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BR9914883A - Processo para a racemização - Google Patents

Processo para a racemização

Info

Publication number
BR9914883A
BR9914883A BR9914883-8A BR9914883A BR9914883A BR 9914883 A BR9914883 A BR 9914883A BR 9914883 A BR9914883 A BR 9914883A BR 9914883 A BR9914883 A BR 9914883A
Authority
BR
Brazil
Prior art keywords
general formula
vii
compounds
racemization
racemization process
Prior art date
Application number
BR9914883-8A
Other languages
English (en)
Inventor
Maria Bakonyi
Tiborne Bai
Zsolt Dombrady
Katalin Gaspar
Attila Supic
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of BR9914883A publication Critical patent/BR9914883A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Processing Of Stones Or Stones Resemblance Materials (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Glass Compositions (AREA)

Abstract

''PROCESSO PARA A RACEMIZAçãO'' A invenção refere-se ao processo de racemização das [2-(2-tienil) etil amino] (2-halogenofenil) acetamidas óticamente ativas da fórmulas geral (VII) utilizando-se compostos básicos. Os compostos recêmicos resultantes da fórmula geral (VII) podem portanto ser reciclados em sínteses dos compostos terapêuticamente úteis da fórmula geral (VI).
BR9914883-8A 1998-11-09 1999-11-05 Processo para a racemização BR9914883A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9802586A HU226421B1 (en) 1998-11-09 1998-11-09 Process for racemizing optically active 2-(2-chlorophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides
PCT/HU1999/000076 WO2000027840A1 (en) 1998-11-09 1999-11-05 Process for racemization

Publications (1)

Publication Number Publication Date
BR9914883A true BR9914883A (pt) 2001-07-17

Family

ID=89997319

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9914883-8A BR9914883A (pt) 1998-11-09 1999-11-05 Processo para a racemização

Country Status (12)

Country Link
US (2) US6670486B1 (pt)
EP (1) EP1129087B1 (pt)
JP (1) JP4598276B2 (pt)
AT (1) ATE303377T1 (pt)
AU (1) AU1289600A (pt)
BR (1) BR9914883A (pt)
CA (1) CA2347853C (pt)
DE (1) DE69927044T2 (pt)
DK (1) DK1129087T3 (pt)
ES (1) ES2249038T3 (pt)
HU (1) HU226421B1 (pt)
WO (1) WO2000027840A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6767913B2 (en) 2001-12-18 2004-07-27 Teva Pharmaceutical Industries Ltd. Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
US7074928B2 (en) 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
HUP0200438A3 (en) * 2002-02-06 2003-10-28 Egis Gyogyszergyar Nyilvanosan Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them
IL166593A0 (en) 2002-08-02 2006-01-15 Racemization and enantiomer separation of clopidogrel
US6800759B2 (en) 2002-08-02 2004-10-05 Teva Pharmaceutical Industries Ltd. Racemization and enantiomer separation of clopidogrel
EP1606231A1 (en) * 2003-02-03 2005-12-21 Nadkarni, Sunil Sadanand Process for preparation of clopidogrel, its salts and pharmaceutical compositions
WO2004108665A2 (en) * 2003-04-24 2004-12-16 Sun Pharmaceutical Industries Limited A process for preparation of clopidogrel
TW200825093A (en) * 2006-08-03 2008-06-16 Teva Pharma Process for preparing clopidogrel bisulphate
FR2916441B1 (fr) * 2007-05-22 2009-08-28 Clariant Specialty Fine Chem Procede de racemisation d'alpha-aminoacetals optiquement actifs.
KR101722263B1 (ko) 2007-07-05 2017-03-31 애로우헤드 리서치 코오포레이션 바이러스 감염을 치료하기 위한 ｄｓＲＮＡ
FR2927900B1 (fr) * 2008-02-27 2010-09-17 Clariant Specialty Fine Chem Procede de preparation d'alpha-aminoacetals optiquement actifs.
US20110190502A1 (en) * 2008-10-24 2011-08-04 Sandoz Ag Process for the preparation of s-clopidogrel
CN110627808B (zh) * 2018-06-21 2022-04-01 江苏同禾药业有限公司 一种硫酸氢氯吡格雷拆分母液的回收处理工艺

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3632646A (en) * 1967-05-25 1972-01-04 Uniroyal Inc Succinamides
HU178455B (en) * 1979-07-17 1982-05-28 Chinoin Gyogyszer Es Vegyeszet Process for producing new 1-substituted-3-cycloalkyl-sulfonyl-pyrrolidine-2,5-dione derivatives
FR2530247B1 (fr) * 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
NL8501093A (nl) * 1985-04-12 1986-11-03 Stamicarbon Werkwijze voor het racemiseren van een optisch aktief n- benzylideenaminozuuramide.
JPS62252751A (ja) * 1986-04-25 1987-11-04 Nitto Chem Ind Co Ltd α−アミノ酸アミドのラセミ化法
JPH0780823B2 (ja) 1986-08-26 1995-08-30 東ソー株式会社 光学活性フェニルアラニンのラセミ化方法
FR2664596B1 (fr) * 1990-07-10 1994-06-10 Sanofi Sa Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.
HU225503B1 (en) 1997-05-13 2007-01-29 Sanofi Aventis Novel 2-(2-halophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides and process for producing them
HU222283B1 (hu) 1997-05-13 2003-05-28 Sanofi-Synthelabo Eljárás tieno[3,2-c]piridin-származékok előállítására
HU225504B1 (en) 1997-05-13 2007-01-29 Sanofi Aventis Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them

Also Published As

Publication number Publication date
EP1129087A1 (en) 2001-09-05
US7109356B2 (en) 2006-09-19
US6670486B1 (en) 2003-12-30
HUP9802586A2 (hu) 2001-04-28
ES2249038T3 (es) 2006-03-16
DE69927044D1 (de) 2005-10-06
HUP9802586A3 (en) 2001-05-28
JP2002529462A (ja) 2002-09-10
DE69927044T2 (de) 2006-06-22
ATE303377T1 (de) 2005-09-15
HU226421B1 (en) 2008-12-29
CA2347853A1 (en) 2000-05-18
AU1289600A (en) 2000-05-29
US20040106824A1 (en) 2004-06-03
EP1129087B1 (en) 2005-08-31
CA2347853C (en) 2009-08-18
WO2000027840A1 (en) 2000-05-18
JP4598276B2 (ja) 2010-12-15
HU9802586D0 (en) 1999-01-28
DK1129087T3 (da) 2006-01-16

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Legal Events

Date Code Title Description
B25G Requested change of headquarter approved
B25D Requested change of name of applicant approved

Owner name: SANOFI-AVENTIS (FR)

Free format text: ALTERADO DE: SANOFI-SYNTHELABO

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM OS ARTIGOS 8O E 13 DA LPI.

B15V Prolongation of time limit allowed

Free format text: RECONHECIDO O OBSTACULO ADMINISTRATIVO E DEVOLVIDO O PRAZO DE 46 DIAS, NOS TERMOS DO ARTIGO 221 PARAGRAFO 2O DA LPI E DA RESOLUCAO 116/04.

B12B Appeal against refusal [chapter 12.2 patent gazette]