BRPI0417489A - rnai power prediction method - Google Patents
rnai power prediction methodInfo
- Publication number
- BRPI0417489A BRPI0417489A BRPI0417489-5A BRPI0417489A BRPI0417489A BR PI0417489 A BRPI0417489 A BR PI0417489A BR PI0417489 A BRPI0417489 A BR PI0417489A BR PI0417489 A BRPI0417489 A BR PI0417489A
- Authority
- BR
- Brazil
- Prior art keywords
- rnai
- prediction method
- power prediction
- methods
- predicting
- Prior art date
Links
- 108091030071 RNAI Proteins 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 5
- 230000009368 gene silencing by RNA Effects 0.000 abstract 5
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/20—Supervised data analysis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/10—Applications; Uses in screening processes
- C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- General Health & Medical Sciences (AREA)
- Data Mining & Analysis (AREA)
- Biophysics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Artificial Intelligence (AREA)
- Databases & Information Systems (AREA)
- Epidemiology (AREA)
- Evolutionary Computation (AREA)
- Bioethics (AREA)
- Theoretical Computer Science (AREA)
- Software Systems (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Biochemistry (AREA)
- Neurosurgery (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
Abstract
MéTODO DE PREDIçãO DA POTêNCIA DE RNAi. A presente invenção refere-se a métodos para a preparação de um algoritmo para a previsão da potência de RNAi de um reagente de RNAi. A invenção refere-se também a métodos para a previsão da potência de RNAi de um reagente de RNAi e métodos para a inibição da expressão de um dado gene alvo usando esse algoritmo.RNAi POWER PREDICTION METHOD. The present invention relates to methods for preparing an algorithm for predicting the RNAi potency of an RNAi reagent. The invention also relates to methods for predicting the RNAi potency of an RNAi reagent and methods for inhibiting expression of a given target gene using such an algorithm.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52843003P | 2003-12-10 | 2003-12-10 | |
PCT/EP2004/014037 WO2005059132A1 (en) | 2003-12-10 | 2004-12-09 | Rnai potency prediction method |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0417489A true BRPI0417489A (en) | 2007-05-22 |
Family
ID=34699869
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0417489-5A BRPI0417489A (en) | 2003-12-10 | 2004-12-09 | rnai power prediction method |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1694843A1 (en) |
JP (1) | JP2007523632A (en) |
KR (1) | KR20060126499A (en) |
CN (1) | CN1890370A (en) |
AU (1) | AU2004298527A1 (en) |
BR (1) | BRPI0417489A (en) |
CA (1) | CA2545675A1 (en) |
RU (1) | RU2006124515A (en) |
WO (1) | WO2005059132A1 (en) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102006016365B4 (en) * | 2006-04-05 | 2015-08-13 | Qiagen Gmbh | RNA interference tags |
JP2010513246A (en) * | 2006-12-15 | 2010-04-30 | ノバルティス アーゲー | Inhibition of GPR4 |
WO2008122314A1 (en) * | 2007-04-10 | 2008-10-16 | Qiagen Gmbh | Rna interference tags |
US20110020368A1 (en) | 2008-03-25 | 2011-01-27 | Nancy Hynes | Treating cancer by down-regulating frizzled-4 and/or frizzled-1 |
US20110311521A1 (en) | 2009-03-06 | 2011-12-22 | Pico Caroni | Novel therapy for anxiety |
EP2241323A1 (en) | 2009-04-14 | 2010-10-20 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Tenascin-W and brain cancers |
CN101625732B (en) * | 2009-08-03 | 2011-11-30 | 杭州电子科技大学 | Forecasting method of water level of potamic tidewater |
EP2292266A1 (en) | 2009-08-27 | 2011-03-09 | Novartis Forschungsstiftung, Zweigniederlassung | Treating cancer by modulating copine III |
WO2011036118A1 (en) | 2009-09-22 | 2011-03-31 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Treating cancer by modulating mex-3 |
WO2011045352A2 (en) | 2009-10-15 | 2011-04-21 | Novartis Forschungsstiftung | Spleen tyrosine kinase and brain cancers |
EP2542578A1 (en) | 2010-03-05 | 2013-01-09 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Smoc1, tenascin-c and brain cancers |
WO2011131611A1 (en) | 2010-04-19 | 2011-10-27 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Modulating xrn1 |
EP2580239A1 (en) | 2010-06-10 | 2013-04-17 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Treating cancer by modulating mammalian sterile 20-like kinase 3 |
US9181553B2 (en) | 2011-06-06 | 2015-11-10 | Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Method of treatment of breast cancers over-expressing the SHP2 signature genes |
US20140314787A1 (en) | 2011-11-08 | 2014-10-23 | Novartis Forschungsstiftung, Zweigniederlassung, Friedrich Miescher Institute | Treatment for neurodegenerative diseases |
MX2014005927A (en) | 2011-11-15 | 2014-06-05 | Novartis Ag | Combination of a phosphoinositide 3-kinase inhibitor and a modulator of the janus kinase 2-signal transducer and activator of transcription 5 pathway. |
EP2800583A1 (en) | 2012-01-02 | 2014-11-12 | Novartis AG | Cdcp1 and breast cancer |
WO2013144240A1 (en) | 2012-03-29 | 2013-10-03 | Friedrich Miescher Institute For Biomedical Research | Inhibition of interleukin- 8 and/or its receptor cxcrl in the treatment her2/her3 -overexpressing breast cancer |
US20150218238A1 (en) | 2012-06-29 | 2015-08-06 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Resear | Treating diseases by modulating a specific isoform of mkl1 |
EP2870242A1 (en) | 2012-07-05 | 2015-05-13 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | New treatment for neurodegenerative diseases |
US20150224190A1 (en) | 2012-07-06 | 2015-08-13 | Mohamed Bentires-Alj | Combination of a phosphoinositide 3-kinase inhibitor and an inhibitor of the IL-8/CXCR interaction |
US20160178610A1 (en) | 2013-08-07 | 2016-06-23 | Friedrich Miescher Institute For Biomedical Research | New screening method for the treatment Friedreich's ataxia |
US20170137824A1 (en) | 2014-06-13 | 2017-05-18 | Indranil BANERJEE | New treatment against influenza virus |
WO2016001830A1 (en) | 2014-07-01 | 2016-01-07 | Friedrich Miescher Institute For Biomedical Research | Combination of a brafv600e inhibitor and mertk inhibitor to treat melanoma |
EP3197557A1 (en) | 2014-09-24 | 2017-08-02 | Friedrich Miescher Institute for Biomedical Research | Lats and breast cancer |
WO2017072669A1 (en) | 2015-10-28 | 2017-05-04 | Friedrich Miescher Institute For Biomedical Research | Tenascin-w and biliary tract cancers |
CN109360604B (en) * | 2018-11-21 | 2021-09-24 | 南昌大学 | A molecular type prediction system for ovarian cancer |
CN119851749A (en) * | 2024-12-11 | 2025-04-18 | 北京悦康科创医药科技股份有限公司 | SiRNA screening method and device based on deep learning |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0212302D0 (en) * | 2002-05-28 | 2002-07-10 | Isis Innovation | Method of selecting targets for gene silencing by RNA interference |
-
2004
- 2004-12-09 BR BRPI0417489-5A patent/BRPI0417489A/en not_active IP Right Cessation
- 2004-12-09 KR KR1020067011510A patent/KR20060126499A/en not_active Withdrawn
- 2004-12-09 AU AU2004298527A patent/AU2004298527A1/en not_active Abandoned
- 2004-12-09 WO PCT/EP2004/014037 patent/WO2005059132A1/en active Application Filing
- 2004-12-09 RU RU2006124515/13A patent/RU2006124515A/en not_active Application Discontinuation
- 2004-12-09 EP EP04820427A patent/EP1694843A1/en not_active Withdrawn
- 2004-12-09 CN CNA2004800367195A patent/CN1890370A/en active Pending
- 2004-12-09 JP JP2006543479A patent/JP2007523632A/en active Pending
- 2004-12-09 CA CA002545675A patent/CA2545675A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1694843A1 (en) | 2006-08-30 |
JP2007523632A (en) | 2007-08-23 |
AU2004298527A1 (en) | 2005-06-30 |
CA2545675A1 (en) | 2005-06-30 |
CN1890370A (en) | 2007-01-03 |
KR20060126499A (en) | 2006-12-07 |
RU2006124515A (en) | 2008-01-20 |
WO2005059132A1 (en) | 2005-06-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0417489A (en) | rnai power prediction method | |
EP4549582A3 (en) | Methods for spatial analysis using targeted rna depletion | |
NO20071309L (en) | Method of expansion | |
BRPI0612409B8 (en) | peroxycarboxylic acid based surfactant compositions and method of reducing the population of microorganisms on an object | |
DK1954811T3 (en) | Inducible expression systems | |
BRPI0911481A8 (en) | mobile station apparatus, mobile communication system and communication method | |
CY1117797T1 (en) | METHODS OF INTELLACYCULAR PROCESSING SINGLE CHAIN PROCESSES FOR THEIR DOUBLE CHAIN FORM | |
IL194741A (en) | Method of providing access information to an access terminal | |
NO20075471L (en) | Operation of one or more fuel dispensers | |
EP1474433A4 (en) | TARGET LOCALIZATION TARGETED BY RNA INTERFERENCE AND TARGET VALIDATION WITH SHORT INTERFERING NUCLEIC ACID (siNA) | |
BRPI0506679A (en) | Methods of Treating Osteoarthritis with IL-6 Antagonists | |
SG10201408300PA (en) | Processing of amplified dna fragments for sequencing | |
EP2163092A4 (en) | SYSTEMS AND METHODS FOR VIRTUAL INTERACTIVE PRESENCE | |
MY144672A (en) | Inhibitors of cytosolic phospholipase a2 | |
DE602004030354D1 (en) | SYSTEMS WITH INTERCHANGEABLE BELLOWS FOR MANUFACTURING INCLUDED PRODUCTS | |
ATE484231T1 (en) | DEVICE FOR PREDICTING MUSCLE/SKELETAL DISEASES | |
BRPI0519568A2 (en) | aminoacyl trna synthetase compositions and their uses | |
ATE554105T1 (en) | ALTERED ANTIBODIES | |
EP2114241A4 (en) | Method and system for providing analyte monitoring | |
ATE433124T1 (en) | SYSTEM AND METHOD FOR ANALYZING RADAR INFORMATION | |
EA201000383A1 (en) | METHOD OF INHIBITING CLOSTRIDIUM DIFFICILE BY INTRODUCTION OF ORITAWAN | |
MX2009013646A (en) | Methods of diagnosing and treating cancer. | |
SG132661A1 (en) | Illumination system | |
BRPI0411854A (en) | protein vehicles for vaccines | |
WO2013101771A3 (en) | Compositions and method for treating autoimmune diseases |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 6A E 7A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |