BRPI0911571A2 - método para tratar um mamífero, análogo de insulina, ácido nucléico e célula hospedeira - Google Patents

método para tratar um mamífero, análogo de insulina, ácido nucléico e célula hospedeira

Info

Publication number: BRPI0911571A2
Authority: BR; Brazil
Prior art keywords: mammal; treating; nucleic acid; host cell; insulin analog
Prior art date: 2008-04-22

Application number

BRPI0911571A

Other languages

English (en)

Inventor

Whittaker Jonathan

Weiss Michael

Original Assignee

Univ Case Western Reserve

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-04-22

Filing date

2009-04-22

Publication date

2018-04-03

2009-04-22 Application filed by Univ Case Western Reserve filed Critical Univ Case Western Reserve

2018-04-03 Publication of BRPI0911571A2 publication Critical patent/BRPI0911571A2/pt

Links

241000124008 Mammalia Species 0.000 title 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 1
239000004026 insulin derivative Substances 0.000 title 1
150000007523 nucleic acids Chemical class 0.000 title 1
102000039446 nucleic acids Human genes 0.000 title 1
108020004707 nucleic acids Proteins 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Diabetes (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Obesity (AREA)
Hematology (AREA)
Organic Chemistry (AREA)
Emergency Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

BRPI0911571A 2008-04-22 2009-04-22 método para tratar um mamífero, análogo de insulina, ácido nucléico e célula hospedeira BRPI0911571A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US4698508P	2008-04-22	2008-04-22
PCT/US2009/041439 WO2009132129A2 (en)	2008-04-22	2009-04-22	Isoform-specific insulin analogues

Publications (1)

Publication Number	Publication Date
BRPI0911571A2 true BRPI0911571A2 (pt)	2018-04-03

Family

ID=41217411

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0911571A BRPI0911571A2 (pt)	2008-04-22	2009-04-22	método para tratar um mamífero, análogo de insulina, ácido nucléico e célula hospedeira

Country Status (12)

Country	Link
US (1)	US20110195896A1 (pt)
EP (1)	EP2296692A4 (pt)
JP (1)	JP2011521621A (pt)
KR (1)	KR20110021758A (pt)
CN (1)	CN102065885A (pt)
AU (1)	AU2009240636A1 (pt)
BR (1)	BRPI0911571A2 (pt)
CA (1)	CA2722168A1 (pt)
MX (1)	MX2010011329A (pt)
NZ (1)	NZ588857A (pt)
RU (1)	RU2010147076A (pt)
WO (1)	WO2009132129A2 (pt)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8343914B2 (en)	2006-01-06	2013-01-01	Case Western Reserve University	Fibrillation resistant proteins
ES2554773T3 (es)	2006-10-04	2015-12-23	Case Western Reserve University	Insulina y análogos de la insulina resistentes a la fibrilación
WO2009129250A2 (en)	2008-04-14	2009-10-22	Case Western Reserve University	Meal-time insulin analogues of enhanced stability
KR20120129875A (ko)	2008-07-31	2012-11-28	케이스 웨스턴 리저브 유니버시티	염소화 아미노산을 갖는 인슐린 유사체
US9200053B2 (en)	2008-07-31	2015-12-01	Case Western Reserve University	Insulin analogues containing penta-fluoro-Phenylalanine at position B24
CA2747112A1 (en)	2008-12-15	2010-06-24	Zealand Pharma A/S	Glucagon analogues
NZ593813A (en)	2008-12-15	2013-02-22	Zealand Pharma As	Glucagon analogues
ES2439499T3 (es)	2008-12-15	2014-01-23	Zealand Pharma A/S	Análogos de glucagón
AP2011005774A0 (en)	2008-12-15	2011-06-30	Zealand Pharma As	Glucagon analogues.
MY188182A (en)	2009-07-13	2021-11-24	Zealand Pharma As	Acylated glucagon analogues
WO2011028813A2 (en) *	2009-09-01	2011-03-10	Case Western Reserve University	Insulin analogues of enhanced receptor-binding specificity
US8399407B2 (en) *	2009-09-17	2013-03-19	Case Western Reserve University	Non-standard insulin analogues
US9079975B2 (en)	2009-12-11	2015-07-14	Case Western Reserve University	Insulin analogues with chlorinated amino acids
AR081975A1 (es)	2010-06-23	2012-10-31	Zealand Pharma As	Analogos de glucagon
MA34383B1 (fr)	2010-06-24	2013-07-03	Zealand Pharma As	Analogues de glucagon
MA34913B1 (fr)	2011-01-20	2014-02-01	Zealand Pharma As	Combinaison d'analogues du glucagon acylé à des analogues d'insuline
US10995129B2 (en) *	2011-07-13	2021-05-04	Case Western Reserve University	Non-standard insulin analogues
KR102184241B1 (ko)	2012-05-03	2020-12-01	질랜드 파마 에이/에스	Ｇｉｐ-ｇｌｐ-1 이원 작용제 화합물 및 방법
US10442847B2 (en)	2012-07-23	2019-10-15	Zealand Pharma A/S	Glucagon analogues
TWI608013B (zh)	2012-09-17	2017-12-11	西蘭製藥公司	升糖素類似物
CN112266414A (zh) *	2012-11-05	2021-01-26	卡斯西部储备大学	长效单链胰岛素类似物
WO2014088836A1 (en)	2012-12-03	2014-06-12	Merck Sharp & Dohme Corp.	O-glycosylated carboxy terminal portion (ctp) peptide-based insulin and insulin analogues
AU2014232894B2 (en) *	2013-03-15	2018-02-08	Case Western Reserve University	Site 2 insulin analogues
WO2015051052A2 (en)	2013-10-04	2015-04-09	Merck Sharp & Dohme Corp.	Glucose-responsive insulin conjugates
US9988429B2 (en)	2013-10-17	2018-06-05	Zealand Pharma A/S	Glucagon analogues
CN119119235A (zh)	2013-10-17	2024-12-13	西兰制药公司	酰化胰高血糖素类似物
WO2015067716A1 (en)	2013-11-06	2015-05-14	Zealand Pharma A/S	Glucagon-glp-1-gip triple agonist compounds
EA035466B9 (ru)	2013-11-06	2020-08-17	Зилэнд Фарма А/С	Соединения и способы на основе двойного агониста гип и гпп-1
CA2936563A1 (en)	2014-01-13	2015-07-16	Thermalin Diabetes, Llc	Rapid action insulin formulations and pharmaceutical delivery systems
EP3204410B1 (en) *	2014-10-06	2021-01-20	Case Western Reserve University	Biphasic single-chain insulin analogues
CN107001439B (zh)	2014-10-29	2021-12-21	西兰制药公司	Gip激动剂化合物及方法
EA036714B1 (ru)	2014-11-21	2020-12-10	Мерк Шарп И Доум Корп.	Частичные агонисты инсулинового рецептора
ES2763329T3 (es)	2015-04-16	2020-05-28	Zealand Pharma As	Análogo de glucagón acilado
AR105616A1 (es)	2015-05-07	2017-10-25	Lilly Co Eli	Proteínas de fusión
UY36870A (es) *	2015-08-28	2017-03-31	Hanmi Pharm Ind Co Ltd	Análogos de insulina novedosos
WO2017040363A1 (en)	2015-09-02	2017-03-09	Merck Sharp & Dohme Corp.	A process for obtaining insulin with correctly formed disulfide bonds
JP6951825B2 (ja)	2015-09-04	2021-10-20	ザスクリプスリサーチインスティテュート	インスリン免疫グロブリン融合タンパク質
CA3009187A1 (en) *	2015-12-23	2017-06-29	Case Western Reserve University	Encapsulation of ultra-stable insulin analogues within polymer melts
EP3448417A4 (en)	2016-04-26	2019-12-11	Merck Sharp & Dohme Corp.	INSULIN Dimer incretin CONJUGATES
US10953076B2 (en)	2016-05-24	2021-03-23	Merck Sharp & Dohme Corp.	Insulin receptor partial agonists and GLP-1 analogues
US10689430B2 (en)	2016-05-25	2020-06-23	Merck Sharp & Dohme Corp.	Insulin receptor partial agonists
WO2017210077A1 (en) *	2016-06-02	2017-12-07	Indiana University Research And Technology Corporation	Single chain insulin prodrugs
EP3272877A1 (en)	2016-07-18	2018-01-24	ETH Zurich	B-cell-mimetic cells
CA3030642A1 (en)	2016-07-18	2018-01-25	Eth Zurich	B-cell-mimetic cells
JP7286160B2 (ja)	2016-11-21	2023-06-05	ケースウェスタンリザーブユニバーシティ	安定性が増強された速効性インスリン類似体
US11041009B2 (en)	2017-03-23	2021-06-22	Merck Sharp & Dohme Corp.	Glucose responsive insulin comprising a tri-valent sugar cluster for treatment of diabetes
CN114591417B (zh) *	2022-04-22	2023-04-25	四川大学	人源单链胰岛素类似物及其应用

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PH25772A (en) *	1985-08-30	1991-10-18	Novo Industri As	Insulin analogues, process for their preparation
AU616205B2 (en) *	1988-07-20	1991-10-24	Novo Nordisk A/S	Human insulin analogs and preparations containing them
US5716927A (en) *	1988-12-23	1998-02-10	Novo Nordisk A/S	Insulin analogs having a modified B-chain
DE3844211A1 (de) *	1988-12-29	1990-07-05	Hoechst Ag	Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
US5514646A (en) *	1989-02-09	1996-05-07	Chance; Ronald E.	Insulin analogs modified at position 29 of the B chain
DE3936876A1 (de) *	1989-11-06	1991-05-23	Hoechst Ag	Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
ZA928916B (en) *	1991-11-26	1994-05-18	Lilly Co Eli	Tri-arginine insulins
US6011007A (en) *	1993-09-17	2000-01-04	Novo Nordisk A/S	Acylated insulin
US20030104981A1 (en) *	1995-11-03	2003-06-05	Jelena Mandic	Human insulin analogues
DE19652713C2 (de) *	1996-12-18	2001-11-22	Aventis Pharma Gmbh	Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher
DE19726167B4 (de) *	1997-06-20	2008-01-24	Sanofi-Aventis Deutschland Gmbh	Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
WO1999021578A1 (en) *	1997-10-24	1999-05-06	Eli Lilly And Company	Insoluble insulin compositions
US6531448B1 (en) *	1997-12-23	2003-03-11	Eli Lilly And Company	Insoluble compositions for controlling blood glucose
US7449443B2 (en) *	2000-03-23	2008-11-11	California Institute Of Technology	Method for stabilization of proteins using non-natural amino acids
US7316999B2 (en) *	2000-06-02	2008-01-08	Novo Nordisk A/S	Glucose dependent release of insulin from glucose sensing insulin derivatives
KR100449454B1 (ko) *	2000-10-02	2004-09-21	이현철	단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터
WO2003053460A1 (en) *	2001-12-19	2003-07-03	Eli Lilly And Company	Crystalline compositions for controlling blood glucose
US20050014679A1 (en) *	2001-12-20	2005-01-20	Beals John Michael	Insulin molecule having protracted time action
WO2003080666A2 (en) *	2002-03-26	2003-10-02	Council Of Scientific And Industrial Research	An adipocyte insulin and a method of treating diabetes
US7655619B2 (en) *	2002-05-06	2010-02-02	Thomas Jefferson University	Insulin-associated peptides with effects on cerebral health
AU2004234345A1 (en) *	2003-04-29	2004-11-11	Eli Lilly And Company	Insulin analogs having protracted time action
CN1836047B (zh) *	2003-06-17	2010-12-22	赛姆生物系统遗传公司	在植物中生产胰岛素的方法
ES2369895T3 (es) *	2003-12-03	2011-12-07	Novo Nordisk A/S	Insulina monocatenaria.
US8343914B2 (en) *	2006-01-06	2013-01-01	Case Western Reserve University	Fibrillation resistant proteins
ES2554773T3 (es) *	2006-10-04	2015-12-23	Case Western Reserve University	Insulina y análogos de la insulina resistentes a la fibrilación
US7790677B2 (en) *	2006-12-13	2010-09-07	Elona Biotechnologies	Insulin production methods and pro-insulin constructs
WO2009087081A2 (de) *	2008-01-09	2009-07-16	Sanofi-Aventis Deutschland Gmbh	Neue insulinderivate mit extrem verzögertem zeit-/wirkungsprofil
WO2009129250A2 (en) *	2008-04-14	2009-10-22	Case Western Reserve University	Meal-time insulin analogues of enhanced stability
KR20120129875A (ko) *	2008-07-31	2012-11-28	케이스 웨스턴 리저브 유니버시티	염소화 아미노산을 갖는 인슐린 유사체
US8399407B2 (en) *	2009-09-17	2013-03-19	Case Western Reserve University	Non-standard insulin analogues
US20110103575A1 (en) *	2009-10-30	2011-05-05	Telect Inc.	High-density splitter/patch telecommunications system

2009
- 2009-04-22 CN CN2009801244782A patent/CN102065885A/zh active Pending
- 2009-04-22 KR KR1020107025017A patent/KR20110021758A/ko not_active Withdrawn
- 2009-04-22 US US12/989,399 patent/US20110195896A1/en not_active Abandoned
- 2009-04-22 NZ NZ588857A patent/NZ588857A/en not_active IP Right Cessation
- 2009-04-22 EP EP09734135A patent/EP2296692A4/en not_active Withdrawn
- 2009-04-22 CA CA2722168A patent/CA2722168A1/en not_active Abandoned
- 2009-04-22 WO PCT/US2009/041439 patent/WO2009132129A2/en active Application Filing
- 2009-04-22 BR BRPI0911571A patent/BRPI0911571A2/pt not_active IP Right Cessation
- 2009-04-22 AU AU2009240636A patent/AU2009240636A1/en not_active Abandoned
- 2009-04-22 MX MX2010011329A patent/MX2010011329A/es not_active Application Discontinuation
- 2009-04-22 JP JP2011506432A patent/JP2011521621A/ja active Pending
- 2009-04-22 RU RU2010147076/10A patent/RU2010147076A/ru not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP2296692A4 (en)	2012-06-06
EP2296692A2 (en)	2011-03-23
MX2010011329A (es)	2011-03-15
WO2009132129A3 (en)	2010-01-21
AU2009240636A1 (en)	2009-10-29
KR20110021758A (ko)	2011-03-04
NZ588857A (en)	2012-07-27
RU2010147076A (ru)	2012-05-27
JP2011521621A (ja)	2011-07-28
WO2009132129A2 (en)	2009-10-29
US20110195896A1 (en)	2011-08-11
CA2722168A1 (en)	2009-10-29
CN102065885A (zh)	2011-05-18

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Legal Events

Date	Code	Title	Description
2018-04-10	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE AS 5A, 6A, 7A, 8A E 9A ANUIDADES.
2018-07-31	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]