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BR9912142A - 6-benzil-4-oxipirimidinas substituìdas, processopara sua preparação e composições contendo-as - Google Patents

6-benzil-4-oxipirimidinas substituìdas, processopara sua preparação e composições contendo-as

Info

Publication number
BR9912142A
BR9912142A BR9912142-5A BR9912142A BR9912142A BR 9912142 A BR9912142 A BR 9912142A BR 9912142 A BR9912142 A BR 9912142A BR 9912142 A BR9912142 A BR 9912142A
Authority
BR
Brazil
Prior art keywords
benzyl
substituted
treatment
oxypyrimidines
preparation
Prior art date
Application number
BR9912142-5A
Other languages
English (en)
Inventor
Paolo La Colla
Marino Artico
Original Assignee
Novirio Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novirio Pharmaceuticals Ltd filed Critical Novirio Pharmaceuticals Ltd
Publication of BR9912142A publication Critical patent/BR9912142A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

"6-BENZIL-4-OXIPIRIMIDINAS SUBSTITUìDAS, PROCESSOPARA SUA PREPARAçãO E COMPOSIçõES CONTENDO-AS".A invenção se refere a novas 6-benzil-4-oxopirimidinas substituídasde fórmula geral (A) . Esses compostos impedem a transcriptasereversa codificada pelo vírus da imunodeficiência humana (HIV) oupor sais dos mesmos aceitáveis em termos farmacêuticos, eencontram sua aplicação na prevenção e no tratamento deinfecções por HIV e no tratamento da síndrome daimunodeficiência adquirida resultante (AIDS). Composiçõesfarmacêuticas, que contêm os compostos, e um método de usodos presentes compostos e de outros agentes para o tratamentoda AIDS e de uma infecção viral por HIV também são divisados.
BR9912142-5A 1998-07-17 1999-07-19 6-benzil-4-oxipirimidinas substituìdas, processopara sua preparação e composições contendo-as BR9912142A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1998CA000015A IT1305313B1 (it) 1998-07-17 1998-07-17 3,4 - diidro- 6- benzil-4-oxopirimidine sostituite e relativo processodi produzione e impiego nella terapia delle infezioni da hiv-1.
PCT/EP1999/005134 WO2000003998A1 (en) 1998-07-17 1999-07-19 Substituted 6-benzyl-4-oxopyrimidines, process for their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
BR9912142A true BR9912142A (pt) 2001-10-30

Family

ID=11347180

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9912142-5A BR9912142A (pt) 1998-07-17 1999-07-19 6-benzil-4-oxipirimidinas substituìdas, processopara sua preparação e composições contendo-as

Country Status (10)

Country Link
US (2) US6635636B1 (pt)
EP (1) EP1098887A1 (pt)
KR (1) KR100578478B1 (pt)
CN (1) CN1309647A (pt)
AU (2) AU771209B2 (pt)
BR (1) BR9912142A (pt)
CA (1) CA2338014A1 (pt)
HK (1) HK1039122A1 (pt)
IT (1) IT1305313B1 (pt)
WO (1) WO2000003998A1 (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1305313B1 (it) * 1998-07-17 2001-05-04 Colla Paolo 3,4 - diidro- 6- benzil-4-oxopirimidine sostituite e relativo processodi produzione e impiego nella terapia delle infezioni da hiv-1.
US6136335A (en) 1998-12-31 2000-10-24 Hughes Institute Phenethyl-5-bromopyridylthiourea (PBT) and dihydroalkoxybenzyloxopyrimidine (DABO) derivatives exhibiting spermicidal activity
AU6111000A (en) * 1999-07-22 2001-02-13 Vertex Pharmaceuticals Incorporated Inhibitors of viral helcase
EP1343502A2 (en) 2000-11-17 2003-09-17 Idenix (Cayman) Limited Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines
MXPA05004504A (es) 2002-10-31 2005-08-16 Metabasis Therapeutics Inc Nuevos di-esteres de fosfato ciclicos de 1,3-propano-1-aril-dioles y su uso en la preparacion de profarmacos.
US7642277B2 (en) 2002-12-04 2010-01-05 Boehringer Ingelheim International Gmbh Non-nucleoside reverse transcriptase inhibitors
US20050014774A1 (en) * 2003-04-28 2005-01-20 Richard Storer Oxo-pyrimidine compounds
KR100803481B1 (ko) * 2004-07-27 2008-02-14 에프. 호프만-라 로슈 아게 비-뉴클레오사이드 역전사효소 억제제로서의벤질트라이아졸론 화합물
CA2574308C (en) * 2004-07-27 2014-03-25 F. Hoffmann-La Roche Ag Benzyltriazolone compounds as non-nucleoside reverse transcriptase inhibitors
US8293778B2 (en) 2004-07-27 2012-10-23 Roche Palo Alto Llc Heterocyclic antiviral compounds
ITRM20050512A1 (it) * 2005-10-13 2007-04-14 Univ Siena Derivati 6-pirimidinici e pirimidinonici, e loro uso.
CN101553483B (zh) 2006-12-13 2013-04-17 弗·哈夫曼-拉罗切有限公司 作为非核苷逆转录酶抑制剂的2-(哌啶-4-基)-4-苯氧基-或苯基氨基-嘧啶衍生物
CN100519540C (zh) * 2007-01-09 2009-07-29 云南大学 S-dabo类化合物、其合成方法和用途
JO3470B1 (ar) 2012-10-08 2020-07-05 Merck Sharp & Dohme مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv
CN106061984A (zh) 2014-02-13 2016-10-26 配体药物公司 前药化合物及其用途
AU2015241247B2 (en) 2014-04-01 2017-09-14 Merck Sharp & Dohme Llc Prodrugs of HIV reverse transcriptase inhibitors
EP3164136A4 (en) 2014-07-02 2018-04-04 Ligand Pharmaceuticals, Inc. Prodrug compounds and uses therof
JP2021509907A (ja) 2018-01-09 2021-04-08 リガンド・ファーマシューティカルズ・インコーポレイテッド アセタール化合物およびその治療的使用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3956302A (en) * 1974-05-24 1976-05-11 The Upjohn Company Substituted pyrimidines
GB9012592D0 (en) 1990-06-06 1990-07-25 Smithkline Beecham Intercredit Compounds
US5314917A (en) 1991-03-22 1994-05-24 E. B. Michaels Research Associates, Inc. Method for inactivating enveloped viruses and sperm
KR0151811B1 (ko) * 1993-12-21 1998-10-15 강박광 신규한 항바이러스성 2,4-피리미딘디온 유도체 및 그의 제조방법
KR100187475B1 (ko) * 1996-05-17 1999-05-01 이서봉 1-아릴-4-옥소 피롤로(3,2-c)퀴놀린 유도체의 제조방법
US5998411A (en) * 1998-03-17 1999-12-07 Hughes Institute Heterocyclic nonnucleoside inhibitors of reverse transcriptase
IT1305313B1 (it) 1998-07-17 2001-05-04 Colla Paolo 3,4 - diidro- 6- benzil-4-oxopirimidine sostituite e relativo processodi produzione e impiego nella terapia delle infezioni da hiv-1.
US6177437B1 (en) 1998-09-04 2001-01-23 University Of Massachusetts Medical Center Inhibitors of Herpes Simplex virus uracil-DNA glycosylase
US6136335A (en) 1998-12-31 2000-10-24 Hughes Institute Phenethyl-5-bromopyridylthiourea (PBT) and dihydroalkoxybenzyloxopyrimidine (DABO) derivatives exhibiting spermicidal activity
US6117904A (en) 1999-09-03 2000-09-12 Murphy; Donald M. Treatment of pruritus
EP1343502A2 (en) * 2000-11-17 2003-09-17 Idenix (Cayman) Limited Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines
DE60234760D1 (de) * 2001-04-11 2010-01-28 Idenix Cayman Ltd Phenylindole zur behandlung von hiv

Also Published As

Publication number Publication date
HK1039122A1 (zh) 2002-04-12
KR20010099594A (ko) 2001-11-09
WO2000003998A1 (en) 2000-01-27
US20040092539A1 (en) 2004-05-13
KR100578478B1 (ko) 2006-05-11
CN1309647A (zh) 2001-08-22
ITCA980015A1 (it) 2000-01-17
AU5284899A (en) 2000-02-07
IT1305313B1 (it) 2001-05-04
CA2338014A1 (en) 2000-01-27
US6635636B1 (en) 2003-10-21
AU771209B2 (en) 2004-03-18
EP1098887A1 (en) 2001-05-16
AU2004200446A1 (en) 2004-03-11

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: IDENIX PHARMACEUTICALS, INC (KY)

Free format text: ALTERADO DE: NOVIRIO PHARMACEUTICALS LIMITED

B25A Requested transfer of rights approved

Owner name: IDENIX (CAYMAN) LIMITED (KY)

Free format text: TRANSFERIDO DE: IDENIX PHARMACEUTICALS, INC.

B07A Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO DE ACORDO COM OS ARTIGOS 8O, 10 (INCISO VIII) E 25 DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.