CA1202892A - Tumor imaging with radiolabeled monoclonal antibodies - Google Patents
Tumor imaging with radiolabeled monoclonal antibodiesInfo
- Publication number
- CA1202892A CA1202892A CA000414208A CA414208A CA1202892A CA 1202892 A CA1202892 A CA 1202892A CA 000414208 A CA000414208 A CA 000414208A CA 414208 A CA414208 A CA 414208A CA 1202892 A CA1202892 A CA 1202892A
- Authority
- CA
- Canada
- Prior art keywords
- antibody
- chelating agent
- radionuclide
- group
- monoclonal antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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Classifications
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- A61K51/1066—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from skin
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- A—HUMAN NECESSITIES
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cell Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31528681A | 1981-10-27 | 1981-10-27 | |
| US315,286 | 1981-10-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1202892A true CA1202892A (en) | 1986-04-08 |
Family
ID=23223718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000414208A Expired CA1202892A (en) | 1981-10-27 | 1982-10-26 | Tumor imaging with radiolabeled monoclonal antibodies |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPS58135820A (da) |
| AT (1) | AT392004B (da) |
| BE (1) | BE894829A (da) |
| CA (1) | CA1202892A (da) |
| CH (1) | CH653040A5 (da) |
| DE (1) | DE3239410A1 (da) |
| DK (1) | DK164682C (da) |
| ES (2) | ES516797A0 (da) |
| FI (1) | FI82379C (da) |
| FR (1) | FR2515046B1 (da) |
| GB (1) | GB2109407B (da) |
| IL (1) | IL67068A0 (da) |
| IT (1) | IT1153857B (da) |
| LU (1) | LU84441A1 (da) |
| NL (1) | NL8204108A (da) |
| NO (1) | NO169947C (da) |
| SE (1) | SE8206073L (da) |
| ZA (1) | ZA827806B (da) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4957939A (en) * | 1981-07-24 | 1990-09-18 | Schering Aktiengesellschaft | Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging |
| CA1225930A (en) * | 1982-06-07 | 1987-08-25 | Otto A. Gansow | Metal chelate conjugated monoclonal antibodies |
| US4741900A (en) * | 1982-11-16 | 1988-05-03 | Cytogen Corporation | Antibody-metal ion complexes |
| SE8401946L (sv) * | 1983-04-08 | 1984-11-13 | Kureha Chemical Ind Co Ltd | Antikropp mot human prostatacancer |
| GB2140030A (en) * | 1983-04-08 | 1984-11-21 | Kureha Chemical Ind Co Ltd | Monoclonal antibody to human urinary bladder cancer |
| JPS59199636A (ja) * | 1983-04-26 | 1984-11-12 | Nippon Mejifuijitsukusu Kk | 放射性診断剤 |
| US4677058A (en) * | 1983-05-19 | 1987-06-30 | Karl Tryggvason | Detecting malignant cells with monoclonal antibodies specific to type IV collagenase enzyme |
| US4732864A (en) * | 1983-10-06 | 1988-03-22 | E. I. Du Pont De Nemours And Company | Trace-labeled conjugates of metallothionein and target-seeking biologically active molecules |
| JPS60201260A (ja) * | 1984-03-27 | 1985-10-11 | Yamasa Shoyu Co Ltd | 心疾患診断薬 |
| JP2507982B2 (ja) * | 1984-04-10 | 1996-06-19 | 武田薬品工業株式会社 | ヒト癌胎児性抗原反応性モノクロ―ナル抗体の製造法 |
| US4898724A (en) * | 1984-06-04 | 1990-02-06 | The Dow Chemical Company | Organis amine phosphonic acid complexes for the treatment of calcific tumors |
| CA1260827A (en) * | 1984-08-31 | 1989-09-26 | Richard C. Siegel | Antibody-metal ion complexes |
| US4837003A (en) * | 1984-09-13 | 1989-06-06 | Mallinckrodt, Inc. | Radiolabeled antibody fragments |
| US4659839A (en) * | 1984-10-10 | 1987-04-21 | Mallinckrodt, Inc. | Coupling agents for radiolabeled antibody fragments |
| US4897255A (en) * | 1985-01-14 | 1990-01-30 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
| US5242679A (en) * | 1985-01-14 | 1993-09-07 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
| US4986256A (en) * | 1985-02-28 | 1991-01-22 | The United States Of America As Represented By The Department Of Health And Human Services | Use of paramagnetic metalloporphyrins as contrast agents for tumors in MRI imaging |
| US4824986A (en) * | 1985-04-26 | 1989-04-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Metal chelate protein conjugate |
| US4830847A (en) * | 1985-06-28 | 1989-05-16 | The Procter & Gamble Company | Diphosphonate-derivatized macromolecules |
| US4732974A (en) * | 1986-03-05 | 1988-03-22 | Mallinckrodt, Inc. | Metal ion labeling of carrier molecules |
| US4877868A (en) * | 1986-03-12 | 1989-10-31 | Neorx Corporation | Radionuclide antibody coupling |
| US4861869A (en) * | 1986-05-29 | 1989-08-29 | Mallinckrodt, Inc. | Coupling agents for joining radionuclide metal ions with biologically useful proteins |
| US5082930A (en) * | 1986-05-29 | 1992-01-21 | Mallinckrodt Medical, Inc. | Coupling agents for joining radionuclide metal ions with biologically useful proteins |
| US4925804A (en) * | 1986-06-17 | 1990-05-15 | Baxter International Inc. | Interligand metal transfer assay |
| US4831175A (en) * | 1986-09-05 | 1989-05-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
| US5246692A (en) * | 1986-09-05 | 1993-09-21 | The United States Of America As Represented By The Secretary Of Health And Human Services | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
| FR2604092B1 (fr) * | 1986-09-19 | 1990-04-13 | Immunotech Sa | Immunoreactifs destines a cibler les cellules animales pour leur visualisation ou leur destruction in vivo |
| CA1340014C (en) * | 1986-10-27 | 1998-08-25 | Bryan Michael Longenecker | Carcinoma-marking monoclonal antibodies elicited with synthetic asialo-gmi antigen |
| US5227474A (en) * | 1987-02-13 | 1993-07-13 | Abbott Laboratories | Bifunctional chelating agents |
| US5057302A (en) * | 1987-02-13 | 1991-10-15 | Abbott Laboratories | Bifunctional chelating agents |
| DE3710730A1 (de) * | 1987-03-31 | 1988-10-20 | Schering Ag | Substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel |
| US5177192A (en) * | 1987-04-02 | 1993-01-05 | Centocor, Incorporated | Method for labeling antibodies with a metal ion |
| US5053493A (en) * | 1987-04-02 | 1991-10-01 | Centocor Cardiovascular Imaging Partners, L.P. | Method for labeling antibodies with a metal ion |
| US4838274A (en) * | 1987-09-18 | 1989-06-13 | Air Products And Chemicals, Inc. | Perfluoro-crown ethers in fluorine magnetic resonance imaging |
| US5217704A (en) * | 1987-11-06 | 1993-06-08 | Abbott Laboratories | Methods and materials for the preparation of metal labelled antibody solutions |
| US5648471A (en) * | 1987-12-03 | 1997-07-15 | Centocor, Inc. | One vial method for labeling antibodies with Technetium-99m |
| US4867962A (en) * | 1988-02-26 | 1989-09-19 | Neorx Corporation | Functionally specific antibodies |
| US5075099A (en) * | 1988-05-31 | 1991-12-24 | Neorx Corporation | Metal radionuclide chelating compounds for improved chelation kinetics |
| US4988496A (en) * | 1988-05-31 | 1991-01-29 | Neorx Corporation | Metal radionuclide chelating compounds for improved chelation kinetics |
| US5218128A (en) * | 1988-06-15 | 1993-06-08 | Centocor, Inc. | Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom |
| US5688488A (en) * | 1989-04-03 | 1997-11-18 | Purdue Research Foundation | Composition and method for tumor imaging |
| US5792444A (en) * | 1989-05-09 | 1998-08-11 | The General Hospital Corporation | Labeled chemotactic peptides to image focal sites of infection or inflammation |
| US5807535A (en) * | 1992-07-31 | 1998-09-15 | Australian Nuclear Science & Technology Organisation | Metal complexes of hydroxyaryl containing aminocarboxylic acid chelating agents |
| ES2146217T3 (es) * | 1992-07-31 | 2000-08-01 | Australian Nuclear Science Tec | Agentes quelantes de los acidos aminocarboxilicos con hidroxiarilo. |
| US6663866B1 (en) | 1996-08-28 | 2003-12-16 | Immunomedics, Inc. | Stable radioiodine conjugates and methods for their synthesis |
| US6558669B1 (en) | 1996-08-28 | 2003-05-06 | Immunomedics, Inc. | Stable radioiodine conjugates and methods for their synthesis |
| US7521531B2 (en) | 1996-08-28 | 2009-04-21 | Immunomedics, Inc. | Methods for the purification of stable radioiodine conjugates |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4323546A (en) * | 1978-05-22 | 1982-04-06 | Nuc Med Inc. | Method and composition for cancer detection in humans |
| US4272503A (en) * | 1978-05-25 | 1981-06-09 | New England Nuclear Corporation | Reductant composition for technetium-99m and method for making technetium-99m labelled ligands |
| US4311688A (en) * | 1979-10-29 | 1982-01-19 | Serono Laboratories Inc. | Composition and method for cancer detection in humans |
| WO1981002522A1 (en) * | 1980-03-03 | 1981-09-17 | M Goldenberg | Tumor localization and therapy with labeled antibodies and antibody fragments specific to tumor-associated markers |
-
1982
- 1982-10-25 AT AT0391682A patent/AT392004B/de not_active IP Right Cessation
- 1982-10-25 GB GB08230356A patent/GB2109407B/en not_active Expired
- 1982-10-25 NO NO823530A patent/NO169947C/no unknown
- 1982-10-25 ES ES516797A patent/ES516797A0/es active Granted
- 1982-10-25 NL NL8204108A patent/NL8204108A/nl not_active Application Discontinuation
- 1982-10-25 FI FI823633A patent/FI82379C/fi not_active IP Right Cessation
- 1982-10-25 FR FR8217800A patent/FR2515046B1/fr not_active Expired
- 1982-10-25 DE DE19823239410 patent/DE3239410A1/de active Granted
- 1982-10-26 CH CH6239/82A patent/CH653040A5/de not_active IP Right Cessation
- 1982-10-26 JP JP57188921A patent/JPS58135820A/ja active Granted
- 1982-10-26 CA CA000414208A patent/CA1202892A/en not_active Expired
- 1982-10-26 LU LU84441A patent/LU84441A1/fr unknown
- 1982-10-26 IL IL67068A patent/IL67068A0/xx not_active IP Right Cessation
- 1982-10-26 ZA ZA827806A patent/ZA827806B/xx unknown
- 1982-10-26 SE SE8206073A patent/SE8206073L/ not_active Application Discontinuation
- 1982-10-26 DK DK474182A patent/DK164682C/da active
- 1982-10-26 IT IT23932/82A patent/IT1153857B/it active
- 1982-10-27 BE BE0/209345A patent/BE894829A/fr not_active IP Right Cessation
-
1984
- 1984-01-31 ES ES529310A patent/ES529310A0/es active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DK164682B (da) | 1992-08-03 |
| GB2109407A (en) | 1983-06-02 |
| GB2109407B (en) | 1985-12-18 |
| DK474182A (da) | 1983-04-28 |
| FI823633A0 (fi) | 1982-10-25 |
| SE8206073D0 (sv) | 1982-10-26 |
| AT392004B (de) | 1991-01-10 |
| IL67068A0 (en) | 1983-02-23 |
| DE3239410C2 (da) | 1991-12-19 |
| FI82379C (fi) | 1991-03-11 |
| ES8404857A1 (es) | 1984-05-16 |
| FR2515046A1 (fr) | 1983-04-29 |
| NO169947B (no) | 1992-05-18 |
| DK164682C (da) | 1992-12-21 |
| ZA827806B (en) | 1983-08-31 |
| FR2515046B1 (fr) | 1985-11-29 |
| BE894829A (fr) | 1983-02-14 |
| DE3239410A1 (de) | 1983-05-19 |
| NO169947C (no) | 1992-08-26 |
| SE8206073L (sv) | 1983-04-28 |
| ES8505482A1 (es) | 1985-05-16 |
| CH653040A5 (de) | 1985-12-13 |
| ES529310A0 (es) | 1985-05-16 |
| IT8223932A0 (it) | 1982-10-26 |
| ATA391682A (de) | 1990-07-15 |
| FI823633L (fi) | 1983-04-28 |
| FI82379B (fi) | 1990-11-30 |
| ES516797A0 (es) | 1984-05-16 |
| JPH0564130B2 (da) | 1993-09-14 |
| NL8204108A (nl) | 1983-05-16 |
| JPS58135820A (ja) | 1983-08-12 |
| LU84441A1 (fr) | 1983-06-13 |
| NO823530L (no) | 1983-04-28 |
| IT1153857B (it) | 1987-01-21 |
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| MKEX | Expiry |