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BRPI0516574A - amylin family polypeptide-6 (afp-6) analogs and methods for preparing and using them - Google Patents

amylin family polypeptide-6 (afp-6) analogs and methods for preparing and using them

Info

Publication number
BRPI0516574A
BRPI0516574A BRPI0516574-1A BRPI0516574A BRPI0516574A BR PI0516574 A BRPI0516574 A BR PI0516574A BR PI0516574 A BRPI0516574 A BR PI0516574A BR PI0516574 A BRPI0516574 A BR PI0516574A
Authority
BR
Brazil
Prior art keywords
afp
analogs
methods
preparing
family polypeptide
Prior art date
Application number
BRPI0516574-1A
Other languages
Portuguese (pt)
Inventor
Mary Erickson
Ved Srivastava
Sarah Mcquaid
Andrew Young
Richard Pittner
Soumitra Ghosh
Original Assignee
Amylin Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amylin Pharmaceuticals Inc filed Critical Amylin Pharmaceuticals Inc
Publication of BRPI0516574A publication Critical patent/BRPI0516574A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

ANáLOGOS DO POLIPEPTìDEO-6 DA FAMìLIA AMILINA (AFP-6) E MéTODOS PARA PREPARAR E USAR OS MESMOS. A presente invenção se refere a análogos do Polipeptídeo-6 da Família Amílina (AFP-6), os quais incluem derivados e fragmentos, ácidos nucléicos relacionados, constructos de expressão, células hospedeiras, e processos para produção recombinante dos análogos de AFP-6. Os análogos de AFP-6 da invenção incluem uma ou mais modificações da seqüência de aminoácidos. Além disso, são revelados métodos e composições para tratar e prevenir condições tais como distúrbios metabólicos e cardiovasculares, por exemplo, obesidade, diabetes, síndrome metabólica, isquemia do miocárdio, e aumento do risco cardiovascular.ANALOGS OF THE AMILINE FAMILY POLIPEPTIDE-6 (AFP-6) AND METHODS FOR PREPARING AND USING THEM. The present invention relates to Amyline Family Polypeptide-6 (AFP-6) analogs, which include derivatives and fragments, related nucleic acids, expression constructs, host cells, and processes for recombinant production of AFP-6 analogs. The AFP-6 analogs of the invention include one or more amino acid sequence modifications. In addition, methods and compositions for treating and preventing conditions such as metabolic and cardiovascular disorders, for example obesity, diabetes, metabolic syndrome, myocardial ischemia, and increased cardiovascular risk are disclosed.

BRPI0516574-1A 2004-10-08 2005-10-11 amylin family polypeptide-6 (afp-6) analogs and methods for preparing and using them BRPI0516574A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61746804P 2004-10-08 2004-10-08
PCT/US2005/036456 WO2006042242A2 (en) 2004-10-08 2005-10-11 Amylin family polypeptide- 6 (afp- 6) analogs and methods of making and using them

Publications (1)

Publication Number Publication Date
BRPI0516574A true BRPI0516574A (en) 2008-09-16

Family

ID=36148999

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0516574-1A BRPI0516574A (en) 2004-10-08 2005-10-11 amylin family polypeptide-6 (afp-6) analogs and methods for preparing and using them

Country Status (8)

Country Link
US (1) US7928060B2 (en)
EP (3) EP2631244A1 (en)
JP (1) JP2008515443A (en)
CN (1) CN101035806A (en)
AU (1) AU2005295043A1 (en)
BR (1) BRPI0516574A (en)
CA (1) CA2580991A1 (en)
WO (1) WO2006042242A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007012237A (en) 2005-03-31 2007-12-07 Amylin Pharmaceuticals Inc Amylin and amylin agonists for treating psychiatric diseases and disorders.
US20090181890A1 (en) * 2006-03-31 2009-07-16 Amylin Pharmaceuticals , Inc. Amylin and Amylin Agonists for Treating Psychiatric Diseases and Disorders
ES2389747T3 (en) 2007-02-05 2012-10-31 Amylin Pharmaceuticals, Inc. FN-38 peptides for use in the treatment of psychotic and anxiety disorders
EP2187937A1 (en) * 2007-09-11 2010-05-26 Mondobiotech Laboratories AG Use of the peptide pro-gly-thr-cys-glu-ile-cys-ala-tyr-ala-ala-cys-thr-gly-cys as a therapeutic agent
WO2009033707A2 (en) * 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
EP2221065B1 (en) * 2007-11-26 2016-12-28 Japan Science and Technology Agency Therapeutic or prophylactic agent, detection method and detection agent for metabolic syndrome, and method for screening of candidate compound for therapeutic agent for metabolic syndrome
GB201001333D0 (en) 2010-01-27 2010-03-17 Imp Innovations Ltd Novel compounds and their effects on feeding behaviour
RU2664859C2 (en) * 2011-04-07 2018-08-23 Те Борд Оф Трастиз Оф Те Лилэнд Стэнфорд Джуниор Юниверсити Analogues of long-acting peptides
CN104395338B (en) * 2012-04-19 2019-05-10 诺和诺德股份有限公司 Human amylin analogs
CN116063580A (en) 2016-01-04 2023-05-05 艾得佩索拉公司 Peptide analogues
US11701409B2 (en) 2016-02-09 2023-07-18 Adepthera Llc Dosing and use of long-acting CLR/ramp agonists
CN106749612B (en) * 2016-10-14 2020-06-16 四川大学华西医院 Intermediary-related polypeptide and its use in the prevention and treatment of sepsis
WO2019005623A1 (en) 2017-06-30 2019-01-03 Adepthera Llc Peptide analogs
US11274158B2 (en) * 2018-01-30 2022-03-15 Flagship Pioneering Innovations V, Inc. Methods and compositions for treating inflammatory or autoimmune diseases or conditions using calcitonin receptor activators
WO2024164776A1 (en) * 2023-02-10 2024-08-15 杭州先为达生物科技股份有限公司 Polypeptide and derivative thereof, composition, and use thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
NZ229098A (en) 1988-05-13 1992-10-28 Amgen Inc (bg-csf) bovine granulocyte colony stimulating factor, recombinant methods and pharmaceuticals
US5264372A (en) 1991-03-15 1993-11-23 Amylin Pharmaceuticals, Inc. Receptor-based screening methods for amylin agonists and antagonists
HU222249B1 (en) 1991-03-08 2003-05-28 Amylin Pharmaceuticals Inc. Process for producing amyline antagonistic peptide derivatives and pharmaceutical preparatives containing them
US5686511A (en) 1996-06-28 1997-11-11 The Valspar Corporation Esterifying epoxy resin with carboxyl polymer and quenching
BR9811866A (en) 1997-08-08 2000-08-15 Amylin Pharmaceuticals Inc Exendin agonist compounds
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
ATE383867T1 (en) 1997-11-14 2008-02-15 Amylin Pharmaceuticals Inc NOVEL EXENDIN AGONISTS
BR9815670A (en) 1997-11-14 2000-10-17 Amylin Pharmaceuticals Inc Exendin agonist compounds
US6630169B1 (en) 1999-03-31 2003-10-07 Nektar Therapeutics Particulate delivery systems and methods of use
JP2005508324A (en) 2001-09-24 2005-03-31 インペリアル カレッジ イノベーションズ リミテッド Correction of eating behavior
EP2329839B1 (en) 2002-01-10 2015-09-16 Imperial Innovations Limited Modification of feeding behavior by GLP-1 and PYY
AU2003298739A1 (en) 2002-11-26 2004-06-18 The Board Of Trustees Of The Leland Stanford Junior University Intermedin and its uses
WO2005077094A2 (en) 2004-02-11 2005-08-25 Amylin Pharmaceuticals, Inc. Pancreatic polypeptide family motifs and polypeptides comprising the same
CN1961000B (en) 2004-02-11 2011-05-04 安米林药品公司 Hybrid polypeptides with selectable properties
US7399744B2 (en) 2004-03-04 2008-07-15 Amylin Pharmaceuticals, Inc. Methods for affecting body composition

Also Published As

Publication number Publication date
EP2631244A1 (en) 2013-08-28
JP2008515443A (en) 2008-05-15
CN101035806A (en) 2007-09-12
WO2006042242A2 (en) 2006-04-20
US20080207501A1 (en) 2008-08-28
US7928060B2 (en) 2011-04-19
WO2006042242A3 (en) 2007-04-26
EP1797121A2 (en) 2007-06-20
AU2005295043A1 (en) 2006-04-20
EP2314615A3 (en) 2011-07-20
EP2314615A2 (en) 2011-04-27
CA2580991A1 (en) 2006-04-20

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012.