BR9712530A - Interleukin-1beta converting enzyme asparate ester inhibitors - Google Patents
Interleukin-1beta converting enzyme asparate ester inhibitorsInfo
- Publication number
- BR9712530A BR9712530A BR9712530-0A BR9712530A BR9712530A BR 9712530 A BR9712530 A BR 9712530A BR 9712530 A BR9712530 A BR 9712530A BR 9712530 A BR9712530 A BR 9712530A
- Authority
- BR
- Brazil
- Prior art keywords
- interleukin
- converting enzyme
- asparate
- inhibitors
- 1beta
- Prior art date
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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- C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
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- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
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Abstract
Patente de Invenção:<B>"INIBIDORES DE éSTERES DE ASPARATO DE ENZIMA DE CONVERSãO DE INTERLEUCINA-1BETA"<D>. A presente invenção se refere a compostos que são inibidores de enzima de conversão de interleucina-1<225> que possuem a fórmula (I). Esta invenção também se refere a um processo de tratamento de acidente vascular cerebral, doenças inflamatórias, lesão de reperfusão, doença de Alzheimer e shigelose, e a uma composição farmaceuticamente aceitável que contém um composto que é um inibidor de enzima de conversão de interleucina-1<225>.Invention Patent: <B> "INTERLEUCIN-1BETA CONVERSION ENZYME ASPARATE ESTERATE INHIBITORS" <D>. The present invention relates to compounds that are interleukin-1 <225> converting enzyme inhibitors having the formula (I). This invention also relates to a process for treating stroke, inflammatory diseases, reperfusion injury, Alzheimer's disease and shigellosis, and to a pharmaceutically acceptable composition that contains a compound that is an interleukin-1 converting enzyme inhibitor <225>.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2832296P | 1996-10-11 | 1996-10-11 | |
PCT/US1997/018514 WO1998016502A1 (en) | 1996-10-11 | 1997-10-09 | ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9712530A true BR9712530A (en) | 1999-10-19 |
Family
ID=21842807
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9712530-0A BR9712530A (en) | 1996-10-11 | 1997-10-09 | Interleukin-1beta converting enzyme asparate ester inhibitors |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0932598A1 (en) |
JP (1) | JP2001506974A (en) |
KR (1) | KR20000049048A (en) |
AU (1) | AU738341B2 (en) |
BR (1) | BR9712530A (en) |
CA (1) | CA2268098A1 (en) |
IL (1) | IL129091A0 (en) |
NO (1) | NO991677L (en) |
WO (1) | WO1998016502A1 (en) |
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DE60035037T2 (en) * | 1999-04-09 | 2008-01-31 | Cytovia, Inc., San Diego | CASPASE INHIBITORS AND ITS USE |
US6723711B2 (en) | 1999-05-07 | 2004-04-20 | Texas Biotechnology Corporation | Propanoic acid derivatives that inhibit the binding of integrins to their receptors |
ES2228527T5 (en) * | 1999-05-07 | 2013-05-23 | Encysive Pharmaceuticals, Inc. | Derivatives of propanoic acid that inhibit the binding of integrins to their receptors |
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AU2001275279B2 (en) * | 2000-06-07 | 2007-01-04 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
US6355666B1 (en) | 2000-06-23 | 2002-03-12 | Medinox, Inc. | Protected forms of pharmacologically active agents and uses therefor |
WO2002020465A2 (en) * | 2000-09-08 | 2002-03-14 | Merck Frosst Canada & Co. | Gamma-ketoacid dipeptides as inhibitors of caspase-3 |
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PE20050159A1 (en) * | 2003-05-27 | 2005-04-19 | Vertex Pharma | DERIVATIVES OF 3- [2- (3-AMINO-2-OXO-2H-PYRIDIN-1-IL) -ACETILAMINO] -4-OXO-PENTANOICO AS CASPASE INHIBITORS |
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Publication number | Priority date | Publication date | Assignee | Title |
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EP0618223A3 (en) * | 1993-03-08 | 1996-06-12 | Sandoz Ltd | Peptides inhibiting interleukin 1-bêta release useful as antiinflammatory agents. |
CA2122227A1 (en) * | 1993-04-29 | 1994-10-30 | Roland E. Dolle | Peptide analogs as irreversible interleukin-1.beta. protease inhibitors |
-
1997
- 1997-10-09 BR BR9712530-0A patent/BR9712530A/en not_active IP Right Cessation
- 1997-10-09 JP JP51851998A patent/JP2001506974A/en not_active Ceased
- 1997-10-09 KR KR1019990703117A patent/KR20000049048A/en not_active Application Discontinuation
- 1997-10-09 IL IL12909197A patent/IL129091A0/en unknown
- 1997-10-09 CA CA002268098A patent/CA2268098A1/en not_active Abandoned
- 1997-10-09 AU AU49023/97A patent/AU738341B2/en not_active Ceased
- 1997-10-09 EP EP97911715A patent/EP0932598A1/en not_active Withdrawn
- 1997-10-09 WO PCT/US1997/018514 patent/WO1998016502A1/en not_active Application Discontinuation
-
1999
- 1999-04-09 NO NO991677A patent/NO991677L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2001506974A (en) | 2001-05-29 |
CA2268098A1 (en) | 1998-04-23 |
AU4902397A (en) | 1998-05-11 |
WO1998016502A1 (en) | 1998-04-23 |
IL129091A0 (en) | 2000-02-17 |
AU738341B2 (en) | 2001-09-13 |
NO991677L (en) | 1999-06-09 |
EP0932598A1 (en) | 1999-08-04 |
NO991677D0 (en) | 1999-04-09 |
KR20000049048A (en) | 2000-07-25 |
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