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BR9713565A - Pirazóis parasiticidas. - Google Patents

Pirazóis parasiticidas.

Info

Publication number
BR9713565A
BR9713565A BR9713565-8A BR9713565A BR9713565A BR 9713565 A BR9713565 A BR 9713565A BR 9713565 A BR9713565 A BR 9713565A BR 9713565 A BR9713565 A BR 9713565A
Authority
BR
Brazil
Prior art keywords
alkyl
hydrogen
cycloalkyl group
halogens
veterinary
Prior art date
Application number
BR9713565-8A
Other languages
English (en)
Inventor
Bernard Joseph Banks
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9625290.3A external-priority patent/GB9625290D0/en
Priority claimed from GBGB9702235.4A external-priority patent/GB9702235D0/en
Priority claimed from GBGB9712045.5A external-priority patent/GB9712045D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of BR9713565A publication Critical patent/BR9713565A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/561,2-Diazoles; Hydrogenated 1,2-diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/14Ectoparasiticides, e.g. scabicides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18One oxygen or sulfur atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Patente de Invenção:<B>"PIRAZóIS PARASITICIDAS"<D>. Compostos de fórmula (I): ou seu sais aceitáveis para uso farmacêutico, veterinário ou em agricultura, ou um solvato (incluindo hidrato) aceitável para uso farmacêutico, veterinário ou em agricultura de qualquer um dos anteriores, em que R^ 1^ é fenila 2,4,6-trisubstituído ou piridin-2-ila 3,5-dissubstituído; R^ 3^ é alquila C~ 1~ a C~ 4~ substituído opcinalmente com hidróxila ou com um ou mais halogênios; ciano, alcanoíla C~ 1~ a C~ 5~ ou fenila; R^ 5^ é hidrogênio, alquila C~ 1~ a C~ 4~, amino ou halogéneo; R^ 2^ e R^ 4^ são cada um deles selecionados independentemente de entre hidrogênio, alquila, C~ 1~ a C~ 4~, fluor, cloro, e bromo ou, em conjunto com o átomo de carbono a que se encontram ligados, formam um grupo cicloalquila C~ 3~ a C~ 6~; R^ 6^ e R^ 8^ são cada um deles selecionados independentemente de entre hidrogênio, alquila C~ 1~ a C~ 4~, fluor, cloro, e bromo; ou quando R^ 2^ e R^ 4^ não fazem parte de um grupo cicloalquila, R^ 2^ e R^ 6^, em conjunto com os átomos de carbono a que se encontram ligados, podem formar um grupo cicloalquila C~ 5~ a C~ 7~ é hidrogênio, alquila C~ 1~ a C~ 4~ substituído com um ou mais halogênios, ou alcoxila C~ 1~ a C~ 4~; todos são agentes parasiticidas.
BR9713565-8A 1996-12-05 1997-11-25 Pirazóis parasiticidas. BR9713565A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9625290.3A GB9625290D0 (en) 1996-12-05 1996-12-05 Parasiticidal agents
GBGB9702235.4A GB9702235D0 (en) 1997-02-04 1997-02-04 Parasiticidal agents
GBGB9712045.5A GB9712045D0 (en) 1997-06-10 1997-06-10 Parasiticidal agents
PCT/EP1997/006697 WO1998024767A1 (en) 1996-12-05 1997-11-25 Parasiticidal pyrazoles

Publications (1)

Publication Number Publication Date
BR9713565A true BR9713565A (pt) 2000-03-14

Family

ID=27268619

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9713565-8A BR9713565A (pt) 1996-12-05 1997-11-25 Pirazóis parasiticidas.

Country Status (40)

Country Link
US (2) US6075043A (pt)
EP (1) EP0946515B1 (pt)
JP (2) JP3950483B2 (pt)
KR (1) KR100354311B1 (pt)
CN (1) CN1106386C (pt)
AR (1) AR013879A1 (pt)
AT (1) ATE233736T1 (pt)
AU (1) AU720705B2 (pt)
BG (1) BG64127B1 (pt)
BR (1) BR9713565A (pt)
CA (1) CA2273951C (pt)
CO (1) CO5031251A1 (pt)
CZ (1) CZ295295B6 (pt)
DE (1) DE69719547T2 (pt)
DK (1) DK0946515T3 (pt)
DZ (1) DZ2360A1 (pt)
EA (1) EA002278B1 (pt)
ES (1) ES2191870T3 (pt)
HK (1) HK1029111A1 (pt)
HR (1) HRP970663B1 (pt)
HU (1) HUP0000544A3 (pt)
ID (1) ID21556A (pt)
IL (1) IL129866A (pt)
IS (1) IS1982B (pt)
MA (1) MA24414A1 (pt)
MY (1) MY117021A (pt)
NO (2) NO992736D0 (pt)
NZ (1) NZ335611A (pt)
OA (1) OA11055A (pt)
PA (1) PA8442101A1 (pt)
PE (1) PE20199A1 (pt)
PL (1) PL190926B1 (pt)
PT (1) PT946515E (pt)
RS (1) RS49720B (pt)
SK (1) SK285203B6 (pt)
TN (1) TNSN97197A1 (pt)
TW (1) TW524667B (pt)
UA (1) UA60321C2 (pt)
UY (2) UY24798A1 (pt)
WO (1) WO1998024767A1 (pt)

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JP5997779B2 (ja) 2012-02-03 2016-09-28 ゾエティス・サービシーズ・エルエルシー 抗寄生虫薬としてのジヒドロフランアゼチジン誘導体
JO3626B1 (ar) 2012-02-23 2020-08-27 Merial Inc تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها
BR112014027805A2 (pt) 2012-05-09 2017-06-27 Zoetis Llc derivados de azetidina como agentes antiparasitários
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Also Published As

Publication number Publication date
HRP970663B1 (en) 2003-10-31
WO1998024767A1 (en) 1998-06-11
KR100354311B1 (ko) 2002-09-28
CN1258282A (zh) 2000-06-28
PL190926B1 (pl) 2006-02-28
JP2000505812A (ja) 2000-05-16
NO992732D0 (no) 1999-06-04
DE69719547D1 (de) 2003-04-10
HK1029111A1 (en) 2001-03-23
YU25299A (sh) 2002-10-18
NZ335611A (en) 2001-01-26
DK0946515T3 (da) 2003-07-14
BG103454A (en) 2000-01-31
SK285203B6 (sk) 2006-08-03
MY117021A (en) 2004-04-30
PL333922A1 (en) 2000-01-31
DE69719547T2 (de) 2003-10-02
BG64127B1 (bg) 2004-01-30
CZ295295B6 (cs) 2005-06-15
TW524667B (en) 2003-03-21
JP2007211016A (ja) 2007-08-23
IS5050A (is) 1999-05-11
KR20000057432A (ko) 2000-09-15
US6268509B1 (en) 2001-07-31
RS49720B (sr) 2007-12-31
DZ2360A1 (fr) 2002-12-28
HRP970663A2 (en) 1998-10-31
PE20199A1 (es) 1999-03-05
NO992736D0 (no) 1999-06-04
NO992732L (no) 1999-08-05
NO313518B1 (no) 2002-10-14
ATE233736T1 (de) 2003-03-15
PT946515E (pt) 2003-06-30
CN1106386C (zh) 2003-04-23
AR013879A1 (es) 2001-01-31
EA002278B1 (ru) 2002-02-28
IL129866A (en) 2004-05-12
SK74099A3 (en) 2001-02-12
AU5485998A (en) 1998-06-29
CZ195199A3 (cs) 2000-08-16
PA8442101A1 (es) 2000-05-24
IL129866A0 (en) 2000-02-29
CA2273951C (en) 2003-04-01
UA60321C2 (uk) 2003-10-15
UY24923A1 (es) 1998-09-01
CA2273951A1 (en) 1998-06-11
AU720705B2 (en) 2000-06-08
OA11055A (en) 2002-03-07
HUP0000544A3 (en) 2002-01-28
US6075043A (en) 2000-06-13
EP0946515A1 (en) 1999-10-06
TNSN97197A1 (fr) 2005-03-15
UY24798A1 (es) 2000-09-29
EA199900447A1 (ru) 2000-02-28
HUP0000544A2 (hu) 2000-06-28
MA24414A1 (fr) 1998-07-01
CO5031251A1 (es) 2001-04-27
EP0946515B1 (en) 2003-03-05
IS1982B (is) 2005-01-14
JP3950483B2 (ja) 2007-08-01
ID21556A (id) 1999-06-24
ES2191870T3 (es) 2003-09-16

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