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BRPI0510471A - derivado de estradiol ou um derivado de estratopona contendo implante intra-ocular de liberação constante bem como métodos relacionados de fabricação - Google Patents

derivado de estradiol ou um derivado de estratopona contendo implante intra-ocular de liberação constante bem como métodos relacionados de fabricação

Info

Publication number
BRPI0510471A
BRPI0510471A BRPI0510471-8A BRPI0510471A BRPI0510471A BR PI0510471 A BRPI0510471 A BR PI0510471A BR PI0510471 A BRPI0510471 A BR PI0510471A BR PI0510471 A BRPI0510471 A BR PI0510471A
Authority
BR
Brazil
Prior art keywords
derivative
stratopone
well
manufacturing methods
eye
Prior art date
Application number
BRPI0510471-8A
Other languages
English (en)
Inventor
Jane Guo Shiah
Paul W Dickinson
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of BRPI0510471A publication Critical patent/BRPI0510471A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

DERIVADO DE ESTRADIOL OU UM DERIVADO DE ESTRATOPONA CONTENDO IMPLANTE INTRA-OCULAR DE LIBERAçãO CONSTANTE BEM COMO MéTODOS RELACIONADOS DE FABRICAçãO. A presente invenção refere-se a implantes intra-oculares biocompatíveis que incluem um agente antiangiogênico, tal como derivado de estradiol ou uma estratopona e um polímero biodegradável que é eficaz para facilitar liberação do agente antiangiogênico em um olho, por um período de tempo prolongado. Os agentes terapêuticos dos implantes podem estar associados a uma matriz de polímero biodegradável, tal matriz que é substancialmente isenta de poli (álcool vinílico). Os implantes podem ser colocados em um olho para tratar ou reduzir a ocorrência de uma ou mais condições oculares, tais como angiogênese, tumores oculares, e similares.
BRPI0510471-8A 2004-04-30 2005-04-21 derivado de estradiol ou um derivado de estratopona contendo implante intra-ocular de liberação constante bem como métodos relacionados de fabricação BRPI0510471A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/837,379 US20050244471A1 (en) 2004-04-30 2004-04-30 Estradiol derivative and estratopone containing sustained release intraocular implants and related methods
PCT/US2005/014257 WO2005110366A1 (en) 2004-04-30 2005-04-21 An estradiol derivative or an estratopone derivative containing sustained release intraocular implant as well as related methods of manufacturing

Publications (1)

Publication Number Publication Date
BRPI0510471A true BRPI0510471A (pt) 2007-11-06

Family

ID=34966867

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0510471-8A BRPI0510471A (pt) 2004-04-30 2005-04-21 derivado de estradiol ou um derivado de estratopona contendo implante intra-ocular de liberação constante bem como métodos relacionados de fabricação

Country Status (7)

Country Link
US (1) US20050244471A1 (pt)
EP (1) EP1748757A1 (pt)
JP (1) JP2007535367A (pt)
AU (1) AU2005244216A1 (pt)
BR (1) BRPI0510471A (pt)
CA (1) CA2564948A1 (pt)
WO (1) WO2005110366A1 (pt)

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US20050101582A1 (en) 2003-11-12 2005-05-12 Allergan, Inc. Compositions and methods for treating a posterior segment of an eye
US20090148527A1 (en) * 2007-12-07 2009-06-11 Robinson Michael R Intraocular formulation
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US7993634B2 (en) 2004-04-30 2011-08-09 Allergan, Inc. Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods
US7799336B2 (en) 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
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Also Published As

Publication number Publication date
CA2564948A1 (en) 2005-11-24
EP1748757A1 (en) 2007-02-07
US20050244471A1 (en) 2005-11-03
WO2005110366A1 (en) 2005-11-24
AU2005244216A1 (en) 2005-11-24
JP2007535367A (ja) 2007-12-06

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Legal Events

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B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A E 6A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE A 8.6 NA RPI 2099 DE 29/03/2011.