BR9714774A - Soluble paclitaxel prodrugs - Google Patents
Soluble paclitaxel prodrugsInfo
- Publication number
- BR9714774A BR9714774A BR9714774-5A BR9714774A BR9714774A BR 9714774 A BR9714774 A BR 9714774A BR 9714774 A BR9714774 A BR 9714774A BR 9714774 A BR9714774 A BR 9714774A
- Authority
- BR
- Brazil
- Prior art keywords
- paclitaxel
- onium salts
- methods
- new
- prodrugs
- Prior art date
Links
- 229930012538 Paclitaxel Natural products 0.000 title abstract 6
- 229960001592 paclitaxel Drugs 0.000 title abstract 6
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title abstract 6
- 229940002612 prodrug Drugs 0.000 title abstract 3
- 239000000651 prodrug Substances 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Patente de Invenção: <B>"PRó-DROGAS SOLúVEIS DE PACLITAXEL"<D>. Novos sais de 2'-ónio de paclitaxel atuam como pró-drogas em pacientes mamíferos para produzir paclitaxel in vivo. Os métodos de sintetizar estes sais de ónio são divulgados, como são os métodos de tratar pacientes sofrendo de doenças sensíveis ao paclitaxel, por administração de quantidades efetivas dos sais de ónio, e as composições farmacêuticas contendo os novos sais, as quais são adequadas para a administração a pacientes que necessitem de terapia com paclitaxel.Invention Patent: <B> "PACLITAXEL SOLUBLE PRO-DRUGS" <D>. New 2'-onium salts of paclitaxel act as prodrugs in mammalian patients to produce paclitaxel in vivo. Methods of synthesizing these onium salts are disclosed, as are the methods of treating patients suffering from paclitaxel-sensitive diseases, by administering effective amounts of the onium salts, and the pharmaceutical compositions containing the new salts, which are suitable for administration to patients requiring paclitaxel therapy.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR9714774-5A BR9714774A (en) | 1997-06-20 | 1997-06-20 | Soluble paclitaxel prodrugs |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR9714774-5A BR9714774A (en) | 1997-06-20 | 1997-06-20 | Soluble paclitaxel prodrugs |
| PCT/US1997/010746 WO1998058927A1 (en) | 1997-06-20 | 1997-06-20 | Soluble prodrugs of paclitaxel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9714774A true BR9714774A (en) | 2000-07-25 |
Family
ID=25664977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9714774-5A BR9714774A (en) | 1997-06-20 | 1997-06-20 | Soluble paclitaxel prodrugs |
Country Status (1)
| Country | Link |
|---|---|
| BR (1) | BR9714774A (en) |
-
1997
- 1997-06-20 BR BR9714774-5A patent/BR9714774A/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: dismissal - article 86 of industrial property law |
Free format text: REFERENTE A 6A,7A E 8A ANUIDADES. |
|
| B08K | Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87) |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1836 DE 14/03/2006. |