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BRPI0412786A - processo para a preparação de um composto, e, composto - Google Patents

processo para a preparação de um composto, e, composto

Info

Publication number
BRPI0412786A
BRPI0412786A BRPI0412786-2A BRPI0412786A BRPI0412786A BR PI0412786 A BRPI0412786 A BR PI0412786A BR PI0412786 A BRPI0412786 A BR PI0412786A BR PI0412786 A BRPI0412786 A BR PI0412786A
Authority
BR
Brazil
Prior art keywords
compound
formula
hydrogen
give
group
Prior art date
Application number
BRPI0412786-2A
Other languages
English (en)
Inventor
David John Moody
Jonathan William Wiffen
Original Assignee
Avecia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0317393A external-priority patent/GB0317393D0/en
Priority claimed from GB0406760A external-priority patent/GB0406760D0/en
Application filed by Avecia Pharmaceuticals Ltd filed Critical Avecia Pharmaceuticals Ltd
Publication of BRPI0412786A publication Critical patent/BRPI0412786A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE UM COMPOSTO, E, COMPOSTO". A presente invenção refere-se a um processo para a preparação de um composto da fórmula (7) ou seus sais em que R¬ 1¬ representa um hidrogênio ou um grupo hidrocarbila, R¬ 2¬ representa um hidrogênio ou grupo substituinte, R¬ 3¬ representa um hidrogênio ou um grupo hidrocarbila, e X representa um hidrogênio ou grupo substituinte, que compreende: a) cianetar um composto da fórmula (1): em que Y representa um grupo halo, preferivelmente C1 ou Br; P¬ 1¬ representa hidrogênio ou um grupo de proteção, e W representa =O ou OP¬ 2¬, em que P¬ 2¬ representa hidrogênio ou um grupo de proteção, para dar um composto da fórmula (2): b) reduzir o composto da fórmula (2) para dar um composto da fórmula (3): c) acoplar o composto da fórmula (3) com um composto da fórmula (4): para dar um composto da fórmula (5): d) quando W representar _OP¬ 2¬, desproteger e então oxidar o composto da fórmula (5) para dar um composto da fórmula (6): e e) submeter o composto da fórmula (5), quando W representar =O, ou um composto da fórmula (6), à abertura do anel, e remoção de quaisquer grupos de proteção remanescentes, para dar um composto da fórmula (7) ou seus sais:
BRPI0412786-2A 2003-07-25 2004-07-23 processo para a preparação de um composto, e, composto BRPI0412786A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0317393A GB0317393D0 (en) 2003-07-25 2003-07-25 Process and compounds
GB0406760A GB0406760D0 (en) 2004-03-26 2004-03-26 Process and compounds
PCT/GB2004/003206 WO2005012246A1 (en) 2003-07-25 2004-07-23 Process and intermediate compounds useful in the preparation of statins, particularly atorvastatin

Publications (1)

Publication Number Publication Date
BRPI0412786A true BRPI0412786A (pt) 2006-09-26

Family

ID=34117641

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0412786-2A BRPI0412786A (pt) 2003-07-25 2004-07-23 processo para a preparação de um composto, e, composto

Country Status (11)

Country Link
US (2) US7414141B2 (pt)
EP (2) EP2522656A3 (pt)
JP (1) JP4820965B2 (pt)
KR (1) KR101113163B1 (pt)
AU (1) AU2004261468B2 (pt)
BR (1) BRPI0412786A (pt)
CA (1) CA2530163C (pt)
HR (1) HRP20051020A2 (pt)
IL (1) IL173012A (pt)
NO (1) NO335650B1 (pt)
WO (1) WO2005012246A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1671947A1 (en) 2004-12-20 2006-06-21 Ratiopharm GmbH Process for preparing pyrrole derivatives and intermediates
DE102005022284A1 (de) 2005-05-13 2006-11-23 Ratiopharm Gmbh Verfahren zur Herstellung von Statinen
WO2009019561A2 (en) 2007-08-03 2009-02-12 Pfizer Products Inc. Process for preparing chiral compounds
GB0904102D0 (en) * 2009-03-10 2009-04-22 Bradford Pharma Ltd Use of atorvastatin lactols as medicaments
GB0904100D0 (en) * 2009-03-10 2009-04-22 Bradford Pharma Ltd Use of rosuvastatin lactols as medicaments
AU2013202895B2 (en) * 2009-03-10 2014-09-18 Redx Pharma Plc Rosuvastatin and atorvastatin derivatives
GB0904104D0 (en) * 2009-03-10 2009-04-22 Bradford Pharma Ltd Atorvastatin and rosuvastatin derivatives

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
US5003080A (en) * 1988-02-22 1991-03-26 Warner-Lambert Company Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
US5103024A (en) * 1990-10-17 1992-04-07 Warner-Lambert Company Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
US5298627A (en) * 1993-03-03 1994-03-29 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
US5385929A (en) * 1994-05-04 1995-01-31 Warner-Lambert Company [(Hydroxyphenylamino) carbonyl] pyrroles
US5795749A (en) 1995-04-05 1998-08-18 The Scripps Research Institution Use of 2-deoxyribose-5-phosphate aldolase to prepare 2-deoxyfucose, analogues and derivatives
DE10131522A1 (de) * 2001-07-02 2003-01-16 Creavis Tech & Innovation Gmbh Verfahren zur Herstellung gesättigter Alkohole, Ketone, Aldehyde und Carbonsäuren
CA2450820C (en) * 2001-08-16 2011-03-15 Teva Pharmaceutical Industries Ltd. Processes for preparing calcium salt forms of statins
US7078430B2 (en) * 2002-07-08 2006-07-18 Ranbaxy Laboratories Limited HMG CoA-reductase inhibitors
JP2006512086A (ja) * 2002-09-20 2006-04-13 ダイヴァーサ コーポレイション スタチンおよびスタチン中間体の合成のための酵素化学的方法
RS20050760A (sr) * 2003-04-14 2008-04-04 Warner-Lambert Company Llc., Postupak za izradu fenilamida 5-(4- fluorofenil)-1-(2-((2r, 4r)-4-hidroksi- 6-okso-tetrahidro-piran-2-il)etil)-2- izopropil-4-fenil-1h-pirol-3- karboksilne kiseline
NZ543294A (en) 2003-05-02 2008-05-30 Dsm Ip Assets Bv Process for the preparation of (4-hydroxy-6-oxo-tetrahydropyran-2-yl) acetonitrile and derivatives thereof

Also Published As

Publication number Publication date
EP1648866A1 (en) 2006-04-26
CA2530163C (en) 2012-10-02
US20090062553A1 (en) 2009-03-05
US8614335B2 (en) 2013-12-24
HRP20051020A2 (hr) 2006-04-30
IL173012A0 (en) 2006-06-11
WO2005012246A1 (en) 2005-02-10
NO20060903L (no) 2005-01-26
EP2522656A3 (en) 2013-03-20
NO335650B1 (no) 2015-01-19
JP4820965B2 (ja) 2011-11-24
KR101113163B1 (ko) 2012-02-17
US7414141B2 (en) 2008-08-19
KR20060040679A (ko) 2006-05-10
IL173012A (en) 2015-05-31
AU2004261468B2 (en) 2011-04-14
JP2006528655A (ja) 2006-12-21
CA2530163A1 (en) 2005-02-10
AU2004261468A1 (en) 2005-02-10
US20070043221A1 (en) 2007-02-22
EP2522656A2 (en) 2012-11-14

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B25D Requested change of name of applicant approved

Owner name: NPIL PHARMACEUTICALS (UK) LIMITED (GB)

B25D Requested change of name of applicant approved

Owner name: PIRAMAL HEALTHCARE UK LIMITED (GB)

B25G Requested change of headquarter approved

Owner name: PIRAMAL HEALTHCARE UK LIMITED (GB)

B25A Requested transfer of rights approved

Owner name: BRADFORD PHARMA LIMITED (GB)

B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]