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BRPI0409926A - saposina c-dops: um agente antitumor - Google Patents

saposina c-dops: um agente antitumor

Info

Publication number
BRPI0409926A
BRPI0409926A BRPI0409926A BRPI0409926A BR PI0409926 A BRPI0409926 A BR PI0409926A BR PI0409926 A BRPI0409926 A BR PI0409926A BR PI0409926 A BRPI0409926 A BR PI0409926A
Authority
BR
Brazil
Prior art keywords
antitumor agent
saposin
dops
methods
compositions
Prior art date
Application number
Other languages
English (en)
Inventor
Xiaoyang Qi
Original Assignee
Childrens Hosp Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens Hosp Medical Center filed Critical Childrens Hosp Medical Center
Publication of BRPI0409926A publication Critical patent/BRPI0409926A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"SAPOSINA C-DOPS: UM AGENTE ANTITUMOR". A presente invenção refere-se a composições e métodos para o tratamento de indivíduos com distúrbios caracterizados por hiperproliferação de células tais como tumores e cânceres. As composições compreendem agentes que são combinações de saposina C (ou polipeptídeos relacionados com prosaposina e dioleoilfosfatidilserina (ou componentes de folha pequena interna). Este agente antitumor é administrado nos métodos da invenção de acordo com um regime de dosagem. Administração de um agente da invenção resulta em uma resposta terapêutica positiva em um indivíduo com um tumor.
BRPI0409926 2003-04-28 2004-03-17 saposina c-dops: um agente antitumor BRPI0409926A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46616603P 2003-04-28 2003-04-28
US10/801,517 US7834147B2 (en) 2003-04-28 2004-03-16 Saposin C-DOPS: a novel anti-tumor agent
PCT/US2004/008020 WO2004096159A2 (en) 2003-04-28 2004-03-17 Saposin c-dops: a novel anti-tumor agent

Publications (1)

Publication Number Publication Date
BRPI0409926A true BRPI0409926A (pt) 2006-04-25

Family

ID=33423597

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409926 BRPI0409926A (pt) 2003-04-28 2004-03-17 saposina c-dops: um agente antitumor

Country Status (8)

Country Link
US (4) US7834147B2 (pt)
EP (1) EP1635856B1 (pt)
JP (1) JP4762132B2 (pt)
AU (2) AU2004233775C1 (pt)
BR (1) BRPI0409926A (pt)
CA (2) CA2911022C (pt)
ES (1) ES2828094T3 (pt)
WO (1) WO2004096159A2 (pt)

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US7834147B2 (en) * 2003-04-28 2010-11-16 Childrens Hospital Medical Center Saposin C-DOPS: a novel anti-tumor agent
CA2650691C (en) * 2006-04-28 2015-10-06 Children's Hospital Medical Center Fusogenic properties of saposin c and related proteins and peptides for application to transmembrane drug delivery systems
WO2008051818A2 (en) * 2006-10-20 2008-05-02 Children's Hospital Medical Center Spontaneously forming ellipsoidal phospholipid unilamellar vesicles
WO2011084685A2 (en) * 2009-12-17 2011-07-14 Children's Medical Center Corporation Saposin-a derived peptides and uses thereof
EP3666284A1 (en) * 2007-06-22 2020-06-17 Children's Medical Center, Corp. Methods and uses thereof of a fragment of saposin a
AU2013203640B2 (en) * 2007-06-22 2017-04-13 Children's Medical Center Corporation Methods and uses thereof of prosaposin
US9585972B2 (en) 2011-05-09 2017-03-07 Sherry L. Thornton Method for imaging a site of arthritis in an animal
EP4306123A3 (en) 2011-12-22 2024-04-17 Children's Medical Center Corporation Saposin-a derived peptides and uses thereof
WO2014078522A1 (en) * 2012-11-14 2014-05-22 Ohio State Innovation Foundation Materials and methods useful for treating glioblastoma
EP2745834B1 (en) 2012-12-18 2016-09-28 Jens Frauenfeld Salipro particles
EP2971166B1 (en) 2013-03-14 2021-05-19 Children's Medical Center Corporation Psap peptide for treating cd36 expressing cancers
EP3043814B1 (en) 2013-09-13 2020-12-02 Salipro Biotech AB Antigen and method for production thereof
US10646541B2 (en) 2014-03-26 2020-05-12 Children's Medical Center Corporation Cyclic prosaposin peptides and uses thereof
CA3047936A1 (en) 2016-11-21 2018-05-24 Bexion Pharmaceuticals, Inc. A combination therapy including sapc-dops for the treatment of pancreatic cancer
ES2980236T3 (es) 2017-10-16 2024-09-30 Univ Cincinnati Combinación de AS1411 y SAPC-DOPS para el tratamiento de glioblastoma multiforme
EP3697413B1 (en) 2017-10-16 2025-02-26 University of Cincinnati Combination therapy of fractionated radiation and sapc-dops for the treatment of tumors
US10682411B2 (en) 2018-03-23 2020-06-16 Bexion Pharmaceuticals Inc. Saposin C pharmaceutical compositions and methods of treating cancer
WO2021183596A1 (en) * 2020-03-10 2021-09-16 University Of Cincinnati Materials and methods for the treatment of gaucher disease
WO2021183595A1 (en) * 2020-03-10 2021-09-16 University Of Cincinnati Enhanced efficacy of combination of gemcitabine and phosphatidylserine-targeted nanovesicles against pancreatic cancer
CN119013022A (zh) 2022-03-14 2024-11-22 来凯有限公司 癌症的组合治疗

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Also Published As

Publication number Publication date
AU2004233775C1 (en) 2010-03-18
CA2911022A1 (en) 2004-11-11
WO2004096159A3 (en) 2005-09-01
US8937156B2 (en) 2015-01-20
JP2006524681A (ja) 2006-11-02
US20090269373A1 (en) 2009-10-29
US7834147B2 (en) 2010-11-16
US20150125497A1 (en) 2015-05-07
EP1635856A4 (en) 2011-04-06
CA2522833C (en) 2016-01-19
US20190192623A1 (en) 2019-06-27
WO2004096159A2 (en) 2004-11-11
ES2828094T3 (es) 2021-05-25
US20040229799A1 (en) 2004-11-18
AU2010200264B2 (en) 2013-02-14
EP1635856B1 (en) 2020-08-12
JP4762132B2 (ja) 2011-08-31
US10188698B2 (en) 2019-01-29
AU2004233775B2 (en) 2009-10-22
AU2004233775A1 (en) 2004-11-11
AU2010200264A1 (en) 2010-02-25
CA2911022C (en) 2021-07-20
EP1635856A2 (en) 2006-03-22
CA2522833A1 (en) 2004-11-11

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]