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BR9608799A - Análogo pro-grf corpo graxo quimérico com aumentada potência biológica, formulação farmacêutica, e, processos para o aumento do nìvel de hormÈnio de crescimento, para o diagnóstico de deficiências de hormÈnio de crescimento, para o tratamento de retardo do crescimento ou ananismo pituitário, de ferida ou cicratização de ossos e de osteoporose em um paciente, e, para melhoria do anabolismo de proteìna em humanos ou animais. - Google Patents

Análogo pro-grf corpo graxo quimérico com aumentada potência biológica, formulação farmacêutica, e, processos para o aumento do nìvel de hormÈnio de crescimento, para o diagnóstico de deficiências de hormÈnio de crescimento, para o tratamento de retardo do crescimento ou ananismo pituitário, de ferida ou cicratização de ossos e de osteoporose em um paciente, e, para melhoria do anabolismo de proteìna em humanos ou animais.

Info

Publication number
BR9608799A
BR9608799A BR9608799-4A BR9608799A BR9608799A BR 9608799 A BR9608799 A BR 9608799A BR 9608799 A BR9608799 A BR 9608799A BR 9608799 A BR9608799 A BR 9608799A
Authority
BR
Brazil
Prior art keywords
growth hormone
grf
diagnosis
growth
treatment
Prior art date
Application number
BR9608799-4A
Other languages
English (en)
Other versions
BR9608799B1 (pt
Inventor
Michel Ibea
Thierry Abribat
Paul Brazeau
Original Assignee
Theratechnologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27036979&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9608799(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Theratechnologies Inc filed Critical Theratechnologies Inc
Publication of BR9608799A publication Critical patent/BR9608799A/pt
Publication of BR9608799B1 publication Critical patent/BR9608799B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Nutrition Science (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Obesity (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)

Abstract

"ANáLOGO PRO-GRF - CORPO GRAXO QUIMéRICO COM AUMENTADA POTêNCIA BIOLóGICA, FORMULAçãO FARMACêUTICA, E, PROCESSOS PARA O AUMENTO DO NìVEL DE HORMÈNIO DE CRESCIMENTO, PARA O DIAGNóSTICO DE DEFICIêNCIAS DE HORMÈNIO DE CRESCIMENTO, PARA O TRATAMENTO DE RETARDO DO CRESCIMENTO OU ANANISMO PITUITáRIO, DE FERIDA OU CICATRIZAçãO DE OSSOS E DE OSTEOPOROSE EM UM PACIENTE, E, PARA MELHORIA DO ANABOLISMO DE PROTEìNA EM HUMANOS OU ANIMAIS". A presente invenção refere-se a análogos de pro-GRF corpo-graxo quiméricos com aumentada potência biológica, sua aplicação como agentes anabólicos e no diagnóstico e tratamento de deficiências de hormónio de crescimento. Os análogos pro-GRF -corpo graxo quiméricos incluem uma porção hidrófoba (cauda) e podem ser preparados, ou por ancoragem de uma ou várias caudas hidrófobas ao GRF, ou por substituição de um ou vários aminoácidos por um resíduo pseudomicelar na síntese química de GRF. Os análogos de GRF da presente invenção são biodegradáveis, não imunogênicos e demonstram uma melhorada potência anabólica com uma dosagem reduzida e atividade prolongada.
BRPI9608799-4A 1995-05-26 1996-05-22 análogo pró-grf -corpo graxo quimérico com aumentada potência biológica, e, formulação farmacêutica. BR9608799B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45306795A 1995-05-26 1995-05-26
US65164596A 1996-05-22 1996-05-22
PCT/CA1996/000327 WO1996037514A1 (en) 1995-05-26 1996-05-22 Chimeric fatty body-pro-grf analogs with increased biological potency

Publications (2)

Publication Number Publication Date
BR9608799A true BR9608799A (pt) 1999-12-07
BR9608799B1 BR9608799B1 (pt) 2009-12-01

Family

ID=27036979

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI9608799-4A BR9608799B1 (pt) 1995-05-26 1996-05-22 análogo pró-grf -corpo graxo quimérico com aumentada potência biológica, e, formulação farmacêutica.
BRPI9608799A BRPI9608799B8 (pt) 1995-05-26 1996-05-22 análogo pró-grf -corpo graxo quimérico com aumentada potência biológica, e, formulação farmacêutica.

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI9608799A BRPI9608799B8 (pt) 1995-05-26 1996-05-22 análogo pró-grf -corpo graxo quimérico com aumentada potência biológica, e, formulação farmacêutica.

Country Status (13)

Country Link
US (2) US5939386A (pt)
EP (1) EP0828758B1 (pt)
JP (1) JP3576170B2 (pt)
KR (1) KR100543190B1 (pt)
AT (1) ATE204881T1 (pt)
AU (1) AU697119B2 (pt)
BR (2) BR9608799B1 (pt)
CA (1) CA2222068C (pt)
DE (1) DE69614849T2 (pt)
DK (1) DK0828758T3 (pt)
ES (1) ES2163020T3 (pt)
PT (1) PT828758E (pt)
WO (1) WO1996037514A1 (pt)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458764B1 (en) * 1995-05-26 2002-10-01 Theratechnologies Inc. GRF analogs with increased biological potency
US6020311A (en) * 1995-05-26 2000-02-01 Theratechnologies, Inc. GRF analogs with increased biological potency
US6121416A (en) 1997-04-04 2000-09-19 Genentech, Inc. Insulin-like growth factor agonist molecules
US6420518B1 (en) 1997-04-04 2002-07-16 Genetech, Inc. Insulin-like growth factor agonist molecules
US6696063B1 (en) 1998-12-30 2004-02-24 Applied Research Systems Ars Holding N.V. Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy
WO2000040613A1 (en) 1999-01-06 2000-07-13 Genentech, Inc. Insulin-like growth factor (igf) i mutant variants
US6759393B1 (en) 1999-04-12 2004-07-06 Pfizer Inc. Growth hormone and growth hormone releasing hormone compositions
BR0001606A (pt) * 1999-04-12 2001-04-24 Pfizer Prod Inc Composições de hormÈnio de crescimento e de hormÈnio de liberação de hormÈnio de crescimento
EP1282437B1 (en) 2000-05-16 2008-03-19 Genentech, Inc. Treatment of cartilage disorders
JP2004509079A (ja) * 2000-08-02 2004-03-25 セラテクノロジーズ・インコーポレーテッド 効力が増大した修飾生体ペプチド
EP1205551A1 (en) * 2000-11-09 2002-05-15 Pfizer Products Inc. Growth hormone and growth hormone releasing hormone compositions
FR2851461B1 (fr) * 2003-02-21 2007-04-20 Seppic Sa Utilisation de n-octanoyl aminoacides comme actif cosmetique et pharmaceutique amincissant
WO2004105789A1 (en) * 2003-05-29 2004-12-09 Theratechnologies Inc. Grf analog compositions and their use
CN102861321A (zh) 2003-09-12 2013-01-09 特西卡股份有限公司 胰岛素样生长因子-1(igf-1)缺陷的治疗方法
AU2004281084B2 (en) * 2003-10-20 2010-08-12 Theratechnologies Inc. Use of growth hormone releasing factor analogs in treating patients suffering from wasting
EP2952522B1 (en) 2007-01-31 2019-10-30 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
ES2610531T3 (es) 2007-03-28 2017-04-28 President And Fellows Of Harvard College Polipéptidos cosidos
US20100267635A1 (en) * 2009-04-20 2010-10-21 Theratechonolgies Inc. Use of protease inhibitors and grf molecules in combination therapy
US20100267636A1 (en) * 2009-04-20 2010-10-21 Theratechnologies Inc. Use of cytochrome p450-metabolized drugs and grf molecules in combination therapy
RU2582678C2 (ru) 2010-08-13 2016-04-27 Эйлерон Терапьютикс, Инк. Пептидомиметические макроциклы
US20130261058A1 (en) * 2010-09-16 2013-10-03 University Of Miami Acceleration of wound healing by growth hormone releasing hormone and its agonists
MX2013012259A (es) 2011-04-21 2013-11-22 Theratechnologies Inc Analogos del factor de liberacion de la hormona de crecimiento (grf) y usos de estos.
AR088392A1 (es) 2011-10-18 2014-05-28 Aileron Therapeutics Inc Macrociclos peptidomimeticos
US8987414B2 (en) 2012-02-15 2015-03-24 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
MX362492B (es) 2012-02-15 2019-01-21 Aileron Therapeutics Inc Macrociclos peptidomiméticos.
CN102702343A (zh) * 2012-06-14 2012-10-03 吉尔生化（上海）有限公司 一种固相合成替莫瑞林的方法
WO2013190520A2 (en) 2012-06-22 2013-12-27 The General Hospital Corporation Gh-releasing agents in the treatment of vascular stenosis and associated conditions
AU2013337388B2 (en) 2012-11-01 2018-08-02 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
US8871713B2 (en) * 2013-03-01 2014-10-28 Theratechnologies Inc. Formulations of growth hormone releasing factor (GRF) molecules with improved stability
BR112017005598A2 (pt) 2014-09-24 2017-12-12 Aileron Therapeutics Inc macrociclos peptidomiméticos e usos dos mesmos
KR20170129879A (ko) 2015-03-20 2017-11-27 에일러론 테라퓨틱스 인코포레이티드 펩티드모방 거대고리 및 이의 용도
HUE052802T2 (hu) 2016-04-19 2021-05-28 Griffon Pharmaceuticals Int Sa Pegilezett bioaktív peptidek és alkalmazásaik
WO2024091863A1 (en) * 2022-10-25 2024-05-02 Starrock Pharma Llc Combinatorial, and rotational combinatorial therapies for obesity and other diseases

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US4622312A (en) * 1984-09-24 1986-11-11 Hoffmann-La Roche Inc. Growth hormone releasing factor analogs
CA1271600A (en) * 1985-01-07 1990-07-10 David Howard Coy Growth hormone-releasing peptides and method of treating mammals therewith
US4870054A (en) * 1985-09-27 1989-09-26 Recker Robert R Treatment for osteoporosis using GRF or a biologically active analog thereof
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Also Published As

Publication number Publication date
PT828758E (pt) 2002-02-28
DK0828758T3 (da) 2002-01-07
BRPI9608799B8 (pt) 2019-11-05
US5861379A (en) 1999-01-19
AU697119B2 (en) 1998-09-24
KR19990021938A (ko) 1999-03-25
MX9709098A (es) 1998-06-30
EP0828758A1 (en) 1998-03-18
WO1996037514A1 (en) 1996-11-28
BR9608799B1 (pt) 2009-12-01
ES2163020T3 (es) 2002-01-16
JPH11505807A (ja) 1999-05-25
KR100543190B1 (ko) 2006-06-23
ATE204881T1 (de) 2001-09-15
DE69614849T2 (de) 2002-05-16
EP0828758B1 (en) 2001-08-29
US5939386A (en) 1999-08-17
CA2222068C (en) 2007-04-10
JP3576170B2 (ja) 2004-10-13
DE69614849D1 (de) 2001-10-04
CA2222068A1 (en) 1996-11-28
AU5683396A (en) 1996-12-11

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