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CA1099672A - Double-chamber container for administration of two single dosages or two single components and processes of its manufacture - Google Patents

Double-chamber container for administration of two single dosages or two single components and processes of its manufacture

Info

Publication number
CA1099672A
CA1099672A CA289,750A CA289750A CA1099672A CA 1099672 A CA1099672 A CA 1099672A CA 289750 A CA289750 A CA 289750A CA 1099672 A CA1099672 A CA 1099672A
Authority
CA
Canada
Prior art keywords
container
closure member
discharge channel
discharge
foil sections
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA289,750A
Other languages
French (fr)
Inventor
Peter Asp
Dieter Jarsen
Wilhelm Klingelholler
Helmut Franz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Application granted granted Critical
Publication of CA1099672A publication Critical patent/CA1099672A/en
Expired legal-status Critical Current

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3261Flexible containers having several compartments

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Bag Frames (AREA)
  • Package Specialized In Special Use (AREA)
  • Packages (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Abstract

Abstract of the disclosure A two chamber non rigid container of flexible foil material for administering two single doses of a medicament or two separate constituents. The two chambers each communicate via a delivery passage with a common discharge passage which contains a flexible closure member, one end of which closes the junction of the two delivery passages with the discharge passage whilst the other end is sealed into a tear off tab formed from part of the foil material.

Description

1(~9~672 This invention relates to a non-rigid two chamber container of flexible foil material for the administration of two single doses or two individual constituents, for example of medicinal liquids, and to a method of manufacturing such a container.
Single dose non rigid containers consisting of a cha~ber containing a substance have been proposed for instance in British Patent No. 1365848. In cases where two liquids which are incompatible with one another, but which have to be applied simultaneously or where two liquids are to be mixed with one another shortly before application, the use of two single dose containers which each consist of only one chamber and which contain one liquid or the other has proved disadvantageous because the packs can be confused very easily.
Although this problem can be solved to a certain extent by applying strikingly different identification to the outsides of the individual packs, this requires the preparat;on of two kinds of packs and, consequently, means higher costs and more spent on production.
Furthermore there are some areas of application in mediclne which occur in pairs, or example the nostrils~ the eyes and the ears. If known single dose containers are used, for such applications two single dose containe~swould be \

~ 2 --~ ~
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required for the administration of the medicament.
According to the invention there is provided a disposable single-use ccntainer for liquid or semi-liquid pharmaceutical compositions, said container comprising a pair of separate compartments adapted to receive two single doses of the same pharmaceutical composition or single doses of two different pharmaceutical compositions, each of said compartments having a compartment discharge channel; a common container discharse channel communi~
cating with said compartment discharge channels at substantially the same location on said container discharge channel; an elongate flexible thread-like closure member having one end extending beyond said location in said container discharge channel and sealing said compartment discharge channels from each other and from said common container discharge channel, with the other end of said closure member releasably sealed in said common container discharge channel and extending outwardly of the container; which elongate container closure member can be pulled out of said container discharge channel, in use of the container, th0reby to provide a discharge opening through which the contents of both of said compartments can be discharged from the container.
mus the closure member seals the discharge passage outwardly and the delivery passages of the two chambers are cut off from one another, so that premature mixing of the contents cannot take place. When a double-cham-ber single dose container of this Xind is used, substances which are galeni-cally incompatible with one another can be kept separate from one another without risk and not mixed with one another until shortly before application, e.g. at the place of application.
The use of such a double-chamber container instead of two single-dose container~ eliminates any risk of confusion and entails a not inconsider- -able saving of cost and materials; the user has only one pack to deal with, which is more convenient for him in every case.

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.

1(~996~

Preferably, a container according to the invention consists of two malleable foils, for example two deep-drawable laminated aluminium foils, into which are impressed mirror-symmetrically t~o double-chamber halves, associated delivery passage halves communicating with respective discharge passage halves where the two delivery passage halves join together.
After the two halves of the foil have been sealed together, the discharge passage is filled a closure member in the form of a thread. The latter may consist of plastics material (for example, Monofil) or plastics-coated textile material.
One end of the thread shuts ~f~ thé Ju~ction of the two delivery .. ...... .
passages with the discharge passage and the other end is sealed directly in a tear-off tab.
The tear-off tab is formed from extensions of the webs of foil and has a weakened rupture point at the transition to the container. ~--Advantageously, the thread may extend beyond the junction of the two delivery passages, in order thereby to guarantee secure sealing of the two delivery passages from one another.
In this manner, the two liquids in the two chambers cannot be mixed with one another during storage or during transport;
this is necessary , for example, when the two liquids react with one another or are galenically incompatible with one another in the longterm.

~ -~9~67Z

The double-chamber container is opened by twisting and/or pulling off the tear-off tab from the con-tainer, in order to remove the opening thread from the discharge passage and thereby free the opening. As a result, the channel is open for the liquid to pass out o~ the chambers through the delivery passages and the discharge passage.
The two chambers can be emptied simultaneously or successively by exerting pressure, for example, by means of the fingers~
The containers are manuactured by sealing two foil halves stamped to provide the above-mentioned chambers and passages. The half sections are impressed into endless foil strips and the foil strips whose impressions are mirror-symmetrIcal to one another are then secured to one another in a pre-sealing operation, the chambers and passages being sealed~round first with the exception of filling openings .
.. ~
on the chambèrs. -A previously stretched thread introduced into the discharge passage at the same station is .~ ` . . .
simultaneously secured fast ln the tear-off tabby pre-sealing jaws and detached from the thread strand at a theoretical rupture point of the thread by pulling back the thread strand~
The two chambers are subsequently filled by means of filling needles through the unsealed filling openings of the ~chambers and are hermeticall~ closed a a final sealing station.
Accordingly the inventlon provides in a further aspect a 1{~9~6 7Z

method of manufacturing a container as above set forth comprising providing two opposing foil sections, each foil section having impressed therein a predetermined shape so as in the assembled container to form two separate chambers communicating with a discharge passage, sealing together said opposing foil sections in part whilst simultaneously positioning within said discharge passage an elongate flexible closure mem~er, one end of said closure member being positioned within extensions of said foil sections which form a tear off tab, and filling said chambers with the contents of the container through the unsealed part of the containers, and finally sealing the container.
A preLerred embodiment of the invention will now be described with reference to the accompanying drawings.
Figure 1 is a æhematic vlew of the container according to the invention, and Figure 2 is an enlarged fragmentary sectional view of the container.
Referring to the drawings, there is shown a container formed from two separate foil sections having two separate chambers 2,2 each connected by a delivery passage 3 at a junction 4 to an elongate disch~ passage 5. Sealed within the container is a flexible elongate closure member 6 in the form of a plast.ics thread. One end 7 of,the thread q9~Z

projects beyond the junction 4 and the other end 8 is secured by securing means 9 within a tear-off foil tab 10. Tab 10 has a narrowed region 11 at which the tab will tear away from the rest of the container.
The container 12 made of two foil sections is stamped out of an endless foil strip which are sealed together.
The method of filling the container is as follows.
When the oil strips have been joined together, they are left partly unsealed so that the intended contents ~ay be introduced into the respective chambers 2 by means of a filling nozzle. The container is then ful~ sealed. To remove the contents of the container, the tab 10 is torn off and the contents of the container are squeezed from the container by squeezing each chamber separately one after the other, or both simultaneously.~
.
. , . ~ - .
~ ~.. . . .

Claims (4)

THE EMBODIMENTS OF THE INVENTION IN WHICH AN EXCLUSIVE
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. A disposable single-use container for liquid or semi-liquid pharma-ceutical compositions, said container comprising a pair of separate compart-ments adapted to receive two single doses of the same pharmaceutical composi-tion or single doses of two different pharmaceutical compositions, each of said compartments having a compartment discharge channel; a common container discharge channel communicating with said compartment discharge channels at substantially the same location on said container discharge channel; an elon-gate flexible thread-like closure member having one end extending beyond said location in said container discharge channel and sealing said compartment discharge channels from each other and from said common container discharge channel, with the other end of said closure member releasably sealed in said common container discharge channel and extending outwardly of the container;
which elongate container closure member can be pulled out of said container discharge channel, in use of the container, thereby to provide a discharge opening through which the contents of both of said compartments can be discharged from the container.
2. A container as claimed in claim 1 wherein the container is formed of two opposing foil sections and a tear-off portion is formed from ex-tensions of said foil sections.
3. A container according to either claim 1 or 2 wherein the closure member is in the form of a thread of plastics or plastics-coated textile fabric.
4. A method of manufacturing a container as claimed in either claim 1 or 2 comprising providing two opposing foil sections, each foil section having impressed therein a predetermined shape so as in the assembled container to form two separate chambers communicating with a discharge passage sealing together said opposing foil sections in part whilst simultaneously position-ing within said discharge passage an elongate flexible closure member, one end of said closure member being positioned within extensions of said foil sections which form a tear off tab, and filling said chambers with the contents of the container through the unsealed part of the containers, and finally sealing the container.
CA289,750A 1976-10-29 1977-10-28 Double-chamber container for administration of two single dosages or two single components and processes of its manufacture Expired CA1099672A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP2649316.3 1976-10-29
DE19762649316 DE2649316C2 (en) 1976-10-29 1976-10-29 Double chamber container for the administration of two single doses or two single components and process for its production

Publications (1)

Publication Number Publication Date
CA1099672A true CA1099672A (en) 1981-04-21

Family

ID=5991865

Family Applications (1)

Application Number Title Priority Date Filing Date
CA289,750A Expired CA1099672A (en) 1976-10-29 1977-10-28 Double-chamber container for administration of two single dosages or two single components and processes of its manufacture

Country Status (15)

Country Link
JP (1) JPS5356590A (en)
AR (1) AR212485A1 (en)
AT (1) AT355222B (en)
AU (1) AU509479B2 (en)
BE (1) BE860302A (en)
BR (1) BR7707202A (en)
CA (1) CA1099672A (en)
CH (1) CH622751A5 (en)
DE (1) DE2649316C2 (en)
ES (1) ES463208A1 (en)
FR (1) FR2369181A1 (en)
GB (1) GB1547025A (en)
IT (1) IT1090193B (en)
NL (1) NL7711864A (en)
SE (1) SE7712143L (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7905979L (en) * 1978-12-15 1980-06-16 Panpack Ag PACKAGING FOR RECOVERY AND SPRAYING OF SMALL SCIENCES
JPH0646840Y2 (en) * 1984-06-19 1994-11-30 大日本印刷株式会社 Tubular composite container
NL8502154A (en) * 1985-07-29 1987-02-16 Hsm DISPENSER, IN PARTICULAR FOR MILK OR THE LIKE.
FR2586913B1 (en) * 1985-09-10 1990-08-03 Oreal PROCESS FOR FORMING IN SITU A COMPOSITION CONSISTING OF TWO SEPARATELY PACKED PARTS AND DISPENSING ASSEMBLY FOR THE IMPLEMENTATION OF THIS PROCESS
JPH06319782A (en) * 1993-05-10 1994-11-22 Material Eng Tech Lab Inc Medical container
US5509898A (en) * 1993-05-10 1996-04-23 Material Engineering Technology Laboratory, Inc. Container for therapeutic use
FR2750678B1 (en) * 1996-07-05 1998-10-30 Valois DEVICE FOR BIPHASIC DELIVERY OF A SINGLE DOSE
DE19627243A1 (en) * 1996-07-08 1998-01-15 Hassia Verpackung Ag Packaging for two filling material components for oral administration of medication
DE29809474U1 (en) 1998-05-27 1998-08-13 Iymen, Siddik, Dr.rer.nat., 66538 Neunkirchen Tubular bag pack
DE19962436B4 (en) * 1999-12-22 2005-05-25 3M Espe Ag Method for dispensing a flowable substance from a packaging
US6357631B1 (en) * 2000-04-06 2002-03-19 Colgate-Palmolive Company Container with formed memory valve
US6612769B2 (en) * 2000-12-13 2003-09-02 Innovative Properties Company Package and dispensing actuator for multiple-component compositions
DE20021922U1 (en) 2000-12-23 2001-04-05 Chalupka, Jürgen, 90574 Roßtal Packaging unit for multi-component materials
US6769231B2 (en) 2001-07-19 2004-08-03 Baxter International, Inc. Apparatus, method and flexible bag for use in manufacturing
US20030017056A1 (en) * 2001-07-19 2003-01-23 Baxter International Inc. Pump having flexible liner and merchandiser having such a pump
US6752264B2 (en) * 2002-07-03 2004-06-22 Sonoco Development, Inc. Flexible pouch having system for mixing two components
FR2846305B1 (en) * 2002-10-24 2006-02-10 Valois Sas FLUID PRODUCT DISPENSER.
ITMI20101921A1 (en) * 2010-10-20 2012-04-21 New Project S R L SINGLE-DOSE SACHETS WITH SEPARATE COMPARTMENTS FOR BICOMPONENT PRODUCTS FOR HOUSEHOLD USE
CN104703894B (en) * 2012-10-12 2017-01-18 雀巢产品技术援助有限公司 Card for containing food or beverage ingredients
WO2017086885A1 (en) * 2015-11-17 2017-05-26 KRISNAVARIN, Wattana Flexible pouch equipped with multi-layered inner pouch for maintaining temperature and preventing impact
WO2017218767A1 (en) * 2016-06-15 2017-12-21 Chang Robert T Single-use vials for administering eye drops

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3197071A (en) * 1962-12-03 1965-07-27 Colgate Palmolive Co Multiple compartment dispenser
CH517026A (en) * 1969-07-18 1971-12-31 Stadex Ab Tear-away closure device and use of this device

Also Published As

Publication number Publication date
SE7712143L (en) 1978-04-30
AU509479B2 (en) 1980-05-15
DE2649316C2 (en) 1982-04-22
CH622751A5 (en) 1981-04-30
DE2649316A1 (en) 1978-05-03
FR2369181B1 (en) 1981-11-06
AT355222B (en) 1980-02-25
BE860302A (en) 1978-04-28
ATA747277A (en) 1979-07-15
GB1547025A (en) 1979-06-06
FR2369181A1 (en) 1978-05-26
AR212485A1 (en) 1978-07-14
JPS5356590A (en) 1978-05-23
BR7707202A (en) 1978-06-27
AU3013977A (en) 1979-05-03
ES463208A1 (en) 1978-12-16
NL7711864A (en) 1978-05-03
IT1090193B (en) 1985-06-18

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Legal Events

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