BRPI1011604A2 - eletropulverização e ionização de nanopulverização de amostras distintas em formato de gotícula - Google Patents
eletropulverização e ionização de nanopulverização de amostras distintas em formato de gotículaInfo
- Publication number
- BRPI1011604A2 BRPI1011604A2 BRPI1011604A BRPI1011604A BRPI1011604A2 BR PI1011604 A2 BRPI1011604 A2 BR PI1011604A2 BR PI1011604 A BRPI1011604 A BR PI1011604A BR PI1011604 A BRPI1011604 A BR PI1011604A BR PI1011604 A2 BRPI1011604 A2 BR PI1011604A2
- Authority
- BR
- Brazil
- Prior art keywords
- nanopulse
- electrospray
- ionization
- shaped samples
- distinct droplet
- Prior art date
Links
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
- H01J49/165—Electrospray ionisation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
Landscapes
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21845409P | 2009-06-19 | 2009-06-19 | |
| PCT/US2010/039233 WO2010148339A2 (en) | 2009-06-19 | 2010-06-18 | Electrospray and nanospray ionization of discrete samples in droplet format |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1011604A2 true BRPI1011604A2 (pt) | 2019-05-14 |
Family
ID=43357077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1011604A BRPI1011604A2 (pt) | 2009-06-19 | 2010-06-18 | eletropulverização e ionização de nanopulverização de amostras distintas em formato de gotícula |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8431888B2 (pt) |
| EP (1) | EP2443432B1 (pt) |
| JP (1) | JP2012530903A (pt) |
| AU (1) | AU2010262978B2 (pt) |
| BR (1) | BRPI1011604A2 (pt) |
| CA (1) | CA2765842C (pt) |
| WO (1) | WO2010148339A2 (pt) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8506803B2 (en) | 2011-03-01 | 2013-08-13 | Wisconsin Alumni Research Foundation | Integrated electrospray ionization emitter and detection cell for parallel measurements by fluorescence and mass spectrometry |
| WO2013122745A1 (en) * | 2012-02-13 | 2013-08-22 | Waters Technologies Corporation | Ionization of analyte molecules comprised in a flow of gas |
| CN102610482A (zh) * | 2012-03-30 | 2012-07-25 | 武汉大学 | 一种电喷雾离子化方法和实现该方法的装置 |
| GB201211048D0 (en) * | 2012-06-22 | 2012-08-01 | Micromass Ltd | Methods and apparatus for controlling the supply of ions |
| WO2014085003A2 (en) * | 2012-11-30 | 2014-06-05 | Agilent Technologies, Inc. | Mixer bypass sample injection for liquid chromatography |
| JP6078360B2 (ja) * | 2013-01-30 | 2017-02-08 | 株式会社日立ハイテクノロジーズ | 質量分析方法および装置 |
| WO2015092494A1 (en) * | 2013-12-20 | 2015-06-25 | Agilent Technologies, Inc. | Method of conducting electrospray ionization and method of analyzing an analyte utilizing the same |
| GB201409631D0 (en) * | 2014-05-30 | 2014-07-16 | Reckitt Benckiser Brands Ltd | Improved PEI composition |
| US10000789B2 (en) | 2014-06-17 | 2018-06-19 | The Board Of Regents Of The University Of Oklahoma | Cellular probe device, system and analysis method |
| US9595428B2 (en) | 2014-06-17 | 2017-03-14 | The Board Of Regents Of The University Oklahoma | Cellular probe device, system and analysis method |
| GB201414177D0 (en) | 2014-08-11 | 2014-09-24 | Sphere Fluidics Ltd | Droplet Sorting |
| DE102015117365A1 (de) * | 2014-10-14 | 2016-04-14 | Waters Technologies Corporation | Verbesserte detektionsempfindlichkeit in elektrospray-ionisations-massenspektrometrie unter verwendung eines säulennachgeordneten modifizierers und einer mikrofluidischen vorrichtung |
| US9543137B2 (en) | 2014-12-12 | 2017-01-10 | Agilent Technologies, Inc. | Sample droplet generation from segmented fluid flow and related devices and methods |
| CN104616963B (zh) * | 2015-01-30 | 2017-03-22 | 昆山禾信质谱技术有限公司 | 一种等离子体喷雾质谱电离源 |
| US10078038B2 (en) | 2015-02-06 | 2018-09-18 | The Regents Of The University Of Michigan | Controlled coalescence of gas phase segmented droplets |
| EP4400507A3 (en) * | 2015-09-08 | 2024-11-13 | Waters Technologies Corporation | Multidimensional chromatography method for analysis of antibody-drug conjugates |
| CN108472665A (zh) * | 2015-11-12 | 2018-08-31 | 康奈尔大学 | 空气控制的电喷雾制造及其产品 |
| US9673032B1 (en) | 2016-03-31 | 2017-06-06 | Agilent Technologies Inc. | Sample sprayer with adjustable conduit and related methods |
| JP6884562B2 (ja) * | 2016-11-30 | 2021-06-09 | シスメックス株式会社 | 検体処理方法および検体処理装置 |
| US20190019662A1 (en) | 2017-07-14 | 2019-01-17 | Purdue Research Foundation | Electrophoretic mass spectrometry probes and systems and uses thereof |
| CN110085507B (zh) * | 2018-01-26 | 2024-03-26 | 广州禾信仪器股份有限公司 | 敞开式离子源系统和质谱仪 |
| EP3522201B1 (en) * | 2018-02-02 | 2020-10-07 | Tofwerk AG | Autosampler |
| CN108802250B (zh) * | 2018-08-28 | 2020-09-25 | 上海中医药大学 | 超高效液质联用检测脑微透析液中11种神经递质的方法 |
| CN114207775B (zh) | 2019-05-15 | 2023-06-06 | 上海宸安生物科技有限公司 | 用于质谱法的样品输送装置 |
| CN110317728A (zh) * | 2019-07-12 | 2019-10-11 | 中国科学院深圳先进技术研究院 | 基于微流控电喷雾的单细胞全基因组扩增系统和方法 |
| CN114502942A (zh) | 2019-09-30 | 2022-05-13 | Dh科技发展私人贸易有限公司 | 用于在质谱法系统和方法中使用的具有内部取样的取样探针 |
| US11087964B2 (en) * | 2019-11-21 | 2021-08-10 | Thermo Finnigan Llc | Method and apparatus for improved electrospray emitter lifetime |
| US12259370B2 (en) * | 2020-03-08 | 2025-03-25 | The Board Of Regents Of The University Of Oklahoma | Electrospray assisted capillary device for processing ultra low-volume samples |
| WO2021205953A1 (ja) * | 2020-04-08 | 2021-10-14 | ビーエルテック株式会社 | 流れ分析装置及び流れ分析方法 |
| CN115004001B (zh) * | 2020-04-08 | 2023-09-01 | 必艾路泰克株式会社 | 流动分析装置及流动分析方法 |
| US12016687B2 (en) | 2020-06-23 | 2024-06-25 | The Board Of Trustees Of The University Of Illinois | Implantable probes and methods of fabrication |
| US20240087865A1 (en) * | 2020-11-30 | 2024-03-14 | Dh Technologies Development Pte. Ltd. | System and methods for segmented flow analysis |
| EP4315393A1 (en) * | 2021-03-23 | 2024-02-07 | DH Technologies Development PTE. Ltd. | Bubble based sample isolation in a transport liquid |
| CN117121154A (zh) * | 2021-03-30 | 2023-11-24 | Dh科技发展私人贸易有限公司 | 将气泡引入稳态样本流 |
| US11892433B2 (en) * | 2021-08-02 | 2024-02-06 | Thermo Finnigan Llc | Electrospray current measurement in the nanospray and microspray regime |
| EP4473552A1 (en) * | 2022-02-02 | 2024-12-11 | Waters Technologies Corporation | Nanospray reactive sprayer |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5504327A (en) * | 1993-11-04 | 1996-04-02 | Hv Ops, Inc. (H-Nu) | Electrospray ionization source and method for mass spectrometric analysis |
| DE4415480C2 (de) * | 1994-05-02 | 1999-09-02 | Bruker Daltonik Gmbh | Vorrichtung und Verfahren zur massenspektrometrischen Untersuchung von Substanzgemischen durch Kopplung kapillarelektrophoretischer Separation (CE) mit Elektrospray-Ionisierung (ESI) |
| US5993633A (en) * | 1997-07-31 | 1999-11-30 | Battelle Memorial Institute | Capillary electrophoresis electrospray ionization mass spectrometry interface |
| JP4274399B2 (ja) * | 1998-09-17 | 2009-06-03 | アドヴィオン バイオシステムズ インコーポレイテッド | 一体化モノリシックマイクロ加工したエレクトロスプレーと液体クロマトグラフィーのシステムおよび方法 |
| AU745917C (en) | 1999-12-08 | 2007-03-29 | Agouron Pharmaceuticals, Inc. | High-throughput screening of compounds using electrospray ionization mass spectrometry |
| JP2002055081A (ja) * | 2000-06-08 | 2002-02-20 | Pfizer Prod Inc | 分析方法及びこの分析方法のための装置 |
| JP3954361B2 (ja) * | 2001-11-13 | 2007-08-08 | 株式会社ナノ・ソリューション | マイクロスプレーカラムと質量分析計及び質量分析方法 |
| ATE479899T1 (de) * | 2002-05-09 | 2010-09-15 | Univ Chicago | Einrichtugn und verfahren für druckgesteuerten plug-transport und reaktion |
| FR2884437B1 (fr) * | 2005-04-19 | 2007-07-20 | Commissariat Energie Atomique | Dispositif et procede microfluidique de transfert de matiere entre deux phases immiscibles. |
| US20080090298A1 (en) * | 2006-10-16 | 2008-04-17 | James Alexander Apffel | Method and system for identification of protein-protein interaction |
| WO2008118808A1 (en) * | 2007-03-23 | 2008-10-02 | Advion Bioscience, Inc. | Liquid chromatography-mass spectrometry |
-
2010
- 2010-06-18 WO PCT/US2010/039233 patent/WO2010148339A2/en active Application Filing
- 2010-06-18 AU AU2010262978A patent/AU2010262978B2/en active Active
- 2010-06-18 US US13/378,858 patent/US8431888B2/en active Active
- 2010-06-18 JP JP2012516349A patent/JP2012530903A/ja active Pending
- 2010-06-18 CA CA2765842A patent/CA2765842C/en active Active
- 2010-06-18 BR BRPI1011604A patent/BRPI1011604A2/pt not_active Application Discontinuation
- 2010-06-18 EP EP10790290.0A patent/EP2443432B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2443432A4 (en) | 2015-06-24 |
| CA2765842C (en) | 2018-03-13 |
| WO2010148339A2 (en) | 2010-12-23 |
| AU2010262978B2 (en) | 2014-08-28 |
| EP2443432A2 (en) | 2012-04-25 |
| JP2012530903A (ja) | 2012-12-06 |
| US8431888B2 (en) | 2013-04-30 |
| US20120153143A1 (en) | 2012-06-21 |
| AU2010262978A1 (en) | 2012-02-02 |
| EP2443432B1 (en) | 2018-09-05 |
| WO2010148339A3 (en) | 2011-04-21 |
| CA2765842A1 (en) | 2010-12-23 |
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Legal Events
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| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |