[go: up one dir, main page]

BRPI0606639A2 - novo processo para a preparação de indóis substituìdos - Google Patents

novo processo para a preparação de indóis substituìdos

Info

Publication number
BRPI0606639A2
BRPI0606639A2 BRPI0606639-9A BRPI0606639A BRPI0606639A2 BR PI0606639 A2 BRPI0606639 A2 BR PI0606639A2 BR PI0606639 A BRPI0606639 A BR PI0606639A BR PI0606639 A2 BRPI0606639 A2 BR PI0606639A2
Authority
BR
Brazil
Prior art keywords
preparation
new process
substituted indoles
substituted
indoles
Prior art date
Application number
BRPI0606639-9A
Other languages
English (en)
Inventor
Philip Keegan
Eric Merifield
Duncan Gill
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BRPI0606639A2 publication Critical patent/BRPI0606639A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

NOVO PROCESSO PARA A PREPARAçãO DE INDóIS SUBSTITUìDOS. A invenção refere-se a um novo processo para a preparação de indóis substituidos de fórmula (1) ou um sal ou solvato farmaceuticamente aceitável deste, que são úteis como agentes terapêuticos.
BRPI0606639-9A 2005-01-13 2006-01-09 novo processo para a preparação de indóis substituìdos BRPI0606639A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0500604.4A GB0500604D0 (en) 2005-01-13 2005-01-13 Novel process
PCT/GB2006/000060 WO2006075139A2 (en) 2005-01-13 2006-01-09 Novel process for the preparation of substituted indoles

Publications (1)

Publication Number Publication Date
BRPI0606639A2 true BRPI0606639A2 (pt) 2009-07-07

Family

ID=34203986

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0606639-9A BRPI0606639A2 (pt) 2005-01-13 2006-01-09 novo processo para a preparação de indóis substituìdos

Country Status (15)

Country Link
US (1) US7781598B2 (pt)
EP (1) EP1844012A2 (pt)
JP (1) JP2008526936A (pt)
KR (1) KR20070104350A (pt)
CN (1) CN101102999B (pt)
AU (1) AU2006205697B2 (pt)
BR (1) BRPI0606639A2 (pt)
CA (1) CA2594391A1 (pt)
GB (1) GB0500604D0 (pt)
IL (1) IL183965A0 (pt)
MX (1) MX2007008348A (pt)
NO (1) NO20074047L (pt)
NZ (1) NZ556147A (pt)
WO (1) WO2006075139A2 (pt)
ZA (1) ZA200705216B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200307542A (en) 2002-05-30 2003-12-16 Astrazeneca Ab Novel compounds
SE0202241D0 (sv) 2002-07-17 2002-07-17 Astrazeneca Ab Novel Compounds
SE0301569D0 (sv) 2003-05-27 2003-05-27 Astrazeneca Ab Novel compounds
SE0302232D0 (sv) 2003-08-18 2003-08-18 Astrazeneca Ab Novel Compounds
SE0303180D0 (sv) * 2003-11-26 2003-11-26 Astrazeneca Ab Novel compounds
GB0500604D0 (en) 2005-01-13 2005-02-16 Astrazeneca Ab Novel process
EP2125722A2 (en) * 2006-05-26 2009-12-02 AstraZeneca AB Bi-aryl or aryl-heteroaryl substituted indoles
RU2551852C2 (ru) 2009-07-06 2015-05-27 Астразенека Аб Промежуточные соединения и способы получения 4-(ацетиламино)-3-[(4-хлорфенил)тио]-2-метил-1н-индол-1-уксусной кислоты
UA112667C2 (uk) 2011-12-16 2016-10-10 Атопікс Терапеутікс Лімітед Комбінація антагоніста crth2 і інгібітору протонного насоса для лікування еозинофільного езофагіту
CN103288707B (zh) * 2013-05-28 2015-12-23 浙江大学 一种3-苯巯基吲哚衍生物的制备方法

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE790679A (fr) 1971-11-03 1973-04-27 Ici Ltd Derives de l'indole
JPH0615542B2 (ja) 1986-07-22 1994-03-02 吉富製薬株式会社 ピラゾロピリジン化合物
US5095031A (en) 1990-08-20 1992-03-10 Abbott Laboratories Indole derivatives which inhibit leukotriene biosynthesis
WO1993005020A1 (en) 1991-09-06 1993-03-18 Merck & Co., Inc. Indoles as inhibitors of hiv reverse transcriptase
FR2692574B1 (fr) 1992-06-23 1995-06-23 Sanofi Elf Derives hydroxy-4 benzenethio, leur preparation ainsi que leur utilisation pour la preparation de derives aminoalkoxybenzenesulfonyles.
AU6254294A (en) 1993-02-24 1994-09-14 Merck & Co., Inc. Inhibitors of hiv reverse transcriptase
US5486525A (en) 1993-12-16 1996-01-23 Abbott Laboratories Platelet activating factor antagonists: imidazopyridine indoles
US5567711A (en) 1995-04-19 1996-10-22 Abbott Laboratories Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists
TW472045B (en) 1996-09-25 2002-01-11 Astra Ab Protein kinase C inhibitor compounds, method for their preparation, pharmaceutical composition thereof and intermediate used for their preparation
ZA987554B (en) 1997-08-21 2000-02-21 American Home Prod Methods for the solid phase synthesis of substituted indole compounds.
WO1999032112A1 (en) 1997-12-19 1999-07-01 Eli Lilly And Company Method for treating diabetes
US6916841B2 (en) 1998-02-25 2005-07-12 Genetics Institute, Llc Inhibitors of phospholipase enzymes
AU5886500A (en) 1999-06-23 2001-01-09 Sepracor, Inc. Indolyl-benzimidazole antibacterials, and methods of use thereof
WO2001032621A1 (fr) 1999-10-29 2001-05-10 Wakunaga Pharmaceutical Co., Ltd. Nouveaux derives d'indole, et medicaments contenant lesdits derives comme principe actif
WO2001047922A2 (en) 1999-12-24 2001-07-05 Aventis Pharma Limited Azaindoles
CN1431999A (zh) 2000-05-31 2003-07-23 阿斯特拉曾尼卡有限公司 具有血管损伤活性的吲哚衍生物
US6878522B2 (en) 2000-07-07 2005-04-12 Baiyong Li Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2
WO2003013510A1 (en) * 2001-08-07 2003-02-20 Smithkline Beecham P.L.C. 3-arylsulfonyl-7-piperazinyl- indoles, -benzofurans and -benzothiophenes with 5-ht6 receptor affinity for treating cns disorders
US6933316B2 (en) 2001-12-13 2005-08-23 National Health Research Institutes Indole compounds
RU2337909C2 (ru) 2002-02-01 2008-11-10 Ф.Хоффманн-Ля Рош Аг Замещенные индолы и фармацевтическая композиция, обладающая агонистической активностью в отношении альфа-1a/l адренорецептора
SE0200356D0 (sv) 2002-02-05 2002-02-05 Astrazeneca Ab Novel use
SE0200411D0 (sv) 2002-02-05 2002-02-05 Astrazeneca Ab Novel use
WO2003097598A1 (fr) 2002-05-16 2003-11-27 Shionogi & Co., Ltd. Composé comprenant un antagonisme du récepteur de pdg2
SE0201635D0 (sv) 2002-05-30 2002-05-30 Astrazeneca Ab Novel compounds
TW200307542A (en) 2002-05-30 2003-12-16 Astrazeneca Ab Novel compounds
SE0202241D0 (sv) 2002-07-17 2002-07-17 Astrazeneca Ab Novel Compounds
SE0202463D0 (sv) 2002-08-14 2002-08-14 Astrazeneca Ab Novel compounds
US7618979B2 (en) * 2002-10-30 2009-11-17 Merck Frosst Canada Ltd. Pyridopyrrolizine and pyridoindolizine derivatives
CN1713908B (zh) * 2002-12-03 2010-05-12 弗·哈夫曼-拉罗切有限公司 作为5-ht6-受体配体用于治疗中枢神经系统病症的氨基烷氧基吲哚
SE0301569D0 (sv) 2003-05-27 2003-05-27 Astrazeneca Ab Novel compounds
SE0302232D0 (sv) 2003-08-18 2003-08-18 Astrazeneca Ab Novel Compounds
AU2004283139A1 (en) 2003-10-14 2005-05-06 Oxagen Limited Compounds having CRTH2 antagonist activity
SE0303180D0 (sv) 2003-11-26 2003-11-26 Astrazeneca Ab Novel compounds
GB0500604D0 (en) 2005-01-13 2005-02-16 Astrazeneca Ab Novel process
GB2422831A (en) 2005-02-04 2006-08-09 Oxagen Ltd Pyrrolopyridines and their use in the treatment of diseases mediated by PGD2 at the CRTH2 receptor
EP2125722A2 (en) 2006-05-26 2009-12-02 AstraZeneca AB Bi-aryl or aryl-heteroaryl substituted indoles
WO2007140786A1 (en) 2006-06-08 2007-12-13 Neurokey A/S Use of cannabinoid receptor agonists as hypothermia inducing drugs for the treatment of ischemia
MX2008015768A (es) 2006-06-28 2009-01-07 Sanofi Aventis Nuevos inhibidores de cxcr2.

Also Published As

Publication number Publication date
US20080051586A1 (en) 2008-02-28
WO2006075139A3 (en) 2006-10-19
MX2007008348A (es) 2007-08-03
NO20074047L (no) 2007-08-06
ZA200705216B (en) 2008-09-25
US7781598B2 (en) 2010-08-24
IL183965A0 (en) 2007-10-31
KR20070104350A (ko) 2007-10-25
CA2594391A1 (en) 2006-07-20
AU2006205697A1 (en) 2006-07-20
AU2006205697B2 (en) 2009-01-22
JP2008526936A (ja) 2008-07-24
NZ556147A (en) 2010-01-29
WO2006075139A2 (en) 2006-07-20
CN101102999B (zh) 2010-12-29
CN101102999A (zh) 2008-01-09
GB0500604D0 (en) 2005-02-16
EP1844012A2 (en) 2007-10-17

Similar Documents

Publication Publication Date Title
BRPI0606639A2 (pt) novo processo para a preparação de indóis substituìdos
BRPI0410711A (pt) novos compostos
ECSP088623A (es) Derivados de azepinoindol como agentes farmacéuticos
TW200728307A (en) Novel spirochromanone derivatives
BRPI0607309A2 (pt) processos para a preparação de fenilpirazol uréias substituìdas
SE0303180D0 (sv) Novel compounds
SE0302232D0 (sv) Novel Compounds
MY148429A (en) Novel 1,4-benzothiepin-1,1-dioxide derivatives which are substituted with benzyl groups, method for producing drugs containing said compounds and use thereof
UY29919A1 (es) Derivados sustituidos de 3,4-dihidroisoquinolin-1-amino-trifluoroacetato, sus composiciones farmacéuticas y aplicaciones
ES2338590T3 (es) Procedimiento regioselectivo de preparacion de benzoimidazoltiofenos.
EA201200669A1 (ru) ПИРИДОПИРИМИДИНОНОВЫЕ ИНГИБИТОРЫ PI3Kα
BRPI0516911A (pt) método para a preparação de um composto e composto de anilina
SE0203713D0 (sv) Novel compounds
EA200800760A1 (ru) ПИРИДОПИРИМИДИНОНОВЫЕ ИНГИБИТОРЫ PI3Kα
BRPI0607455A2 (pt) composto, processo para a preparação do mesmo, uso de um composto, e composição farmacêutica
NO20085099L (no) Puritonderivativer som HM74A agonister
ATE430744T1 (de) Thiazolylpiperidin-derivate nützlich als h3 rezeptor modulatoren
BRPI0606964A2 (pt) pirrolidinas e piperidinas derivadas do acetileno para uso como antagonistas de mglur5
UY30414A1 (es) Metano sulfonatos, propano-1-sulfonatos y ciclopropan sulfonatos sustituidos con [2,3,4,8-tetrahidroimidazo-[1,5-al-pirimidin-8-il]-fenilo, composiciones farmacéuticas conteniéndolos y aplicaciones.
MX2007011847A (es) Derivados de pirimidindiona como antagonistas del receptor de procineticina 2.
CY1108880T1 (el) Παραγωγα καρβοξαμιδιου ως ανταγωνιστες μουσκαρινικου υποδοχεα
DE602006014305D1 (de) Pyrroloä2,3-büpyridinderivate als modulatoren des h3-rezeptors
ATE449776T1 (de) Pyrroloä2,3-cüpyridinderivate
ATE520651T1 (de) Substituierte phenylmethylbicyclocarbonsäureamidverbindungen
CY1113820T1 (el) Παραγωγα 4-αλκοξυπυριδαζινης ως ταχεως διασπομενοι ανταγωνιστες υποδοχεα ντοπαμινης 2

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2288 DE 11/11/2014.