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BRPI1013493A2 - composto de pirimidina - Google Patents

composto de pirimidina

Info

Publication number
BRPI1013493A2
BRPI1013493A2 BRPI1013493A BRPI1013493A BRPI1013493A2 BR PI1013493 A2 BRPI1013493 A2 BR PI1013493A2 BR PI1013493 A BRPI1013493 A BR PI1013493A BR PI1013493 A BRPI1013493 A BR PI1013493A BR PI1013493 A2 BRPI1013493 A2 BR PI1013493A2
Authority
BR
Brazil
Prior art keywords
pyrimidine compound
pyrimidine
compound
Prior art date
Application number
BRPI1013493A
Other languages
English (en)
Inventor
Fusako Nishigaki
Hirokazu Kubota
Hisao Hamaguchi
Takeshi Hondo
Yoshinori Okamoto
Yuji Matsushima
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of BRPI1013493A2 publication Critical patent/BRPI1013493A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2012008082A (es) 2010-01-11 2013-02-07 Astraea Therapeutics Llc Moduladores del receptor nicotinico de acetilcolina.
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
WO2011133920A1 (en) 2010-04-23 2011-10-27 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081626A1 (es) 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
US8815882B2 (en) * 2010-11-10 2014-08-26 Genentech, Inc. Pyrazole aminopyrimidine derivatives as LRRK2 modulators
CN102283845B (zh) * 2011-07-07 2012-10-03 济南环肽医药科技有限公司 1,4,5,6-四氢-2-甲基-4-嘧啶羧酸及1,4,5,6-四氢-2-甲基-5-羟基-4-嘧啶羧酸在制备肺结核治疗药物中的应用
CA2871926A1 (en) 2012-05-03 2013-11-07 Saint Louis College Of Pharmacy Compositions and methods for increasing neurotrophic peptides
RU2697707C9 (ru) * 2013-11-27 2019-10-03 Саншайн Лейк Фарма Ко., Лтд. Процессы приготовления производных соединений дигидропиримидина и их промежуточных продуктов
GB201511382D0 (en) 2015-06-29 2015-08-12 Imp Innovations Ltd Novel compounds and their use in therapy
MX2019000536A (es) * 2016-07-14 2019-04-01 Pfizer Nuevas pirimidinas carboxamidas como inhibidores de enzima vanina-1.
CN114206443B (zh) * 2019-05-10 2024-02-09 浙江海正药业股份有限公司 芳环或杂芳环类衍生物及其制备方法和用途
WO2022127909A1 (zh) * 2020-12-17 2022-06-23 上海美悦生物科技发展有限公司 一种嘧啶甲酰胺类化合物及其应用
US20240116850A1 (en) * 2020-12-23 2024-04-11 The Broad Institute, Inc. Compositions and methods related to bicyclo[2.2.1] heptanamine-containing compounds
US11840495B2 (en) 2020-12-23 2023-12-12 The Broad Institute, Inc. Compositions and methods related to di-substituted bicyclo[2.2.1] heptanamine-containing compounds

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA831247B (en) * 1982-02-24 1984-04-25 Nyegaard & Co As Substituted pyrimidin-2-ones and the salts thereof
HUT63941A (en) * 1992-05-15 1993-11-29 Hoechst Ag Process for producing 4-alkyl-substituted pyrimidine-5-carboxanilide derivatives, and fungicidal compositions comprising same
US5532237A (en) 1995-02-15 1996-07-02 Merck Frosst Canada, Inc. Indole derivatives with affinity for the cannabinoid receptor
US5811428A (en) * 1995-12-18 1998-09-22 Signal Pharmaceuticals, Inc. Pyrimidine carboxamides and related compounds and methods for treating inflammatory conditions
JPH11512399A (ja) 1995-09-01 1999-10-26 シグナル ファーマシューティカルズ，インコーポレイテッド ピリミジンカルボキサミドおよび関連化合物ならびに炎症状態を処置するための方法
US5935966A (en) 1995-09-01 1999-08-10 Signal Pharmaceuticals, Inc. Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions
WO1997009325A1 (en) * 1995-09-01 1997-03-13 Signal Pharmaceuticals, Inc. Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions
JP4703077B2 (ja) * 1999-09-09 2011-06-15 クミアイ化学工業株式会社 ピリミジン誘導体及びそれを含有する除草剤
KR100760434B1 (ko) 1999-09-17 2007-10-04 밀레니엄 파머슈티컬스 인코퍼레이티드 벤즈아미드 및 관련된 Ｘａ 인자의 억제제
WO2004009027A2 (en) 2002-07-19 2004-01-29 Myriad Genetics, Inc Method and composition for treating and preventing herpesvirus infection
UY27939A1 (es) 2002-08-21 2004-03-31 Glaxo Group Ltd Compuestos
DE60308699T2 (de) * 2002-08-21 2007-08-23 Glaxo Group Ltd., Greenford 2-phenylamino-4-trifluoromethyl-5-(benzyl- oder pyridin-4-ylmethyl)carbamoylpyrimidin-derivate als selektive cb2 cannabinoid-rezeptor modulatoren
GB0222493D0 (en) 2002-09-27 2002-11-06 Glaxo Group Ltd Compounds
GB0222495D0 (en) 2002-09-27 2002-11-06 Glaxo Group Ltd Compounds
EP1546115A4 (en) * 2002-09-27 2010-08-04 Merck Sharp & Dohme Substituted pyrimidines
TW200505902A (en) 2003-03-20 2005-02-16 Schering Corp Cannabinoid receptor ligands
GB0402357D0 (en) 2004-02-03 2004-03-10 Glaxo Group Ltd Novel compounds
GB0402356D0 (en) 2004-02-03 2004-03-10 Glaxo Group Ltd Novel compounds
EP1718620A1 (en) * 2004-02-23 2006-11-08 Glaxo Group Limited Pyrimidine derivatives as cannabinoid receptor modulators
JP2007523206A (ja) 2004-02-24 2007-08-16 グラクソ　グループ　リミテッド Ｃｂ２受容体モジュレーターとしてのピリジン誘導体およびその使用
GB0404105D0 (en) 2004-02-24 2004-03-31 Glaxo Group Ltd Novel compounds
TW200611695A (en) 2004-06-09 2006-04-16 Glaxo Group Ltd Pyrrolopyridine derivatives
ZA200703517B (en) 2004-10-22 2008-08-27 Pharmos Corp Orally effective cannabinoid analogs
JP2008519034A (ja) 2004-11-03 2008-06-05 バーテックス ファーマシューティカルズ インコーポレイテッド イオンチャネル調節剤としてのピリミジン誘導体および使用方法
PE20070239A1 (es) 2005-08-09 2007-04-01 Glaxo Group Ltd Derivados de imidazopiridina con actividad sobre los receptores cannabinoides
GB0516379D0 (en) 2005-08-09 2005-09-14 Glaxo Group Ltd Compounds
GB0602042D0 (en) 2006-02-01 2006-03-15 Glaxo Group Ltd Compounds
UY30284A1 (es) 2006-04-14 2007-11-30 Abbott Gmbh & Amp Compuestos de ariloxietilamina apropiados para tratar trastornos que responden a la modulacion del receptor de dopamina d3
US7563797B2 (en) 2006-08-28 2009-07-21 Forest Laboratories Holding Limited Substituted imidazo(1,2-A)pyrimidines and imidazo(1,2-A) pyridines as cannabinoid receptor ligands
GB0705803D0 (en) 2007-03-28 2007-05-02 Glaxo Group Ltd Novel compounds
WO2009137081A2 (en) 2008-05-07 2009-11-12 Massachusetts Institute Of Technology Small molecule inhibitors of plasmodium falciparum dihydroorotate dehydrogenase
CN102256963B (zh) * 2008-12-19 2014-06-11 贝林格尔.英格海姆国际有限公司 作为ccr2受体拮抗剂用于治疗炎症、哮喘和copd的环状嘧啶-4-甲酰胺

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