[go: up one dir, main page]

BRPI0409571A - métodos e kits para a manutenção de gravidez, tratamento de cistos foliculares, e sincronização da ovulação empregando-se hormÈnio de luteinização - Google Patents

métodos e kits para a manutenção de gravidez, tratamento de cistos foliculares, e sincronização da ovulação empregando-se hormÈnio de luteinização

Info

Publication number
BRPI0409571A
BRPI0409571A BRPI0409571-5A BRPI0409571A BRPI0409571A BR PI0409571 A BRPI0409571 A BR PI0409571A BR PI0409571 A BRPI0409571 A BR PI0409571A BR PI0409571 A BRPI0409571 A BR PI0409571A
Authority
BR
Brazil
Prior art keywords
pregnancy
kits
hormone
mammals
methods
Prior art date
Application number
BRPI0409571-5A
Other languages
English (en)
Inventor
Kevin Mcsweeney
Mark Colgin
Diane Newman
Jay W Roth
Roger Hurst
Original Assignee
Aspenbio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aspenbio Inc filed Critical Aspenbio Inc
Publication of BRPI0409571A publication Critical patent/BRPI0409571A/pt
Publication of BRPI0409571B1 publication Critical patent/BRPI0409571B1/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/24Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61DVETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D19/00Instruments or methods for reproduction or fertilisation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06Antiabortive agents; Labour repressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

"MéTODOS E KITS PARA MANUTENçãO DE GRAVIDEZ, TRATAMENTO DE CISTOS FOLICULARES, E SINCRONIZAçãO DE OVULAçãO EMPREGANDO-SE HORMÈNIO DE LUTEINIZAçãO". A presente invenção refere-se a métodos e kits para manter gravidez em mamíferos. A gravidez é mantida por administração de quantidades eficazes de hormónio de luteinização (LH) ou gonadotropina coriónica (CG). Ambos LH e CG podem ser empregados sozinhos, em combinação entre si, ou em combinação com hormónio de crescimento (GH) ou hormónio de estimulação de folículo (FSH). Hormónios são administrados em torno do Dia 4 a cerca do Dia 7, seguindo a inseminação. Quantidades eficazes de LH variam de cerca de 10 microgramas a cerca de 25 miligramas, preferivelmente cerca de 2 a cerca de 8 mg, e de CG varia de cerca de 100 IU (unidades internacionais) a cerca de 2000 IU. Os mamíferos tratáveis pelos métodos desta invenção incluem ungulados e mamíferos relacionados, incluindo bovinos. Kits fornecidos por esta invenção incluem quantidades eficazes de um ou mais hormónios, um dispositivo para administrar o(s) hormónio(s) e instruções. Esta invenção também fornece métodos para tratar cistos foliculares e para sincronizar a ovulação em mamíferos empregando-se LH.
BRPI0409571A 2003-03-04 2004-03-04 método para manter uma ou mais gravidezes em um ou mais mamíferos BRPI0409571B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45229703P 2003-03-04 2003-03-04
US51600203P 2003-10-31 2003-10-31
PCT/US2004/006789 WO2004078061A2 (en) 2003-03-04 2004-03-04 Methods and kits for maintaining pregnancy, treating follicular cysts, and synchronizing ovulation using luteinizing hormone

Publications (2)

Publication Number Publication Date
BRPI0409571A true BRPI0409571A (pt) 2006-04-18
BRPI0409571B1 BRPI0409571B1 (pt) 2016-05-31

Family

ID=32965585

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409571A BRPI0409571B1 (pt) 2003-03-04 2004-03-04 método para manter uma ou mais gravidezes em um ou mais mamíferos

Country Status (9)

Country Link
US (1) US10105417B2 (pt)
EP (1) EP1610803B8 (pt)
AT (1) ATE491464T1 (pt)
AU (1) AU2010201830A1 (pt)
BR (1) BRPI0409571B1 (pt)
CA (1) CA2518268C (pt)
DE (1) DE602004030546D1 (pt)
NZ (1) NZ542549A (pt)
WO (1) WO2004078061A2 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1684782B1 (en) 2003-10-03 2015-09-30 Thorn BioScience, LLC Process for the synchronization of ovulation for timed breeding without heat detection
WO2010099567A1 (en) * 2009-03-02 2010-09-10 Pork Crc Ltd A method of increasing litter size in mammals
US8905913B2 (en) 2009-04-23 2014-12-09 Jbs United Animal Health Ii Llc Method and composition for synchronizing time of insemination
US8541187B2 (en) 2011-03-01 2013-09-24 Bio Tracking, LLC Systems and methods for detecting animal pregnancy
EP2925339B1 (en) 2012-11-28 2020-04-29 United-AH II, LLC Method for synchronizing time of insemination in gilts
CN103340700B (zh) * 2013-05-23 2016-08-10 中国农业大学 诱导牛生产双犊的方法
EP3074031A4 (en) * 2013-11-27 2017-08-09 JBS United Animal Health II LLC Method and composition for synchronizing time of insemination in gilts
CN105801684B (zh) * 2016-03-29 2017-04-05 长春金赛药业有限责任公司 重组人生长激素及其促进卵泡发育的应用
BR112021022860A2 (pt) 2019-05-16 2022-01-18 Ceva Sante Animale Composições e métodos para aumentar o desempenho da reprodução em mamíferos não humanos com uso de hormônio luteinizante recombinante

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2799621A (en) 1953-02-19 1957-07-16 Armour & Co Preparation of adrenocorticotropin and gonadotropins from pituitary material
DE1717042A1 (de) * 1963-03-11 1972-11-09 Serono Ist Farm Verfahren zur Gewinnung von gonadotropen Hypophysenhormonen aus Urin
CA918067A (en) * 1966-04-08 1973-01-02 Eli Lilly And Company Method of improving conception rate in domestic female mammals
IE33484B1 (en) * 1968-08-06 1974-07-10 Lilly Co Eli Method of increasing pregnancy rate and live births in cows
US3574829A (en) * 1968-08-06 1971-04-13 Lilly Co Eli Method of improving the conception rate in ewes
US3636193A (en) * 1969-03-07 1972-01-18 Lilly Co Eli Method of improving the conception rate in cows
US3947569A (en) * 1972-04-12 1976-03-30 American Home Products Corporation Process for preparing the releasing hormone of luteinizing hormone (LH) and of follicle stimulating hormone (FSH), salts and compositions thereof, and intermediates therefor
US3832469A (en) * 1973-04-16 1974-08-27 American Home Prod Estrus and ovulation regulation
US3892855A (en) 1973-10-10 1975-07-01 Searle & Co Method for fertile breeding control in female bovine
GB1533928A (en) * 1976-04-14 1978-11-29 Ici Ltd Oestrus regulation
US4634665A (en) * 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US6455275B1 (en) * 1980-02-25 2002-09-24 The Trustees Of Columbia University In The City Of New York DNA construct for producing proteinaceous materials in eucaryotic cells
US5179017A (en) * 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en) * 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
DE3200459A1 (de) * 1982-01-09 1983-07-21 Hoechst Ag, 6230 Frankfurt Verfahren zur behandlung der azyklie bei schafen oder rindern
US5639639A (en) * 1983-11-02 1997-06-17 Genzyme Corporation Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof
US4840896A (en) * 1983-11-02 1989-06-20 Integrated Genetics, Inc. Heteropolymeric protein
US4923805A (en) * 1983-11-02 1990-05-08 Integrated Genetics, Inc. Fsh
US5156957A (en) 1983-11-02 1992-10-20 Genzyme Corporation Follicle stimulating hormone
US6455282B1 (en) 1983-11-02 2002-09-24 Genzyme Corporation Cells, vectors and methods for producing biologically active TSH
US4599227A (en) * 1983-11-07 1986-07-08 Wisconsin Alumni Research Foundation Injectable pharmaceutical preparation for the induction of multiple follicular growth
US4610687A (en) 1984-08-06 1986-09-09 Board Of Trustees Operating Michigan State University Method for breeding control in female bovines
NZ216122A (en) * 1985-05-10 1989-07-27 Univ Melbourne Stimulating ovulation in mares by administering gonadotrophin-releasing hormones
US4686103A (en) * 1985-07-25 1987-08-11 Iowa State University Research Foundation, Inc. Method of managing cattle breeding herds
US5366894A (en) 1986-06-30 1994-11-22 Pharmaceutical Proteins Limited Peptide production
US4780451B1 (en) 1987-01-23 1995-04-04 Asua International Inc Composition and method for producing superovulation in cattle
US5162306A (en) * 1987-01-23 1992-11-10 Donaldson Lloyd E Composition and method for producing superovulation in mammals
DK49987A (da) * 1987-01-30 1988-07-31 Nordisk Gentofte Fremgangsmaade til behandling af infertilitet og middel til anvendelse ved fremgangsmaaden
US4873316A (en) 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
EP0310288A3 (en) 1987-10-01 1990-05-09 Bunge (Australia) Proprietary Limited Improved ovulation treatment
WO1990002757A1 (en) 1988-09-02 1990-03-22 Integrated Genetics, Inc. Heteropolymeric protein
US5338835A (en) 1989-02-21 1994-08-16 Washington University CTP-extended form of FSH
US5705478A (en) 1989-02-21 1998-01-06 Washington University Covalently linked β subunits of the glycoprotein hormones as antagonists
ATE148171T1 (de) 1989-02-21 1997-02-15 Univ Washington Modifizierte formen von fortpflanzungshormonen
US5792460A (en) 1989-02-21 1998-08-11 Washington University Modified glycoprotein hormones having a CTP at the amino terminus
US6225449B1 (en) 1991-10-04 2001-05-01 Washington University Hormone analogs with multiple CTP extensions
US4997646A (en) * 1989-02-23 1991-03-05 University Of Florida Research Foundation, Inc. Use of interferons of the alpha family to enhance fertility in mammals
DE69027992D1 (de) * 1989-05-05 1996-09-05 North Sydney Area Health Serv Steigerung der fruchtbarkeit
US5008244A (en) * 1989-05-15 1991-04-16 Pitman-Moore, Inc. Method for increasing fertility in animals
US5240832A (en) 1989-06-20 1993-08-31 Genzyme Corporation Heteropolymeric protein production methods
US5366888A (en) * 1990-07-09 1994-11-22 Amrad Corporation Limited Enhanced maintenance of pregnancy using leukaemia inhibitory factor in embryo culturing
US5508261A (en) * 1991-06-18 1996-04-16 University Of Medicine & Dentistry Of New Jersey Analogs of glycoprotein hormones having altered receptor binding specificity and activity and methods for preparing and using same
US6448469B1 (en) 1991-10-02 2002-09-10 Genzyme Corporation Production of membrane proteins in the milk of transgenic nonhuman mammals
US6028177A (en) 1991-10-04 2000-02-22 Washington University Methods of detecting single-chain forms of the glycoprotein hormone quartet
US5985611A (en) 1992-04-30 1999-11-16 Washington University Recombinant production of gonadotropins in secretory cells
US5667839A (en) 1993-01-28 1997-09-16 Collagen Corporation Human recombinant collagen in the milk of transgenic animals
US6737515B2 (en) 1993-11-19 2004-05-18 Washington University Follicle stimulating hormone-glycosylation analogs
US6238890B1 (en) 1994-02-18 2001-05-29 Washington University Single chain forms of the glycoprotein hormone quartet
MX9601320A (es) 1994-08-12 1997-05-31 Univ Washington Formas de cadena unica de cuarteto de hormona de glicoproteina.
WO1996025496A1 (en) * 1995-02-17 1996-08-22 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) PRODUCTION OF BIOLOGICALLY ACTIVE RECOMBINANT BOVINE FOLLICLE STIMULATING HORMONE (REC bFSH) IN THE BACULOVIRUS EXPRESSION SYSTEM
US5589457A (en) * 1995-07-03 1996-12-31 Ausa International, Inc. Process for the synchronization of ovulation
US6403631B1 (en) 1995-11-24 2002-06-11 Equitech Laboratories, Inc. Method and compositions for enhancing pregnancy success in an animal
US5792785A (en) 1995-11-24 1998-08-11 Equitech Laboratories, Inc. Method for enhancing pregnancy success in an animal
US20040006018A1 (en) * 1996-02-14 2004-01-08 Genentech, Inc. Cardiotrophin and uses therefor
US5733735A (en) 1996-06-11 1998-03-31 Washington University Assay system to determine receptor antagonist target site
US5968513A (en) * 1996-06-24 1999-10-19 University Of Maryland Biotechnology Institute Method of promoting hematopoiesis using derivatives of human chorionic gonadotropin
AU4964197A (en) 1996-11-12 1998-06-03 Teikoku Hormone Mfg. Co., Ltd. Recombinant single-stranded equine chorionic gonadotropin
TW518235B (en) 1997-01-15 2003-01-21 Akzo Nobel Nv A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage
CA2281949A1 (en) 1997-02-25 1998-08-27 Genzyme Transgenics Corporation Transgenically produced non-secreted proteins
US5883073A (en) 1997-04-03 1999-03-16 Washington University Single-chain double-alpha peptide
FR2768627B1 (fr) 1997-09-19 2000-03-24 Agronomique Inst Nat Rech Medicament veterinaire contenant de la choriogonadotropine equine modifiee pour induire l'ovulation chez la jument et stimuler la production de testosterone chez l'etalon
US6414123B1 (en) * 1997-10-21 2002-07-02 Vitro Diagnostics, Inc. Method for purifying FSH
US5990288A (en) * 1997-10-21 1999-11-23 Vitro Diagnostics, Inc. Method for purifying FSH
US6103501A (en) 1997-11-17 2000-08-15 Washington University Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof
US6635256B1 (en) 1998-10-19 2003-10-21 Washington University Glycoprotein hormone compositions comprising two β subunits and methods of use thereof
WO2000009113A1 (en) * 1998-08-17 2000-02-24 Trout William E Use of zeranol to modulate reproductive cycles
JP3601995B2 (ja) * 1999-03-01 2004-12-15 パイオニア株式会社 情報記録媒体のストッカー及びチェンジャー
US6635739B2 (en) * 1999-10-15 2003-10-21 Theresa Siler-Khodr Non-mammalian GnRH analogs and uses thereof in regulation of fertility and pregnancy
JP2003518478A (ja) 1999-12-16 2003-06-10 ファルマシア・アンド・アップジョン・カンパニー 酢酸メレンゲストロールおよび酢酸トレンボロンを含有する埋め込み剤組成物
US6381870B1 (en) * 2000-01-07 2002-05-07 Milliken & Company Bag for home dry cleaning process
US7053054B2 (en) 2000-02-22 2006-05-30 Applied Research Systems Ars Holding N.V. Purified LH
US6548508B2 (en) * 2000-10-20 2003-04-15 Pfizer, Inc. Use of PDE V inhibitors for improved fecundity in mammals
US6987172B2 (en) 2001-03-05 2006-01-17 Washington University In St. Louis Multifunctional single chain glycoprotein hormones comprising three or more β subunits
AU2003208679A1 (en) * 2002-02-08 2003-09-02 Advanced Animal Technology Limited Control of a biological function
US20040204358A1 (en) * 2003-01-28 2004-10-14 Advisys, Inc. Reducing culling in herd animals growth hormone releasing hormone (GHRH)

Also Published As

Publication number Publication date
WO2004078061A2 (en) 2004-09-16
US10105417B2 (en) 2018-10-23
ATE491464T1 (de) 2011-01-15
CA2518268A1 (en) 2004-09-16
BRPI0409571B1 (pt) 2016-05-31
DE602004030546D1 (de) 2011-01-27
NZ542549A (en) 2008-11-28
WO2004078061A3 (en) 2004-12-29
WO2004078061B1 (en) 2005-02-17
AU2004218365A1 (en) 2004-09-16
US20040266697A1 (en) 2004-12-30
EP1610803A2 (en) 2006-01-04
AU2010201830A1 (en) 2010-05-27
CA2518268C (en) 2013-12-10
EP1610803A4 (en) 2008-03-19
EP1610803B1 (en) 2010-12-15
EP1610803B8 (en) 2011-09-14

Similar Documents

Publication Publication Date Title
Armstrong et al. Alteration of the bovine estrous cycle with oxytocin
Mellado et al. Effect of buck stimulus on mature and pre-pubertal norgestomet-treated goats
Ungerfeld et al. Short term primings with different progestogen intravaginal devices (MAP, FGA and CIDR) for eCG-estrous induction in anestrus ewes
Evans et al. Effect of ram exposure at the end of progestagen treatment on estrus synchronisation and fertility during the breeding season in ewes
Coccia et al. GnRH antagonists
IL157841A0 (en) Activation of natural killer cells by adenosine a3 receptor agonists
RU2007139457A (ru) Лечение или профилактика синдрома гиперстимуляции яичников (ohss) с использованием агониста дофамина
BRPI0409571A (pt) métodos e kits para a manutenção de gravidez, tratamento de cistos foliculares, e sincronização da ovulação empregando-se hormÈnio de luteinização
CA2330131C (en) Method for the treatment of fertility disorders
Gardón et al. Synchronization protocols in Spanish Merino sheep: reduction in time to estrus by the addition of eCG to a progesterone-based estrus synchronization protocol
Lofstedt Control of the estrous cycle in the mare
Sebastian et al. Effect of season and duration of FSH treatment on embryo production in sheep
US20050049200A1 (en) LHRH-antagonists in the treatment of fertility disorders
Olivennes et al. GnRH antagonist in single-dose applications
Conners et al. PRESERVATION OF NORMAL CONCENTRATIONS OF PITUITARY GONADOTROPINS DESPITE ACHIEVEMENT OF NORMAL SERUM TESTOTERONE LEVELS IN HYPOGONADAL MEN TREATED WITH A 4.5% NASAL TESTOSTERONE GEL: MP89-06
CA1294873C (en) Method of regulating animal reproduction
Waldron et al. Effect of concomitant injection of prostaglandin and PMSG on pregnancy rate and prolificacy of artificially inseminated Spanish goats synchronized with controlled internal drug release devices
Kirkwood et al. Human chorionic gonadotropin at parturition fails to consistently induce ovulation in sows
Olivennes GnRH antagonists: do they open new pathways to safer treatment in assisted reproductive techniques?
INGALE et al. An Overview on the Protocols used in the Management of Infertility.
Harika et al. Hypersensitization to human menopausal gonadotropins with anaphylactic shock syndrome during a fifth in vitro fertilization cycle
BASAR et al. ARTIFICIAL REOPRODUCTIVE TECHNIQUE OUTCOMES IN MALE HYPOGONODOTROPIC HYPOGONODISM REGARDING SPERM SOURCE: MP89-07
WO2000032224A3 (en) Calcitonin for the modulation of sperm function
Nasreen et al. Role of Aromatase Inhibitor to Improve Semen Quality in Case of Eugonadotropic Hypogonadism
AR037671A1 (es) Uso de leptina o un analogo para la fabricacion de un medicamento para el tratamiento de infertilidad femenina

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 31/05/2016, OBSERVADAS AS CONDICOES LEGAIS.