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BRPI0912927A2 - "método de detectar um tumor independente de vegf em um indivíduo e método de tratar um tumor independente de vegf em um indivíduo" - Google Patents

"método de detectar um tumor independente de vegf em um indivíduo e método de tratar um tumor independente de vegf em um indivíduo"

Info

Publication number
BRPI0912927A2
BRPI0912927A2 BRPI0912927-8A BRPI0912927A BRPI0912927A2 BR PI0912927 A2 BRPI0912927 A2 BR PI0912927A2 BR PI0912927 A BRPI0912927 A BR PI0912927A BR PI0912927 A2 BRPI0912927 A2 BR PI0912927A2
Authority
BR
Brazil
Prior art keywords
individual
independent tumor
vegf
treating
detecting
Prior art date
Application number
BRPI0912927-8A
Other languages
English (en)
Inventor
Ferrara Napoleone
Willis Brandon
Filvaroff Ellen
Original Assignee
Genentech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech, Inc. filed Critical Genentech, Inc.
Publication of BRPI0912927A2 publication Critical patent/BRPI0912927A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809Methods for determination or identification of nucleic acids involving differential detection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001102Receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • G01N33/575
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/58Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

"método de detectar um tumor independente de vegf em um indivíduo e método de tratar um tumor independente de vegf em um indivíduo" são fornecidos métodos para identificar ou diagnosticar tumor independente de vegfs e métodos para tratar tumor independente de vegfs.
BRPI0912927-8A 2008-08-29 2009-08-28 "método de detectar um tumor independente de vegf em um indivíduo e método de tratar um tumor independente de vegf em um indivíduo" BRPI0912927A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9316108P 2008-08-29 2008-08-29
US61/093,161 2008-08-29
PCT/US2009/055434 WO2010025414A2 (en) 2008-08-29 2009-08-28 Diagnostics and treatments for vegf-independent tumors

Publications (1)

Publication Number Publication Date
BRPI0912927A2 true BRPI0912927A2 (pt) 2019-10-01

Family

ID=41571323

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0912927-8A BRPI0912927A2 (pt) 2008-08-29 2009-08-28 "método de detectar um tumor independente de vegf em um indivíduo e método de tratar um tumor independente de vegf em um indivíduo"

Country Status (13)

Country Link
US (1) US20100055099A1 (pt)
EP (1) EP2321433A2 (pt)
JP (1) JP2012501188A (pt)
KR (1) KR20110068987A (pt)
CN (1) CN102137939A (pt)
AR (1) AR073231A1 (pt)
AU (1) AU2009285540A1 (pt)
BR (1) BRPI0912927A2 (pt)
CA (1) CA2734172A1 (pt)
IL (1) IL211088A0 (pt)
MX (1) MX2011002082A (pt)
TW (1) TW201012935A (pt)
WO (1) WO2010025414A2 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011513427A (ja) * 2008-03-06 2011-04-28 ジェネンテック, インコーポレイテッド c−met及びEGFRアンタゴニストの併用療法
ES2363358B1 (es) * 2009-04-03 2012-06-21 FUNDACIÓ INSTITUT DE RECERCA HOSPITAL UNIVERSITARI VALL D'HEBRON (Titular al Agentes terapéuticos para el tratamiento de enfermedades asociadas con una proliferación celular indeseable.
AU2011281700B2 (en) * 2010-07-19 2017-02-09 F. Hoffmann-La Roche Ag Blood plasma biomarkers for bevacizumab combination therapies for treatment of pancreatic cancer
EP2704745B1 (en) 2011-05-05 2016-12-14 Duke University Methods of developing a prognosis for pancreatic cancer and predicting responsiveness to cancer therapeutics
CN103323601B (zh) * 2012-03-22 2016-04-20 北京蛋白质组研究中心 S100a9蛋白检测物在制备筛查肝细胞癌试剂盒中的应用
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
CN103499694A (zh) * 2013-10-14 2014-01-08 中南大学 检测结直肠癌及其恶性程度的免疫组化试剂盒
CA2943329A1 (en) 2014-03-24 2015-10-01 Genentech, Inc. Cancer treatment with c-met antagonists and correlation of the latter with hgf expression
US9968688B2 (en) * 2014-11-12 2018-05-15 Verily Life Sciences Llc Shielded targeting agents, methods, and in vivo diagnostic system
HK1242996A1 (zh) * 2014-11-14 2018-07-06 豪夫迈.罗氏有限公司 预测对vegf拮抗剂的响应
US10037603B2 (en) * 2015-05-04 2018-07-31 Siemens Healthcare Gmbh Method and system for whole body bone removal and vascular visualization in medical image data
WO2017201166A1 (en) 2016-05-17 2017-11-23 Duke University Methods of predicting responsiveness of a cancer to a vegf targeting agent and methods of prognosing and treating cancer
JP6886854B2 (ja) * 2017-04-13 2021-06-16 シスメックス株式会社 被検物質の情報取得方法
CN107807241A (zh) * 2017-11-03 2018-03-16 太原瑞盛生物科技有限公司 一种血管内表皮生长因子受体1的磁微粒化学发光检测试剂盒及制备方法
EP4586274A3 (en) * 2018-07-05 2025-10-01 Boston Scientific Scimed, Inc. Devices, systems, and methods for determining inflammation and/or fibrosis
EP4025910A4 (en) * 2019-09-06 2024-02-07 UT-Battelle, LLC METHODS OF IMMUNOREGULATION BY MODULATING PLASMINOGEN-APPLE-NEMATODE DOMAIN (PAN) PROTEINS
WO2021207365A1 (en) * 2020-04-07 2021-10-14 The Wistar Institute Of Anatomy And Biology Reawakening of dormant tumor cells by modified lipids derived from stress activated neutrophils
CN111583992B (zh) * 2020-05-11 2023-08-29 广州金域医学检验中心有限公司 Rna水平融合基因突变导致肿瘤的负荷分析系统和方法
CN114958758B (zh) * 2021-02-18 2024-04-23 南京启真基因工程有限公司 一种乳腺癌模型猪的构建方法及应用

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030206899A1 (en) * 1991-03-29 2003-11-06 Genentech, Inc. Vascular endothelial cell growth factor antagonists
US6582959B2 (en) * 1991-03-29 2003-06-24 Genentech, Inc. Antibodies to vascular endothelial cell growth factor
WO1994004679A1 (en) * 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
US5686292A (en) * 1995-06-02 1997-11-11 Genentech, Inc. Hepatocyte growth factor receptor antagonist antibodies and uses thereof
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
US20020032315A1 (en) * 1997-08-06 2002-03-14 Manuel Baca Anti-vegf antibodies
US6884879B1 (en) * 1997-04-07 2005-04-26 Genentech, Inc. Anti-VEGF antibodies
CN100480269C (zh) * 1997-04-07 2009-04-22 基因技术股份有限公司 抗-血管内皮生长因子的抗体
US6297238B1 (en) * 1999-04-06 2001-10-02 Basf Aktiengesellschaft Therapeutic agents
US6703020B1 (en) * 1999-04-28 2004-03-09 Board Of Regents, The University Of Texas System Antibody conjugate methods for selectively inhibiting VEGF
DE60042021D1 (de) * 1999-07-29 2009-05-28 Gilead Sciences Inc Nukleinsäureliganden für den hepatozytischen wachstumsfaktor/dispersionsfaktor (hgf/sf) und seines c-met rezeptors
SK542003A3 (en) * 2000-06-23 2003-09-11 Schering Ag Combinations and compositions which interfere with VEGF/VEGF and angiopoietin/Tie receptor function and their use
US6599902B2 (en) * 2001-05-30 2003-07-29 Sugen, Inc. 5-aralkysufonyl-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors
US7425564B2 (en) * 2001-06-22 2008-09-16 Kirin Beer Kabushiki Kaisha Quinoline derivative and quinazoline derivative inhibiting self-phosphorylation of hepatocytus prolifertor receptor and medicinal composition containing the same
AU2002357193A1 (en) * 2001-12-19 2003-07-09 Smithkline Beecham Corporation Thienopyrimidine compounds as protein tyrosine kinase inhibitors
US6790852B2 (en) * 2002-04-18 2004-09-14 Hoffmann-La Roche Inc. 2-(2,6-dichlorophenyl)-diarylimidazoles
JP2006503864A (ja) * 2002-10-01 2006-02-02 ジヨンソン・アンド・ジヨンソン・フアーマシユーチカル・リサーチ・アンド・デベロツプメント・インコーポレーテツド タンパク質チロシンキナーゼ阻害剤としての4,6−ジアミノ置換−2−[オキシ又はアミノキシ]−[1,3,5]トリアジン
JP4695588B2 (ja) * 2003-02-26 2011-06-08 スージェン, インク. プロテインキナーゼ阻害剤としてのアミノヘテロアリール化合物
JP2006522124A (ja) * 2003-04-03 2006-09-28 バーテックス ファーマシューティカルズ インコーポレイテッド プロテインキナーゼのインヒビターとして有用な組成物
US20050186208A1 (en) * 2003-05-30 2005-08-25 Genentech, Inc. Treatment with anti-VEGF antibodies
US20060009493A1 (en) * 2003-07-02 2006-01-12 Sugen, Inc. Indolinone hydrazides as c-Met inhibitors
US7122548B2 (en) * 2003-07-02 2006-10-17 Sugen, Inc. Triazolotriazine compounds and uses thereof
US7758859B2 (en) * 2003-08-01 2010-07-20 Genentech, Inc. Anti-VEGF antibodies
US20050106667A1 (en) * 2003-08-01 2005-05-19 Genentech, Inc Binding polypeptides with restricted diversity sequences
EP1660487B1 (en) * 2003-08-15 2008-03-19 Vertex Pharmaceuticals Incorporated Pyrrole compositions useful as inhibitors of c-met
EP1697352B1 (en) * 2003-09-24 2012-06-27 Vertex Pharmceuticals Incorporated 4-azole substituted imidazole compositions useful as inhibitors or c-met receptor tyrosine kinase
EP1711495A2 (en) * 2004-01-23 2006-10-18 Amgen Inc. Quinoline, quinazoline, pyridine and pyrimidine counds and their use in the treatment of inflammation, angiogenesis and cancer
CA2564355C (en) * 2004-05-07 2012-07-03 Amgen Inc. Protein kinase modulators and method of use
US20060009360A1 (en) * 2004-06-25 2006-01-12 Robert Pifer New adjuvant composition
KR20080106946A (ko) * 2006-03-29 2008-12-09 제넨테크, 인크. 종양의 진단 및 치료

Also Published As

Publication number Publication date
WO2010025414A2 (en) 2010-03-04
WO2010025414A3 (en) 2010-05-14
KR20110068987A (ko) 2011-06-22
US20100055099A1 (en) 2010-03-04
TW201012935A (en) 2010-04-01
EP2321433A2 (en) 2011-05-18
AR073231A1 (es) 2010-10-20
CA2734172A1 (en) 2010-03-04
IL211088A0 (en) 2011-04-28
MX2011002082A (es) 2011-06-20
JP2012501188A (ja) 2012-01-19
AU2009285540A1 (en) 2010-03-04
CN102137939A (zh) 2011-07-27

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Legal Events

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B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]