BRPI0907237A2 - Anticorpo anti-cldn6 - Google Patents
Anticorpo anti-cldn6Info
- Publication number
- BRPI0907237A2 BRPI0907237A2 BRPI0907237-3A BRPI0907237A BRPI0907237A2 BR PI0907237 A2 BRPI0907237 A2 BR PI0907237A2 BR PI0907237 A BRPI0907237 A BR PI0907237A BR PI0907237 A2 BRPI0907237 A2 BR PI0907237A2
- Authority
- BR
- Brazil
- Prior art keywords
- cldn6 antibody
- cldn6
- antibody
- Prior art date
Links
Classifications
-
- G01N33/5758—
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- G01N33/5759—
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Hospice & Palliative Care (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008004423 | 2008-01-11 | ||
| PCT/JP2009/000082 WO2009087978A1 (ja) | 2008-01-11 | 2009-01-09 | 抗cldn6抗体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0907237A2 true BRPI0907237A2 (pt) | 2015-07-14 |
Family
ID=40853092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0907237-3A BRPI0907237A2 (pt) | 2008-01-11 | 2009-01-09 | Anticorpo anti-cldn6 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9274119B2 (pt) |
| EP (3) | EP4282428A3 (pt) |
| JP (1) | JP5848863B2 (pt) |
| KR (1) | KR20100116179A (pt) |
| CN (1) | CN101918450A (pt) |
| AU (1) | AU2009203464A1 (pt) |
| BR (1) | BRPI0907237A2 (pt) |
| CA (1) | CA2711557A1 (pt) |
| MX (1) | MX2010007500A (pt) |
| RU (1) | RU2010133547A (pt) |
| SG (1) | SG187457A1 (pt) |
| WO (1) | WO2009087978A1 (pt) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9809815B2 (en) * | 2009-02-20 | 2017-11-07 | Ganymed Pharmaceuticals Ag | Methods and compositions for diagnosis and treatment of cancer |
| EP2494361B2 (en) | 2009-10-26 | 2019-01-09 | Externautics S.p.A. | Ovary tumor markers and methods of use thereof |
| US8921058B2 (en) | 2009-10-26 | 2014-12-30 | Externautics Spa | Prostate tumor markers and methods of use thereof |
| EP2322555A1 (en) | 2009-11-11 | 2011-05-18 | Ganymed Pharmaceuticals AG | Antibodies specific for claudin 6 (CLDN6) |
| DK2499161T3 (da) * | 2009-11-11 | 2017-11-27 | Ganymed Pharmaceuticals Gmbh | Antistoffer, der er specifikke for claudin 6 (cldn6) |
| MY197016A (en) | 2010-02-24 | 2023-05-20 | Immunogen Inc | Folate receptor 1 antibodies and immunoconjugates and uses thereof |
| AU2011262758B8 (en) * | 2010-06-11 | 2014-09-04 | Kyowa Kirin Co., Ltd. | Anti-tim-3 antibody |
| EP2404936A1 (en) | 2010-07-06 | 2012-01-11 | Ganymed Pharmaceuticals AG | Cancer therapy using CLDN6 target-directed antibodies in vivo |
| FI3434767T3 (fi) | 2010-11-30 | 2026-02-12 | Chugai Seiyaku Kk | Sytotoksisuutta aiheuttava terapeuttinen aine |
| PT2694106T (pt) | 2011-04-01 | 2018-03-05 | Immunogen Inc | Métodos para aumentar eficácia de terapia de cancro de folr1 |
| HUE041781T2 (hu) * | 2011-05-13 | 2019-05-28 | Ganymed Pharmaceuticals Gmbh | Ellenanyagok klaudin-6-ot expresszáló rák kezelésére |
| CN107011440B (zh) * | 2011-05-13 | 2021-03-05 | 加尼梅德药物公司 | 用于治疗表达密蛋白6之癌症的抗体 |
| AU2012298877B2 (en) | 2011-08-22 | 2018-01-04 | Emergent Biosolutions Canada Inc. | Clostridium difficile antibodies |
| EA031069B1 (ru) * | 2012-02-17 | 2018-11-30 | Сиэтл Дженетикс, Инк. | АНТИТЕЛА ПРОТИВ ИНТЕГРИНОВ αVβ6 И ИХ ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ ЗЛОКАЧЕСТВЕННЫХ НОВООБРАЗОВАНИЙ |
| WO2013143555A1 (en) * | 2012-03-26 | 2013-10-03 | Biontech Ag | Rna formulation for immunotherapy |
| SG10201804260QA (en) | 2012-08-31 | 2018-07-30 | Immunogen Inc | Diagnostic assays and kits for detection of folate receptor 1 |
| WO2014132647A1 (ja) * | 2013-03-01 | 2014-09-04 | 公益財団法人ヒューマンサイエンス振興財団 | 抗体、フラグメント、医薬組成物、分子及び腫瘍マーカー |
| WO2015014376A1 (en) * | 2013-07-31 | 2015-02-05 | Biontech Ag | Diagnosis and therapy of cancer involving cancer stem cells |
| JP2016536330A (ja) | 2013-08-30 | 2016-11-24 | イミュノジェン, インコーポレイテッド | 葉酸受容体1の検出用の抗体及びアッセイ |
| US10053511B2 (en) * | 2013-11-06 | 2018-08-21 | Abbvie Stemcentrx Llc | Anti-claudin antibodies and methods of use |
| CN113307873B (zh) | 2013-11-11 | 2025-02-18 | 中外制药株式会社 | 含有改变了抗体可变区的抗原结合分子 |
| PT3708579T (pt) * | 2014-04-01 | 2024-07-17 | Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh | Imunorrecetores e epitopos de células t específicos para claudina-6 |
| MA40921A (fr) * | 2014-11-05 | 2017-09-12 | Abbvie Stemcentrx Llc | Récepteurs antigéniques chimériques anti-cldn et procédés d'utilisation |
| TWI831044B (zh) | 2014-11-11 | 2024-02-01 | 日商中外製藥股份有限公司 | 抗原結合分子、包含抗原結合分子的醫藥組合物以及製造及選擇抗原結合分子之方法 |
| CN106146666B (zh) * | 2015-03-26 | 2019-09-06 | 科济生物医药(上海)有限公司 | 靶向cldn6的免疫效应细胞及其制备方法和应用 |
| WO2017049149A1 (en) | 2015-09-17 | 2017-03-23 | Immunogen, Inc. | Therapeutic combinations comprising anti-folr1 immunoconjugates |
| US11479601B2 (en) | 2016-06-29 | 2022-10-25 | The Regents Of The University Of California | Antibodies specific to Sonic Hedgehog and method of use thereof |
| WO2018123949A1 (ja) * | 2016-12-28 | 2018-07-05 | 国立医薬品食品衛生研究所長が代表する日本国 | 抗クローディン-2モノクローナル抗体 |
| WO2019048040A1 (en) * | 2017-09-06 | 2019-03-14 | Ganymed Pharmaceuticals Gmbh | ANTIBODIES USEFUL IN THE DIAGNOSIS OF CANCER |
| HUE067603T2 (hu) * | 2017-09-18 | 2024-10-28 | Univ California | Klaudin-6 antitestek és rákkezelési eljárások |
| TWI820044B (zh) | 2017-09-29 | 2023-11-01 | 日商第一三共股份有限公司 | 抗體-吡咯并苯二氮呯衍生物複合體 |
| US11952422B2 (en) | 2017-12-05 | 2024-04-09 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule comprising altered antibody variable region binding CD3 and CD137 |
| EP3735463A4 (en) * | 2018-01-05 | 2022-03-02 | Chugai Seiyaku Kabushiki Kaisha | Cytotoxicity-inducing therapeutic agent |
| WO2020168059A1 (en) | 2019-02-15 | 2020-08-20 | Integral Molecular, Inc. | Claudin 6 antibodies and uses thereof |
| CA3134055A1 (en) | 2019-03-20 | 2020-09-24 | The Regents Of The University Of California | Claudin-6 antibodies and drug conjugates |
| EP3950061A4 (en) | 2019-03-25 | 2022-11-16 | Daiichi Sankyo Company, Limited | ANTIBODY PYRROLOBENZODIAZEPINE DERIVATIVE CONJUGATE |
| MX2022000111A (es) * | 2019-07-10 | 2022-02-10 | Chugai Pharmaceutical Co Ltd | Moleculas de union a claudina-6 y usos de las mismas. |
| MX2022006132A (es) | 2019-12-05 | 2022-06-17 | Seagen Inc | Anticuerpos anti alfa-v beta-6 (avb6) y conjugados de anticuerpo-farmaco. |
| PH12022552323A1 (en) | 2020-03-31 | 2023-12-04 | Chugai Pharmaceutical Co Ltd | Claudin-6 targeting multispecific antigen-binding molecules and uses thereof |
| WO2022096700A1 (en) | 2020-11-06 | 2022-05-12 | Amgen Research (Munich) Gmbh | Polypeptide constructs selectively binding to cldn6 and cd3 |
| CN116940377A (zh) * | 2021-03-05 | 2023-10-24 | 上海吉倍生物技术有限公司 | 抗cldn6抗体及其用途 |
| JP2024511319A (ja) | 2021-03-09 | 2024-03-13 | ゼンコア インコーポレイテッド | Cd3及びcldn6に結合するヘテロ二量体抗体 |
| WO2023053282A1 (ja) | 2021-09-29 | 2023-04-06 | 中外製薬株式会社 | がんの治療に用いるための細胞傷害誘導治療剤 |
| KR20250046264A (ko) * | 2022-07-29 | 2025-04-02 | 레전드 바이오테크 아일랜드 리미티드 | 클라우딘6 겹합 모이어티 및 이의 용도 |
| JP2025527491A (ja) * | 2022-08-15 | 2025-08-22 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | Cldn4に対する抗体及びその使用方法 |
| EP4566633A1 (en) | 2022-10-31 | 2025-06-11 | Astellas Pharma, Inc. | Antibody-drug complex containing toll-like receptor 7/8 dual agonist compound |
| IL319951A (en) | 2022-11-30 | 2025-05-01 | Integral Molecular Inc | Antibodies targeting claudin 6, including its bispecific formats |
| WO2024235175A1 (zh) * | 2023-05-12 | 2024-11-21 | 智泽童康(广州)生物科技有限公司 | 抗cldn6抗体及其用途 |
| WO2024243561A1 (en) | 2023-05-25 | 2024-11-28 | The Regents Of The University Of California | Methods of treating cancer |
| WO2025162270A1 (zh) * | 2024-02-01 | 2025-08-07 | 江苏恒瑞医药股份有限公司 | 抗cldn6抗体、其抗体-药物偶联物及其医药用途 |
| CN118812714B (zh) * | 2024-08-21 | 2025-05-27 | 广州百吉生物制药有限公司 | 一种紧密连接蛋白抗体b3及其应用 |
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| JPS58201994A (ja) | 1982-05-21 | 1983-11-25 | Hideaki Hagiwara | 抗原特異的ヒト免疫グロブリンの生産方法 |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
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| CA2119930C (en) | 1991-09-23 | 2002-10-01 | Hendricus R. J. M. Hoogenboom | Production of chimeric antibodies - a combinatorial approach |
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| CA2124967C (en) | 1991-12-17 | 2008-04-08 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
| CA2131151A1 (en) | 1992-03-24 | 1994-09-30 | Kevin S. Johnson | Methods for producing members of specific binding pairs |
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| US5648267A (en) | 1992-11-13 | 1997-07-15 | Idec Pharmaceuticals Corporation | Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same |
| EP0754225A4 (en) | 1993-04-26 | 2001-01-31 | Genpharm Int | HETEROLOGIC ANTIBODY-PRODUCING TRANSGENIC NON-HUMAN ANIMALS |
| GB9313509D0 (en) | 1993-06-30 | 1993-08-11 | Medical Res Council | Chemisynthetic libraries |
| JPH09506508A (ja) | 1993-12-03 | 1997-06-30 | メディカル リサーチ カウンシル | 組換え結合タンパク質およびペプチド |
| HU221385B1 (en) | 1994-07-13 | 2002-09-28 | Chugai Pharmaceutical Co Ltd | Reconstituted human antibody against human interleukin-8 |
| DK2180007T4 (da) | 1998-04-20 | 2017-11-27 | Roche Glycart Ag | Glycosyleringsteknik for antistoffer til forbedring af antistofafhængig cellecytotoxicitet |
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| DK1176195T3 (da) | 1999-04-09 | 2013-06-24 | Kyowa Hakko Kirin Co Ltd | Fremgangsmåde til at kontrollere aktiviteten af immunologisk funktionelt molekyle |
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| AU2002307037B2 (en) | 2001-04-02 | 2008-08-07 | Biogen Idec Inc. | Recombinant antibodies coexpressed with GnTIII |
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| US20040132101A1 (en) * | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
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| WO2003104453A1 (ja) | 2002-06-05 | 2003-12-18 | 中外製薬株式会社 | 抗体作製方法 |
| AU2003244817B2 (en) * | 2002-06-28 | 2010-08-26 | Domantis Limited | Antigen-binding immunoglobulin single variable domains and dual-specific constructs |
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| ATE541857T1 (de) | 2002-09-27 | 2012-02-15 | Xencor Inc | Optimierte fc-varianten und herstellungsverfahren dafür |
| US20090061485A1 (en) | 2004-12-22 | 2009-03-05 | Chugai Seiyaku Kabushiki Kaisha | Method of Producing an Antibody Using a Cell in Which the Function of Fucose Transporter Is Inhibited |
| JP2007020155A (ja) | 2005-06-08 | 2007-01-25 | Canon Inc | 画像処理装置、画像処理方法、プログラム、及び記憶媒体 |
| CA2624189A1 (en) * | 2005-10-03 | 2007-04-12 | Xencor, Inc. | Fc variants with optimized fc receptor binding properties |
| JP5060068B2 (ja) | 2006-06-23 | 2012-10-31 | 一般財団法人ファインセラミックスセンター | 固体酸化物形燃料電池及びその製造方法 |
-
2009
- 2009-01-09 US US12/735,359 patent/US9274119B2/en active Active
- 2009-01-09 EP EP23193707.9A patent/EP4282428A3/en active Pending
- 2009-01-09 WO PCT/JP2009/000082 patent/WO2009087978A1/ja not_active Ceased
- 2009-01-09 RU RU2010133547/10A patent/RU2010133547A/ru not_active Application Discontinuation
- 2009-01-09 EP EP09700588.8A patent/EP2241578B1/en not_active Revoked
- 2009-01-09 CN CN2009801019661A patent/CN101918450A/zh active Pending
- 2009-01-09 BR BRPI0907237-3A patent/BRPI0907237A2/pt not_active IP Right Cessation
- 2009-01-09 CA CA2711557A patent/CA2711557A1/en not_active Abandoned
- 2009-01-09 EP EP16165434.8A patent/EP3064512B1/en active Active
- 2009-01-09 AU AU2009203464A patent/AU2009203464A1/en not_active Abandoned
- 2009-01-09 KR KR1020107017001A patent/KR20100116179A/ko not_active Withdrawn
- 2009-01-09 JP JP2009548907A patent/JP5848863B2/ja active Active
- 2009-01-09 MX MX2010007500A patent/MX2010007500A/es active IP Right Grant
- 2009-01-09 SG SG2013002365A patent/SG187457A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3064512A2 (en) | 2016-09-07 |
| JPWO2009087978A1 (ja) | 2011-05-26 |
| CN101918450A (zh) | 2010-12-15 |
| US20110059469A1 (en) | 2011-03-10 |
| EP2241578B1 (en) | 2016-04-20 |
| CA2711557A1 (en) | 2009-07-16 |
| AU2009203464A1 (en) | 2009-07-16 |
| EP3064512A3 (en) | 2016-10-19 |
| WO2009087978A1 (ja) | 2009-07-16 |
| EP2241578A4 (en) | 2012-09-12 |
| RU2010133547A (ru) | 2012-02-20 |
| SG187457A1 (en) | 2013-02-28 |
| MX2010007500A (es) | 2010-10-20 |
| US9274119B2 (en) | 2016-03-01 |
| EP2241578A1 (en) | 2010-10-20 |
| EP3064512B1 (en) | 2023-08-30 |
| EP3064512C0 (en) | 2023-08-30 |
| KR20100116179A (ko) | 2010-10-29 |
| JP5848863B2 (ja) | 2016-01-27 |
| EP4282428A3 (en) | 2024-03-20 |
| EP4282428A2 (en) | 2023-11-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
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