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BR9612064A - Process for preparing 9,11-beta-epoxide steroids - Google Patents

Process for preparing 9,11-beta-epoxide steroids

Info

Publication number
BR9612064A
BR9612064A BR9612064A BR9612064A BR9612064A BR 9612064 A BR9612064 A BR 9612064A BR 9612064 A BR9612064 A BR 9612064A BR 9612064 A BR9612064 A BR 9612064A BR 9612064 A BR9612064 A BR 9612064A
Authority
BR
Brazil
Prior art keywords
beta
preparing
epoxide steroids
steroids
epoxide
Prior art date
Application number
BR9612064A
Other languages
Portuguese (pt)
Inventor
Xiaoyong Fu
Tiruvettipuram K Thiruvengadam
Chou-Hong Tann
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of BR9612064A publication Critical patent/BR9612064A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
BR9612064A 1995-12-20 1996-12-18 Process for preparing 9,11-beta-epoxide steroids BR9612064A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57556295A 1995-12-20 1995-12-20
PCT/US1996/019600 WO1997022616A1 (en) 1995-12-20 1996-12-18 PROCESS FOR PREPARATION OF 9,11β-EPOXIDE STEROIDS

Publications (1)

Publication Number Publication Date
BR9612064A true BR9612064A (en) 1999-02-23

Family

ID=24300812

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9612064A BR9612064A (en) 1995-12-20 1996-12-18 Process for preparing 9,11-beta-epoxide steroids

Country Status (12)

Country Link
EP (1) EP0873352A1 (en)
JP (1) JP2000502102A (en)
KR (1) KR20000064495A (en)
CN (1) CN1209138A (en)
AU (1) AU1331097A (en)
BR (1) BR9612064A (en)
CZ (1) CZ191398A3 (en)
IL (1) IL125004A0 (en)
MX (1) MX9804957A (en)
NO (1) NO982877L (en)
PL (1) PL327141A1 (en)
WO (1) WO1997022616A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2805720B1 (en) 2008-05-28 2019-08-07 ReveraGen BioPharma, Inc. Non-hormonal steroid modulators of NF-KB for treatment of disease
EP2556083A4 (en) 2010-04-05 2013-12-04 Validus Biopharma Inc Non-hormonal steroid modulators of nf- kappa b for treatment of disease
CN103588853A (en) * 2013-11-28 2014-02-19 浙江省天台县奥锐特药业有限公司 Method for preparing 9,11beta-epoxy steroid compound
WO2017004205A1 (en) 2015-06-29 2017-01-05 Reveragen Biopharma, Inc. NON-HORMONAL STEROID MODULATORS OF NF-κB FOR TREATMENT OF DISEASE
CN107266519B (en) * 2016-04-08 2021-06-29 天津金耀集团有限公司 Novel crystal form of 9 beta, 11 beta-epoxy-17 alpha-hydroxy-16 alpha-methyl-21-chloro-1, 4 pregnadiene-3, 20-diketone and preparation method thereof
CN109180767A (en) * 2018-09-04 2019-01-11 浙江仙琚制药股份有限公司 A method of preparing momestasone furoate
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1145170B (en) * 1959-03-13 1963-03-14 Scherico Ltd Process for the preparation of 9,11-oxidosteroids of the androstane and pregnane series
GB1244604A (en) * 1967-08-25 1971-09-02 Organon Labor Ltd Substituted methylene steroids and their preparation
GB1416427A (en) * 1972-01-12 1975-12-03 Akzo Nv Alkylated pregnanes and process for obtaining same
DE2617655C2 (en) * 1976-04-21 1984-11-08 F. Hoffmann-La Roche & Co Ag, Basel Corticoids, processes for their production and pharmaceutical preparations containing them
DE3064460D1 (en) * 1979-01-24 1983-09-08 Akzo Nv Novel alkylated pregnanes, processes for their preparation and pharmaceutical compositions containing same
DD268954A1 (en) * 1983-04-22 1989-06-14 Jenapharm Veb PROCESS FOR THE PREPARATION OF 9ALPHA HALOGEN 11BETA FORMYLOXYSTEROIDS OF THE PREGNANIUM SERIES
FR2675146A1 (en) * 1991-04-10 1992-10-16 Roussel Uclaf NOVEL STEROUID DERIVATIVES OF PREGNA-1,4-DIENE-3,20-DIONE, THEIR PREPARATION, THEIR APPLICATION TO THE PREPARATION OF SUBSTITUTED 16,17-METHYLENE DIOXY DERIVATIVES, AND NOVEL INTERMEDIATES

Also Published As

Publication number Publication date
EP0873352A1 (en) 1998-10-28
CN1209138A (en) 1999-02-24
IL125004A0 (en) 1999-01-26
NO982877D0 (en) 1998-06-19
CZ191398A3 (en) 1998-11-11
WO1997022616A1 (en) 1997-06-26
PL327141A1 (en) 1998-11-23
MX9804957A (en) 1998-09-30
NO982877L (en) 1998-08-20
JP2000502102A (en) 2000-02-22
AU1331097A (en) 1997-07-14
KR20000064495A (en) 2000-11-06

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law