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BRPI0512251A - método enantioseletivo para separação de derivados do ácido 2-trifluormetil-2h-cromeno-3-carboxìlico substituìdo - Google Patents

método enantioseletivo para separação de derivados do ácido 2-trifluormetil-2h-cromeno-3-carboxìlico substituìdo

Info

Publication number
BRPI0512251A
BRPI0512251A BRPI0512251-1A BRPI0512251A BRPI0512251A BR PI0512251 A BRPI0512251 A BR PI0512251A BR PI0512251 A BRPI0512251 A BR PI0512251A BR PI0512251 A BRPI0512251 A BR PI0512251A
Authority
BR
Brazil
Prior art keywords
carboxylic acid
trifluoromethyl
substituted
chromen
enantioselective
Prior art date
Application number
BRPI0512251-1A
Other languages
English (en)
Inventor
Brian P Chekal
Ernst Freund
Charles Minard Grill
Elke Huthmann
Markus Juza
Vera Leshchinskaya
Mark Thomas Maloney
Lawarence Marvin Miller Jr
Ying Wang
Ming Zeng
Original Assignee
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc
Publication of BRPI0512251A publication Critical patent/BRPI0512251A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Recycling of the fraction to be distributed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Recycling of the fraction to be distributed
    • B01D15/1857—Reactive simulated moving beds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Sustainable Development (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

MéTODO ENANTIOSELETIVO PARA SEPARAçãO DE DERIVADOS DO áCIDO 2-TRIFLUORMETIL-2H-CROMENO-3 -CARBOXìLICO SUBSTITUìDO Essa invenção se refere a um método para separação de enantiómeros de um ácido ou éster 2-trifluormetil-2H-cromeno-3-carboxílico substituído, um ácido ou éster de 2-trifluormetil-1,2-diidro-quinolina-3-carboxílíco substituído, um ácido ou éster de 2-trifluormetil-2H-tiocromeno-3-carboxílico substituído, um ácido ou éster de 3-trifluormetil-3, 4-diidro-naftaleno-2-carboxílico substituído ou um sal farmaceuticamente aceitável dos ácidos ou ésteres, empregando cristalização fracional enantioseletiva, cromatografia líquida de alto desempenho enantioseletiva, cromatografia de reciclagem de estado firme enantioseletiva ou cromatografia de múltiplas colunas enantioseletiva.
BRPI0512251-1A 2004-07-23 2005-07-11 método enantioseletivo para separação de derivados do ácido 2-trifluormetil-2h-cromeno-3-carboxìlico substituìdo BRPI0512251A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59051604P 2004-07-23 2004-07-23
PCT/IB2005/002202 WO2006011047A1 (en) 2004-07-23 2005-07-11 Enantioselective method for separing substituted 2-trifluoromethyl-2h-chromene-3-carboxylic acid derivatives

Publications (1)

Publication Number Publication Date
BRPI0512251A true BRPI0512251A (pt) 2008-02-19

Family

ID=34979492

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0512251-1A BRPI0512251A (pt) 2004-07-23 2005-07-11 método enantioseletivo para separação de derivados do ácido 2-trifluormetil-2h-cromeno-3-carboxìlico substituìdo

Country Status (9)

Country Link
US (1) US20060020022A1 (pt)
EP (1) EP1773802A1 (pt)
JP (1) JP2008507502A (pt)
AR (1) AR050179A1 (pt)
BR (1) BRPI0512251A (pt)
CA (1) CA2574363A1 (pt)
MX (1) MX2007000880A (pt)
TW (1) TW200616992A (pt)
WO (1) WO2006011047A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8076511B2 (en) * 2007-05-18 2011-12-13 Ampac Fine Chemicals Llc. Preparative-scale separation of enantiomers of chiral carboxylic acids
US8608967B2 (en) * 2011-03-03 2013-12-17 The Board Of Trustees Of The University Of Arkansas Multiple stationary phase matrix and uses thereof
WO2013103841A1 (en) * 2012-01-05 2013-07-11 Clinical Reference Laboratory, Inc. METHODS FOR QUANTITATIVE CHIRAL DETERMINATION OF THE d- AND l- ENANTIOMERS OF AMPHETAMINE AND METHAMPHETAMINE
TWI646091B (zh) 2012-12-28 2019-01-01 日商衛斯克慧特股份有限公司 鹽類及晶形
CN111333563B (zh) * 2018-12-19 2023-11-07 上海科胜药物研发有限公司 一种布瓦西坦中间体的制备方法
MX2021008612A (es) 2019-01-22 2021-08-19 Askat Inc Proceso para la transformacion asimetrica impulsada por solubilidad diferencial de acidos 2h-cromeno-3-carboxilicos sustituidos.

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5514818A (en) * 1993-09-17 1996-05-07 Daicel Chemical Industries, Ltd. Resolution of stereoisomers of aliphatic epoxides
CN1136183C (zh) * 1994-02-25 2004-01-28 代科化学工业株式会社 光学活性甲羟戊酸内酯类化合物的制造方法
US6043271A (en) * 1994-08-03 2000-03-28 Sarawak Medichem Pharmaceuticals, Inc. Method for the preparation of (±)-calanolide A and intermediates thereof
US5892060A (en) * 1994-08-03 1999-04-06 Sarawak Medichem Pharmaceuticals, Inc. Method for the preparation of (+)-calanolide a and analogues thereof
US6277879B1 (en) * 1994-08-03 2001-08-21 Sarawak Medichem Pharmaceuticals, Inc. Calanolide analogues and methods of their use
US5489697A (en) * 1994-08-03 1996-02-06 Medichem Research, Inc. Method for the preparation of (+)-calanolide A and intermediates thereof
US5977385A (en) * 1994-08-03 1999-11-02 Sarawak Medichem Pharmaceuticals Method for the preparation of (+)-calanolide A and analogues thereof
US6458955B1 (en) * 1994-12-16 2002-10-01 Uop Llc Process for preparation of pharmaceutically desired enantiomers
US6455736B1 (en) * 1994-12-16 2002-09-24 Uop Llc Process for preparation of pharmaceutically desired sertraline and sertraline analogs
US5630943A (en) * 1995-11-30 1997-05-20 Merck Patent Gesellschaft Mit Beschrankter Haftung Discontinuous countercurrent chromatographic process and apparatus
AU3867997A (en) * 1996-08-27 1998-03-19 Shionogi & Co., Ltd. Chromene-3-carboxylate derivatives
EP0975560A4 (en) * 1997-03-18 2004-10-06 Chiral Technologies Inc CHIRAL SEPARATION OF AMINO ACIDS
US6077850A (en) * 1997-04-21 2000-06-20 G.D. Searle & Co. Substituted benzopyran analogs for the treatment of inflammation
US6063284A (en) * 1997-05-15 2000-05-16 Em Industries, Inc. Single column closed-loop recycling with periodic intra-profile injection
US5928515A (en) * 1997-12-12 1999-07-27 Uop Llc Adsorptive separation of 3-hydroxytetrahydrofuran enantiomers
US6107492A (en) * 1998-05-08 2000-08-22 Ucb, S.A. Process for the preparation of levetiracetam
EA200100347A1 (ru) * 1998-10-15 2001-10-22 Саравак Медичем Фармасьютикалс, Инк. Метод и композиция для лечения и профилактики туберкулеза
US20020103141A1 (en) * 1998-12-23 2002-08-01 Mckearn John P. Antiangiogenic combination therapy for the treatment of cancer
AU2002248221B2 (en) * 2000-10-31 2006-08-17 Merck & Co., Inc. Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders
ZA200502325B (en) * 2002-09-20 2006-11-29 Nissan Chemical Ind Ltd Method for producing a 3,5-dihydroxy-6-heptenoate
US20050148627A1 (en) * 2003-03-31 2005-07-07 Jeffery Carter Benzopyran compounds for use in the treatment and prevention of inflammation related conditions
US7259266B2 (en) * 2003-03-31 2007-08-21 Pharmacia Corporation Benzopyran compounds useful for treating inflammatory conditions

Also Published As

Publication number Publication date
EP1773802A1 (en) 2007-04-18
JP2008507502A (ja) 2008-03-13
US20060020022A1 (en) 2006-01-26
WO2006011047A1 (en) 2006-02-02
AR050179A1 (es) 2006-10-04
TW200616992A (en) 2006-06-01
CA2574363A1 (en) 2006-02-02
MX2007000880A (es) 2007-03-12

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Legal Events

Date Code Title Description
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DE INT.CL.: A01B 71/04; C07D 311/92; C07D 215/48; C07D 335/06; C07D 335/08

Ipc: C07D 311/24 (2006.01), C07D 311/92 (2006.01), C07D

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.