BRPI0415489A - derivados de n-heterociclilmetilbenzamidas, sua preparação e sua aplicação em terapêutica - Google Patents
derivados de n-heterociclilmetilbenzamidas, sua preparação e sua aplicação em terapêuticaInfo
- Publication number
- BRPI0415489A BRPI0415489A BRPI0415489-4A BRPI0415489A BRPI0415489A BR PI0415489 A BRPI0415489 A BR PI0415489A BR PI0415489 A BRPI0415489 A BR PI0415489A BR PI0415489 A BRPI0415489 A BR PI0415489A
- Authority
- BR
- Brazil
- Prior art keywords
- alkoxy
- alkyl
- nhso
- halo
- optionally substituted
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000003936 benzamides Chemical class 0.000 abstract 2
- 150000004677 hydrates Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 125000001544 thienyl group Chemical group 0.000 abstract 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 2
- 229920002554 vinyl polymer Polymers 0.000 abstract 2
- 239000004471 Glycine Substances 0.000 abstract 1
- 102000010726 Glycine Plasma Membrane Transport Proteins Human genes 0.000 abstract 1
- 108010063380 Glycine Plasma Membrane Transport Proteins Proteins 0.000 abstract 1
- 229940088352 Glycine transporter inhibitor Drugs 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000002075 anti-alcohol Effects 0.000 abstract 1
- 230000001773 anti-convulsant effect Effects 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 230000002460 anti-migrenic effect Effects 0.000 abstract 1
- 230000000648 anti-parkinson Effects 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 229960003965 antiepileptics Drugs 0.000 abstract 1
- 239000000939 antiparkinson agent Substances 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 239000003176 neuroleptic agent Substances 0.000 abstract 1
- 230000000701 neuroleptic effect Effects 0.000 abstract 1
- 230000000324 neuroprotective effect Effects 0.000 abstract 1
- 230000001777 nootropic effect Effects 0.000 abstract 1
- 125000002971 oxazolyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- -1 pyrrolidino, piperidino Chemical group 0.000 abstract 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 229940125725 tranquilizer Drugs 0.000 abstract 1
- 239000003204 tranquilizing agent Substances 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"DERIVADOS DE N-HETEROCICLILMETILBENZAMIDAS, SUA PREPARAçãO E SUA APLICAçãO EM TERAPêUTICA". Composto de fórmula geral (I) na qual R representa ou um átomo de hidrogênio ou um grupo vinila; n representa 0 ou 1 ou 2; X representa um grupo de fórmula CH ou um átomo de nitrogênio; R, representa ou um grupo fenila ou naftila, ou um grupo ciclohexila, ou um grupo heteroarila; R~ 2~ representa ou um átomo de hidrogênio, ou um ou vários substituintes escolhidos entre os átomos de halogênio e os grupos trifluormetila, alquila, alcóxi, tienila, fenilóxi, hidróxi, mercapto, tioalquila, ciano ou um grupo de fórmula geral -NR~ 4~R~ 5~, SO~ 2~NR~ 4~R~ 5~, SO~ 2~-alquila, -SO~ 2~-fenila, -CONR~ 4~R~ 5~, -COOR~ 7~-, -CO-alquila, -CO-fenila, NHCOR~ 8~, -NHSO~ 2~-alquila, -NHSO~ 2~-fenila e -NHSO~ 2~ NR~ 4~R~ 5~ ou um grupo divalente de fórmula -OCF~ 2~O-; R~ 4~ e R~ 5~ representam cada um deles um átomo de hidrogênio ou um grupo alquila ou R~ 4~ e R~ 5~ formam com o átomo de nitrogênio que os porta um ciclo pirrolidina, um ciclo piperidina ou um ciclo morfolina. Aplicação em terapêutica.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0312165A FR2861076B1 (fr) | 2003-10-17 | 2003-10-17 | Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique |
| PCT/FR2004/002643 WO2005037783A2 (fr) | 2003-10-17 | 2004-10-15 | Composes tricycliques comme inhibiteurs de transport de glycine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0415489A true BRPI0415489A (pt) | 2006-12-26 |
Family
ID=34385252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0415489-4A BRPI0415489A (pt) | 2003-10-17 | 2004-10-15 | derivados de n-heterociclilmetilbenzamidas, sua preparação e sua aplicação em terapêutica |
Country Status (33)
| Country | Link |
|---|---|
| US (3) | US7288656B2 (pt) |
| EP (1) | EP1680421B1 (pt) |
| JP (1) | JP4853918B2 (pt) |
| KR (1) | KR101125305B1 (pt) |
| CN (2) | CN101684118B (pt) |
| AT (1) | ATE386036T1 (pt) |
| AU (1) | AU2004281217B2 (pt) |
| BR (1) | BRPI0415489A (pt) |
| CA (1) | CA2542647C (pt) |
| CR (1) | CR8342A (pt) |
| CY (1) | CY1108925T1 (pt) |
| DE (1) | DE602004011806T2 (pt) |
| DK (1) | DK1680421T3 (pt) |
| EC (1) | ECSP066511A (pt) |
| ES (1) | ES2300837T3 (pt) |
| FR (1) | FR2861076B1 (pt) |
| HK (2) | HK1142887A1 (pt) |
| HR (1) | HRP20080186T3 (pt) |
| IL (1) | IL174940A (pt) |
| MA (1) | MA28099A1 (pt) |
| ME (1) | ME00111B (pt) |
| NO (1) | NO335462B1 (pt) |
| NZ (1) | NZ547163A (pt) |
| OA (1) | OA13317A (pt) |
| PL (1) | PL1680421T3 (pt) |
| PT (1) | PT1680421E (pt) |
| RS (2) | RS20060314A (pt) |
| RU (1) | RU2346945C2 (pt) |
| SG (1) | SG147435A1 (pt) |
| TN (1) | TNSN06110A1 (pt) |
| UA (1) | UA81186C2 (pt) |
| WO (1) | WO2005037783A2 (pt) |
| ZA (1) | ZA200603861B (pt) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2842804B1 (fr) | 2002-07-29 | 2004-09-03 | Sanofi Synthelabo | Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique |
| FR2861076B1 (fr) * | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique |
| FR2861071B1 (fr) * | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-[phenyl(alkylpiperidin-2-yl) methyl]benzamide, leur prepartation et leur application en therapeutique |
| FR2861074B1 (fr) * | 2003-10-17 | 2006-04-07 | Sanofi Synthelabo | Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique |
| WO2006038070A2 (en) * | 2004-03-30 | 2006-04-13 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
| FR2906251B1 (fr) * | 2006-09-22 | 2008-11-07 | Sanofi Aventis Sa | Derives de pyrrolizine, indolizine et quinolizine, leur preparation et leur application en therapeutique |
| US11817637B2 (en) | 2006-11-18 | 2023-11-14 | Rfmicron, Inc. | Radio frequency identification (RFID) moisture tag(s) and sensors with extended sensing via capillaries |
| US9582981B2 (en) | 2014-10-08 | 2017-02-28 | Rfmicron, Inc. | Radio frequency identification (RFID) moisture tag(s) and sensors with extended sensing via capillaries |
| TW200911808A (en) * | 2007-07-23 | 2009-03-16 | Astrazeneca Ab | Novel compounds |
| US8420670B2 (en) | 2007-08-22 | 2013-04-16 | Abbott Laboratories | 4-benzylaminoquinolines, pharmaceutical compositions containing them, and their use in therapy |
| EP2527328A1 (en) | 2008-04-01 | 2012-11-28 | Abbott GmbH & Co. KG | Tetrahydroisoquinolines, pharmaceutical compositions containing them, and their use in therapy |
| KR20110095400A (ko) * | 2008-12-04 | 2011-08-24 | 사노피 | 아자비사이클로－트리플루오로메틸 벤즈아미드 유도체의 신규한 다형태 |
| JP2012516326A (ja) * | 2009-01-28 | 2012-07-19 | アストラゼネカ・アクチエボラーグ | ２−アザ−ビシクロ［２．２．１］ヘプタン化合物及びそれらの使用 |
| WO2010087761A1 (en) * | 2009-01-28 | 2010-08-05 | Astrazeneca Ab | 2-aza-bicyclo[2.2.2]octane compounds and uses thereof |
| FR2941953B1 (fr) * | 2009-02-10 | 2011-04-08 | Sanofi Aventis | Derives de n-°(2-aza-bicyclo°2.1.1!hex-1-yl)-benzamide, leur preparation et leur application en therapeutique |
| FR2941954B1 (fr) * | 2009-02-10 | 2011-04-08 | Sanofi Aventis | Derives de n-°(6-aza-bicyclo°3.2.1!oct-1-yl)-aryl-methyl! benzamide, leur preparation et leur application en therapeutique |
| AR075442A1 (es) | 2009-02-16 | 2011-03-30 | Abbott Gmbh & Co Kg | Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia |
| TW201038569A (en) | 2009-02-16 | 2010-11-01 | Abbott Gmbh & Co Kg | Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy |
| FR2943056A1 (fr) * | 2009-03-16 | 2010-09-17 | Sanofi Aventis | Derives de n-°2-aza-bicyclo°2.1.1!hex-1-yl)-aryl-methyl!- heterobenzamide, leur preparation et leur application en therapeutique |
| KR20110132565A (ko) * | 2009-03-16 | 2011-12-08 | 사노피 | Ｎ-〔（２-아자-비시클로〔２.１.１〕헥스-１-일）-아릴-메틸〕-헤테로벤즈아미드의 유도체, 그의 제조 방법 및 그의 치료 용도 |
| FR2943059A1 (fr) * | 2009-03-16 | 2010-09-17 | Sanofi Aventis | Derives de n-°6-aza-bicyclo°3.2.1!oct-5-yl)-aryl-methyl!- heterobenzamide,leur preparation et leur application en therapeutique |
| FR2944284A1 (fr) * | 2009-04-14 | 2010-10-15 | Sanofi Aventis | Derives de n-°7-aza-bicyclo°2.2.1!hept-1-yl)-aryl-methyl! -benzamide, leur preparation et leur application en therapeutique |
| US8153653B2 (en) * | 2010-06-22 | 2012-04-10 | Hoffmann-La Roche Inc. | Amido-tropane derivatives |
| US8846743B2 (en) | 2010-08-13 | 2014-09-30 | Abbott Laboratories | Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9051280B2 (en) | 2010-08-13 | 2015-06-09 | AbbVie Deutschland GmbH & Co. KG | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9045459B2 (en) * | 2010-08-13 | 2015-06-02 | AbbVie Deutschland GmbH & Co. KG | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US8877794B2 (en) | 2010-08-13 | 2014-11-04 | Abbott Laboratories | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US8883839B2 (en) | 2010-08-13 | 2014-11-11 | Abbott Laboratories | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9309200B2 (en) | 2011-05-12 | 2016-04-12 | AbbVie Deutschland GmbH & Co. KG | Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| CA2844275A1 (en) | 2011-08-05 | 2013-02-14 | AbbVie Deutschland GmbH & Co. KG | Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
| JP2014533675A (ja) | 2011-11-18 | 2014-12-15 | アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー | Ｎ置換アミノベンゾシクロヘプテン、アミノテトラリン、アミノインダンおよびフェナルキルアミン誘導体、これらを含有する医薬組成物、および治療におけるこれらの使用 |
| ES2668841T3 (es) | 2011-11-29 | 2018-05-22 | Vivozon Inc. | Derivado novedoso de benzamida y uso del mismo |
| US9365512B2 (en) | 2012-02-13 | 2016-06-14 | AbbVie Deutschland GmbH & Co. KG | Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9650334B2 (en) | 2013-03-15 | 2017-05-16 | Abbvie Inc. | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9656955B2 (en) | 2013-03-15 | 2017-05-23 | Abbvie Inc. | Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| MX2016004934A (es) | 2013-10-17 | 2016-12-20 | Abbvie Deutschland | Derivados de aminotetralina y aminoindano, composiciones farmaceuticas que los contienen, y su uso en terapia. |
| WO2015055770A1 (en) | 2013-10-17 | 2015-04-23 | AbbVie Deutschland GmbH & Co. KG | Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy |
| US9550754B2 (en) | 2014-09-11 | 2017-01-24 | AbbVie Deutschland GmbH & Co. KG | 4,5-dihydropyrazole derivatives, pharmaceutical compositions containing them, and their use in therapy |
| JP6906227B2 (ja) * | 2017-08-18 | 2021-07-21 | 国立大学法人千葉大学 | ハロゲン結合ドナー／有機塩基複合型化合物及び酸塩基複合触媒 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4066662A (en) | 1973-12-14 | 1978-01-03 | Science Union Et Cie., Societe Francaise De Recherche Medicale | N-substituted-2-aminomethyl-3-azabicyclo(3,3,0)octane compounds |
| CA1223873A (en) | 1982-04-14 | 1987-07-07 | Francis D. King | Pharmaceutically active compounds |
| ES2051753T3 (es) | 1986-12-16 | 1994-07-01 | Robins Co Inc A H | N-(1-azabiciclo(2.2.2)octo-3-il) benzamidas y tiobenzamidas ansioliticas. |
| GB8720805D0 (en) | 1987-09-04 | 1987-10-14 | Naylor R J | 2-alkoxy-n-(1-azabicyclo(2 2 2)oct-3-yl)benzamides & thiobenzamides |
| SK13092000A3 (sk) * | 1998-03-06 | 2001-03-12 | Janssen Pharmaceutica N. V. | Inhibítory prenosu glycínu, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a ich použitie |
| FR2861076B1 (fr) * | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique |
-
2003
- 2003-10-17 FR FR0312165A patent/FR2861076B1/fr not_active Expired - Lifetime
-
2004
- 2004-10-15 RU RU2006116889/04A patent/RU2346945C2/ru not_active IP Right Cessation
- 2004-10-15 ME MEP-2008-122A patent/ME00111B/me unknown
- 2004-10-15 EP EP04791554A patent/EP1680421B1/fr not_active Expired - Lifetime
- 2004-10-15 PL PL04791554T patent/PL1680421T3/pl unknown
- 2004-10-15 ZA ZA200603861A patent/ZA200603861B/en unknown
- 2004-10-15 ES ES04791554T patent/ES2300837T3/es not_active Expired - Lifetime
- 2004-10-15 CA CA2542647A patent/CA2542647C/fr not_active Expired - Fee Related
- 2004-10-15 RS YUP-2006/0314A patent/RS20060314A/sr unknown
- 2004-10-15 KR KR1020067007370A patent/KR101125305B1/ko not_active Expired - Fee Related
- 2004-10-15 CN CN2009101638818A patent/CN101684118B/zh not_active Expired - Fee Related
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Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2483 DE 07-08-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |