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CA1046508A - Process for the preparation of daunomycins - Google Patents

Process for the preparation of daunomycins

Info

Publication number
CA1046508A
CA1046508A CA222,610A CA222610A CA1046508A CA 1046508 A CA1046508 A CA 1046508A CA 222610 A CA222610 A CA 222610A CA 1046508 A CA1046508 A CA 1046508A
Authority
CA
Canada
Prior art keywords
trifluoroacetyl
chloro
bis
daunosamine
epi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA222,610A
Other languages
English (en)
French (fr)
Inventor
Federico Arcamone
Aurelio Di Marco
Sergio Penco
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmaceutici Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia SpA filed Critical Farmaceutici Italia SpA
Application granted granted Critical
Publication of CA1046508A publication Critical patent/CA1046508A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA222,610A 1974-03-20 1975-03-20 Process for the preparation of daunomycins Expired CA1046508A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1225474A GB1457559A (en) 1974-03-20 1974-03-20 Daunomycins

Publications (1)

Publication Number Publication Date
CA1046508A true CA1046508A (en) 1979-01-16

Family

ID=10001195

Family Applications (1)

Application Number Title Priority Date Filing Date
CA222,610A Expired CA1046508A (en) 1974-03-20 1975-03-20 Process for the preparation of daunomycins

Country Status (13)

Country Link
JP (1) JPS5833880B2 (sv)
AT (1) AT338419B (sv)
BE (1) BE826848A (sv)
CA (1) CA1046508A (sv)
CH (1) CH615198A5 (sv)
DE (1) DE2510926C3 (sv)
DK (1) DK146541C (sv)
FR (1) FR2264554B1 (sv)
GB (1) GB1457559A (sv)
NL (1) NL176636C (sv)
SE (1) SE434843B (sv)
SU (1) SU589926A3 (sv)
ZA (1) ZA751687B (sv)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6087340A (en) * 1985-08-02 2000-07-11 Pharmacia & Upjohn, Inc. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US6107285A (en) * 1985-08-02 2000-08-22 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2678274A1 (fr) * 1991-06-25 1992-12-31 Medgenix Group Sa N-leucyl epirubicine application a titre de medicament antitumoral et procede de preparation.

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6087340A (en) * 1985-08-02 2000-07-11 Pharmacia & Upjohn, Inc. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US6107285A (en) * 1985-08-02 2000-08-22 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US6284738B1 (en) 1985-08-02 2001-09-04 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US7005421B2 (en) 1985-08-02 2006-02-28 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside

Also Published As

Publication number Publication date
ZA751687B (en) 1976-02-25
JPS50126657A (sv) 1975-10-04
DK109275A (sv) 1975-09-21
JPS5833880B2 (ja) 1983-07-22
DK146541B (da) 1983-10-31
NL7503079A (nl) 1975-09-23
NL176636C (nl) 1985-05-17
DK146541C (da) 1984-04-09
DE2510926B2 (de) 1979-07-19
NL176636B (nl) 1984-12-17
BE826848A (fr) 1975-09-19
AT338419B (de) 1977-08-25
FR2264554A1 (sv) 1975-10-17
FR2264554B1 (sv) 1978-07-28
ATA202875A (de) 1976-12-15
GB1457559A (en) 1976-12-08
SE434843B (sv) 1984-08-20
DE2510926A1 (de) 1975-09-25
DE2510926C3 (de) 1980-03-13
CH615198A5 (en) 1980-01-15
SE7503084L (sv) 1975-09-22
SU589926A3 (ru) 1978-01-25
AU7919775A (en) 1976-09-23

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