BRPI0311233A2 - diagnóstico de carcinoma hepatocelular - Google Patents

diagnóstico de carcinoma hepatocelular

Info

Publication number: BRPI0311233A2
Authority: BR; Brazil
Prior art keywords: diagnosis; hepatocellular carcinoma; hepatocellular; carcinoma
Prior art date: 2002-05-23

Application number

BRPI0311233A

Other languages

English (en)

Inventor

Jorge Filmus

Mariana Capurro

Original Assignee

Sunnybrook & Womens College

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-05-23

Filing date

2003-05-22

Publication date

2016-06-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29584393&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0311233(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-05-22 Application filed by Sunnybrook & Womens College filed Critical Sunnybrook & Womens College

2016-06-28 Publication of BRPI0311233A2 publication Critical patent/BRPI0311233A2/pt

2019-08-13 Publication of BRPI0311233B1 publication Critical patent/BRPI0311233B1/pt

2021-07-27 Publication of BRPI0311233B8 publication Critical patent/BRPI0311233B8/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/303—Liver or Pancreas
- G01N33/57525—
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Cell Biology (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Food Science & Technology (AREA)
Biotechnology (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Analytical Chemistry (AREA)
Genetics & Genomics (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

BRPI0311233A 2002-05-23 2003-05-22 métodos in vitro para triagem de um paciente para carcinoma hepatocelular (hcc), e para diagnosticar hcc em um paciente, bem como método e kit para detectar ou determinar o nível de gpc3 em uma amostra BRPI0311233B8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US38234002P	2002-05-23	2002-05-23
US60/382,340		2002-05-23
PCT/CA2003/000752 WO2003100429A2 (en)	2002-05-23	2003-05-22	Diagnosis of hepatocellular carcinoma

Publications (3)

Publication Number	Publication Date
BRPI0311233A2 true BRPI0311233A2 (pt)	2016-06-28
BRPI0311233B1 BRPI0311233B1 (pt)	2019-08-13
BRPI0311233B8 BRPI0311233B8 (pt)	2021-07-27

Family

ID=29584393

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0311233A BRPI0311233B8 (pt)	2002-05-23	2003-05-22	métodos in vitro para triagem de um paciente para carcinoma hepatocelular (hcc), e para diagnosticar hcc em um paciente, bem como método e kit para detectar ou determinar o nível de gpc3 em uma amostra

Country Status (17)

Country	Link
US (1)	US7883853B2 (pt)
EP (1)	EP1506406B1 (pt)
JP (1)	JP4455324B2 (pt)
CN (1)	CN100401068C (pt)
AT (1)	ATE425461T1 (pt)
AU (1)	AU2003229191B2 (pt)
BR (1)	BRPI0311233B8 (pt)
CA (1)	CA2482881C (pt)
DE (1)	DE60326567D1 (pt)
ES (1)	ES2324029T3 (pt)
IL (1)	IL164848A0 (pt)
MX (1)	MXPA04011132A (pt)
NZ (1)	NZ536521A (pt)
PT (1)	PT1506406E (pt)
RU (1)	RU2319969C2 (pt)
WO (1)	WO2003100429A2 (pt)
ZA (1)	ZA200410077B (pt)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2002330482A1 (en)	2002-09-04	2004-03-29	Perseus Proteomics Inc.	Method of diagnosing cancer by detecting gpc3
WO2004022595A1 (ja) *	2002-09-04	2004-03-18	Chugai Seiyaku Kabushiki Kaisha	MRL/lprマウスを用いた抗体の作製
AU2002338020A1 (en) *	2002-09-04	2004-03-29	Chugai Seiyaku Kabushiki Kaisha	Antibody against blood-solubilized n-terminal peptide in gpc3
WO2004067571A1 (fr) *	2003-01-30	2004-08-12	Wu, Mengchao	Anticorps monoclonal contre l'hepatome humain et utilisation de celui-ci
US20080008710A1 (en) *	2003-09-04	2008-01-10	Hiroyuki Aburatani	Therapeutic Agent And Diagnostic Agent For Cholangiocarcinoma
WO2005085861A2 (en) *	2004-03-03	2005-09-15	Oridis Biomed Forschungs- Und Entwicklungs Gmbh	Nucleic acids and encoded polypeptides for use in liver disorders and epithelial cancer
JP4658926B2 (ja)	2004-04-28	2011-03-23	株式会社ペルセウスプロテオミクス	肝癌治療後の再発予測判定薬
CN102702353A (zh) *	2004-07-09	2012-10-03	中外制药株式会社	抗-磷脂酰肌醇蛋白聚糖3抗体
WO2006022407A1 (ja) *	2004-08-24	2006-03-02	Chugai Seiyaku Kabushiki Kaisha	抗グリピカン３抗体を用いたアジュバント療法
EP1813944A4 (en) *	2004-10-05	2009-11-11	Perseus Proteomics Inc	DRUG TO MONITOR THE INJURY OF HEPATITIS
UA93488C2 (uk) *	2004-10-26	2011-02-25	Чугаі Сейяку Кабусікі Кайся	Композиція анти-гліпікан 3-антитіл, що мають модифікований цукровий ланцюг
US20070087005A1 (en) *	2005-10-14	2007-04-19	Lazar Gregory A	Anti-glypican-3 antibody
WO2007053659A2 (en) *	2005-11-01	2007-05-10	Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Method of screening for hepatocellular carcinoma
JP5619603B2 (ja) *	2008-03-17	2014-11-05	国立大学法人宮崎大学	抗グリピカン３抗体を用いる肝癌細胞の検出法
CN101393217B (zh) *	2008-09-27	2012-05-30	中国人民解放军第二军医大学	一种原发性肝癌血清标志物的检测试剂盒
US20110257035A1 (en) *	2008-10-21	2011-10-20	Bayer Healthcare Llc	Identification of signature genes associated with hepatocellular carcinoma
KR20100098324A (ko) *	2009-02-27	2010-09-06	포항공과대학교 산학협력단	Ｔｍ７ｓｆ３를 유효성분으로 함유하는 간암 진단용 조성물, 및 항 ｔｍ７ｓｆ３ 항체를 유효성분으로 함유하는 간암 진단 키트, 및 간암 예방 또는 치료용 약학 조성물
CN102356316B (zh)	2009-03-05	2015-07-08	独立行政法人产业技术综合研究所	肝内胆管癌的检出、辨别方法
CN102180969B (zh) *	2011-01-30	2013-04-10	中国人民解放军军事医学科学院微生物流行病研究所	抗肝癌活性单克隆抗体及其应用
CN102183660A (zh) *	2011-03-09	2011-09-14	倪温慨	检测Glypican-3的时间分辨免疫荧光试剂盒
CN102353791A (zh) *	2011-06-30	2012-02-15	倪润洲	一种分离检测afp亚型的新方法
TWI693073B (zh)	2012-12-21	2020-05-11	日商中外製藥股份有限公司	對ｇｐｃ３標的治療劑療法為有效之患者投與的ｇｐｃ３標的治療劑
EP3557260B1 (en)	2012-12-21	2022-05-18	Chugai Seiyaku Kabushiki Kaisha	Gpc3-targeting drug which is administered to patient responsive to gpc3-targeting drug therapy
WO2015097928A1 (ja)	2013-12-24	2015-07-02	中外製薬株式会社	可溶性ｇｐｃ３タンパク質の測定方法
US20160000946A1 (en) *	2013-03-14	2016-01-07	The Board Of Trustees Of The Leland Stanford Junior University	Radiolabeled anti-glypican-3 immunoconjugates for immuno-pet imaging of hepatocellular carcinoma
WO2015020242A1 (ko) *	2013-08-06	2015-02-12	Kim Hyun Kee	소 간세포암 및 간경변에 잠재되어 있는 간세포암 진단용 조성물
KR102409014B1 (ko)	2014-05-08	2022-06-14	추가이 세이야쿠 가부시키가이샤	Gpc3 표적 치료제 요법이 유효한 환자에게 투여되는 gpc3 표적 치료제
KR20170003582A (ko) *	2014-05-22	2017-01-09	제넨테크, 인크.	항-gpc3 항체 및 면역접합체
MA40764A (fr)	2014-09-26	2017-08-01	Chugai Pharmaceutical Co Ltd	Agent thérapeutique induisant une cytotoxicité
KR101704533B1 (ko) *	2014-10-13	2017-02-09	경북대학교병원	간암 바이오마커로서의 ＥＲＲγ 및 이의 용도
EP3318879B1 (en)	2015-07-01	2020-10-21	Chugai Seiyaku Kabushiki Kaisha	Gpc3-targeting therapeutic agent which is administered to patient for whom the gpc3-targeting therapeutic agent is effective
BR112018002386A8 (pt) *	2015-08-03	2022-10-18	Carsgen Therapeutics Ltd	Anticorpo contra glypican-3 e aplicação do mesmo
CN108738347B (zh) *	2016-03-10	2022-01-14	国立癌症研究中心	辅助肝细胞癌患者的再发风险预测的方法、装置、计算机程序制品及试剂盒
EP4112641A1 (en)	2016-03-15	2023-01-04	Chugai Seiyaku Kabushiki Kaisha	Methods of treating cancers using pd-1 axis binding antagonists and anti-gpc3 antibodies
EP3684413A1 (en)	2017-09-20	2020-07-29	Chugai Seiyaku Kabushiki Kaisha	Dosage regimen for combination therapy using pd-1 axis binding antagonists and gpc3 targeting agent
CA3237201A1 (en)	2021-11-16	2023-05-25	Sotio Biotech Inc.	Treatment of myxoid/round cell liposarcoma patients
CN114813266B (zh) *	2022-03-15	2025-08-22	中国人民解放军海军军医大学第三附属医院	血液样本中gpc-3复合物的富集、检测方法及应用
CN121358779A (zh)	2023-06-16	2026-01-16	信立泰(成都)生物技术有限公司	一种抗gpc3抗体或抗原结合片段及其用途

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YU218175A (en) *	1974-09-12	1984-04-30	Schwartzhaupt Kg	Process for total or individual determination of lactate dehydrogenase isoenzyme
US5171850A (en) *	1988-08-31	1992-12-15	The Ontario Cancer Institute	Intestinal oncofetal gene
JP2946216B2 (ja)	1989-07-12	1999-09-06	武田薬品工業株式会社	新規ハイブリドーマ，モノクローナル抗体および用途
EP0477739A3 (en)	1990-09-27	1992-12-09	F. Hoffmann-La Roche Ag	Glycosyl-phosphatidylinositol-specific phospholipase d
AU2422999A (en)	1998-01-27	1999-08-09	Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw	New members of the glypican gene family
CA2346264A1 (en) *	1998-10-16	2000-04-27	Regents Of The University Of California	Glypicans for the detection and treatment of human carcinoma
US20040236080A1 (en) *	2001-06-22	2004-11-25	Hiroyuki Aburatani	Cell proliferation inhibitors containing anti-glypican 3 antibody

2003
- 2003-05-22 DE DE60326567T patent/DE60326567D1/de not_active Expired - Lifetime
- 2003-05-22 NZ NZ536521A patent/NZ536521A/en not_active IP Right Cessation
- 2003-05-22 ES ES03724724T patent/ES2324029T3/es not_active Expired - Lifetime
- 2003-05-22 BR BRPI0311233A patent/BRPI0311233B8/pt not_active IP Right Cessation
- 2003-05-22 IL IL16484803A patent/IL164848A0/xx not_active IP Right Cessation
- 2003-05-22 WO PCT/CA2003/000752 patent/WO2003100429A2/en not_active Ceased
- 2003-05-22 CA CA2482881A patent/CA2482881C/en not_active Expired - Lifetime
- 2003-05-22 CN CNB038107910A patent/CN100401068C/zh not_active Expired - Lifetime
- 2003-05-22 US US10/514,294 patent/US7883853B2/en not_active Expired - Lifetime
- 2003-05-22 MX MXPA04011132A patent/MXPA04011132A/es active IP Right Grant
- 2003-05-22 AU AU2003229191A patent/AU2003229191B2/en not_active Expired
- 2003-05-22 EP EP03724724A patent/EP1506406B1/en not_active Revoked
- 2003-05-22 AT AT03724724T patent/ATE425461T1/de not_active IP Right Cessation
- 2003-05-22 PT PT03724724T patent/PT1506406E/pt unknown
- 2003-05-22 RU RU2004136285/15A patent/RU2319969C2/ru active
- 2003-05-22 JP JP2004507835A patent/JP4455324B2/ja not_active Expired - Lifetime
2004
- 2004-12-14 ZA ZA2004/10077A patent/ZA200410077B/en unknown

Also Published As

Publication number	Publication date
CA2482881C (en)	2016-11-08
RU2004136285A (ru)	2005-10-10
JP2005526979A (ja)	2005-09-08
RU2319969C2 (ru)	2008-03-20
IL164848A0 (en)	2005-12-18
PT1506406E (pt)	2009-06-03
JP4455324B2 (ja)	2010-04-21
NZ536521A (en)	2006-04-28
EP1506406A2 (en)	2005-02-16
CN1653336A (zh)	2005-08-10
US7883853B2 (en)	2011-02-08
CN100401068C (zh)	2008-07-09
DE60326567D1 (de)	2009-04-23
AU2003229191A1 (en)	2003-12-12
ES2324029T3 (es)	2009-07-29
EP1506406B1 (en)	2009-03-11
AU2003229191B2 (en)	2009-07-30
MXPA04011132A (es)	2005-08-15
BRPI0311233B8 (pt)	2021-07-27
HK1074251A1 (en)	2005-11-04
BRPI0311233B1 (pt)	2019-08-13
US20050233392A1 (en)	2005-10-20
WO2003100429A3 (en)	2004-02-19
ZA200410077B (en)	2005-12-28
CA2482881A1 (en)	2003-12-04
ATE425461T1 (de)	2009-03-15
WO2003100429A2 (en)	2003-12-04

Publication	Publication Date	Title
BRPI0311233A2 (pt)	2016-06-28	diagnóstico de carcinoma hepatocelular
DE60325132D1 (de)	2009-01-22	Endoskopische Kapsel
EP1583997A4 (en)	2010-03-24	Photoresist DISTANCE
DE602004026245D1 (de)	2010-05-12	Endoskop
DE602004021746D1 (de)	2009-08-13	Endoskop
PL374898A1 (pl)	2005-11-14	Metoda ulepszonej diagnostyki dysplazji
EP1482307A4 (en)	2006-05-03	BIOSENSOR
DE602004001278D1 (de)	2006-08-03	Kochgerät
DE60304102D1 (de)	2006-05-11	Hautreinigungszusammensetzung
DE602004007867D1 (de)	2007-09-13	Kochgerät
EP1477118A4 (en)	2010-08-04	ULTRASOUND DEVICE
EP1500371A4 (en)	2011-07-27	ULTRASOUND DEVICE
EP1665987A4 (en)	2009-12-09	ULTRASOUND DEVICE
NO20045554L (no)	2004-12-20	Fremgangsmate for behandling av diabetes
FI5838U1 (fi)	2003-06-30	Kuori
DE60327130D1 (de)	2009-05-28	Entwicklungsgerät
EP1500370A4 (en)	2006-08-02	Ultrasonograph
DE50305758D1 (de)	2007-01-04	Mikroendoskop
DE60326190D1 (de)	2009-04-02	des Körpers
DE602004000627D1 (de)	2006-05-24	Hautreinigungsmittel
DE10347306B4 (de)	2005-10-20	Schirmanbindung
DE60303647D1 (de)	2006-04-27	Kochgerät
EP1683468A4 (en)	2010-06-23	Endoscope
DE60317022D1 (de)	2007-12-06	Biosensor
DE60314798D1 (de)	2007-08-23	Entwicklungsgerät

Legal Events

Date	Code	Title	Description
2021-07-27	B16C	Correction of notification of the grant [chapter 16.3 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 22/05/2003, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO
2024-03-19	B21F	Lapse acc. art. 78, item iv - on non-payment of the annual fees in time	Free format text: REFERENTE A 21A ANUIDADE.
2024-07-09	B24J	Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)	Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2776 DE 19-03-2024 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.