[go: up one dir, main page]

BRPI0416968A - formas sólidas de anticorpos anti-egfr - Google Patents

formas sólidas de anticorpos anti-egfr

Info

Publication number
BRPI0416968A
BRPI0416968A BRPI0416968-9A BRPI0416968A BRPI0416968A BR PI0416968 A BRPI0416968 A BR PI0416968A BR PI0416968 A BRPI0416968 A BR PI0416968A BR PI0416968 A BRPI0416968 A BR PI0416968A
Authority
BR
Brazil
Prior art keywords
antibody
egfr antibodies
present
solid forms
solid
Prior art date
Application number
BRPI0416968-9A
Other languages
English (en)
Inventor
Susanne Matheus
Hanns-Christian Mahler
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34625406&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0416968(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BRPI0416968A publication Critical patent/BRPI0416968A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Metallurgy (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"FORMAS SóLIDAS DE ANTICORPOS ANTI-EGFR". A presente invenção refere-se a formas sólidas de anticorpos contra o receptor EGF, particularmente precipitados e cristais de anticorpos monoclonais contra o receptor EGF, particularmente preferivelmente de Mab C225 (cetuximab) e Mab h425 (EMD 72000), que resulta na proteína de anticorpo biologicamente ativa através da dissolução ou suspensão em meio aquoso, obtenível pela precipitação do anticorpo e/ou de suas variantes e/ou fragmentos dissolvidos ou suspensos em meio aquoso por intermédio de um reagente de precipitação. A presente invenção também se refere a preparações farmacêuticas compreendendo pelo menos uma forma sólida dos anticorpos acima mencionados na forma de precipitado não-cistalino, precipitado cristalino ou na forma solúvel ou suspensa, e opcionalmente excipientes e/ou adjuvantes e/ou ingredientes farmacêuticos ativos adicionais, e a um processo para a preparação de formas sólidas de anticorpos anti-EGFR de acordo com a presente invenção.
BRPI0416968-9A 2003-11-29 2004-11-12 formas sólidas de anticorpos anti-egfr BRPI0416968A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10355904A DE10355904A1 (de) 2003-11-29 2003-11-29 Feste Formen von anti-EGFR-Antikörpern
PCT/EP2004/012837 WO2005051355A1 (de) 2003-11-29 2004-11-12 Feste formen von anti-egfr-antikörpern

Publications (1)

Publication Number Publication Date
BRPI0416968A true BRPI0416968A (pt) 2007-02-21

Family

ID=34625406

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0416968-9A BRPI0416968A (pt) 2003-11-29 2004-11-12 formas sólidas de anticorpos anti-egfr

Country Status (21)

Country Link
US (1) US7960516B2 (pt)
EP (2) EP1686961A1 (pt)
KR (2) KR20120093406A (pt)
CN (1) CN1886118A (pt)
AR (1) AR046677A1 (pt)
AU (1) AU2004292742B9 (pt)
BR (1) BRPI0416968A (pt)
CA (1) CA2547446C (pt)
CO (1) CO5690537A2 (pt)
DE (1) DE10355904A1 (pt)
EC (1) ECSP066681A (pt)
IL (1) IL175935A (pt)
MX (1) MXPA06005968A (pt)
MY (1) MY148228A (pt)
NZ (1) NZ548210A (pt)
PE (1) PE20050667A1 (pt)
RU (1) RU2397755C2 (pt)
TW (1) TWI350291B (pt)
UA (1) UA84893C2 (pt)
WO (1) WO2005051355A1 (pt)
ZA (1) ZA200605348B (pt)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7060808B1 (en) * 1995-06-07 2006-06-13 Imclone Systems Incorporated Humanized anti-EGF receptor monoclonal antibody
US20030224001A1 (en) * 1998-03-19 2003-12-04 Goldstein Neil I. Antibody and antibody fragments for inhibiting the growth of tumors
ZA200007412B (en) * 1998-05-15 2002-03-12 Imclone Systems Inc Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases.
BR0010524A (pt) * 1999-05-14 2002-05-28 Imclone Systems Inc Tratamento de tumores humanos refratários com antagonistas de receptor de fator de crescimento epidérmico
AU9500201A (en) * 2000-08-09 2002-02-18 Imclone Systems Inc Treatment of hyperproliferative diseases with epidermal growth factor receptor antagonists
US20080008704A1 (en) * 2001-03-16 2008-01-10 Mark Rubin Methods of treating colorectal cancer with anti-epidermal growth factor antibodies
US20080026068A1 (en) * 2001-08-16 2008-01-31 Baxter Healthcare S.A. Pulmonary delivery of spherical insulin microparticles
US20050158296A1 (en) 2002-01-11 2005-07-21 Starr Christopher M. Use of p97 as an enzyme delivery system for the delivery of therapeutic lysosomal enzymes
EP1622941A2 (en) * 2003-03-20 2006-02-08 ImClone Systems Incorporated Method of producing an antibody to epidermal growth factor receptor
JP4734319B2 (ja) * 2004-03-19 2011-07-27 イムクローン・リミテッド・ライアビリティ・カンパニー ヒト抗上皮成長因子受容体抗体
ES2422757T3 (es) 2004-05-12 2013-09-13 Baxter Int Uso terapéutico de microesferas de ácido nucleico
JP5634009B2 (ja) * 2004-05-12 2014-12-03 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ タンパク質を含み、そして高濃度のタンパク質で注射性能を示すミクロスフェア
PT1758558E (pt) 2004-05-12 2013-12-05 Baxter Healthcare Sa Microesferas contendo oligonucleótidos, sua utilização para o fabrico de um medicamento para o tratamento de diabetes do tipo 1
US8728525B2 (en) * 2004-05-12 2014-05-20 Baxter International Inc. Protein microspheres retaining pharmacokinetic and pharmacodynamic properties
AU2007281737B2 (en) 2006-08-04 2013-09-19 Baxter Healthcare S.A. Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes
BRPI0717335A2 (pt) 2006-10-27 2013-12-10 Abbott Biotech Ltd Anticorpos anti-htnfalfa cristalinos
CA2682135A1 (en) 2007-04-17 2008-10-30 Baxter International Inc. Nucleic acid microparticles for pulmonary delivery
SG183709A1 (en) * 2007-08-08 2012-09-27 Abbott Lab Compositions and methods for crystallizing antibodies
WO2009051726A1 (en) * 2007-10-15 2009-04-23 Biogen Idec Ma Inc. Methods of manufacturing a biologic using a stable storage intermediate
US8323615B2 (en) 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing multi-phasic dispersions
US8367427B2 (en) 2008-08-20 2013-02-05 Baxter International Inc. Methods of processing compositions containing microparticles
US8323685B2 (en) 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing compositions containing microparticles
US10143652B2 (en) * 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
CN102153648B (zh) * 2011-01-27 2012-07-04 中国人民解放军军事医学科学院生物工程研究所 一种抗egfr人源化抗体l4-h3及其编码基因与应用
EP3088005B1 (en) 2011-07-05 2019-01-02 biOasis Technologies Inc P97-antibody conjugates
WO2013022738A1 (en) 2011-08-05 2013-02-14 Bioasis Technologies, Inc. P97 fragments with transfer activity
JP6433424B2 (ja) 2012-07-31 2018-12-05 バイオアシス テクノロジーズ インコーポレイテッド 脱リン酸化されたリソソーム蓄積症タンパク質およびその使用方法
WO2014160438A1 (en) 2013-03-13 2014-10-02 Bioasis Technologies Inc. Fragments of p97 and uses thereof
AU2014312190A1 (en) 2013-08-28 2016-02-18 Bioasis Technologies Inc. CNS-targeted conjugates of antibodies
CA2935195A1 (en) 2014-02-03 2015-08-06 Bioasis Technologies, Inc. P97 fusion proteins
WO2015126729A1 (en) 2014-02-19 2015-08-27 Bioasis Technologies, Inc. P97-ids fusion proteins
CN106413757B (zh) 2014-05-01 2022-01-14 比奥阿赛斯技术有限公司 p97-多核苷酸结合物
WO2016088858A1 (ja) * 2014-12-04 2016-06-09 Ｄｅｌｔａ－Ｆｌｙ Ｐｈａｒｍａ株式会社 新規ｐｅｇ誘導体
EP3251698A4 (en) * 2015-02-15 2018-10-17 Jiangsu Hengrui Medicine Co. Ltd. Ligand-cytotoxicity drug conjugate, preparing method therefor, and application thereof
CN111529717A (zh) * 2015-02-17 2020-08-14 上海美雅珂生物技术有限责任公司 抗体药物偶联物
AR103726A1 (es) 2015-02-27 2017-05-31 Merck Sharp & Dohme Cristales de anticuerpos monoclonales anti-pd-1 humanos
TW201709932A (zh) * 2015-06-12 2017-03-16 西雅圖遺傳學公司 Ｃｄ１２３抗體及其共軛物
MX2017017049A (es) * 2015-06-30 2018-03-06 Seattle Genetics Inc Anticuerpos anti antigeno de celulas nk y linfocitos t y b (ntb-a) y composiciones y metodos relacionados.
CN105810072A (zh) * 2016-03-25 2016-07-27 淮海工学院 一种蛋白质结晶的教学试剂盒及其方法
WO2017205465A2 (en) 2016-05-24 2017-11-30 Griswold Karl Edwin Antibodies and methods of making same
JOP20190260A1 (ar) 2017-05-02 2019-10-31 Merck Sharp & Dohme صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها
BR112019022873A8 (pt) 2017-05-02 2023-04-11 Merck Sharp & Dohme Formulação, e, vaso ou dispositivo de injeção.
WO2018218633A1 (en) 2017-06-02 2018-12-06 Beijing Percans Oncology Co. Ltd. Combination therapies for treating cancers
WO2019195959A1 (en) 2018-04-08 2019-10-17 Cothera Biosciences, Inc. Combination therapy for cancers with braf mutation
SG11202012608VA (en) * 2018-06-18 2021-02-25 Bayer Ag Binder/active agent conjugates directed against cxcr5, having enzymatically cleavable linkers and improved activity profile
BR112021002622A2 (pt) 2018-08-13 2021-05-11 Beijing Percans Oncology Co. Ltd. biomarcadores para terapia de câncer
MX2021005394A (es) 2018-11-07 2021-07-06 Merck Sharp & Dohme Llc Co-formulaciones de anticuerpos anti-gen de activacion de linfocitos 3 (anti-lag3) y anticuerpos anti-muerte programada-1 (anti-pd-1).
US20230009076A1 (en) * 2019-06-28 2023-01-12 Serina Therapeutics, Inc. Polyoxazoline-drug conjugates with novel pharmacokinetic properties
EP3954393A1 (en) 2020-08-13 2022-02-16 Bioasis Technologies Inc. Combination therapies for delivery across the blood brain barrier
CN114099422A (zh) * 2020-08-25 2022-03-01 泰州迈博太科药业有限公司 一种重组抗egfr单抗前体的制剂
KR20230117589A (ko) * 2020-12-04 2023-08-08 상하이 후단-장지앙 바이오-파마슈티컬 컴퍼니 리미티드 항체 약물 접합체, 이의 중간체, 제조 방법 및 용도
CN115073437B (zh) * 2021-03-11 2023-07-18 北京师范大学 基于二氰基吡喃的大环多胺[12]aneN3化合物及其制备方法与用途
CN114652826B (zh) * 2022-01-24 2022-10-14 景泽生物医药(合肥)有限公司 抗egfr抗体的用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
AU4128089A (en) * 1988-09-15 1990-03-22 Rorer International (Overseas) Inc. Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same
ATE139258T1 (de) 1990-01-12 1996-06-15 Cell Genesys Inc Erzeugung xenogener antikörper
US5747469A (en) 1991-03-06 1998-05-05 Board Of Regents, The University Of Texas System Methods and compositions comprising DNA damaging agents and p53
AU658396B2 (en) * 1991-03-06 1995-04-13 Merck Patent Gesellschaft Mit Beschrankter Haftung Humanized and chimeric monoclonal antibodies
WO1993000807A1 (en) 1991-07-03 1993-01-21 Cryolife, Inc. Method for stabilization of biomaterials
ATE381614T1 (de) 1992-07-24 2008-01-15 Amgen Fremont Inc Bildung von xenogenen antikörpern
ATE188874T1 (de) 1992-08-18 2000-02-15 Centro Inmunologia Molecular Monoklonale antikörper gegen den epidermalen wachstumsfaktorrezeptor, zellen und verfahren zur ihrer herstellung und sie erhaltende zusammensetzungen
EP1978033A3 (en) 1995-04-27 2008-12-24 Amgen Fremont Inc. Human antibodies derived from immunized xenomice
CA2222231A1 (en) * 1995-06-07 1996-12-19 Imclone Systems Incorporated Antibody and antibody fragments for inhibiting the growth of tumors
US7060808B1 (en) 1995-06-07 2006-06-13 Imclone Systems Incorporated Humanized anti-EGF receptor monoclonal antibody
EP0852951A1 (de) 1996-11-19 1998-07-15 Roche Diagnostics GmbH Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern
GB9904387D0 (en) 1999-02-25 1999-04-21 Pharmacia & Upjohn Spa Antitumour synergistic composition
EP2325205A3 (en) * 2000-12-28 2011-10-12 Altus Pharmaceuticals Inc. Crystals of whole antibodies and fragments thereof and methods for making and using them
CA2444483A1 (en) * 2001-04-26 2002-11-07 Board Of Regents, The University Of Texas System Diagnostic imaging compositions, their methods of synthesis and use
DE10133394A1 (de) 2001-07-13 2003-01-30 Merck Patent Gmbh Flüssige Formulierung enthaltend Cetuximab
DE10163459A1 (de) * 2001-12-21 2003-07-03 Merck Patent Gmbh Lyophilisierte Zubereitung enthaltend Antikörper gegen EGF-Rezeptor
US20110142822A1 (en) * 2004-06-14 2011-06-16 Kussie Paul H Crystal of egfr extracellular domain and cetuximab fab fragment, and uses thereof

Also Published As

Publication number Publication date
TW200530268A (en) 2005-09-16
TWI350291B (en) 2011-10-11
ECSP066681A (es) 2006-10-25
IL175935A0 (en) 2006-10-05
AR046677A1 (es) 2005-12-14
DE10355904A1 (de) 2005-06-30
US20070122411A1 (en) 2007-05-31
IL175935A (en) 2013-10-31
CN1886118A (zh) 2006-12-27
KR20120093406A (ko) 2012-08-22
RU2397755C2 (ru) 2010-08-27
AU2004292742A1 (en) 2005-06-09
AU2004292742B2 (en) 2011-08-25
AU2004292742B9 (en) 2011-11-24
MY148228A (en) 2013-03-29
NZ548210A (en) 2010-10-29
ZA200605348B (en) 2007-04-25
WO2005051355A1 (de) 2005-06-09
PE20050667A1 (es) 2005-09-27
CO5690537A2 (es) 2006-10-31
EP1974723A2 (de) 2008-10-01
CA2547446A1 (en) 2005-06-09
MXPA06005968A (es) 2006-07-06
KR20060111539A (ko) 2006-10-27
CA2547446C (en) 2013-05-14
RU2006123005A (ru) 2008-01-20
EP1686961A1 (de) 2006-08-09
EP1974723A3 (de) 2010-06-09
UA84893C2 (en) 2008-12-10
US7960516B2 (en) 2011-06-14

Similar Documents

Publication Publication Date Title
BRPI0416968A (pt) formas sólidas de anticorpos anti-egfr
RU2432364C2 (ru) ПОЛИКЛОНАЛЬНОЕ АНТИТЕЛО ПРОТИВ Nogo, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И ПРИМЕНЕНИЕ АНТИТЕЛА ДЛЯ ИЗГОТОВЛЕНИЯ ЛЕКАРСТВЕННОГО СРЕДСТВА
RS20110024A (en) ANTIBODIES THAT BLOCK CRIPTO AND USE IT
DK1347730T3 (da) Rekombinante anti-CD30-antistoffer og anvendelser deraf
WO2004066931A3 (en) Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents
HRP20151257T1 (hr) Monoklonska protutijela na klaudin-18 za lijeäśenje karcinoma
BR0111823A (pt) Polipeptìdeo, vacina, método para imunizar um animal contra um micróbio patogênico, método para identificar polipeptìdeo antigênicos, anticorpo, ou pelo menos uma parte eficaz deste, vetor, célula, método para a produção do anticorpo, linhagem celular de hibridomas, e, uso dos anticorpos.
BR0107613A (pt) Bloqueio do crescimento de axÈnios mediado por receptor nogo
CN101830974A (zh) 淀粉样β(1-42)蛋白寡聚体、其衍生物及抗体、其制备方法和用途
BRPI0619357B8 (pt) anticorpos monoclonais, composição farmacêutica, vacina, uso dos mesmos para tratamento ou prevenção de doença de alzheimer, métodos in vitro para diagnosticar e para identificar compostos apropriados para imunização de doença de alzheimer e kits
NO20052242L (no) Noytraliserende antistoffer mot GDF-8 og deres anvendelse.
BRPI9906735B8 (pt) 'composição farmacêutica líquida aquosa e método para prevenção de precipitações de cristais e para prevenção da coloração de gatifloxacina.'
BRPI0613382A8 (pt) anticorpos isolados, anticorpo monoclonal, célula de hibridoma, método de identificação, método de inibição do crescimento de uma célula, método de tratamento terapêutico, método de determinação da presença de uma proteína, métodos de diagnósticos da presença de tumor
BR0317896A (pt) Complexos de cristais de proteìna e polìmeros iÈnicos
BRPI0412245A (pt) anticorpos de rg1 e usos destes
BR0211296A (pt) Peptìdeo imunogênico derivado da proteìna g do vrs do sub-grupo a ou b, sequência de ácido nucleico, composição farmacêutica, anticorpos policlonais ou monoclonais, kit de diagnóstico, utilização de um peptìdeo imunogênico, e, conjugado
Kitajima et al. Differential distribution of spicule matrix proteins in the sea urchin embryo skeleton
WO2022150654A3 (en) Antigen-binding polypeptides specific for coronaviruses and uses thereof
BRPI0203949B8 (pt) polipeptídeo se36, processo para purificação do polipeptídeo se36, vacina para malária, agente de diagnóstico para malária e fragmento de dna sintético
DK1165615T3 (da) Monoklonale antistoffer mod humant protein Mcm3, proces til deres fremstilling af deres anvendelse
WO2002100343A3 (en) N-terminally truncated galectin-3 and antibodies for treating cancer
NL8302484A (nl) Interferon-preparaat en werkwijze voor de bereiding daarvan.
CN114805584A8 (zh) 抗原结合蛋白及其用途
ES2139568T3 (es) Complejo proteico.
CN101011573A (zh) 高分子量凝集素的生产

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2280 DE 16/09/2014.