BR9916096A - Derivados de bacterioclorofila substituìdos compaládio e utilização dos mesmos - Google Patents
Derivados de bacterioclorofila substituìdos compaládio e utilização dos mesmosInfo
- Publication number
- BR9916096A BR9916096A BR9916096-0A BR9916096A BR9916096A BR 9916096 A BR9916096 A BR 9916096A BR 9916096 A BR9916096 A BR 9916096A BR 9916096 A BR9916096 A BR 9916096A
- Authority
- BR
- Brazil
- Prior art keywords
- palladium
- bacteriochlorophyll derivatives
- derivatives replaced
- choh
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Patente de Invenção: "DERIVADOS DE BACTERIOCLOROFILASUBSTITUìDOS COM PALáDIO E UTILIZAçãO DOS MESMOS".Derivados de bacterioclorofila substituídos por paládio de fórmula(I), em que A representa OH, OR~ 1~, -O-(CH~ 2~)~ n~-Y,-S-(CH~ 2~)1~Y, -NH-(CH~ 2~)~ n~-Y, -0(CH~ 2~)~ 2~-NH~ 2~,-O-(CH~ 2~)~ 2~-OH, -NH-(CH~ 2~)~ n~-^ +^N, o, X^ -^,-NH-(CH~ 2~)~ 2~-NH=BOC ou -N(CH~ 2~-CH=CH~ 2~)~ 2~; emque R~ 1~ representa Na^ +^, K^ +^ (Ca^ 2+^)~ 0,5~, (Mg^2+^)~ 0,5~, Li^ +^, NH~ 4~^ +^, +NH~ 3~-C(CH~ 2~OH)~ 3~,~NH~ 3~-CH~ 2~-(CHOH)~ 4~-CH~ 2~OH, +NH~ 2~(CH~3~)-CH~ 2~-(CHOH)~ 4~-CH~ 2~0H ou ^ +^N(C~ n'~,H~2n'+1~)~ 4~; R~ 2~ representa H, OH ou COOR~ 4~, em que R~4~ é C~ 1~-C~ 12~ alquila ou C~ 3~-C~ 12~ cicioalquila; R~ 3~representa H, OH ou C~ 1~-C~ 12~ alquila ou alcóxi; n é 1, 2, 3, 4,5 ou 6, Y é -NR'~ 1~,R'~ 2~ OU ^ +^NR'~ 1~R'~ 2~R'~ 3~, X^ -^em que R'~ 1~ R'~ 2~ e R'~ 3~ independentemente um do outrorepresentam -CH~ 3~ OU -C~ 2~H~ 5~; X é F, Cl, Br ou I, n' é 1,2, 3 ou 4 e suas formas oxidadas, são úteis no campo da terapiafotodinâmica (PDT).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98403110 | 1998-12-09 | ||
| PCT/IL1999/000673 WO2000033833A1 (en) | 1998-12-09 | 1999-12-09 | Palladium-substituted bacteriochlorophyll derivatives and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR9916096A true BR9916096A (pt) | 2001-11-13 |
| BR9916096B1 BR9916096B1 (pt) | 2013-11-19 |
| BRPI9916096B8 BRPI9916096B8 (pt) | 2021-05-25 |
Family
ID=8235584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9916096A BRPI9916096B8 (pt) | 1998-12-09 | 1999-12-09 | derivados de bacterioclorofila substituídos com paládio, processos para sua preparação, composição compreendendo esses derivados e seu uso. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6569846B1 (pt) |
| EP (1) | EP1137411B1 (pt) |
| JP (1) | JP4796227B2 (pt) |
| CN (1) | CN1160069C (pt) |
| AT (1) | ATE347554T1 (pt) |
| AU (1) | AU771292B2 (pt) |
| BR (1) | BRPI9916096B8 (pt) |
| CA (1) | CA2353554C (pt) |
| CY (1) | CY1106450T1 (pt) |
| DE (1) | DE69934328T2 (pt) |
| DK (1) | DK1137411T3 (pt) |
| ES (1) | ES2277454T3 (pt) |
| HK (1) | HK1040638B (pt) |
| HU (1) | HU228208B1 (pt) |
| IL (1) | IL143591A0 (pt) |
| NO (1) | NO331426B1 (pt) |
| NZ (1) | NZ512093A (pt) |
| PL (1) | PL201172B1 (pt) |
| PT (1) | PT1137411E (pt) |
| RU (1) | RU2234508C2 (pt) |
| SI (1) | SI1137411T1 (pt) |
| WO (1) | WO2000033833A1 (pt) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7897140B2 (en) * | 1999-12-23 | 2011-03-01 | Health Research, Inc. | Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents |
| WO2002013820A1 (en) * | 2000-08-11 | 2002-02-21 | Ceramoptec Industries, Inc. | Photosensitizing ointment |
| EP1277470A1 (fr) * | 2001-07-17 | 2003-01-22 | Steba Biotech N.V. | Formulation galénique injectable pour utilisation dans un diagnostic ou une thérapie photodynamique et son procédé de préparation |
| BR0304716A (pt) * | 2002-05-08 | 2004-07-13 | Yeda Res & Dev | Método para formação de imagens de mri-bold on line, sensibilizada |
| JP4529344B2 (ja) * | 2002-06-03 | 2010-08-25 | ニプロ株式会社 | 腫瘍組織の酸素濃度を上昇させるためのポルフィリン酸素輸液製剤 |
| AU2003248747A1 (en) | 2002-06-27 | 2004-01-19 | Health Research, Inc. | Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy |
| EP2036908A3 (en) * | 2002-07-02 | 2009-05-13 | Health Research, INC. | Efficient synthesis of pyropheophorbide a derivates |
| IL152900A0 (en) * | 2002-11-17 | 2003-06-24 | Yeda Res & Dev | Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses |
| ES2602460T3 (es) * | 2004-06-07 | 2017-02-21 | Yeda Research And Development Co., Ltd. | Derivados de bacterioclorofila catiónicos y usos de los mismos |
| US20060222592A1 (en) * | 2005-04-05 | 2006-10-05 | Clemens Burda | Nanoparticles and methods of manufacturing nanoparticles for electronic and non-electronic applications |
| EP2244787A1 (en) * | 2008-01-28 | 2010-11-03 | Yeda Research And Development Company Ltd. | Endoscopic imaging photodynamic therapy system and methods of use |
| DK2257309T3 (da) | 2008-02-27 | 2020-01-20 | Yeda Res And Development Company Ltd | Rgd-(bakterie)chlorophyl-konjugater til anvendelse ved diagnose af tumorer, der omfatter nekrotiske domæner |
| US20120034155A1 (en) * | 2010-08-03 | 2012-02-09 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Artificial cells |
| GB0819594D0 (en) | 2008-10-24 | 2008-12-03 | Univ Coimbrra | Process |
| EP2425873A1 (fr) | 2010-09-07 | 2012-03-07 | Steba Maor SA | Modélisation de l'action d'une fibre optique dans un traitement par therapie photodynamique, et assistance à la planification d'un tel traitement |
| CN103405769A (zh) * | 2013-03-07 | 2013-11-27 | 北京亿仁赛博医疗科技研发中心有限公司 | 光敏剂在制备治疗疾病的病毒灭活药物中的应用 |
| HUE053222T2 (hu) | 2013-03-11 | 2021-06-28 | Tookad Ip Sarl | Eljárás bakterioklorofill-a elõállítására |
| EP2976347B1 (en) | 2013-03-15 | 2022-01-19 | McFarland, Sherri Ann | Metal-based coordination complexes as photodynamic compounds and their use |
| CA3020067A1 (en) | 2016-04-10 | 2017-10-19 | Yeda Research And Development Co. Ltd. | Combinational therapies for treatment of cancer comprising a bacteriochlorophyll derivative |
| US10933134B2 (en) | 2017-03-16 | 2021-03-02 | Memorial Sloan Kettering Cancer Center | Combination therapies for treatment of cancer |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5002962A (en) * | 1988-07-20 | 1991-03-26 | Health Research, Inc. | Photosensitizing agents |
| US5171741A (en) * | 1989-04-21 | 1992-12-15 | Health Research, Inc. | Bacteriochlorophyll-a derivatives useful in photodynamic therapy |
| IL102645A (en) * | 1992-07-26 | 1998-02-22 | Yeda Res & Dev | Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them |
| IL116126A0 (en) * | 1995-11-24 | 1996-01-31 | Yeda Res & Dev | Process for the preparation of bacteriochlorophyllis some novel compounds of this type and pharmaceutical compositions comprising them |
-
1999
- 1999-12-09 EP EP99958470A patent/EP1137411B1/en not_active Expired - Lifetime
- 1999-12-09 AU AU15834/00A patent/AU771292B2/en not_active Expired
- 1999-12-09 SI SI9930949T patent/SI1137411T1/sl unknown
- 1999-12-09 JP JP2000586326A patent/JP4796227B2/ja not_active Expired - Lifetime
- 1999-12-09 HU HU0105411A patent/HU228208B1/hu unknown
- 1999-12-09 ES ES99958470T patent/ES2277454T3/es not_active Expired - Lifetime
- 1999-12-09 CN CNB99816058XA patent/CN1160069C/zh not_active Expired - Lifetime
- 1999-12-09 BR BRPI9916096A patent/BRPI9916096B8/pt not_active IP Right Cessation
- 1999-12-09 AT AT99958470T patent/ATE347554T1/de active
- 1999-12-09 RU RU2001118842/04A patent/RU2234508C2/ru active
- 1999-12-09 DE DE69934328T patent/DE69934328T2/de not_active Expired - Lifetime
- 1999-12-09 WO PCT/IL1999/000673 patent/WO2000033833A1/en active IP Right Grant
- 1999-12-09 NZ NZ512093A patent/NZ512093A/xx unknown
- 1999-12-09 PT PT99958470T patent/PT1137411E/pt unknown
- 1999-12-09 PL PL348201A patent/PL201172B1/pl unknown
- 1999-12-09 US US09/857,772 patent/US6569846B1/en not_active Expired - Lifetime
- 1999-12-09 CA CA2353554A patent/CA2353554C/en not_active Expired - Lifetime
- 1999-12-09 IL IL14359199A patent/IL143591A0/xx active IP Right Grant
- 1999-12-09 DK DK99958470T patent/DK1137411T3/da active
-
2001
- 2001-06-07 NO NO20012807A patent/NO331426B1/no not_active IP Right Cessation
-
2002
- 2002-03-28 HK HK02102403.5A patent/HK1040638B/zh unknown
-
2007
- 2007-02-15 CY CY20071100207T patent/CY1106450T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O E 13 DA LPI. |
|
| B12B | Appeal against refusal [chapter 12.2 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 19/11/2013, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 09/12/1999 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
|
| B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 09/12/2019 |