BR9612801A - Pharmaceutical dosage form with multiple coatings of enteric polymers for colonic supply. - Google Patents
Pharmaceutical dosage form with multiple coatings of enteric polymers for colonic supply.Info
- Publication number
- BR9612801A BR9612801A BR9612801-1A BR9612801A BR9612801A BR 9612801 A BR9612801 A BR 9612801A BR 9612801 A BR9612801 A BR 9612801A BR 9612801 A BR9612801 A BR 9612801A
- Authority
- BR
- Brazil
- Prior art keywords
- dosage form
- coating layer
- colon
- enteric polymer
- dissolve
- Prior art date
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- Medicinal Preparation (AREA)
Abstract
Patente de Invenção: <B>"FORMA DE DOSAGEM FARMACêUTICA COM MúLTIPLOS REVESTIMENTOS DE POLìMEROS ENTéRICOS PARA O FORNECIMENTO COLÈNICO"<D>. A presente invenção se refere a uma composição farmacêutica em uma forma de dosagem unitária para a administração peroral em um ser humano ou animal inferior, tendo um trato gastrointestinal compreendendo um intestino delgado e um cólon com um lúmen através do mesmo tendo uma entrada para o cólon a partir do intestino delgado, compreendendo: a. uma quantidade eficaz e segura de um agente terapeuticamente ativo incorporado na ou revestido sobre a superfície de uma forma de dosagem selecionada do grupo que comnsiste de um substrato esférico, um substrato elíptico, uma cápsula dura ou um comprimido comprimido, com um diâmetro máximo de cerca de 3 mm a cerca de 10 mm; e b. um material de revestimento de polímero entérico comprenendendo pelo menos uma camada de revestimento interna e uma camadaa de revestimento externa; em que a forma de dosagem tem uma superfície regular livre de arestas ou curvas acetuadas; o substrato elíptico e a cápsula dura têm uma razão dos diâmetros longos para diâmetros curtos de não mais do que cerca de 1,5; o agente terapeuticamente ativo é liberado em um ponto próximo da entrada do, ou dentro do cólon; cada (uma das) camada(s) de revestimento interno é (são) um polímero entérico que começa a se dissolver em meios aquosos em um pH entre cerca de 5 a cerca de 6,3; e a camada de revestimento externa é um polímero entérico que começa a se dissolver em meios aquosos em um pH entre cerca de 6,8 a cerca de 7,2.Invention Patent: <B> "PHARMACEUTICAL DOSAGE FORM WITH MULTIPLE ENTERETIC POLYMER COATINGS FOR COLLECTIVE SUPPLY" <D>. The present invention relates to a pharmaceutical composition in a unit dosage form for peroral administration in a human or lower animal, having a gastrointestinal tract comprising a small intestine and a colon with a lumen through it having an entrance to the colon. from the small intestine, comprising: a. an effective and safe amount of a therapeutically active agent incorporated into or coated on the surface of a dosage form selected from the group consisting of a spherical substrate, an elliptical substrate, a hard capsule or a compressed tablet, with a maximum diameter of about from 3 mm to about 10 mm; and b. an enteric polymer coating material comprising at least one inner coating layer and an outer coating layer; wherein the dosage form has a regular surface free of sharp edges or curves; the elliptical substrate and the hard capsule have a ratio of long diameters to short diameters of no more than about 1.5; the therapeutically active agent is released at a point near the entrance to, or into the colon; each (one) of the inner coating layer (s) is (are) an enteric polymer that begins to dissolve in aqueous media at a pH between about 5 to about 6.3; and the outer coating layer is an enteric polymer that begins to dissolve in aqueous media at a pH between about 6.8 to about 7.2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR9612801-1A BR9612801A (en) | 1996-11-15 | 1996-11-15 | Pharmaceutical dosage form with multiple coatings of enteric polymers for colonic supply. |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1996/018258 WO1998022096A1 (en) | 1996-11-15 | 1996-11-15 | Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery |
| BR9612801-1A BR9612801A (en) | 1996-11-15 | 1996-11-15 | Pharmaceutical dosage form with multiple coatings of enteric polymers for colonic supply. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9612801A true BR9612801A (en) | 2000-03-28 |
Family
ID=25664824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9612801-1A BR9612801A (en) | 1996-11-15 | 1996-11-15 | Pharmaceutical dosage form with multiple coatings of enteric polymers for colonic supply. |
Country Status (1)
| Country | Link |
|---|---|
| BR (1) | BR9612801A (en) |
-
1996
- 1996-11-15 BR BR9612801-1A patent/BR9612801A/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Free format text: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A,8A,9A E 9A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1886 DE 27/02/2007. |