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BRPI0410998A - indole derivatives with apoptosis inducing effect - Google Patents

indole derivatives with apoptosis inducing effect

Info

Publication number
BRPI0410998A
BRPI0410998A BRPI0410998-8A BRPI0410998A BRPI0410998A BR PI0410998 A BRPI0410998 A BR PI0410998A BR PI0410998 A BRPI0410998 A BR PI0410998A BR PI0410998 A BRPI0410998 A BR PI0410998A
Authority
BR
Brazil
Prior art keywords
indole derivatives
apoptosis inducing
inducing effect
medicaments
derivatives
Prior art date
Application number
BRPI0410998-8A
Other languages
Portuguese (pt)
Inventor
Matthias Gerlach
Tilmann Schuster
Peter Emig
Peter Schmidt
Silke Bassner
Eckhard Guenther
Original Assignee
Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP03012868A external-priority patent/EP1484329A1/en
Priority claimed from EP04011598A external-priority patent/EP1595878A1/en
Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh
Publication of BRPI0410998A publication Critical patent/BRPI0410998A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"DERIVADOS DE INDOL COM EFEITO DE INDUçãO DE APOPTOSE". A presente invenção refere-se a derivados de indol usados como medicamentos para o tratamento de doenças tumorais, particularmente no caso de medicamentos contra outros ingredientes ativos e carcinoma com metástase."INDOL DERIVATIVES WITH APOPTOSIS INDUCTION EFFECT". The present invention relates to indole derivatives used as medicaments for the treatment of tumoral diseases, particularly in the case of medicaments against other active ingredients and metastatic carcinoma.

BRPI0410998-8A 2003-06-05 2004-05-25 indole derivatives with apoptosis inducing effect BRPI0410998A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US47627703P 2003-06-05 2003-06-05
EP03012868A EP1484329A1 (en) 2003-06-06 2003-06-06 Indole derivatives with apoptosis inducing activity
EP04011598A EP1595878A1 (en) 2004-05-15 2004-05-15 Indole derivatives with apoptosis inducing activity
PCT/EP2004/005593 WO2004108702A1 (en) 2003-06-05 2004-05-25 Indole derivatives with apoptosis-inducing effect

Publications (1)

Publication Number Publication Date
BRPI0410998A true BRPI0410998A (en) 2006-07-04

Family

ID=43661564

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0410998-8A BRPI0410998A (en) 2003-06-05 2004-05-25 indole derivatives with apoptosis inducing effect

Country Status (12)

Country Link
EP (1) EP1641777A1 (en)
JP (1) JP4878285B2 (en)
KR (1) KR101132599B1 (en)
CN (1) CN1816543B (en)
AU (1) AU2004245198B2 (en)
BR (1) BRPI0410998A (en)
CA (1) CA2526663C (en)
MX (1) MXPA05013121A (en)
NZ (1) NZ543853A (en)
RS (1) RS20050901A (en)
RU (1) RU2327696C2 (en)
WO (1) WO2004108702A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2628039A1 (en) * 2005-11-11 2007-05-18 Aeterna Zentaris Gmbh Novel pyridopyrazines and their use as modulators of kinases
US8217042B2 (en) 2005-11-11 2012-07-10 Zentaris Gmbh Pyridopyrazines and their use as modulators of kinases
EP1790342A1 (en) 2005-11-11 2007-05-30 Zentaris GmbH Pyridopyrazine derivatives and their use as signal transduction modulators
CA2631082C (en) 2005-11-23 2015-02-03 Board Of Regents Of The University Of Texas System Oncogenic ras-specific cytotoxic compound and methods of use thereof
EP2610244A1 (en) * 2006-08-07 2013-07-03 Ironwood Pharmaceuticals, Inc. Indole compounds
JP2010511041A (en) * 2006-11-28 2010-04-08 ジオファーム オンコロジー， インコーポレイテッド Use of indolyl-3-glyoxylic acid derivatives containing indibulin alone or in combination with additional agents for treating cancer
RS54647B1 (en) * 2008-10-16 2016-08-31 Array Biopharma, Inc. Inhibitors of mitosis for increasing apoptosis in therapy
WO2012017325A2 (en) * 2010-07-19 2012-02-09 Procaps Sa Apparatus and process for encapsulating microparticles with liquid in soft gel capsules

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9216009D0 (en) * 1992-07-28 1992-09-09 Almirall Lab New indol derivatives
DE19814838C2 (en) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylic acid derivatives with anti-tumor effects
TWI269654B (en) * 1999-09-28 2007-01-01 Baxter Healthcare Sa N-substituted indole-3-glyoxylamide compounds having anti-tumor action
DE19962300A1 (en) * 1999-12-23 2001-06-28 Asta Medica Ag New N-benzylindolyl glyoxylic acid derivatives are useful as antitumor agents
IT1318641B1 (en) * 2000-07-25 2003-08-27 Novuspharma Spa AMID ACIDS 2- (1H-INDOL-3-IL) -2-OXO-ACETICS WITH ANTI-TUMOR ACTIVITY.
DE10037310A1 (en) * 2000-07-28 2002-02-07 Asta Medica Ag New indole derivatives and their use as medicines
AU2002323474B2 (en) * 2001-09-13 2006-10-05 Synta Pharmaceuticals Corp 3-glyoxlylamideindoles for treating cancer

Also Published As

Publication number Publication date
JP4878285B2 (en) 2012-02-15
WO2004108702A1 (en) 2004-12-16
KR20060034230A (en) 2006-04-21
CN1816543A (en) 2006-08-09
RS20050901A (en) 2007-12-31
AU2004245198B2 (en) 2009-04-23
CN1816543B (en) 2011-01-19
AU2004245198A1 (en) 2004-12-16
CA2526663A1 (en) 2004-12-16
KR101132599B1 (en) 2012-06-21
MXPA05013121A (en) 2006-03-17
EP1641777A1 (en) 2006-04-05
CA2526663C (en) 2011-07-19
RU2006100022A (en) 2006-05-27
RU2327696C2 (en) 2008-06-27
JP2007523850A (en) 2007-08-23
NZ543853A (en) 2009-09-25

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25G Requested change of headquarter approved

Owner name: ZENTARIS GMBH (DE)

Free format text: SEDE ALTERADA CONFORME PETICAO NO 020060058923-RJ DE 27.04.2006.

B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2259 DE 22/04/2014.