Prior art keywords: dispenser; housing; fluid; drug; units
Prior art date: 1987-06-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

CA000570389A

Other languages

English (en)

French (fr)

Inventor

Patrick S.L. Wong

Felix Theeuwes

James B. Eckenhoff

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Alza Corp

Original Assignee

Alza Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-06-25

Filing date

1988-06-24

Publication date

1992-05-26

1988-06-24 Application filed by Alza Corp filed Critical Alza Corp

1992-05-26 Application granted granted Critical

1992-05-26 Publication of CA1301572C publication Critical patent/CA1301572C/en

2009-05-26 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

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239000000203 mixture Substances 0.000 claims description 36
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239000000463 material Substances 0.000 claims description 24
229940088597 hormone Drugs 0.000 claims description 19
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239000013060 biological fluid Substances 0.000 description 1
JEJBBWQXAMSBQT-UHFFFAOYSA-N butanedioic acid;propanoic acid Chemical compound CCC(O)=O.OC(=O)CCC(O)=O JEJBBWQXAMSBQT-UHFFFAOYSA-N 0.000 description 1
NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 description 1
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MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 1
239000001527 calcium lactate Substances 0.000 description 1
235000011086 calcium lactate Nutrition 0.000 description 1
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PBUBJNYXWIDFMU-UHFFFAOYSA-L calcium;butanedioate Chemical compound [Ca+2].[O-]C(=O)CCC([O-])=O PBUBJNYXWIDFMU-UHFFFAOYSA-L 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
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210000003169 central nervous system Anatomy 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical class OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 1
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239000011248 coating agent Substances 0.000 description 1
229910000428 cobalt oxide Inorganic materials 0.000 description 1
IVMYJDGYRUAWML-UHFFFAOYSA-N cobalt(ii) oxide Chemical compound [Co]=O IVMYJDGYRUAWML-UHFFFAOYSA-N 0.000 description 1
238000013267 controlled drug release Methods 0.000 description 1
238000013270 controlled release Methods 0.000 description 1
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239000010949 copper Substances 0.000 description 1
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239000003246 corticosteroid Substances 0.000 description 1
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UCVPKAZCQPRWAY-UHFFFAOYSA-N dibenzyl benzene-1,2-dicarboxylate Chemical compound C=1C=CC=C(C(=O)OCC=2C=CC=CC=2)C=1C(=O)OCC1=CC=CC=C1 UCVPKAZCQPRWAY-UHFFFAOYSA-N 0.000 description 1
HBGGXOJOCNVPFY-UHFFFAOYSA-N diisononyl phthalate Chemical compound CC(C)CCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCC(C)C HBGGXOJOCNVPFY-UHFFFAOYSA-N 0.000 description 1
MCWXGJITAZMZEV-UHFFFAOYSA-N dimethoate Chemical compound CNC(=O)CSP(=S)(OC)OC MCWXGJITAZMZEV-UHFFFAOYSA-N 0.000 description 1
125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
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239000011888 foil Substances 0.000 description 1
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150000002367 halogens Chemical class 0.000 description 1
IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 1
BZIRFHQRUNJZTH-UHFFFAOYSA-N hexadecanoic acid;pentanoic acid Chemical compound CCCCC(O)=O.CCCCCCCCCCCCCCCC(O)=O BZIRFHQRUNJZTH-UHFFFAOYSA-N 0.000 description 1
229920001519 homopolymer Polymers 0.000 description 1
150000003840 hydrochlorides Chemical class 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
230000002706 hydrostatic effect Effects 0.000 description 1
239000005554 hypnotics and sedatives Substances 0.000 description 1
229940005535 hypnotics and sedatives Drugs 0.000 description 1
230000006872 improvement Effects 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
150000002484 inorganic compounds Chemical class 0.000 description 1
CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
229960000367 inositol Drugs 0.000 description 1
239000003589 local anesthetic agent Substances 0.000 description 1
229960005015 local anesthetics Drugs 0.000 description 1
229910052943 magnesium sulfate Inorganic materials 0.000 description 1
235000019341 magnesium sulphate Nutrition 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
229940018415 meclizine hydrochloride Drugs 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
ZAGYPHYWSKQMPX-UHFFFAOYSA-N morpholin-4-yl butanoate Chemical compound CCCC(=O)ON1CCOCC1 ZAGYPHYWSKQMPX-UHFFFAOYSA-N 0.000 description 1
229920001206 natural gum Polymers 0.000 description 1
231100000344 non-irritating Toxicity 0.000 description 1
BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 description 1
235000016709 nutrition Nutrition 0.000 description 1
ZQPPMHVWECSIRJ-KTKRTIGZSA-M oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC([O-])=O ZQPPMHVWECSIRJ-KTKRTIGZSA-M 0.000 description 1
229940049964 oleate Drugs 0.000 description 1
150000002894 organic compounds Chemical class 0.000 description 1
239000002357 osmotic agent Substances 0.000 description 1
208000014837 parasitic helminthiasis infectious disease Diseases 0.000 description 1
239000002245 particle Substances 0.000 description 1
239000001814 pectin Substances 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
239000008188 pellet Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
125000005498 phthalate group Chemical class 0.000 description 1
229920001084 poly(chloroprene) Polymers 0.000 description 1
229920001390 poly(hydroxyalkylmethacrylate) Polymers 0.000 description 1
229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
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229920000058 polyacrylate Polymers 0.000 description 1
239000004584 polyacrylic acid Substances 0.000 description 1
229920002647 polyamide Polymers 0.000 description 1
229920000447 polyanionic polymer Polymers 0.000 description 1
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229920000139 polyethylene terephthalate Polymers 0.000 description 1
239000005020 polyethylene terephthalate Substances 0.000 description 1
239000004926 polymethyl methacrylate Substances 0.000 description 1
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229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
229910000057 polysulfane Inorganic materials 0.000 description 1
239000004800 polyvinyl chloride Substances 0.000 description 1
229920000915 polyvinyl chloride Polymers 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
IWZKICVEHNUQTL-UHFFFAOYSA-M potassium hydrogen phthalate Chemical compound [K+].OC(=O)C1=CC=CC=C1C([O-])=O IWZKICVEHNUQTL-UHFFFAOYSA-M 0.000 description 1
OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 1
229910052939 potassium sulfate Inorganic materials 0.000 description 1
235000011151 potassium sulphates Nutrition 0.000 description 1
230000001072 progestational effect Effects 0.000 description 1
QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
229960001860 salicylate Drugs 0.000 description 1
239000012266 salt solution Substances 0.000 description 1
CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
229920002379 silicone rubber Polymers 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
235000010265 sodium sulphite Nutrition 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
235000010356 sorbitol Nutrition 0.000 description 1
235000012424 soybean oil Nutrition 0.000 description 1
239000003549 soybean oil Substances 0.000 description 1
101150008563 spir gene Proteins 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000001797 sucrose acetate isobutyrate Substances 0.000 description 1
235000010983 sucrose acetate isobutyrate Nutrition 0.000 description 1
UVGUPMLLGBCFEJ-SWTLDUCYSA-N sucrose acetate isobutyrate Chemical compound CC(C)C(=O)O[C@H]1[C@H](OC(=O)C(C)C)[C@@H](COC(=O)C(C)C)O[C@@]1(COC(C)=O)O[C@@H]1[C@H](OC(=O)C(C)C)[C@@H](OC(=O)C(C)C)[C@H](OC(=O)C(C)C)[C@@H](COC(C)=O)O1 UVGUPMLLGBCFEJ-SWTLDUCYSA-N 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
OKUCEQDKBKYEJY-UHFFFAOYSA-N tert-butyl 3-(methylamino)pyrrolidine-1-carboxylate Chemical compound CNC1CCN(C(=O)OC(C)(C)C)C1 OKUCEQDKBKYEJY-UHFFFAOYSA-N 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
229960004869 thiethylperazine Drugs 0.000 description 1
RVBRTNPNFYFDMZ-SPIKMXEPSA-N thiethylperazine maleate Chemical compound [H+].[H+].[H+].[H+].[O-]C(=O)\C=C/C([O-])=O.[O-]C(=O)\C=C/C([O-])=O.C12=CC(SCC)=CC=C2SC2=CC=CC=C2N1CCCN1CCN(C)CC1 RVBRTNPNFYFDMZ-SPIKMXEPSA-N 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
229960002622 triacetin Drugs 0.000 description 1
150000005691 triesters Chemical class 0.000 description 1
125000005591 trimellitate group Chemical group 0.000 description 1
PVNIQBQSYATKKL-UHFFFAOYSA-N tripalmitin Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCC PVNIQBQSYATKKL-UHFFFAOYSA-N 0.000 description 1
YPDXSCXISVYHOB-UHFFFAOYSA-N tris(7-methyloctyl) benzene-1,2,4-tricarboxylate Chemical compound CC(C)CCCCCCOC(=O)C1=CC=C(C(=O)OCCCCCCC(C)C)C(C(=O)OCCCCCCC(C)C)=C1 YPDXSCXISVYHOB-UHFFFAOYSA-N 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Anesthesiology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Medicinal Preparation (AREA)
Medical Preparation Storing Or Oral Administration Devices (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CA000570389A 1987-06-25 1988-06-24 Multi - unit delivery system Expired - Lifetime CA1301572C (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US6690587A	1987-06-25	1987-06-25
US066,905		1987-06-25

Publications (1)

Publication Number	Publication Date
CA1301572C true CA1301572C (en)	1992-05-26

Family

ID=22072483

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA000570389A Expired - Lifetime CA1301572C (en)	1987-06-25	1988-06-24	Multi - unit delivery system

Country Status (9)

Country	Link
JP (1)	JP2732530B2 (de)
AU (1)	AU602221B2 (de)
CA (1)	CA1301572C (de)
DE (1)	DE3821424C2 (de)
ES (1)	ES2009014A6 (de)
FR (1)	FR2617045B1 (de)
GB (1)	GB2206046B (de)
IT (1)	IT1219401B (de)
NZ (1)	NZ225058A (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9655894B2 (en)	2001-05-02	2017-05-23	Purdue Pharma L.P.	Once-A day oxycodone formulations

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US6200600B1 (en) *	1989-02-16	2001-03-13	Btg International Limited	Controlled delay release device
US5342624A (en) *	1989-02-16	1994-08-30	British Technology Group Ltd.	Dispensing device
EP0424535A4 (en) *	1989-04-21	1991-10-16	Moskovsky Avtomobilestroitelny Institut (Vtuz-Zil)	Device for controlled dosing of active substances into an operative medium
US5474784A (en) *	1990-03-02	1995-12-12	British Technology Group Limited	Dispensing device
GB9004702D0 (en) *	1990-03-02	1990-04-25	Polysystems Limited	Dispensing device
US5017381A (en) *	1990-05-02	1991-05-21	Alza Corporation	Multi-unit pulsatile delivery system
US5156850A (en) *	1990-08-31	1992-10-20	Alza Corporation	Dosage form for time-varying patterns of drug delivery
US6440457B1 (en)	1993-05-27	2002-08-27	Alza Corporation	Method of administering antidepressant dosage form
DE4342091A1 (de) *	1993-12-09	1995-06-14	Asta Medica Ag	Erzeugnisse zur Anwendung von initial hohen Dosen von Cetrorelix und Herstellung einer Kombinationspackung zur Verwendung bei Therapie von Krankheiten
CA2193806A1 (en) *	1994-06-22	1995-12-28	Michael Cardamone	Controlled release device and method
CN100484518C (zh) *	1996-08-16	2009-05-06	阿尔萨公司	药物剂量逐渐增加的剂型
US6919373B1 (en)	1996-11-12	2005-07-19	Alza Corporation	Methods and devices for providing prolonged drug therapy
EP2263658A1 (de) *	2000-10-30	2010-12-22	Euro-Celtique S.A.	Hydrocodon-Formulierungen mit gesteuerter Freisetzung
US20050232995A1 (en)	2002-07-29	2005-10-20	Yam Nyomi V	Methods and dosage forms for controlled delivery of paliperidone and risperidone
JP4824602B2 (ja) *	2007-02-22	2011-11-30	富士工業株式会社	ガイド付き振り出し竿の竿先保護カバー
JP4824601B2 (ja) *	2007-02-22	2011-11-30	富士工業株式会社	ガイド付き振り出し竿の竿先保護カバー
SMT202100236T1 (it) *	2009-12-17	2021-05-07	Taris Biomedical Llc	Dispositivo impiantabile con tollerabilita' intravescicale

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Publication number	Priority date	Publication date	Assignee	Title
US4350271A (en) *	1980-08-22	1982-09-21	Alza Corporation	Water absorbing fluid dispenser
US4449983A (en) *	1982-03-22	1984-05-22	Alza Corporation	Simultaneous delivery of two drugs from unit delivery device
US4576604A (en) *	1983-03-04	1986-03-18	Alza Corporation	Osmotic system with instant drug availability
AU2815684A (en) *	1983-03-31	1984-10-25	English Glass Company Limited, The	Multi-dose syringe and cannulae therefor
US4692336A (en) *	1984-03-19	1987-09-08	Alza Corporation	Self controlled release device for administering beneficial agent to recipient
ES8800043A1 (es) *	1985-08-16	1987-10-16	Alza Corp	Un dispositivo distribuidor para descargar una formulacion de agente beneficioso a un entorno de uso
US4675174A (en) *	1985-08-16	1987-06-23	Alza Corporation	Veterinary dispenser delivering beneficial agent by gas power generated in situ
JPH0778017B2 (ja) *	1985-12-28	1995-08-23	住友製薬株式会社	パルス的かつ持続放出性製剤
US4723958A (en) *	1986-05-23	1988-02-09	Merck & Co., Inc.	Pulsatile drug delivery system

1988
- 1988-06-15 GB GB8814220A patent/GB2206046B/en not_active Expired - Lifetime
- 1988-06-17 NZ NZ225058A patent/NZ225058A/en unknown
- 1988-06-20 AU AU18169/88A patent/AU602221B2/en not_active Expired
- 1988-06-23 ES ES8801959A patent/ES2009014A6/es not_active Expired
- 1988-06-24 JP JP63156609A patent/JP2732530B2/ja not_active Expired - Lifetime
- 1988-06-24 CA CA000570389A patent/CA1301572C/en not_active Expired - Lifetime
- 1988-06-24 DE DE3821424A patent/DE3821424C2/de not_active Expired - Lifetime
- 1988-06-24 IT IT67602/88A patent/IT1219401B/it active
- 1988-06-27 FR FR888808592A patent/FR2617045B1/fr not_active Expired - Lifetime

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9655894B2 (en)	2001-05-02	2017-05-23	Purdue Pharma L.P.	Once-A day oxycodone formulations
US9655893B2 (en)	2001-05-02	2017-05-23	Purdue Pharma L.P.	Once-a-day oxycodone formulations
US10660886B2 (en)	2001-05-02	2020-05-26	Purdue Pharma L.P.	Oxycodone formulations

Also Published As

Publication number	Publication date
IT8867602A0 (it)	1988-06-24
GB2206046A (en)	1988-12-29
DE3821424A1 (de)	1989-01-05
FR2617045B1 (fr)	1991-09-13
JP2732530B2 (ja)	1998-03-30
GB2206046B (en)	1991-04-03
JPS6452457A (en)	1989-02-28
DE3821424C2 (de)	1997-02-20
AU602221B2 (en)	1990-10-04
AU1816988A (en)	1989-01-05
NZ225058A (en)	1990-11-27
GB8814220D0 (en)	1988-07-20
ES2009014A6 (es)	1989-08-16
IT1219401B (it)	1990-05-11
FR2617045A1 (fr)	1988-12-30

Publication	Publication Date	Title
US5023088A (en)	1991-06-11	Multi-unit delivery system
US5110597A (en)	1992-05-05	Multi-unit delivery system
US5391381A (en)	1995-02-21	Dispenser capable of delivering plurality of drug units
US4874388A (en)	1989-10-17	Multi-layer delivery system
US5340590A (en)	1994-08-23	Delivery system with bilayer osmotic engine
US4957494A (en)	1990-09-18	Multi-layer delivery system
CA1301572C (en)	1992-05-26	Multi - unit delivery system
US5499979A (en)	1996-03-19	Delivery system comprising kinetic forces
US5236689A (en)	1993-08-17	Multi-unit delivery system
EP0482075B1 (de)	1994-05-04	Orale osmotische vorrichtung mit einem hydrogel als treibendes teil
US5443459A (en)	1995-08-22	Osmotic device for delayed delivery of agent
US5776493A (en)	1998-07-07	Oral osmotic device for delivery of nystatin with hydrogel driving member
AU645315B2 (en)	1994-01-13	Osmotic dosage system for liquid drug delivery
EP1117383B1 (de)	2005-11-23	Therapeutische formulierung enthaltende dosierungsform
US4940465A (en)	1990-07-10	Dispenser comprising displaceable matrix with solid state properties
EP0293066B1 (de)	1993-04-07	Dispenser mit einer beweglichen Matrix mit Feststoffeigenschaften
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