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BRPI0512326A - composições compreendendo anfotericina b, métodos e sistemas - Google Patents

composições compreendendo anfotericina b, métodos e sistemas

Info

Publication number
BRPI0512326A
BRPI0512326A BRPI0512326-7A BRPI0512326A BRPI0512326A BR PI0512326 A BRPI0512326 A BR PI0512326A BR PI0512326 A BRPI0512326 A BR PI0512326A BR PI0512326 A BRPI0512326 A BR PI0512326A
Authority
BR
Brazil
Prior art keywords
amphotericin
particles
methods
systems
compositions
Prior art date
Application number
BRPI0512326-7A
Other languages
English (en)
Inventor
Sarma Duddu
Srinivas Palakodaty
David Lechuga-Ballesteros
Danforth Miller
Christopher Frantz
Trixie Tan
Richard Malcolmson
Keith Washco
Theresa Sweeney
Thomas E Tarara
Sarvajna K Dwivedi
Michael A Eldon
Alan R Kugler
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Publication of BRPI0512326A publication Critical patent/BRPI0512326A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0041—Details of the piercing or cutting means with movable piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Otolaryngology (AREA)
  • Inorganic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

COMPOSIçõES COMPREENDENDO ANFOTERICINA B, MéTODOS E SISTEMAS. Uma composição inclui partículas incluindo pelo menos cerca de 95% em peso de anfotericina B, em que as partículas possuem um diâmetro médio de massa que varia de cerca de 1,1 Ám a cerca de 1,9<109>m. Outra composição inclui também partículas incluindo no mínimo cerca de 95% em peso de anfotericina B, em que no mínimo cerca de 80% em peso das partículas possuem um diâmetro geométrico que varia de cerca de 1,1 Ám a cerca de 1,9<109>m. E ainda uma outra composição inclui partículas incluindo anfotericina B, em que as partículas possuem um diâmetro médio de massa inferior a cerca de 1,9<109>m e em que a anfotericina B possui um nível de cristalinidade de no mínimo cerca de 20%. Formas de dosagem unitária, sistemas de fornecimento e métodos podem envolver composições semelhantes.
BRPI0512326-7A 2004-06-21 2005-06-21 composições compreendendo anfotericina b, métodos e sistemas BRPI0512326A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58158604P 2004-06-21 2004-06-21
PCT/US2005/021886 WO2006002140A2 (en) 2004-06-21 2005-06-21 Compositions comprising amphotericin b

Publications (1)

Publication Number Publication Date
BRPI0512326A true BRPI0512326A (pt) 2008-02-26

Family

ID=35414832

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0512326-7A BRPI0512326A (pt) 2004-06-21 2005-06-21 composições compreendendo anfotericina b, métodos e sistemas

Country Status (10)

Country Link
US (1) US7326691B2 (pt)
EP (1) EP1773301A2 (pt)
JP (1) JP2008503586A (pt)
CN (1) CN101442989B (pt)
AU (1) AU2005258040A1 (pt)
BR (1) BRPI0512326A (pt)
CA (1) CA2567785A1 (pt)
IL (1) IL179835A0 (pt)
MX (1) MXPA06015220A (pt)
WO (1) WO2006002140A2 (pt)

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GB0503738D0 (en) * 2005-02-23 2005-03-30 Optinose As Powder delivery devices
US8524734B2 (en) * 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US7838532B2 (en) * 2005-05-18 2010-11-23 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
AU2006297394B9 (en) * 2005-09-29 2013-09-19 Novartis Ag Receptacles and kits, such as for dry powder packaging
US20120128728A1 (en) * 2005-12-28 2012-05-24 Novartis Pharma Ag Compositions Comprising Amphotericin B
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ES2749927T3 (es) * 2014-05-16 2020-03-24 Univ Illinois Derivado de anfotericina b con toxicidad reducida
WO2017034961A1 (en) * 2015-08-21 2017-03-02 Trilogy Therapeutics, Inc. Methods of treating lung infection with caspofungin
BR112018009899A8 (pt) * 2015-11-18 2019-02-26 Glaxosmithkline Ip No 2 Ltd composição, inalador, forma de dosagem única, métodos para fabricar partículas, para melhorar as exacerbações induzidas por infecção respiratória de um distúrbio respiratório, para prevenir as exacerbações induzidas por infecção respiratória de um distúrbio respiratório, para reduzir a incidência das exacerbações induzidas por infecção respiratória de um distúrbio respiratório, para reduzir a gravidade das exacerbações induzidas por infecção respiratória de um distúrbio respiratório, para prevenir uma infecção respiratória viral e para fabricar uma partícula de inalação de pó seco de ribavirina controlada na forma polimorfa cristalina, partículas fabricadas, método de tratamento, pluralidade de partículas, e, recipiente de dose.
CA3076336A1 (en) * 2017-09-20 2019-03-28 Atopic Medical, LLC Compositions and methods for treating and ameliorating respiratory conditions and inflammation of mucosa

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Also Published As

Publication number Publication date
US7326691B2 (en) 2008-02-05
WO2006002140A9 (en) 2006-04-20
CN101442989A (zh) 2009-05-27
WO2006002140A2 (en) 2006-01-05
WO2006002140A3 (en) 2007-03-01
CA2567785A1 (en) 2006-01-05
US20060025355A1 (en) 2006-02-02
EP1773301A2 (en) 2007-04-18
JP2008503586A (ja) 2008-02-07
CN101442989B (zh) 2013-04-03
MXPA06015220A (es) 2007-12-13
AU2005258040A1 (en) 2006-01-05
IL179835A0 (en) 2007-05-15

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B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]