BR9908466A - Process to modulate the immune response, in a mammal, to an antigen, implantable device to modulate an immune response to an antigen, and, processes to obtain immune cells from a mammal, for immunization of a mammal with an antigen, for the production of hybridomas producing human monoclonal antibodies against a pre-selected antigen, to transfect a mammal's immune cells with genetic material, and for the treatment or prophylaxis of a disease or condition caused by an immune response - Google Patents
Process to modulate the immune response, in a mammal, to an antigen, implantable device to modulate an immune response to an antigen, and, processes to obtain immune cells from a mammal, for immunization of a mammal with an antigen, for the production of hybridomas producing human monoclonal antibodies against a pre-selected antigen, to transfect a mammal's immune cells with genetic material, and for the treatment or prophylaxis of a disease or condition caused by an immune responseInfo
- Publication number
- BR9908466A BR9908466A BR9908466-0A BR9908466A BR9908466A BR 9908466 A BR9908466 A BR 9908466A BR 9908466 A BR9908466 A BR 9908466A BR 9908466 A BR9908466 A BR 9908466A
- Authority
- BR
- Brazil
- Prior art keywords
- antigen
- mammal
- immune response
- immune
- modulate
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
"PROCESSO PARA MODULAR A RESPOSTA IMUNE, EM UM MAMìFERO, A UM ANTìGENO, DISPOSITIVO IMPLANTáVEL PARA MODULAR UMA RESPOSTA IMUNE A UM ANTìGENO, E, PROCESSOS PARA OBTER CéLULAS IMUNES DE UM MAMìFERO, PARA IMUNIZAçãO DE UM MAMìFERO COM UM ANTìGENO, PARA A PRODUçãO DE HIBRIDOMAS PRODUZINDO ANTICORPOS MONOCLONAIS HUMANOS CONTRA UM ANTìGENO PRé-SELECIONADO, PARA TRANSFECTAR CéLULAS IMUNES DE UM MAMìFERO COM MATERIAL GENéTICO, E PARA O TRATAMENTO OU PROFILAXIA DE UMA DOENçA OU CONDIçãO CAUSADA POR UMA RESPOSTA IMUNE" A presente invenção proporciona processos e dispositivos para induzir, estimular, bloquear e reduzir a resposta imune de um mamífero a um antígeno, utilizando um dispositivo implantável que expõe o antígeno de uma maneira controlada a células do sistema imune. O dispositivo compreende uma matriz porosa contida dentro de um recipiente perfurado, impermeável. Através da manipulação da biodisponibilidade de antígeno dentro do dispositivo, e da temporização da introdução do antígeno no dispositivo relativamente ao tempo de implante do dispositivo dentro do mamífero, pode-se induzir uma resposta robusta e de longo prazo contra um antígeno, ou uma resposta imune existente ou potencial pode ser regulada descendentemente ou bloqueada. Os processos e dispositivos podem ser usados para vacinação terapêutica, e em mamíferos não-expostos para vacinação profilática. A imunidade pode ser celular, humoral ou mucosa. A supressão da resposta imune é útil para o tratamento ou a profilaxia de condições, como alergias, doença autoimune, e no desenvolvimento de tolerância em mamíferos para suprimir uma resposta imune a antigos de transplante. O dispositivo também pode ser usado para cultivar células imunes para reintrodução posterior no mamífero, e para preparar soro imune e hibridomas."PROCESS TO MODULATE THE IMMUNE RESPONSE, IN A MAMMALIAN, TO AN ANTIGEN, IMPLANTABLE DEVICE FOR MODULATING AN IMMUNE RESPONSE TO AN ANTIGEN, AND, PROCESSES TO OBTAIN IMMUNE CELLS FROM A MAMMALIAN, FOR IMMUNIZATION OF A MOMMOMOUSE FOR A MOMMOMOUSE FOR A MOMMOMOUSE FOR A MOMMUSICIAN. OF HIBRIDOMES PRODUCING HUMAN MONOCLONAL ANTIBODIES AGAINST A PRE-SELECTED ANTIGEN, FOR TRANSFECTING IMMUNE CELLS OF A MAMMALIAN WITH GENETIC MATERIAL, AND FOR THE TREATMENT OR PROPHYLAXIS OF A DISEASE OR CONDITION AND PROVISION OF PROCESSES CAUSED BY A PROVISION CAUSED BY A PROCESS RESULTED BY A , stimulate, block and reduce a mammal's immune response to an antigen, using an implantable device that exposes the antigen in a controlled manner to cells of the immune system. The device comprises a porous matrix contained within a perforated, impermeable container. By manipulating the antigen bioavailability within the device, and by timing the introduction of the antigen into the device relative to the implantation time of the device into the mammal, a robust and long-term response against an antigen, or an immune response, can be induced. existing or potential can be downwardly regulated or blocked. The processes and devices can be used for therapeutic vaccination, and in non-exposed mammals for prophylactic vaccination. Immunity can be cellular, humoral or mucous. Suppression of the immune response is useful for the treatment or prophylaxis of conditions, such as allergies, autoimmune disease, and in developing tolerance in mammals to suppress an immune response to transplant recipients. The device can also be used to grow immune cells for further reintroduction in the mammal, and to prepare immune serum and hybridomas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3340298A | 1998-03-02 | 1998-03-02 | |
| PCT/US1999/004637 WO1999044583A2 (en) | 1998-03-02 | 1999-03-02 | Methods and devices for modulating the immune response |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9908466A true BR9908466A (en) | 2000-12-05 |
Family
ID=21870212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9908466-0A BR9908466A (en) | 1998-03-02 | 1999-03-02 | Process to modulate the immune response, in a mammal, to an antigen, implantable device to modulate an immune response to an antigen, and, processes to obtain immune cells from a mammal, for immunization of a mammal with an antigen, for the production of hybridomas producing human monoclonal antibodies against a pre-selected antigen, to transfect a mammal's immune cells with genetic material, and for the treatment or prophylaxis of a disease or condition caused by an immune response |
Country Status (4)
| Country | Link |
|---|---|
| BR (1) | BR9908466A (en) |
| CA (1) | CA2322435A1 (en) |
| IL (1) | IL138207A0 (en) |
| WO (1) | WO1999044583A2 (en) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| US6958158B2 (en) * | 2001-05-11 | 2005-10-25 | Ortho-Mcneil Pharmaceutical, Inc. | Immune modulation device for use in animals |
| US20030118630A1 (en) * | 2001-12-07 | 2003-06-26 | Anthony Cerami | Immune modulation device for use in animals |
| WO2003092646A1 (en) * | 2002-05-03 | 2003-11-13 | Children's Hospital Medical Center | Simulated vernix compositions for skin cleansing and other applications |
| WO2004075855A2 (en) | 2003-02-26 | 2004-09-10 | Biomed Solutions, Llc | Process for in vivo treatment of specific biological targets in bodily fluid |
| AU2006326405B2 (en) | 2005-12-13 | 2013-10-31 | President And Fellows Of Harvard College | Scaffolds for cell transplantation |
| CA2715460C (en) | 2008-02-13 | 2020-02-18 | President And Fellows Of Harvard College | Continuous cell programming devices |
| KR102157971B1 (en) | 2010-10-06 | 2020-09-18 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | Injectable, pore-forming hydrogels for materials-based cell therapies |
| EP2596802A1 (en) * | 2011-11-23 | 2013-05-29 | PLS-Design GmbH | Pharmaceutical composition for treatment of allergic reactions |
| EP3662896B1 (en) | 2012-04-16 | 2024-02-28 | President and Fellows of Harvard College | Mesoporous silica compositions for modulating immune responses |
| EP3137105A4 (en) | 2014-04-30 | 2017-12-27 | President and Fellows of Harvard College | Combination vaccine devices and methods of killing cancer cells |
| CA3012602A1 (en) | 2015-01-30 | 2016-08-04 | President And Fellows Of Harvard College | Peritumoral and intratumoral materials for cancer therapy |
| US11150242B2 (en) | 2015-04-10 | 2021-10-19 | President And Fellows Of Harvard College | Immune cell trapping devices and methods for making and using the same |
| CN115531609A (en) | 2016-02-06 | 2022-12-30 | 哈佛学院校长同事会 | Remodeling hematopoietic niches to reconstitute immunity |
| US11555177B2 (en) | 2016-07-13 | 2023-01-17 | President And Fellows Of Harvard College | Antigen-presenting cell-mimetic scaffolds and methods for making and using the same |
| WO2020061129A1 (en) | 2018-09-19 | 2020-03-26 | President And Fellows Of Harvard College | Compositions and methods for labeling and modulation of cells in vitro and in vivo |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4919929A (en) * | 1984-02-01 | 1990-04-24 | Stolle Research & Development Corporation | Mammal immunization |
| US4732155A (en) * | 1985-08-27 | 1988-03-22 | The Children's Medical Center Corporation | Implantable chemoattractant system |
| EP0300102B1 (en) * | 1987-07-21 | 1993-03-24 | The Stolle Research And Development Corporation | Improved method of obtaining immune regulatory factors by mammal immunization |
| WO1993017662A1 (en) * | 1992-03-02 | 1993-09-16 | Daratech Pty. Ltd. | Improved implants |
-
1999
- 1999-03-02 BR BR9908466-0A patent/BR9908466A/en not_active IP Right Cessation
- 1999-03-02 CA CA002322435A patent/CA2322435A1/en not_active Abandoned
- 1999-03-02 IL IL138207??A patent/IL138207A0/en unknown
- 1999-03-02 WO PCT/US1999/004637 patent/WO1999044583A2/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999044583A2 (en) | 1999-09-10 |
| WO1999044583A3 (en) | 1999-11-11 |
| CA2322435A1 (en) | 1999-09-10 |
| IL138207A0 (en) | 2001-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTA A 5O, 6O, 7O E 8O ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007. |