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BR9507477A - Diagnostic image analysis methods using metal complexes of macrocyclic ligands containing nitrogen - Google Patents

Diagnostic image analysis methods using metal complexes of macrocyclic ligands containing nitrogen

Info

Publication number
BR9507477A
BR9507477A BR9507477A BR9507477A BR9507477A BR 9507477 A BR9507477 A BR 9507477A BR 9507477 A BR9507477 A BR 9507477A BR 9507477 A BR9507477 A BR 9507477A BR 9507477 A BR9507477 A BR 9507477A
Authority
BR
Brazil
Prior art keywords
image analysis
metal complexes
containing nitrogen
analysis methods
diagnostic image
Prior art date
Application number
BR9507477A
Other languages
Portuguese (pt)
Inventor
John Charles Alexander
Patrick James Lennon
Anil Shrikrishna Modak
William Lojda Neumann
Dennis Patrick Riley
Randy Herman Weiss
Original Assignee
Searle & Co
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co, Monsanto Co filed Critical Searle & Co
Publication of BR9507477A publication Critical patent/BR9507477A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
BR9507477A 1994-04-22 1995-03-24 Diagnostic image analysis methods using metal complexes of macrocyclic ligands containing nitrogen BR9507477A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23159994A 1994-04-22 1994-04-22
US39746995A 1995-03-01 1995-03-01
PCT/US1995/003763 WO1995028968A1 (en) 1994-04-22 1995-03-24 Diagnostic image analysis with metal complexes

Publications (1)

Publication Number Publication Date
BR9507477A true BR9507477A (en) 1997-09-16

Family

ID=26925257

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9507477A BR9507477A (en) 1994-04-22 1995-03-24 Diagnostic image analysis methods using metal complexes of macrocyclic ligands containing nitrogen

Country Status (13)

Country Link
EP (1) EP0756495A1 (en)
JP (1) JPH10500401A (en)
CN (1) CN1152880A (en)
AU (1) AU706642B2 (en)
BR (1) BR9507477A (en)
CA (1) CA2188530A1 (en)
CZ (1) CZ307096A3 (en)
FI (1) FI964236A (en)
HU (1) HUT76318A (en)
NO (1) NO964476L (en)
NZ (1) NZ283279A (en)
PL (1) PL316968A1 (en)
WO (1) WO1995028968A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6525041B1 (en) * 1995-06-06 2003-02-25 Pharmacia Corporation Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
WO1996040658A1 (en) * 1995-06-07 1996-12-19 Monsanto Company Process for preparing substituted polyazamacrocycles
JP2000513322A (en) * 1995-08-17 2000-10-10 モンサント カンパニー Biomolecular conjugates of manganese complexes of nitrogen-containing macrocyclic ligands useful as catalysts for dismutating superoxide
CA2229777A1 (en) * 1995-08-17 1997-02-27 Monsanto Company Methods of diagnostic image analysis using metal complexes of nitrogen-containing macrocyclic ligands
JPH11511168A (en) * 1995-08-17 1999-09-28 モンサント カンパニー Diagnostic imaging method using biomolecule conjugate of metal complex of nitrogen-containing macrocyclic ligand
JP2000507929A (en) * 1996-03-13 2000-06-27 モンサント カンパニー Iron Complexes with Nitrogen-Containing Macrocycle Ligands Effective as Catalysts for Dismutatin Superoxide
US6214817B1 (en) 1997-06-20 2001-04-10 Monsanto Company Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity
JP2003500174A (en) 1999-05-27 2003-01-07 フアルマシア・コーポレーシヨン Biomaterials modified with superoxide dismutase mimics
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
EP1362861B1 (en) * 1999-09-13 2005-12-14 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
EP1246830B1 (en) * 1999-09-13 2003-11-12 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
US20040137638A1 (en) 2002-03-04 2004-07-15 Slomczynska Urszula J. Chromatography of metal complexes
ES2331911T3 (en) * 2002-06-17 2010-01-20 Saltigo Gmbh PROCEDURE FOR THE PREPARATION OF MONO-N-SULFONILATED DIAMINS.
FR2857967B1 (en) * 2003-07-25 2015-04-24 Centre Nat Rech Scient LANTHANIDE COMPLEXES, THEIR PREPARATION AND USES THEREOF
HUE044234T2 (en) 2006-10-12 2019-10-28 Galera Labs Llc Methods of treating oral mucositis
DK3098225T3 (en) * 2008-12-02 2019-03-25 Univ Melbourne NITROGEN CONTAINING MACROCYCLIC CONJUGATES AS RADIO PHARMACY
CA3120505A1 (en) 2011-09-26 2013-04-04 Galera Labs, Llc Methods for treatment of diseases
EP3738967A1 (en) 2015-08-11 2020-11-18 Galera Labs, LLC Pentaaza macrocyclic ring complexes possessing oral bioavailability
IL300085A (en) 2016-05-03 2023-03-01 Galera Labs Llc Combined treatment for cancer
WO2018045348A2 (en) 2016-09-01 2018-03-08 Galera Labs, Llc Combination cancer therapy with pentaaza macrocyclic ring complex and ascorbate compound
IL295620B2 (en) 2017-04-13 2024-01-01 Galera Labs Llc Combination cancer immunotherapy with pentaaza macrocyclic ring complex

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001212A (en) * 1973-10-03 1977-01-04 E. I. Du Pont De Nemours And Company Macrocyclic polyamines
US3930867A (en) * 1974-01-07 1976-01-06 E. I. Du Pont De Nemours And Company Macrocyclic polyamines as sensitizers for silver halide emulsions
NO149961C (en) * 1981-06-01 1984-07-25 Borregaard Ind PROCEDURE FOR THE PREPARATION OF N- (2-HYDROXYethyl) DERIVATIVES OF MACROCYCLIC POLYAMINES, CONTAINING MULTIPLE 1.4 NITROGEN ATOMS IN THE RING
JPS6314780A (en) * 1986-07-08 1988-01-21 Tosoh Corp Crown ether-linked macrocyclic polyamines and their production method
FR2614020B1 (en) * 1987-04-14 1989-07-28 Guerbet Sa NOVEL NITROGEN CYCLIC LIGANDS, METAL COMPLEXES FORMED BY SUCH LIGANDS, DIAGNOSTIC COMPOSITIONS CONTAINING THESE COMPLEXES AND PROCESS FOR PREPARING LIGANDS.
US4994560A (en) * 1987-06-24 1991-02-19 The Dow Chemical Company Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies
JPH03197468A (en) * 1989-12-26 1991-08-28 Teijin Ltd Bifunctional large cyclic chelate ligand and its preparation
US5162109A (en) * 1990-09-13 1992-11-10 Mallinckrodt Medical, Inc. Magnetic resonance imaging agents
WO1992021017A1 (en) * 1991-05-23 1992-11-26 Unger Evan C Liposoluble compounds for magnetic resonance imaging
DE69224839T2 (en) * 1991-07-19 1998-10-08 Monsanto Co Manganese complexes with nitrogen-containing macrocyclic ligands, effective as superoxide dismutase catalysts.
US6204259B1 (en) * 1993-01-14 2001-03-20 Monsanto Company Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide

Also Published As

Publication number Publication date
FI964236A (en) 1996-12-19
AU706642B2 (en) 1999-06-17
NO964476L (en) 1996-12-11
HUT76318A (en) 1997-08-28
NO964476D0 (en) 1996-10-21
AU2128895A (en) 1995-11-16
CN1152880A (en) 1997-06-25
NZ283279A (en) 1998-01-26
PL316968A1 (en) 1997-03-03
JPH10500401A (en) 1998-01-13
WO1995028968A1 (en) 1995-11-02
HU9602927D0 (en) 1996-12-30
EP0756495A1 (en) 1997-02-05
CZ307096A3 (en) 1997-09-17
FI964236A0 (en) 1996-10-21
CA2188530A1 (en) 1995-11-02

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Legal Events

Date Code Title Description
FB36 Technical and formal requirements: requirement - article 36 of industrial property law
FA8 Dismissal: dismissal - article 36, par. 1 of industrial property law