CA1059030A - Induction de l'ovulation a l'aide de gonadotrophine chorionique humaine partiellement desialylee - Google Patents
Induction de l'ovulation a l'aide de gonadotrophine chorionique humaine partiellement desialyleeInfo
- Publication number
- CA1059030A CA1059030A CA245,964A CA245964A CA1059030A CA 1059030 A CA1059030 A CA 1059030A CA 245964 A CA245964 A CA 245964A CA 1059030 A CA1059030 A CA 1059030A
- Authority
- CA
- Canada
- Prior art keywords
- hcg
- chorionic gonadotropin
- human chorionic
- desialylated
- ovulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108010062540 Chorionic Gonadotropin Proteins 0.000 title claims abstract description 38
- 102000011022 Chorionic Gonadotropin Human genes 0.000 title claims abstract description 38
- 229940084986 human chorionic gonadotropin Drugs 0.000 title claims abstract description 38
- 230000016087 ovulation Effects 0.000 title abstract description 15
- 230000006698 induction Effects 0.000 title abstract 2
- 239000003708 ampul Substances 0.000 claims description 9
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 2
- 239000008101 lactose Substances 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 abstract description 8
- SQVRNKJHWKZAKO-PFQGKNLYSA-N N-acetyl-beta-neuraminic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-PFQGKNLYSA-N 0.000 abstract description 6
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 3
- 108010039846 asialo-human chorionic gonadotropin Proteins 0.000 description 19
- 108010073521 Luteinizing Hormone Proteins 0.000 description 10
- 102000009151 Luteinizing Hormone Human genes 0.000 description 10
- 229940040129 luteinizing hormone Drugs 0.000 description 10
- 108090000288 Glycoproteins Proteins 0.000 description 9
- 102000003886 Glycoproteins Human genes 0.000 description 9
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 8
- 230000004071 biological effect Effects 0.000 description 8
- 229940088597 hormone Drugs 0.000 description 8
- 239000005556 hormone Substances 0.000 description 8
- 108010057021 Menotropins Proteins 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 7
- 230000007423 decrease Effects 0.000 description 6
- 238000002560 therapeutic procedure Methods 0.000 description 6
- 241000700159 Rattus Species 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 238000011282 treatment Methods 0.000 description 5
- 241000283973 Oryctolagus cuniculus Species 0.000 description 4
- 210000001672 ovary Anatomy 0.000 description 4
- 239000000186 progesterone Substances 0.000 description 4
- 229960003387 progesterone Drugs 0.000 description 4
- 125000005629 sialic acid group Chemical group 0.000 description 4
- 102000005348 Neuraminidase Human genes 0.000 description 3
- 108010006232 Neuraminidase Proteins 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 description 2
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 description 2
- 102000006771 Gonadotropins Human genes 0.000 description 2
- 108010086677 Gonadotropins Proteins 0.000 description 2
- 102000011923 Thyrotropin Human genes 0.000 description 2
- 108010061174 Thyrotropin Proteins 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229940028334 follicle stimulating hormone Drugs 0.000 description 2
- 230000003325 follicular Effects 0.000 description 2
- 239000002622 gonadotropin Substances 0.000 description 2
- 229940094892 gonadotropins Drugs 0.000 description 2
- 208000000509 infertility Diseases 0.000 description 2
- 230000036512 infertility Effects 0.000 description 2
- 231100000535 infertility Toxicity 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 230000035800 maturation Effects 0.000 description 2
- 229960002985 medroxyprogesterone acetate Drugs 0.000 description 2
- PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 description 2
- 230000035935 pregnancy Effects 0.000 description 2
- 238000011450 sequencing therapy Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 201000005670 Anovulation Diseases 0.000 description 1
- 206010002659 Anovulatory cycle Diseases 0.000 description 1
- 108010002913 Asialoglycoproteins Proteins 0.000 description 1
- 241000193403 Clostridium Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000034702 Multiple pregnancies Diseases 0.000 description 1
- 206010033157 Ovarian enlargement Diseases 0.000 description 1
- 206010033165 Ovarian failure Diseases 0.000 description 1
- 102000004451 Pituitary Gonadotropins Human genes 0.000 description 1
- 108010081865 Pituitary Gonadotropins Proteins 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000000184 acid digestion Methods 0.000 description 1
- 231100000552 anovulation Toxicity 0.000 description 1
- 230000002513 anti-ovulatory effect Effects 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000007398 colorimetric assay Methods 0.000 description 1
- 210000004246 corpus luteum Anatomy 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- -1 for example Substances 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000021267 infertility disease Diseases 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 210000004731 jugular vein Anatomy 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 210000003101 oviduct Anatomy 0.000 description 1
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 description 1
- 229960002695 phenobarbital Drugs 0.000 description 1
- 208000016685 primary ovarian failure Diseases 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Reproductive Health (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT48202/75A IT1057895B (it) | 1975-02-17 | 1975-02-17 | Gonadotropina corionica umana parzialmente desalinizzata per indurre l'ouvulazione |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1059030A true CA1059030A (fr) | 1979-07-24 |
Family
ID=11265181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA245,964A Expired CA1059030A (fr) | 1975-02-17 | 1976-02-17 | Induction de l'ovulation a l'aide de gonadotrophine chorionique humaine partiellement desialylee |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4062942A (fr) |
| BE (1) | BE838657A (fr) |
| CA (1) | CA1059030A (fr) |
| DE (1) | DE2606309C3 (fr) |
| FR (1) | FR2300573A1 (fr) |
| GB (1) | GB1523825A (fr) |
| IL (1) | IL49054A (fr) |
| IT (1) | IT1057895B (fr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4196123A (en) * | 1978-11-20 | 1980-04-01 | Eugenia Rosemberg | Hybrid chorionic gonadotropin preparations and methods for stimulating ovulation using same |
| US4589402A (en) * | 1984-07-26 | 1986-05-20 | Serono Laboratories, Inc. | Method of in vitro fertilization |
| US4970071A (en) * | 1985-01-18 | 1990-11-13 | Mcmichael John | Immunotherapeutic methods and compositions employing antigens characteristic of non human malignant neoplasms |
| US4966753A (en) * | 1987-08-18 | 1990-10-30 | Molecular Rx, Inc. | Immunotherapeutic methods and compositions employing antigens characteristic of malignant neoplasms |
| IE64738B1 (en) * | 1990-03-20 | 1995-09-06 | Akzo Nv | Stabilized gonadotropin containing preparations |
| US5384132A (en) * | 1990-03-20 | 1995-01-24 | Akzo N.V. | Stabilized gonadotropin containing preparations |
| US5270057A (en) * | 1990-03-20 | 1993-12-14 | Akzo N.V. | Stabilized gonadotropin containing preparations |
| US5416071A (en) * | 1991-03-12 | 1995-05-16 | Takeda Chemical Industries, Ltd. | Water-soluble composition for sustained-release containing epo and hyaluronic acid |
| CN1138864A (zh) * | 1994-01-20 | 1996-12-25 | 阿克佐诺贝尔公司 | 具有卵泡刺激作用的糖蛋白异构体的新组合物 |
| CN1608078B (zh) * | 2001-10-22 | 2012-07-25 | 默克雪兰诺有限公司 | 用于卵泡生成的促性腺激素 |
| SI1765085T1 (sl) | 2004-05-17 | 2015-11-30 | The General Hospital Corporation | Sestavki, ki vsebujejo ženske zarodne matične celice in postopki njihove uporabe |
| US7994131B2 (en) * | 2004-10-07 | 2011-08-09 | Stem Cell Therapeutics Corp. | Stimulation of proliferation of pluripotential stem cells through administration of pregnancy associated compounds |
| WO2012142500A2 (fr) | 2011-04-14 | 2012-10-18 | The General Hospital Corporation | Compositions et méthodes de transfert d'énergie autologue des mitochondries dans les cellules germinales |
| BR112013033797A2 (pt) | 2011-06-29 | 2017-02-14 | Harvard College | composição, célula isolada, mitocôndria isolada , métodos de preparo de um oócito, de fertilização in vitro, de melhora de fertilidade em um indivíduo, de sustentação de desenvolvimento embrionário, de recuperação ou aumento de função ovariana em um indivíduo, de preparo de um tecido ou célula do mesmo, e de produção de um oócito, oócito, e, agente bioenergético |
-
1975
- 1975-02-17 IT IT48202/75A patent/IT1057895B/it active
-
1976
- 1976-02-17 IL IL49054A patent/IL49054A/xx unknown
- 1976-02-17 GB GB6259/76A patent/GB1523825A/en not_active Expired
- 1976-02-17 DE DE2606309A patent/DE2606309C3/de not_active Expired
- 1976-02-17 US US05/658,490 patent/US4062942A/en not_active Expired - Lifetime
- 1976-02-17 FR FR7604293A patent/FR2300573A1/fr active Granted
- 1976-02-17 CA CA245,964A patent/CA1059030A/fr not_active Expired
- 1976-02-17 BE BE164402A patent/BE838657A/fr not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE2606309B2 (de) | 1980-05-14 |
| IL49054A (en) | 1979-09-30 |
| DE2606309A1 (de) | 1976-08-26 |
| GB1523825A (en) | 1978-09-06 |
| IT1057895B (it) | 1982-03-30 |
| FR2300573A1 (fr) | 1976-09-10 |
| BE838657A (fr) | 1976-08-17 |
| IL49054A0 (en) | 1976-04-30 |
| US4062942A (en) | 1977-12-13 |
| FR2300573B1 (fr) | 1979-03-23 |
| DE2606309C3 (de) | 1981-01-22 |
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