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BRPI0507811A - derivados de 7h-pirrolopirimidina - Google Patents

derivados de 7h-pirrolopirimidina

Info

Publication number
BRPI0507811A
BRPI0507811A BRPI0507811-3A BRPI0507811A BRPI0507811A BR PI0507811 A BRPI0507811 A BR PI0507811A BR PI0507811 A BRPI0507811 A BR PI0507811A BR PI0507811 A BRPI0507811 A BR PI0507811A
Authority
BR
Brazil
Prior art keywords
derivatives
preparation
pharmaceutical compositions
pyrrolopyrimidine derivatives
pyrrolo
Prior art date
Application number
BRPI0507811-3A
Other languages
English (en)
Inventor
Giorgio Caravatti
Andrea Vaupel
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0507811A publication Critical patent/BRPI0507811A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"DERIVADOS DE 7H-PIRROLOPIRIMIDINA". A presente invenção refere-se a derivados de 7 H-pirrol¢2,3-d!pirimidina de fórmula I em que os símbolos e substituintes são como definidos na descrição, aos processos para a preparação dos mesmos, às composições farmacêuticas compreendendo estes derivados e ao uso destes derivados - sozinhos ou em combinação com um ou mais outros compostos farmaceuticamente ativos - para a preparação de composições farmacêuticas para o tratamento especialmente de uma doença proliferativa, como um tumor.
BRPI0507811-3A 2004-02-18 2005-02-17 derivados de 7h-pirrolopirimidina BRPI0507811A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0403606.7A GB0403606D0 (en) 2004-02-18 2004-02-18 Organic compounds
PCT/EP2005/001635 WO2005077951A2 (en) 2004-02-18 2005-02-17 7h-pyrrolopyrimidine derivatives

Publications (1)

Publication Number Publication Date
BRPI0507811A true BRPI0507811A (pt) 2007-07-10

Family

ID=32039961

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0507811-3A BRPI0507811A (pt) 2004-02-18 2005-02-17 derivados de 7h-pirrolopirimidina

Country Status (16)

Country Link
US (1) US7625894B2 (pt)
EP (1) EP1718651B1 (pt)
JP (1) JP2007523115A (pt)
KR (1) KR20060124705A (pt)
CN (1) CN1922184A (pt)
AT (1) ATE429435T1 (pt)
AU (1) AU2005212832B2 (pt)
BR (1) BRPI0507811A (pt)
CA (1) CA2553889A1 (pt)
DE (1) DE602005014087D1 (pt)
ES (1) ES2322814T3 (pt)
GB (1) GB0403606D0 (pt)
PL (1) PL1718651T3 (pt)
PT (1) PT1718651E (pt)
RU (1) RU2006133264A (pt)
WO (1) WO2005077951A2 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201001030A1 (ru) 2007-12-19 2011-02-28 Амген Инк. Конденсированные соединения пиридина, пиримидина и триазина в качестве ингибиторов клеточного цикла
CA2719538C (en) 2008-04-07 2014-03-18 Amgen Inc. Gem-disubstituted and spirocyclic amino pyridines/pyrimidines as cell cycle inhibitors
AU2012230896B9 (en) 2011-03-23 2015-06-18 Amgen Inc. Fused tricyclic dual inhibitors of CDK 4/6 and FLT3
JP6318156B2 (ja) 2012-09-06 2018-04-25 プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． キナーゼをモジュレートするための化合物および方法、ならびにその指標
RU2674261C2 (ru) * 2013-03-11 2018-12-06 Мерк Патент Гмбх Производные 6-[4-(1н-имидазол-2-ил)пиперидин-1-ил]пиримидин-4-амина в качестве модуляторов активности киназ
WO2014145576A2 (en) 2013-03-15 2014-09-18 Northwestern University Substituted pyrrolo(2,3-d)pyrimidines for the treatment of cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69712745T2 (de) 1996-01-23 2002-10-31 Novartis Ag, Basel Pyrrolopyrimidinen und verfahren zu deren herstellung
CA2262421C (en) 1996-08-23 2007-10-02 Novartis Ag Substituted pyrrolopyrimidines and processes for their preparation
IL131582A0 (en) * 1997-03-19 2001-01-28 Basf Ag Pyrrolo [2,3d] pyrimidines and their use as tyrosine kinase inhibitors
PA8474101A1 (es) * 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
GB0119249D0 (en) 2001-08-07 2001-10-03 Novartis Ag Organic compounds
EP1441736A2 (en) 2001-10-29 2004-08-04 Novartis AG Use of 7h-pyrrolo[2,3-d]pyrimidine derivatives in the treatment of solid tumor diseases
WO2004093812A2 (en) * 2003-04-22 2004-11-04 Irm Llc Compounds that induce neuronal differentiation in embryonic stem cells
WO2005069865A2 (en) * 2004-01-13 2005-08-04 Ambit Biosciences Corporation Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases
AR047470A1 (es) * 2004-01-29 2006-01-18 Novartis Ag Derivados de pirrolo-pirimidina utiles para el tratamiento de enfermedades proliferativas,composiciones farmaceuticas que los contienen,y procesos para su preparacion

Also Published As

Publication number Publication date
PL1718651T3 (pl) 2009-09-30
AU2005212832A1 (en) 2005-08-25
AU2005212832B2 (en) 2009-11-05
PT1718651E (pt) 2009-07-17
CA2553889A1 (en) 2005-08-25
ES2322814T3 (es) 2009-06-29
CN1922184A (zh) 2007-02-28
GB0403606D0 (en) 2004-03-24
RU2006133264A (ru) 2008-04-10
KR20060124705A (ko) 2006-12-05
WO2005077951A3 (en) 2006-03-02
ATE429435T1 (de) 2009-05-15
EP1718651B1 (en) 2009-04-22
JP2007523115A (ja) 2007-08-16
US20070135460A1 (en) 2007-06-14
DE602005014087D1 (de) 2009-06-04
US7625894B2 (en) 2009-12-01
WO2005077951A2 (en) 2005-08-25
EP1718651A2 (en) 2006-11-08

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2099 DE 29/03/2011.