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BRPI0914919A2 - Método para selecionar um primeiro grupo de células de uma população de células e aparelho. Sistema, método e processo para detectar e alterar seletivamente uma subpopulação de células desejada em uma população de células de espécime. - Google Patents

Método para selecionar um primeiro grupo de células de uma população de células e aparelho. Sistema, método e processo para detectar e alterar seletivamente uma subpopulação de células desejada em uma população de células de espécime.

Info

Publication number
BRPI0914919A2
BRPI0914919A2 BRPI0914919-8A BRPI0914919A BRPI0914919A2 BR PI0914919 A2 BRPI0914919 A2 BR PI0914919A2 BR PI0914919 A BRPI0914919 A BR PI0914919A BR PI0914919 A2 BRPI0914919 A2 BR PI0914919A2
Authority
BR
Brazil
Prior art keywords
cell population
altering
cells
selecting
group
Prior art date
Application number
BRPI0914919-8A
Other languages
English (en)
Inventor
Mark Luscher
Original Assignee
Microbix Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbix Biosystems Inc filed Critical Microbix Biosystems Inc
Publication of BRPI0914919A2 publication Critical patent/BRPI0914919A2/pt

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/04Cell isolation or sorting
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404Handling flow, e.g. hydrodynamic focusing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404Handling flow, e.g. hydrodynamic focusing
    • G01N15/1409Handling samples, e.g. injecting samples
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/149Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Sustainable Development (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BRPI0914919-8A 2008-06-30 2009-06-30 Método para selecionar um primeiro grupo de células de uma população de células e aparelho. Sistema, método e processo para detectar e alterar seletivamente uma subpopulação de células desejada em uma população de células de espécime. BRPI0914919A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7708308P 2008-06-30 2008-06-30
PCT/IB2009/006480 WO2010001254A2 (en) 2008-06-30 2009-06-30 Method and apparatus for sorting cells

Publications (1)

Publication Number Publication Date
BRPI0914919A2 true BRPI0914919A2 (pt) 2015-08-25

Family

ID=41447919

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0914919-8A BRPI0914919A2 (pt) 2008-06-30 2009-06-30 Método para selecionar um primeiro grupo de células de uma população de células e aparelho. Sistema, método e processo para detectar e alterar seletivamente uma subpopulação de células desejada em uma população de células de espécime.

Country Status (13)

Country Link
US (2) US8004661B2 (pt)
EP (1) EP2304020B1 (pt)
CN (1) CN102119212B (pt)
BR (1) BRPI0914919A2 (pt)
CA (1) CA2728289C (pt)
DK (1) DK2304020T3 (pt)
ES (1) ES2709073T3 (pt)
MX (1) MX2011000182A (pt)
NZ (1) NZ590166A (pt)
PL (1) PL2304020T3 (pt)
RU (1) RU2520848C2 (pt)
UA (2) UA102854C2 (pt)
WO (1) WO2010001254A2 (pt)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69830598T2 (de) * 1997-01-31 2006-05-18 The Horticulture And Food Research Institute Of New Zealand Limited Optische vorrichtung und methode
DK2258172T3 (en) 2000-05-09 2017-08-07 Xy Llc Flow cytometer for differentiation of X-chromosome-bearing and Y-chromosome-bearing populations of spermatozoa
US7605002B2 (en) * 2002-09-06 2009-10-20 Epigem Limited Modular microfluidic system
US20100022414A1 (en) 2008-07-18 2010-01-28 Raindance Technologies, Inc. Droplet Libraries
EP2306174B1 (en) 2003-03-28 2016-05-11 Inguran, LLC Flow cytometry nozzle for orienting particles and corresponding method
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
EP3913375A1 (en) 2006-01-11 2021-11-24 Bio-Rad Laboratories, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
WO2012158207A2 (en) * 2011-05-13 2012-11-22 E.I. Spectra, Llc Method for mutiplexed microfluidic bead-based immunoassay
US20110189714A1 (en) * 2010-02-03 2011-08-04 Ayliffe Harold E Microfluidic cell sorter and method
US9452429B2 (en) 2006-02-02 2016-09-27 E. I. Spectra, Llc Method for mutiplexed microfluidic bead-based immunoassay
US20110189650A1 (en) * 2010-02-03 2011-08-04 Ayliffe Harold E Microfluidic cell sorter with electroporation
EP3031918B1 (en) 2006-05-11 2018-03-14 Raindance Technologies Inc. Microfluidic devices
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
WO2008097559A2 (en) 2007-02-06 2008-08-14 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
WO2010111231A1 (en) 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation of microfluidic droplets
US10351905B2 (en) * 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
EP4484577A3 (en) 2010-02-12 2025-03-26 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
EP3447155A1 (en) 2010-09-30 2019-02-27 Raindance Technologies, Inc. Sandwich assays in droplets
US20120125126A1 (en) * 2010-11-19 2012-05-24 Becton, Dickinson And Company Fluidics with thermal compensation for a flow-type particle analyzer
EP2673614B1 (en) 2011-02-11 2018-08-01 Raindance Technologies, Inc. Method for forming mixed droplets
AU2012217757B2 (en) * 2011-02-15 2015-12-03 Microbix Biosystems Inc. Methods, systems, and apparatus for performing flow cytometry
WO2012161764A1 (en) * 2011-02-16 2012-11-29 Fox Daniel N Magnetic sorting of mammalian sperm having damaged membranes
US9150852B2 (en) 2011-02-18 2015-10-06 Raindance Technologies, Inc. Compositions and methods for molecular labeling
WO2012123412A1 (en) * 2011-03-11 2012-09-20 Deutsches Rheuma-Forschungszentrum Berlin Flow cytometer disinfection module
EP2503376B1 (de) * 2011-03-24 2020-02-19 Fisba Ag Vorrichtung und Verfahren zur Bilderfassung
WO2012167142A2 (en) 2011-06-02 2012-12-06 Raindance Technolgies, Inc. Enzyme quantification
GB201110454D0 (en) * 2011-06-21 2011-08-03 College The Microfluidic photoporation
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
EP2795290B1 (en) 2011-12-20 2021-03-03 Becton Dickinson and Company Method, system, computer-readable storage medium and cell sorter to improve yield of sorted particles
JP5924077B2 (ja) * 2012-03-30 2016-05-25 ソニー株式会社 微小粒子分取装置及び微小粒子分取装置における軌道方向判定方法
US9454007B1 (en) * 2012-05-07 2016-09-27 Lockheed Martin Corporation Free-space lens design and lenses therefrom
US8980200B2 (en) * 2012-06-07 2015-03-17 Bio-Rad Laboratories, Inc. Condensed geometry nozzle for flow cytometry
CN103575632B (zh) * 2012-08-09 2015-09-23 深圳开立生物医疗科技股份有限公司 一种鞘流装置及血液分析仪
WO2014082096A1 (en) 2012-11-26 2014-05-30 The Trustees Of Columbia University In The City Of New York Method for culture of human and mouse prostate organoids and uses thereof
EP2950079B1 (en) 2013-01-28 2021-06-16 Sony Corporation Fine particle fractionation device, fine particle fractionation method and program
CN109100288A (zh) * 2013-03-15 2018-12-28 艾瑞思国际股份有限公司 用于血液样品中的粒子分析的鞘流体系统和方法
AU2014257116B2 (en) * 2013-04-26 2017-05-25 Becton, Dickinson And Company Methods and systems for the collection of light using total internal reflectance
CN105829865B (zh) * 2013-09-05 2018-12-04 伯乐生命医学产品有限公司 按需的微粒分配系统
US10343165B2 (en) 2013-09-05 2019-07-09 Bio-Rad Laboratories, Inc. On-demand particle dispensing system
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
WO2015061216A1 (en) * 2013-10-21 2015-04-30 Cytoflow, Llc Cytometer flowcell
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
CN103744185B (zh) * 2013-12-30 2016-03-30 维林光电(苏州)有限公司 一种基于流式细胞仪用多色光源光腰位置的定标系统的定标方法
CN105980831B (zh) 2014-02-13 2021-01-12 索尼公司 粒子分捡装置、粒子分捡方法、程序以及粒子分捡系统
US9377400B2 (en) 2014-03-31 2016-06-28 Redshift Systems Corporation Motion modulation fluidic analyzer system
US9551645B2 (en) 2014-07-10 2017-01-24 Kinetic River Corp. Flow cytometry apparatus and methods
FR3024738B1 (fr) * 2014-08-11 2018-06-15 Genes Diffusion Dispostif et procede de selection de cellules eucaryotes dans un canal de transport par alteration des cellules eucaryotes au moyen d'un rayonnemement electromagnetique
CN104498321B (zh) * 2014-11-06 2017-03-22 徐小杨 卵细胞自动识别分选装置
WO2016100954A1 (en) * 2014-12-19 2016-06-23 Captl Llc Flow cytometry using hydrodynamically planar flow
RU2622761C2 (ru) * 2015-01-23 2017-06-19 Вячеслав Геннадьевич Певгов Способ ранней диагностики заболеваний путем оптического измерения физических характеристик нативной биологической жидкости
DE102015002750A1 (de) * 2015-03-05 2016-09-08 Mann + Hummel Gmbh Messeinrichtung zur Ermittlung von Partikeln in einem Messfluid
EP3268720A4 (en) * 2015-03-10 2018-11-21 Microbix Biosystems Inc. Methods, systems and apparatus for sorting and processing analytes
US10036698B2 (en) 2015-06-19 2018-07-31 Captl Llc Time-sequential cytometry
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
CN108139312B (zh) 2015-10-19 2021-02-05 索尼公司 图像处理设备、微粒分选设备和图像处理方法
EP3408312B1 (en) 2016-01-28 2022-08-10 Saint-Gobain Performance Plastics Corporation Method for making an article
FR3050269B1 (fr) * 2016-04-15 2018-05-11 Ecole Superieure De Physique Et De Chimie Industrielles De La Ville De Paris (Espci) Procede de selection et de recuperation de produits et systeme associe
CN107442186B (zh) * 2016-05-31 2020-06-09 深圳汇芯生物医疗科技有限公司 微流控芯片、基于微流控芯片的分析装置及分析方法
FR3061910A1 (fr) 2017-01-18 2018-07-20 Genes Diffusion Dispostif et procede de discrimination de spermatozoides
USD868991S1 (en) 2017-03-28 2019-12-03 Becton, Dickinson And Company Register block
USD869676S1 (en) 2017-03-28 2019-12-10 Becton, Dickinson And Company Particle sorting module
EP4435113A1 (en) 2017-05-18 2024-09-25 10x Genomics, Inc. Methods and systems for sorting droplets and beads
US10544413B2 (en) 2017-05-18 2020-01-28 10X Genomics, Inc. Methods and systems for sorting droplets and beads
CN113049477B (zh) * 2017-06-14 2024-05-21 芯易诊有限公司 用于细胞分析的装置和方法
EP3655776A2 (en) * 2017-07-18 2020-05-27 Avectas Limited Payload delivery across cell membranes using continuous flow fluidic system
US10610865B2 (en) 2017-08-22 2020-04-07 10X Genomics, Inc. Droplet forming devices and system with differential surface properties
WO2019083844A1 (en) 2017-10-23 2019-05-02 Cytochip Inc. DEVICES AND METHOD FOR MEASURING TARGET ANALYTES AND PARTICLES
WO2019083852A1 (en) 2017-10-26 2019-05-02 10X Genomics, Inc. MICROFLUIDIC CHANNEL NETWORKS FOR PARTITIONING
NO346147B1 (en) 2017-11-09 2022-03-21 Spinchip Diagnostics As Method and apparatus for controlling a focus point of stationary beam focusing on a sample in a rotating cartridge placed in a rotating disc
USD864415S1 (en) 2018-01-30 2019-10-22 Becton, Dickinson And Company Particle sorting system
USD876668S1 (en) 2018-01-30 2020-02-25 Becton, Dickinson And Company Particle sorting module mount
USD872296S1 (en) 2018-01-30 2020-01-07 Becton, Dickinson And Company Particle sorting module
USD882817S1 (en) 2018-01-30 2020-04-28 Becton, Dickinson And Company Sample container
CN108801883B (zh) * 2018-04-19 2021-01-05 深圳市趣方科技有限公司 一种微小悬浮颗粒流动光学检测机构以及检测方法
US11427804B2 (en) 2018-06-15 2022-08-30 Abs Global, Inc. Apparatus and method for cell kill confirmation
JP6541085B1 (ja) * 2018-06-29 2019-07-10 株式会社片岡製作所 細胞処理装置
WO2020072030A1 (en) * 2018-10-01 2020-04-09 Hewlett-Packard Development Company, L.P. Microscopy systems
WO2020159542A1 (en) * 2019-02-01 2020-08-06 Hewlett-Packard Development Company, L.P. Cell sorting devices
WO2020176882A1 (en) 2019-02-28 2020-09-03 10X Genomics, Inc. Devices, systems, and methods for increasing droplet formation efficiency
JP2020143991A (ja) * 2019-03-06 2020-09-10 ソニー株式会社 微小粒子測定装置、微小粒子分取装置、微小粒子測定システム及び微小粒子分取システム
US12186751B2 (en) 2019-06-28 2025-01-07 10X Genomics, Inc. Devices and systems incorporating acoustic ordering and methods of use thereof
US10598586B1 (en) * 2019-07-31 2020-03-24 Horiba Instruments Incorporated Apparatus and method for analyzing particles
US12059679B2 (en) 2019-11-19 2024-08-13 10X Genomics, Inc. Methods and devices for sorting droplets and particles
CN110887823A (zh) * 2019-11-22 2020-03-17 同济大学 一种顺序注射-荧光法测定水样中铁的装置及方法
EP4107507A4 (en) * 2020-02-19 2024-02-28 Becton, Dickinson and Company STROBOSCOPIC LASER EXCITATION SYSTEMS AND METHODS OF USE
CN111323361B (zh) * 2020-03-17 2022-05-10 南通大学 一种快速分离精子头、精子尾和正常有活力精子的方法
CN111521549B (zh) * 2020-05-13 2021-01-01 洹仪科技(上海)有限公司 一种颗粒分选装置及方法
CN112730408B (zh) * 2020-12-24 2024-07-09 贝克曼库尔特生物科技(苏州)有限公司 液流检测系统和液流检测方法以及分选装置
EP4314765A4 (en) * 2021-03-24 2024-10-16 Becton, Dickinson and Company Closed-system sorting flow cytometer adapters and methods of use thereof

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2656508A (en) * 1949-08-27 1953-10-20 Wallace H Coulter Means for counting particles suspended in a fluid
US3380584A (en) * 1965-06-04 1968-04-30 Atomic Energy Commission Usa Particle separator
US3497690A (en) * 1967-09-21 1970-02-24 Bausch & Lomb Method and apparatus for classifying biological cells by measuring the size and fluorescent response thereof
DE1815352C3 (de) 1968-12-18 1975-03-20 Wolfgang Prof. Dr. Dittrich Automatisches MeB- und Zählgerät für die Teilchen einer Dispersion
US3657537A (en) * 1970-04-03 1972-04-18 Bausch & Lomb Computerized slit-scan cyto-fluorometer for automated cell recognition
BE793185A (fr) * 1971-12-23 1973-04-16 Atomic Energy Commission Appareil pour analyser et trier rapidement des particules telles que des cellules biologiques
US4021117A (en) 1975-08-07 1977-05-03 Hildegard Gohde Process for automatic counting and measurement of particles
US4188542A (en) * 1978-03-20 1980-02-12 Coulter Electronics, Inc. Mirror image ellipsoid radiation collector and method
US4284355A (en) 1979-10-29 1981-08-18 Ortho Diagnostics, Inc. Automated method for cell volume determination
US4395397A (en) * 1981-09-17 1983-07-26 Sidney Farber Cancer Institute, Inc. Apparatus and method for killing unwanted cells
US4629687A (en) * 1982-07-29 1986-12-16 Board Of Trustees Of Michigan State University Positive selection sorting of cells
US4998022A (en) 1988-03-22 1991-03-05 Conax Buffalo Corporation Optical liquid level sensor using a polytetrafluoroethylene perfluoroalkoxy material
JPH02168160A (ja) 1988-12-22 1990-06-28 Omron Tateisi Electron Co 細胞選別装置
ATE142788T1 (de) * 1989-05-10 1996-09-15 Us Agriculture Verfahren zur vorwahl des geschlechts der nachkommenschaft
US5406421A (en) * 1992-01-31 1995-04-11 Olympus Optical Co., Ltd. Cover slip for use in microscope
US5658892A (en) * 1993-01-15 1997-08-19 The General Hospital Corporation Compound delivery using high-pressure impulse transients
NO930980L (no) 1993-03-18 1994-09-19 Flowtech As Optisk konfigurasjon for væskeströmcytofotometer
JPH06302897A (ja) 1993-04-19 1994-10-28 Sumitomo Electric Ind Ltd レーザ装置、その運転方法およびその応用
NO932088L (no) * 1993-06-08 1995-01-05 Oddbjoern Gjelsnes Anordning for anvendelse ved væskeströmscytometri
DE69830598T2 (de) * 1997-01-31 2006-05-18 The Horticulture And Food Research Institute Of New Zealand Limited Optische vorrichtung und methode
US5874266A (en) * 1997-03-27 1999-02-23 Palsson; Bernhard O. Targeted system for removing tumor cells from cell populations
US6534308B1 (en) * 1997-03-27 2003-03-18 Oncosis, Llc Method and apparatus for selectively targeting specific cells within a mixed cell population
JPH1123809A (ja) * 1997-06-30 1999-01-29 Fuji Photo Optical Co Ltd 多焦点レンズ及び多焦点レンズの製造方法
US5985216A (en) 1997-07-24 1999-11-16 The United States Of America, As Represented By The Secretary Of Agriculture Flow cytometry nozzle for high efficiency cell sorting
SE9800360D0 (sv) 1998-02-06 1998-02-06 Goeteborg University Science I Method, apparatus and flow cell for high sensitivity detection of fluorescent molecules
US7649153B2 (en) 1998-12-11 2010-01-19 International Business Machines Corporation Method for minimizing sample damage during the ablation of material using a focused ultrashort pulsed laser beam
US6707551B2 (en) 2000-01-24 2004-03-16 Amnis Corporation Multipass cavity for illumination and excitation of moving objects
JP2003512616A (ja) 1999-10-20 2003-04-02 ベクトン・ディキンソン・アンド・カンパニー フロー血球計において粒子検出光源としてインコヒーレント光放出半導体デバイスを使用する装置及びその方法
GB9926161D0 (en) * 1999-11-04 2000-01-12 Pig Improvement Company Uk Lim Methods
US6594009B2 (en) * 2001-02-27 2003-07-15 Honeywell International Inc. Flow cytometer and ultraviolet light disinfecting systems
US6797139B2 (en) * 2001-03-19 2004-09-28 Applera Corporation Detection cell for guiding excitation light therein and method for using same
JP4412712B2 (ja) * 2001-12-04 2010-02-10 独立行政法人理化学研究所 大型湾曲両面フレネルレンズの製造方法及び装置
DE60332406D1 (de) 2002-03-15 2010-06-17 Affymetrix Inc System und Verfahren zur Abtastung von biologischen Materialien
US7193775B2 (en) * 2002-05-30 2007-03-20 Dmetrix, Inc. EPI-illumination system for an array microscope
AU2003236961A1 (en) 2002-06-20 2004-01-06 Koninklijke Philips Electronics N.V. Apparatus with display
US7118676B2 (en) * 2003-09-04 2006-10-10 Arryx, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
MXPA05001654A (es) * 2002-08-15 2005-10-18 Xy Inc Citometro de flujo de alta resolucion.
US6936828B2 (en) * 2003-02-14 2005-08-30 Honeywell International Inc. Particle detection system and method
EP2306174B1 (en) 2003-03-28 2016-05-11 Inguran, LLC Flow cytometry nozzle for orienting particles and corresponding method
US7369696B2 (en) * 2003-04-02 2008-05-06 Ge Healthcare Uk Limited Classification of cells into subpopulations using cell classifying data
CA2566749C (en) * 2003-05-15 2017-02-21 Xy, Inc. Efficient haploid cell sorting for flow cytometer systems
NZ530972A (en) 2004-02-05 2005-04-29 Embrionics Ltd A method and apparatus for orientating and selecting cells
US20060192940A1 (en) * 2005-01-20 2006-08-31 Phi-Wilson Janette T Modular flow cytometry system
US7355696B2 (en) * 2005-02-01 2008-04-08 Arryx, Inc Method and apparatus for sorting cells
WO2007022641A1 (en) 2005-08-25 2007-03-01 Institut National D'optique Flow cytometry analysis across optical fiber
US8101426B2 (en) 2007-03-02 2012-01-24 Icyt Mission Technology, Inc. System and method for the measurement of multiple fluorescence emissions in a flow cytometry system
DE102007018862A1 (de) 2007-04-18 2008-10-23 Carl Zeiss Microimaging Gmbh Objektivwechseleinrichtung für Mikroskope
WO2009002537A1 (en) * 2007-06-25 2008-12-31 Tufts University Optical array device and methods of use thereof for screening, analysis and manipulation of particles
CL2008002118A1 (es) 2007-07-19 2008-12-19 Xy Llc Metodo para la produccion de un embrion equino de sexo seleccionado mediante la inyeccion intracitoplasmatica de esperma utilizando espermatozoides de equino seleccionados por sexo.
CA2727478A1 (en) 2008-06-13 2009-12-17 Xy, Llc Lubricious microfluidic flow path system

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EP2304020B1 (en) 2018-11-07
RU2520848C2 (ru) 2014-06-27
CN102119212B (zh) 2014-08-20
CA2728289A1 (en) 2010-01-07
MX2011000182A (es) 2011-08-03
US20120038914A1 (en) 2012-02-16
EP2304020A2 (en) 2011-04-06
CN102119212A (zh) 2011-07-06
EP2304020A4 (en) 2017-10-11
UA102854C2 (ru) 2013-08-27
PL2304020T3 (pl) 2019-06-28
WO2010001254A2 (en) 2010-01-07
ES2709073T3 (es) 2019-04-15
US8467040B2 (en) 2013-06-18
CA2728289C (en) 2016-11-29
RU2011102290A (ru) 2012-08-10
DK2304020T3 (en) 2019-02-04
US20090325217A1 (en) 2009-12-31
US8004661B2 (en) 2011-08-23
NZ590166A (en) 2013-09-27
UA115521C2 (uk) 2017-11-27
WO2010001254A3 (en) 2010-04-01

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